LOCUS       NM_145837               1311 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus interleukin 17D (Il17d), mRNA.
ACCESSION   NM_145837 XM_979616 XM_991920
VERSION     NM_145837.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1311)
  AUTHORS   Huang,J., Lee,H.Y., Zhao,X., Han,J., Su,Y., Sun,Q., Shao,J., Ge,J.,
            Zhao,Y., Bai,X., He,Y., Wang,X., Wang,X. and Dong,C.
  TITLE     Interleukin-17D regulates group 3 innate lymphoid cell function
            through its receptor CD93
  JOURNAL   Immunity 54 (4), 673-686 (2021)
   PUBMED   33852831
REFERENCE   2  (bases 1 to 1311)
  AUTHORS   Washington,A. Jr., Varki,N., Valderrama,J.A., Nizet,V. and Bui,J.D.
  TITLE     Evaluation of IL-17D in Host Immunity to Group A Streptococcus
            Infection
  JOURNAL   J Immunol 205 (11), 3122-3129 (2020)
   PUBMED   33077643
REFERENCE   3  (bases 1 to 1311)
  AUTHORS   Lee,Y., Clinton,J., Yao,C. and Chang,S.H.
  TITLE     Interleukin-17D Promotes Pathogenicity During Infection by
            Suppressing CD8 T Cell Activity
  JOURNAL   Front Immunol 10, 1172 (2019)
   PUBMED   31244826
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1311)
  AUTHORS   Seelige,R., Saddawi-Konefka,R., Adams,N.M., Picarda,G., Sun,J.C.,
            Benedict,C.A. and Bui,J.D.
  TITLE     Interleukin-17D and Nrf2 mediate initial innate immune cell
            recruitment and restrict MCMV infection
  JOURNAL   Sci Rep 8 (1), 13670 (2018)
   PUBMED   30209334
  REMARK    GeneRIF: Mice deficient in IL-17D or the transcription factor
            Nuclear factor (erythroid-derived 2)-like 2 (Nrf2), an inducer of
            IL-17D, featured an early decreased number of innate immune cells
            at the point of viral entry and were more susceptible to mouse
            cytomegalovirus infection.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1311)
  AUTHORS   Seelige,R., Washington,A. Jr. and Bui,J.D.
  TITLE     The ancient cytokine IL-17D is regulated by Nrf2 and mediates tumor
            and virus surveillance
  JOURNAL   Cytokine 91, 10-12 (2017)
   PUBMED   27940089
  REMARK    GeneRIF: a new role for nuclear factor erythroid-derived 2-like 2
            (Nrf2) in regulating early anti-cancer immune responses by inducing
            IL-17D and recruiting natural killer (NK) cells.
            Review article
REFERENCE   6  (bases 1 to 1311)
  AUTHORS   Saddawi-Konefka,R., Seelige,R., Gross,E.T., Levy,E., Searles,S.C.,
            Washington,A. Jr., Santosa,E.K., Liu,B., O'Sullivan,T.E.,
            Harismendy,O. and Bui,J.D.
  TITLE     Nrf2 Induces IL-17D to Mediate Tumor and Virus Surveillance
  JOURNAL   Cell Rep 16 (9), 2348-2358 (2016)
   PUBMED   27545889
  REMARK    GeneRIF: Nrf2 Induces IL-17D to mediate tumor and virus
            surveillance.
REFERENCE   7  (bases 1 to 1311)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   8  (bases 1 to 1311)
  AUTHORS   Hurst,S.D., Muchamuel,T., Gorman,D.M., Gilbert,J.M., Clifford,T.,
            Kwan,S., Menon,S., Seymour,B., Jackson,C., Kung,T.T.,
            Brieland,J.K., Zurawski,S.M., Chapman,R.W., Zurawski,G. and
            Coffman,R.L.
  TITLE     New IL-17 family members promote Th1 or Th2 responses in the lung:
            in vivo function of the novel cytokine IL-25
  JOURNAL   J Immunol 169 (1), 443-453 (2002)
   PUBMED   12077275
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154675.2.
            
            On Mar 14, 2022 this sequence version replaced NM_145837.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF458063.1, AK131917.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               AC154675.2         145094-145275
            183-478             AC154675.2         145658-145953
            479-1311            AC154675.2         162688-163520
FEATURES             Location/Qualifiers
     source          1..1311
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 30.1 cM"
     gene            1..1311
                     /gene="Il17d"
                     /gene_synonym="IL-17D"
                     /note="interleukin 17D"
                     /db_xref="GeneID:239114"
                     /db_xref="MGI:MGI:2446510"
     exon            1..182
                     /gene="Il17d"
                     /gene_synonym="IL-17D"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..785
                     /gene="Il17d"
                     /gene_synonym="IL-17D"
                     /codon_start=1
                     /product="interleukin-17D precursor"
                     /protein_id="NP_665836.2"
                     /db_xref="CCDS:CCDS49507.1"
                     /db_xref="GeneID:239114"
                     /db_xref="MGI:MGI:2446510"
                     /translation="MLGTLVWMLAVGFLLALAPGRAAGALRTGRRPARPRDCADRPEE
                     LLEQLYGRLAAGVLSAFHHTLQLGPREQARNASCPAGGRAADRRFRPPTNLRSVSPWA
                     YRISYDPARFPRYLPEAYCLCRGCLTGLYGEEDFRFRSTPVFSPAVVLRRTAACAGGR
                     SVYAEHYITIPVGCTCVPEPDKSADSANSSMDKLLLGPADRPAGR"
     exon            183..478
                     /gene="Il17d"
                     /gene_synonym="IL-17D"
                     /inference="alignment:Splign:2.1.0"
     exon            479..1311
                     /gene="Il17d"
                     /gene_synonym="IL-17D"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1285..1290
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il17d"
                     /gene_synonym="IL-17D"
                     /note="hexamer: ATTAAA"
     polyA_site      1311
                     /gene="Il17d"
                     /gene_synonym="IL-17D"
                     /note="major polyA site"
ORIGIN      
        1 agtcaccacc tcctcctcct ccagccaggc ggaccgccag tccacttctg taggggcgac
       61 acccagcccg caggccacac gccccgcgtg tgcggcgccc ttatttactt cgcagaagag
      121 ccttcagccc ccctcctaac aagtctggaa agcatcacgg cgacgcgatg ttggggacac
      181 tggtctggat gctcgcggtc ggcttcctgc tggcactggc gccgggccgc gcggcgggcg
      241 cgctgaggac cgggaggcgc ccggcgcggc cgcgggactg cgcggaccgg ccggaggagc
      301 tcctggagca gctgtacggg cggctggcgg ccggcgtgct cagcgccttc caccacacgc
      361 tgcagctcgg gccgcgcgag caggcgcgca atgccagctg cccggccggg ggcagggccg
      421 ccgaccgccg cttccggcca cccaccaacc tgcgcagcgt gtcgccctgg gcgtacagga
      481 tttcctacga ccctgctcgc tttccgaggt acctgcccga agcctactgc ctgtgccgag
      541 gctgcctgac cgggctctac ggggaggagg acttccgctt tcgcagcaca cccgtcttct
      601 ctccagccgt ggtgctgcgg cgcacagcgg cctgcgcggg cggccgctct gtgtacgccg
      661 aacactacat caccatcccg gtgggctgca cctgcgtgcc cgagccggac aagtccgcgg
      721 acagtgcgaa ctccagcatg gacaagctgc tgctggggcc cgccgacagg cctgcggggc
      781 gctgatgccg gggactgccc gccatggccc agcttcctgc atgcatcagg tcccctggcc
      841 ctgacaaaac ccaccccatg atccctggcc gctgcctaat ttttccaaaa ggacagctac
      901 ataagcttta aatatatttt tcaaagtaga cactacatat ctacaactat tttgaatagt
      961 ggcagaaact attttcatat tagtaattta gagcaagcat gttgttttta aacttctttg
     1021 atatacaagc acatcacaca catcccgttt tcctctagta ggattcttga gtgcataatt
     1081 gtagtgctca gatgaacttc cttctgctgc actgtgccct gtccctgagt ctctcctgtg
     1141 gcccaagctt actaaggtga taatgagtgc tccggatctg ggcacctaag gtctccaggt
     1201 ccctggagag ggagggatgt gggggggcta ggaaccaagc gcccctttgt tctttagctt
     1261 atggatggtc ttaactttat aaagattaaa gtttttggtg ttattctttc a
//
