LOCUS       NM_145834                719 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus interleukin 17C (Il17c), mRNA.
ACCESSION   NM_145834 XM_001478158 XM_001478613
VERSION     NM_145834.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 719)
  AUTHORS   Zhang,F., Yin,J., Liu,L., Liu,S., Zhang,G., Kong,Y., Wang,Y.,
            Wang,N., Chen,X. and Wang,F.
  TITLE     IL-17C neutralization protects the kidney against acute injury and
            chronic injury
  JOURNAL   EBioMedicine 92, 104607 (2023)
   PUBMED   37263138
  REMARK    GeneRIF: IL-17C neutralization protects the kidney against acute
            injury and chronic injury.
REFERENCE   2  (bases 1 to 719)
  AUTHORS   Lin,X., Gaudino,S.J., Jang,K.K., Bahadur,T., Singh,A., Banerjee,A.,
            Beaupre,M., Chu,T., Wong,H.T., Kim,C.K., Kempen,C., Axelrad,J.,
            Huang,H., Khalid,S., Shah,V., Eskiocak,O., Parks,O.B., Berisha,A.,
            McAleer,J.P., Good,M., Hoshino,M., Blumberg,R., Bialkowska,A.B.,
            Gaffen,S.L., Kolls,J.K., Yang,V.W., Beyaz,S., Cadwell,K. and
            Kumar,P.
  TITLE     IL-17RA-signaling in Lgr5+ intestinal stem cells induces expression
            of transcription factor ATOH1 to promote secretory cell lineage
            commitment
  JOURNAL   Immunity 55 (2), 237-253 (2022)
   PUBMED   35081371
REFERENCE   3  (bases 1 to 719)
  AUTHORS   Vella,G., Ritzmann,F., Wolf,L., Kamyschnikov,A., Stodden,H.,
            Herr,C., Slevogt,H., Bals,R. and Beisswenger,C.
  TITLE     IL-17C contributes to NTHi-induced inflammation and lung damage in
            experimental COPD and is present in sputum during acute
            exacerbations
  JOURNAL   PLoS One 16 (1), e0243484 (2021)
   PUBMED   33411748
  REMARK    GeneRIF: IL-17C contributes to NTHi-induced inflammation and lung
            damage in experimental COPD and is present in sputum during acute
            exacerbations.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 719)
  AUTHORS   Wang,F., Yin,J., Lin,Y., Zhang,F., Liu,X., Zhang,G., Kong,Y.,
            Lu,Z., Wu,R., Wang,N., Xing,T. and Qian,Y.
  TITLE     IL-17C has a pathogenic role in kidney ischemia/reperfusion injury
  JOURNAL   Kidney Int 97 (6), 1219-1229 (2020)
   PUBMED   32331702
  REMARK    GeneRIF: IL-17C has a pathogenic role in kidney
            ischemia/reperfusion injury.
REFERENCE   5  (bases 1 to 719)
  AUTHORS   Nies,J.F. and Panzer,U.
  TITLE     IL-17C/IL-17RE: Emergence of a Unique Axis in TH17 Biology
  JOURNAL   Front Immunol 11, 341 (2020)
   PUBMED   32174926
  REMARK    GeneRIF: IL-17C/IL-17RE: Emergence of a Unique Axis in TH17
            Biology.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 719)
  AUTHORS   Hu,Y., Ota,N., Peng,I., Refino,C.J., Danilenko,D.M., Caplazi,P. and
            Ouyang,W.
  TITLE     IL-17RC is required for IL-17A- and IL-17F-dependent signaling and
            the pathogenesis of experimental autoimmune encephalomyelitis
  JOURNAL   J Immunol 184 (8), 4307-4316 (2010)
   PUBMED   20231694
REFERENCE   7  (bases 1 to 719)
  AUTHORS   Zheng,Y., Valdez,P.A., Danilenko,D.M., Hu,Y., Sa,S.M., Gong,Q.,
            Abbas,A.R., Modrusan,Z., Ghilardi,N., de Sauvage,F.J. and Ouyang,W.
  TITLE     Interleukin-22 mediates early host defense against attaching and
            effacing bacterial pathogens
  JOURNAL   Nat Med 14 (3), 282-289 (2008)
   PUBMED   18264109
REFERENCE   8  (bases 1 to 719)
  AUTHORS   Yamaguchi,Y., Fujio,K., Shoda,H., Okamoto,A., Tsuno,N.H.,
            Takahashi,K. and Yamamoto,K.
  TITLE     IL-17B and IL-17C are associated with TNF-alpha production and
            contribute to the exacerbation of inflammatory arthritis
  JOURNAL   J Immunol 179 (10), 7128-7136 (2007)
   PUBMED   17982105
  REMARK    GeneRIF: IL-17B and IL-17C play an important role in the
            pathogenesis of inflammatory arthritis.
REFERENCE   9  (bases 1 to 719)
  AUTHORS   Kesavan,C., Baylink,D.J., Kapoor,S. and Mohan,S.
  TITLE     Novel loci regulating bone anabolic response to loading: expression
            QTL analysis in C57BL/6JXC3H/HeJ mice cross
  JOURNAL   Bone 41 (2), 223-230 (2007)
   PUBMED   17543594
REFERENCE   10 (bases 1 to 719)
  AUTHORS   Hurst,S.D., Muchamuel,T., Gorman,D.M., Gilbert,J.M., Clifford,T.,
            Kwan,S., Menon,S., Seymour,B., Jackson,C., Kung,T.T.,
            Brieland,J.K., Zurawski,S.M., Chapman,R.W., Zurawski,G. and
            Coffman,R.L.
  TITLE     New IL-17 family members promote Th1 or Th2 responses in the lung:
            in vivo function of the novel cytokine IL-25
  JOURNAL   J Immunol 169 (1), 443-453 (2002)
   PUBMED   12077275
  REMARK    GeneRIF: Intranasal administration of adenovirus expressing IL-17
            results in bronchoalveolar lavage neutrophilia and Th1-type
            inflammatory gene expression in the lung.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC145853.1.
            
            [WARNING] On Sep 4, 2024 this sequence was replaced by NM_145834.5.
            
            On Jul 12, 2017 this sequence version replaced NM_145834.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC145853.1, AF458061.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-719               BC145853.1         1-719
FEATURES             Location/Qualifiers
     source          1..719
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 71.03 cM"
     gene            1..719
                     /gene="Il17c"
                     /gene_synonym="IL-17C"
                     /note="interleukin 17C"
                     /db_xref="GeneID:234836"
                     /db_xref="MGI:MGI:2446486"
     exon            1..386
                     /gene="Il17c"
                     /gene_synonym="IL-17C"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..648
                     /gene="Il17c"
                     /gene_synonym="IL-17C"
                     /note="cytokine CX2"
                     /codon_start=1
                     /product="interleukin-17C"
                     /protein_id="NP_665833.4"
                     /db_xref="CCDS:CCDS90473.1"
                     /db_xref="GeneID:234836"
                     /db_xref="MGI:MGI:2446486"
                     /translation="MTHQDPPSWGKPRSHRTLRCYSAEELSHGQAPPHLLTRSARWEQ
                     ALPVALVASLEATGHRRQHEGPLAGTQCPVLRPEEVLEADTHERSISPWRYRIDTDEN
                     RYPQKLAVAECLCRGCINAKTGRETAALNSVQLLQSLLVLRRQPCSRDGTADPTPGSF
                     AFHTEFIRVPVGCTCVLPRSTQ"
     exon            387..719
                     /gene="Il17c"
                     /gene_synonym="IL-17C"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaaccttgg gaggaaatgg gtgttctctg ggcttcccct aaccatgcac ctgccttgct
       61 ccacagagtc tcctgcttct aggctggttg cctactggga tgacccacca agatcccccg
      121 tcctggggga aaccccgaag ccataggacc ctgcggtgct actctgctga ggaattatct
      181 cacggccagg ctcctccaca cctgctaact cgaagtgcca ggtgggagca ggccctccct
      241 gtggccctgg tggccagttt ggaggccacg ggccacagga gacagcatga aggacctcta
      301 gctggaacac agtgccccgt gctgcggccg gaggaggtgc tggaagctga cactcacgag
      361 cgctccatct caccatggag atatcgcatc gacacagatg agaaccgcta cccacagaag
      421 ctggcggtgg cagaatgctt gtgtcgtgga tgcatcaacg ccaagacagg ccgtgagaca
      481 gctgccctga actcggtgca gctgctgcag agcctgctgg tactacggcg acagccctgc
      541 tcccgagacg gcacggcgga ccctacacca ggatccttcg ccttccacac cgagttcatc
      601 cgcgtgcctg tcggctgcac ctgcgttctt cccaggtcta cacagtgatg acttctgtcg
      661 tggccccact gtggcgcatc acaatccttc caggacagac attccaggca cctccacag
//
