LOCUS       NM_019508                692 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Mus musculus interleukin 17B (Il17b), mRNA.
ACCESSION   NM_019508
VERSION     NM_019508.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 692)
  AUTHORS   Xiao,Y., Hu,Y., Gao,Y., Wang,L., Zhang,L., Ma,Q., Ning,Z., Yu,L.,
            Li,H., Liu,J., Wang,J., Yang,Y., Xiong,H. and Dong,G.
  TITLE     IL-17B alleviates the pathogenesis of systemic lupus erythematosus
            by inhibiting FASN-mediated differentiation of B cells
  JOURNAL   JCI Insight 9 (18), e181906 (2024)
   PUBMED   39115936
  REMARK    GeneRIF: IL-17B alleviates the pathogenesis of systemic lupus
            erythematosus by inhibiting FASN-mediated differentiation of B
            cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 692)
  AUTHORS   Huang,Y., Wu,L., Zhao,Y., Guo,J., Li,R., Ma,S. and Ying,Z.
  TITLE     Schwann cell promotes macrophage recruitment through IL-17B/IL-17RB
            pathway in injured peripheral nerves
  JOURNAL   Cell Rep 43 (2), 113753 (2024)
   PUBMED   38341853
REFERENCE   3  (bases 1 to 692)
  AUTHORS   Zhang,X., Zhang,X., Song,X., Xiang,C., He,C., Xie,Y., Zhou,Y.,
            Wang,N., Guo,G., Zhang,W., Li,Y., Liu,K., Zou,Q., Guo,H. and Shi,Y.
  TITLE     Interleukin 17 B regulates colonic myeloid cell infiltration in a
            mouse model of DSS-induced colitis
  JOURNAL   Front Immunol 14, 1055256 (2023)
   PUBMED   36814913
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 692)
  AUTHORS   Li,Y., Chen,J., Yang,Y., Wang,Y., Zhang,Y., Zhou,Y., Bao,Y.,
            Zhang,Z. and Lu,Y.
  TITLE     Necroptosis Plays a Crucial Role in Vascular Injury during DVT and
            Is Enhanced by IL-17B
  JOURNAL   J Immunol Res 2022, 6909764 (2022)
   PUBMED   36046722
  REMARK    GeneRIF: Necroptosis Plays a Crucial Role in Vascular Injury during
            DVT and Is Enhanced by IL-17B.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 692)
  AUTHORS   Yang,D., Chen,X., Wang,J., Lou,Q., Lou,Y., Li,L., Wang,H., Chen,J.,
            Wu,M., Song,X. and Qian,Y.
  TITLE     Dysregulated Lung Commensal Bacteria Drive Interleukin-17B
            Production to Promote Pulmonary Fibrosis through Their Outer
            Membrane Vesicles
  JOURNAL   Immunity 50 (3), 692-706 (2019)
   PUBMED   30824326
REFERENCE   6  (bases 1 to 692)
  AUTHORS   Chen,Z., Laurence,A., Kanno,Y., Pacher-Zavisin,M., Zhu,B.M.,
            Tato,C., Yoshimura,A., Hennighausen,L. and O'Shea,J.J.
  TITLE     Selective regulatory function of Socs3 in the formation of
            IL-17-secreting T cells
  JOURNAL   Proc Natl Acad Sci U S A 103 (21), 8137-8142 (2006)
   PUBMED   16698929
  REMARK    GeneRIF: Socs3 is an essential negative regulator of IL-23
            signaling, inhibition of which constrains the generation of
            IL-17-secreting T-cell differentiation
REFERENCE   7  (bases 1 to 692)
  AUTHORS   Vegvari,A., Szabo,Z., Szanto,S., Nesterovitch,A.B., Mikecz,K.,
            Glant,T.T. and Adarichev,V.A.
  TITLE     Two major interacting chromosome loci control disease
            susceptibility in murine model of spondyloarthropathy
  JOURNAL   J Immunol 175 (4), 2475-2483 (2005)
   PUBMED   16081819
REFERENCE   8  (bases 1 to 692)
  AUTHORS   You,Z., DuRaine,G., Tien,J.Y., Lee,C., Moseley,T.A. and Reddi,A.H.
  TITLE     Expression of interleukin-17B in mouse embryonic limb buds and
            regulation by BMP-7 and bFGF
  JOURNAL   Biochem Biophys Res Commun 326 (3), 624-631 (2005)
   PUBMED   15596145
  REMARK    GeneRIF: expressed in the mouse embryonic limb buds and may play a
            role in chondrogenesis and osteogenesis
REFERENCE   9  (bases 1 to 692)
  AUTHORS   Moore,E.E., Presnell,S., Garrigues,U., Guilbot,A., LeGuern,E.,
            Smith,D., Yao,L., Whitmore,T.E., Gilbert,T., Palmer,T.D.,
            Horner,P.J. and Kuestner,R.E.
  TITLE     Expression of IL-17B in neurons and evaluation of its possible role
            in the chromosome 5q-linked form of Charcot-Marie-Tooth disease
  JOURNAL   Neuromuscul Disord 12 (2), 141-150 (2002)
   PUBMED   11738356
REFERENCE   10 (bases 1 to 692)
  AUTHORS   Shi,Y., Ullrich,S.J., Zhang,J., Connolly,K., Grzegorzewski,K.J.,
            Barber,M.C., Wang,W., Wathen,K., Hodge,V., Fisher,C.L., Olsen,H.,
            Ruben,S.M., Knyazev,I., Cho,Y.H., Kao,V., Wilkinson,K.A.,
            Carrell,J.A. and Ebner,R.
  TITLE     A novel cytokine receptor-ligand pair. Identification, molecular
            characterization, and in vivo immunomodulatory activity
  JOURNAL   J Biol Chem 275 (25), 19167-19176 (2000)
   PUBMED   10749887
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF184970.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF184970.1, BC002271.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..692
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 34.67 cM"
     gene            1..692
                     /gene="Il17b"
                     /gene_synonym="1110006O16Rik; 1700006N07Rik; Zcyto7"
                     /note="interleukin 17B"
                     /db_xref="GeneID:56069"
                     /db_xref="MGI:MGI:1928397"
     exon            1..70
                     /gene="Il17b"
                     /gene_synonym="1110006O16Rik; 1700006N07Rik; Zcyto7"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..592
                     /gene="Il17b"
                     /gene_synonym="1110006O16Rik; 1700006N07Rik; Zcyto7"
                     /note="gene for cytokine-like protein; IL-17B; cytokine
                     CX1; cytokine-like protein ZCYTO7; neuronal
                     interleukin-17-related factor"
                     /codon_start=1
                     /product="interleukin-17B precursor"
                     /protein_id="NP_062381.1"
                     /db_xref="CCDS:CCDS29286.1"
                     /db_xref="GeneID:56069"
                     /db_xref="MGI:MGI:1928397"
                     /translation="MDWPHSLLFLLAISIFLAPSHPRNTKGKRKGQGRPSPLAPGPHQ
                     VPLDLVSRVKPYARMEEYERNLGEMVAQLRNSSEPAKKKCEVNLQLWLSNKRSLSPWG
                     YSINHDPSRIPADLPEARCLCLGCVNPFTMQEDRSMVSVPVFSQVPVRRRLCPQPPRP
                     GPCRQRVVMETIAVGCTCIF"
     exon            71..360
                     /gene="Il17b"
                     /gene_synonym="1110006O16Rik; 1700006N07Rik; Zcyto7"
                     /inference="alignment:Splign:2.1.0"
     exon            361..692
                     /gene="Il17b"
                     /gene_synonym="1110006O16Rik; 1700006N07Rik; Zcyto7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggttcctg gcgggtggca gctgcgggcc tgccgcctga cttggtggga tggactggcc
       61 gcacagcctg ctcttcctcc tggccatctc catcttcctg gcgccaagcc acccccggaa
      121 caccaaaggc aaaagaaaag ggcaagggag gcccagtccc ttggcccctg ggcctcatca
      181 ggtgccgctg gacctggtgt ctcgagtaaa gccctacgct cgaatggaag agtatgagcg
      241 gaaccttggg gagatggtgg cccagctgag gaacagctcc gagccagcca agaagaaatg
      301 tgaagtcaat ctacagctgt ggttgtccaa caagaggagc ctgtccccat ggggctacag
      361 catcaaccac gaccccagcc gcatccctgc ggacttgccc gaggcgcggt gcctatgttt
      421 gggttgcgtg aatcccttca ccatgcagga ggaccgtagc atggtgagcg tgccagtgtt
      481 cagccaggtg ccggtgcgcc gccgcctctg tcctcaacct cctcgccctg ggccctgccg
      541 ccagcgtgtc gtcatggaga ccatcgctgt gggttgcacc tgcatcttct gagccaacca
      601 ccaacccggt ggcctctgca acaaccctcc ctccctgcac ccactgtgac cctcaaggct
      661 gataaacagt aaacgctgtt ctttgtaaag ga
//
