LOCUS       NM_010552               1171 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus interleukin 17A (Il17a), mRNA.
ACCESSION   NM_010552
VERSION     NM_010552.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1171)
  AUTHORS   Penninger,P., Brezovec,H., Tsymala,I., Teufl,M., Phan-Canh,T.,
            Bitencourt,T., Brinkmann,M., Glaser,W., Ellmeier,W., Bonelli,M. and
            Kuchler,K.
  TITLE     HDAC1 fine-tunes Th17 polarization in vivo to restrain tissue
            damage in fungal infections
  JOURNAL   Cell Rep 43 (12), 114993 (2024)
   PUBMED   39580799
REFERENCE   2  (bases 1 to 1171)
  AUTHORS   Hajam,I.A., Tsai,C.M., Gonzalez,C., Caldera,J.R., Lazaro Diez,M.,
            Du,X., Aralar,A., Lin,B., Duong,W. and Liu,G.Y.
  TITLE     Pathobiont-induced suppressive immune imprints thwart T cell
            vaccine responses
  JOURNAL   Nat Commun 15 (1), 10335 (2024)
   PUBMED   39681568
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1171)
  AUTHORS   Zhong,X., Wu,H., Zhang,W., Shi,Y., Gwack,Y., Xue,H.H. and Sun,Z.
  TITLE     Distinct RORgammat-dependent Th17 immune responses are required for
            autoimmune pathogenesis and protection against bacterial infection
  JOURNAL   Cell Rep 43 (11), 114951 (2024)
   PUBMED   39504243
REFERENCE   4  (bases 1 to 1171)
  AUTHORS   Lee,Y., Awasthi,A., Yosef,N., Quintana,F.J., Xiao,S., Peters,A.,
            Wu,C., Kleinewietfeld,M., Kunder,S., Hafler,D.A., Sobel,R.A.,
            Regev,A. and Kuchroo,V.K.
  TITLE     Induction and molecular signature of pathogenic TH17 cells
  JOURNAL   Nat Immunol 13 (10), 991-999 (2012)
   PUBMED   22961052
REFERENCE   5  (bases 1 to 1171)
  AUTHORS   Torchinsky,M.B., Garaude,J., Martin,A.P. and Blander,J.M.
  TITLE     Innate immune recognition of infected apoptotic cells directs
            T(H)17 cell differentiation
  JOURNAL   Nature 458 (7234), 78-82 (2009)
   PUBMED   19262671
  REMARK    GeneRIF: infected apoptotic cells are a critical component of the
            innate immune signals instructing T(H)17 differentiation, and point
            to pathogens particularly adept at triggering apoptosis that might
            preferentially induce T(H)17-mediated immunity
REFERENCE   6  (bases 1 to 1171)
  AUTHORS   Lubberts,E., Joosten,L.A., Oppers,B., van den Bersselaar,L.,
            Coenen-de Roo,C.J., Kolls,J.K., Schwarzenberger,P., van de Loo,F.A.
            and van den Berg,W.B.
  TITLE     IL-1-independent role of IL-17 in synovial inflammation and joint
            destruction during collagen-induced arthritis
  JOURNAL   J Immunol 167 (2), 1004-1013 (2001)
   PUBMED   11441109
  REMARK    GeneRIF: IL-17 contributes to joint destruction during
            collagen-induced arthritis in an IL-1-independent manner and
            represents a target for the treatment of destructive arthritis.
REFERENCE   7  (bases 1 to 1171)
  AUTHORS   Kennedy,J., Rossi,D.L., Zurawski,S.M., Vega,F. Jr., Kastelein,R.A.,
            Wagner,J.L., Hannum,C.H. and Zlotnik,A.
  TITLE     Mouse IL-17: a cytokine preferentially expressed by alpha beta TCR
            + CD4-CD8-T cells
  JOURNAL   J Interferon Cytokine Res 16 (8), 611-617 (1996)
   PUBMED   8877732
REFERENCE   8  (bases 1 to 1171)
  AUTHORS   Yao,Z., Timour,M., Painter,S., Fanslow,W. and Spriggs,M.
  TITLE     Complete nucleotide sequence of the mouse CTLA8 gene
  JOURNAL   Gene 168 (2), 223-225 (1996)
   PUBMED   8654948
REFERENCE   9  (bases 1 to 1171)
  AUTHORS   Yao,Z., Fanslow,W.C., Seldin,M.F., Rousseau,A.M., Painter,S.L.,
            Comeau,M.R., Cohen,J.I. and Spriggs,M.K.
  TITLE     Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a
            novel cytokine receptor
  JOURNAL   Immunity 3 (6), 811-821 (1995)
   PUBMED   8777726
REFERENCE   10 (bases 1 to 1171)
  AUTHORS   Rouvier,E., Luciani,M.F., Mattei,M.G., Denizot,F. and Golstein,P.
  TITLE     CTLA-8, cloned from an activated T cell, bearing AU-rich messenger
            RNA instability sequences, and homologous to a herpesvirus saimiri
            gene
  JOURNAL   J Immunol 150 (12), 5445-5456 (1993)
   PUBMED   8390535
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK040420.1.
            
            On Apr 6, 2007 this sequence version replaced NM_010552.2.
            
            Summary: This gene encodes a pro-inflammatory cytokine that is a
            member of the interleukin-17 family. The encoded protein plays a
            central role in host defense against diverse pathogens. The encoded
            protein is produced by activated T-cells and certain cell types of
            innate immune system. The active protein functions as either a
            homodimer with other interleukin-17 family members and signals
            through the interleukin-17 receptor to induce inflammatory cytokine
            production. Aberrant expression of this gene is associated with
            autoinflammatory diseases including rheumatoid arthritis, psoriasis
            and multiple sclerosis. [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK040420.1, U43088.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1171              AK040420.1         2-1172
FEATURES             Location/Qualifiers
     source          1..1171
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 6.45 cM"
     gene            1..1171
                     /gene="Il17a"
                     /gene_synonym="Ctla-8; Ctla8; IL-17; IL-17A; Il17"
                     /note="interleukin 17A"
                     /db_xref="GeneID:16171"
                     /db_xref="MGI:MGI:107364"
     exon            1..84
                     /gene="Il17a"
                     /gene_synonym="Ctla-8; Ctla8; IL-17; IL-17A; Il17"
                     /inference="alignment:Splign:2.1.0"
     exon            85..296
                     /gene="Il17a"
                     /gene_synonym="Ctla-8; Ctla8; IL-17; IL-17A; Il17"
                     /inference="alignment:Splign:2.1.0"
     exon            297..1171
                     /gene="Il17a"
                     /gene_synonym="Ctla-8; Ctla8; IL-17; IL-17A; Il17"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atccacctca cacgaggcac aagtgcaccc agcaccagct gatcaggacg cgcaaacatg
       61 agtccaggga gagcttcatc tgtgtctctg atgctgttgc tgctgctgag cctggcggct
      121 acagtgaagg cagcagcgat catccctcaa agctcagcgt gtccaaacac tgaggccaag
      181 gacttcctcc agaatgtgaa ggtcaacctc aaagtcttta actcccttgg cgcaaaagtg
      241 agctccagaa ggccctcaga ctacctcaac cgttccacgt caccctggac tctccaccgc
      301 aatgaagacc ctgatagata tccctctgtg atctgggaag ctcagtgccg ccaccagcgc
      361 tgtgtcaatg cggagggaaa gctggaccac cacatgaatt ctgttctcat ccagcaagag
      421 atcctggtcc tgaagaggga gcctgagagc tgccccttca ctttcagggt cgagaagatg
      481 ctggtgggtg tgggctgcac ctgcgtggcc tcgattgtcc gccaggcagc ctaaacagag
      541 acccgcggct gacccctaag aaacccccac gtttctcagc aaacttactt gcatttttaa
      601 aacagttcgt gctattgatt ttcagcaagg aatgtggatt cagaggcaga ttcagaattg
      661 tctgccctcc acaatgaaaa gaaggtgtaa aggggtccca aactgcttcg tgtttgtttt
      721 tctgtggact ttaaattatt tgtgtattta caatatccca agatagcttt gaagcgtaac
      781 ttattttaat gaagtatcta cattattatt atgtttcttt ctgaagaaga caaaattcaa
      841 gactcagaaa ttttattatt taaaaggtaa agcctatatt tatatgagct atttatgaat
      901 ctatttattt ttcttcagta tttgaagtat taagaacatg attttcagat ctacctaggg
      961 aagtcctaag taagattaaa tattaatgga aatttcagct ttactatttg tttatttaag
     1021 gttctctcct ctgaatgggg tgaaaaccaa acttagtttt atgtttaata actttttaaa
     1081 ttattgaaga ttcaaaaaat tggataattt agctccctac tctgttttaa aaaaaaattg
     1141 taacaatatc actgtaataa taaagttttg g
//
