LOCUS       NM_001360087            5475 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus interleukin 16 (Il16), transcript variant 1, mRNA.
ACCESSION   NM_001360087 XM_017321989
VERSION     NM_001360087.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5475)
  AUTHORS   Zhang,J., Zhao,W., Zhou,Y., Xi,S., Xu,X., Du,X., Zheng,X., Hu,W.,
            Sun,R., Tian,Z., Fu,B. and Wei,H.
  TITLE     Pyroptotic T cell-derived active IL-16 has a driving function in
            ovarian endometriosis development
  JOURNAL   Cell Rep Med 5 (3), 101476 (2024)
   PUBMED   38508138
  REMARK    GeneRIF: Pyroptotic T cell-derived active IL-16 has a driving
            function in ovarian endometriosis development.
REFERENCE   2  (bases 1 to 5475)
  AUTHORS   Reyes-Farias,M., Fernandez-Garcia,P., Corrales,P., Gonzalez,L.,
            Soria-Gondek,A., Martinez,E., Pellitero,S., Tarasco,J., Moreno,P.,
            Sumoy,L., Medina-Gomez,G., Sanchez-Infantes,D. and Herrero,L.
  TITLE     Interleukin-16 is increased in obesity and alters adipogenesis and
            inflammation in vitro
  JOURNAL   Front Endocrinol (Lausanne) 15, 1346317 (2024)
   PUBMED   38544694
  REMARK    GeneRIF: Interleukin-16 is increased in obesity and alters
            adipogenesis and inflammation in vitro.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5475)
  AUTHORS   Hung,C.H., Lee,T.L., Huang,A.Y., Yang,K.C., Shyu,Y.C., Wen,S.C.,
            Lu,M.J., Yuan,S. and Shen,C.J.
  TITLE     A Positive Regulatory Feedback Loop between EKLF/KLF1 and TAL1/SCL
            Sustaining the Erythropoiesis
  JOURNAL   Int J Mol Sci 22 (15), 8024 (2021)
   PUBMED   34360789
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5475)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5475)
  AUTHORS   Li,C., Dai,J., Dong,G., Ma,Q., Li,Z., Zhang,H., Yan,F., Zhang,J.,
            Wang,B., Shi,H., Zhu,Y., Yao,X., Si,C. and Xiong,H.
  TITLE     Interleukin-16 aggravates ovalbumin-induced allergic inflammation
            by enhancing Th2 and Th17 cytokine production in a mouse model
  JOURNAL   Immunology 157 (3), 257-267 (2019)
   PUBMED   31120548
  REMARK    GeneRIF: IL-16 enhanced lung allergic inflammatory response may be
            associated with the up-regulation of IgE and the promotion of Th2
            and Th17 cytokine production.
REFERENCE   6  (bases 1 to 5475)
  AUTHORS   Bannert,N., Kurth,R. and Baier,M.
  TITLE     The gene encoding mouse interleukin-16 consists of seven exons and
            maps to chromosome 7 D2-D3
  JOURNAL   Immunogenetics 49 (7-8), 704-706 (1999)
   PUBMED   10369931
REFERENCE   7  (bases 1 to 5475)
  AUTHORS   Keane,J., Nicoll,J., Kim,S., Wu,D.M., Cruikshank,W.W., Brazer,W.,
            Natke,B., Zhang,Y., Center,D.M. and Kornfeld,H.
  TITLE     Conservation of structure and function between human and murine
            IL-16
  JOURNAL   J Immunol 160 (12), 5945-5954 (1998)
   PUBMED   9637508
REFERENCE   8  (bases 1 to 5475)
  AUTHORS   Hayes,B.B., Gerber,P.C., Griffey,S.S. and Meade,B.J.
  TITLE     Contact hypersensitivity to dicyclohexylcarbodiimide and
            diisopropylcarbodiimide in female B6C3F1 mice
  JOURNAL   Drug Chem Toxicol 21 (2), 195-206 (1998)
   PUBMED   9598300
REFERENCE   9  (bases 1 to 5475)
  AUTHORS   Bannert,N., Adler,H.S., Werner,A., Baier,M. and Kurth,R.
  TITLE     Molecular cloning and sequence analysis of interleukin 16 from
            nonhuman primates and from the mouse
  JOURNAL   Immunogenetics 47 (5), 390-397 (1998)
   PUBMED   9510557
REFERENCE   10 (bases 1 to 5475)
  AUTHORS   Mohr,A.M., Upperman,J.S., Taneja,R., Wang,M.T., Rameshwar,P. and
            Livingston,D.H.
  TITLE     Differential effects of acute hypoxia and endotoxin on the
            secretion and expression of bone marrow interleukin-1 and
            interleukin-6
  JOURNAL   Shock 7 (5), 324-331 (1997)
   PUBMED   9165666
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116389.12 and AC158576.3.
            
            On Jan 26, 2018 this sequence version replaced XM_017321989.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.82512.1,
                                           SRR9219379.13611.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-335               AC116389.12        134553-134887
            336-748             AC116389.12        144254-144666
            749-857             AC116389.12        178758-178866
            858-991             AC158576.3         179187-179320       c
            992-1102            AC158576.3         176996-177106       c
            1103-1217           AC158576.3         174358-174472       c
            1218-1291           AC158576.3         170857-170930       c
            1292-1508           AC158576.3         169405-169621       c
            1509-1626           AC158576.3         166463-166580       c
            1627-1759           AC158576.3         163247-163379       c
            1760-1847           AC158576.3         159435-159522       c
            1848-2335           AC158576.3         157169-157656       c
            2336-2480           AC158576.3         151650-151794       c
            2481-3564           AC158576.3         148250-149333       c
            3565-3733           AC158576.3         147252-147420       c
            3734-3835           AC158576.3         145086-145187       c
            3836-4094           AC158576.3         142673-142931       c
            4095-4217           AC158576.3         142199-142321       c
            4218-5475           AC158576.3         139190-140447       c
FEATURES             Location/Qualifiers
     source          1..5475
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 47.43 cM"
     gene            1..5475
                     /gene="Il16"
                     /gene_synonym="mKIAA4048"
                     /note="interleukin 16"
                     /db_xref="GeneID:16170"
                     /db_xref="MGI:MGI:1270855"
     exon            1..335
                     /gene="Il16"
                     /gene_synonym="mKIAA4048"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..4405
                     /gene="Il16"
                     /gene_synonym="mKIAA4048"
                     /note="isoform 1 is encoded by transcript variant 1;
                     pro-interleukin-16"
                     /codon_start=1
                     /product="pro-interleukin-16 isoform 1"
                     /protein_id="NP_001347016.1"
                     /db_xref="GeneID:16170"
                     /db_xref="MGI:MGI:1270855"
                     /translation="MGLALWGQKCICNGQVQQLGCGCPALPAGGGHHQYALWHIYRRT
                     PLLGCQATSPRPLCSWHLVPGRANWTHAVAAKSSSSVTHRPRPGEQERKKRGLTSSLR
                     MEPHGHSGKSRKSTKFRSISRSLILCNAKTSDDGSSPDEKYPDPFETSLCQGKEGFFH
                     SSMQLADTFEAGLSNIPDLALASDSAQLAAAGSDRGKHCRKMFFMKESSSTSSKEKSG
                     KPEAQSSSFLFPKACHQRTRSNSTSVNPYSAGEIDFPMTKKSAAPTDRQPYSLCSNRK
                     SLSQQLDYPILGTARPTRSLSTAQLGQLSGGLQASVISNIVLMKGQAKGLGFSIVGGK
                     DSIYGPIGIYVKSIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKG
                     LLTLTVRTRLTTPPSLCSHLSPPLCRSLSSSTCGAQDSSPFSLESPASPASTAKPNYR
                     IMVEVSLKKEAGVGLGIGLCSIPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEIN
                     DSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQAVEGVKFGKDR
                     HQWSLEGVKRLESSWHGRPTLEKEREKHSAPPHRRAQKIMVRSSSDSSYMSGSPGGSP
                     CSAGAEPQPSEREGSTHSPSLSPGEEQEPCPGVPSRPQQESPPLPESLERESHPPLRL
                     KKSFEILVRKPTSSKPKPPPRKYFKNDSEPQKKLEEKEKVTDPSGHTLPTCSQETREL
                     LPLLLQEDTAGRAPCTAACCPGPAASTQTSSSTEGESRRSASPETPASPGKHPLLKRQ
                     ARMDYSFDITAEDPWVRISDCIKNLFSPIMSENHSHTPLQPNTSLGEEDGTQGCPEGG
                     LSKMDAANGAPRVYKSADGSTVKKGPPVAPKPAWFRQSLKGLRNRAPDPRRPPEVASA
                     IQPTPVSRDPPGPQPQASSSIRQRISSFENFGSSQLPDRGVQRLSLQPSSGETTKFPG
                     KQDGGRFSGLLGQGATVTAKHRQTEVESMSTTFPNSSEVRDPGLPESPPPGQRPSTKA
                     LSPDPLLRLLTTQSEDTQGPGLKMPSQRARSFPLTRTQSCETKLLDEKASKLYSISSQ
                     LSSAVMKSLLCLPSSVSCGQITCIPKERVSPKSPCNNSSAAEGFGEAMASDTGFSLNL
                     SELREYSEGLTEPGETEDRNHCSSQAGQSVISLLSAEELEKLIEEVRVLDEATLKQLD
                     SIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSING
                     KSLKGATHNDALAILRQARDPRQAVIVTRRTTVEATHDLNSSTDSAASASAASDISVE
                     SKEATVCTVTLEKTSAGLGFSLEGGKGSLHGDKPLTINRIFKGTEQGEMVQPGDEILQ
                     LAGTAVQGLTRFEAWNVIKALPDGPVTIVIRRTSLQCKQTTASADS"
     exon            336..748
                     /gene="Il16"
                     /gene_synonym="mKIAA4048"
                     /inference="alignment:Splign:2.1.0"
     exon            749..857
                     /gene="Il16"
                     /gene_synonym="mKIAA4048"
                     /inference="alignment:Splign:2.1.0"
     exon            858..991
                     /gene="Il16"
                     /gene_synonym="mKIAA4048"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1102
                     /gene="Il16"
                     /gene_synonym="mKIAA4048"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1217
                     /gene="Il16"
                     /gene_synonym="mKIAA4048"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1291
                     /gene="Il16"
                     /gene_synonym="mKIAA4048"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1508
                     /gene="Il16"
                     /gene_synonym="mKIAA4048"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1626
                     /gene="Il16"
                     /gene_synonym="mKIAA4048"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1759
                     /gene="Il16"
                     /gene_synonym="mKIAA4048"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..1847
                     /gene="Il16"
                     /gene_synonym="mKIAA4048"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..2335
                     /gene="Il16"
                     /gene_synonym="mKIAA4048"
                     /inference="alignment:Splign:2.1.0"
     exon            2336..2480
                     /gene="Il16"
                     /gene_synonym="mKIAA4048"
                     /inference="alignment:Splign:2.1.0"
     exon            2481..3564
                     /gene="Il16"
                     /gene_synonym="mKIAA4048"
                     /inference="alignment:Splign:2.1.0"
     exon            3565..3733
                     /gene="Il16"
                     /gene_synonym="mKIAA4048"
                     /inference="alignment:Splign:2.1.0"
     exon            3734..3835
                     /gene="Il16"
                     /gene_synonym="mKIAA4048"
                     /inference="alignment:Splign:2.1.0"
     exon            3836..4094
                     /gene="Il16"
                     /gene_synonym="mKIAA4048"
                     /inference="alignment:Splign:2.1.0"
     exon            4095..4217
                     /gene="Il16"
                     /gene_synonym="mKIAA4048"
                     /inference="alignment:Splign:2.1.0"
     exon            4218..5475
                     /gene="Il16"
                     /gene_synonym="mKIAA4048"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4664..4669
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il16"
                     /gene_synonym="mKIAA4048"
                     /note="hexamer: AATAAA"
     polyA_site      4696
                     /gene="Il16"
                     /gene_synonym="mKIAA4048"
                     /note="major polyA site"
     regulatory      5208..5213
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il16"
                     /gene_synonym="mKIAA4048"
                     /note="hexamer: AATAAA"
     polyA_site      5231
                     /gene="Il16"
                     /gene_synonym="mKIAA4048"
     regulatory      5346..5351
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il16"
                     /gene_synonym="mKIAA4048"
                     /note="hexamer: AATAAA"
     polyA_site      5367
                     /gene="Il16"
                     /gene_synonym="mKIAA4048"
     regulatory      5447..5452
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il16"
                     /gene_synonym="mKIAA4048"
                     /note="hexamer: AATAAA"
     regulatory      5453..5458
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il16"
                     /gene_synonym="mKIAA4048"
                     /note="hexamer: AACAAA"
     polyA_site      5466
                     /gene="Il16"
                     /gene_synonym="mKIAA4048"
     polyA_site      5469
                     /gene="Il16"
                     /gene_synonym="mKIAA4048"
ORIGIN      
        1 ccaggagctg tggtgcctgc gacactcgtc cctgggggag agaattagat gccacagaag
       61 cagctcctag actactagct ccctgcactg tgacccagat gtcaggatcc atgcagaata
      121 gggattcttc atgggtcttg cactgtgggg gcagaagtgc atctgtaatg gacaggtgca
      181 gcagctagga tgtggctgcc ctgctctgcc agctggagga ggtcaccacc aatatgctct
      241 ttggcacatc tacaggcgca ccccgctgct gggatgtcag gcaacatcac cccgtcccct
      301 ctgctcatgg catctcgtac ctggccgggc taactggact catgcagtgg cagctaaatc
      361 cagttcatct gtcactcacc ggccaaggcc tggagaacag gagaggaaga agcgtggcct
      421 cacttcctct ctgaggatgg aaccccacgg ccactccgga aagagccgga aatccacgaa
      481 atttcgctcc atctcccgtt ccctgatcct ctgtaacgcc aagaccagtg atgacggctc
      541 cagcccagat gagaagtacc ctgacccttt tgagacttca ctgtgccagg gcaaggaggg
      601 tttctttcac tcctccatgc agctggcaga cacatttgag gctgggctca gcaatatccc
      661 agacctcgca ctggcctcgg actctgctca actcgcagca gctgggagcg atcgaggcaa
      721 gcactgcagg aagatgttct tcatgaagga atcttcttca acttcctcta aagaaaagtc
      781 tggaaaacca gaagcacaaa gtagcagctt cctgtttcct aaagcttgcc accaaaggac
      841 acgcagcaac tccaccagtg ttaaccccta cagtgctgga gaaatcgatt ttccaatgac
      901 caagaaatct gcagctccca ccgaccggca gccctactcc ctctgtagca acaggaagtc
      961 cctctctcaa caactggact acccaatttt gggcactgca agaccaactc ggtcactgag
     1021 cacagctcag ctcgggcagc tgtctggggg tctgcaggcg tcagtcatct ccaacatagt
     1081 gctgatgaag ggccaagcaa agggcctggg cttcagcatt gttggaggaa aggacagcat
     1141 ttacggccct attggaattt atgtgaagag catctttgca gggggagcag ctgcagctga
     1201 tggacggctt caggaaggtg atgaaattct ggaactcaat ggtgaatcaa tggctggcct
     1261 aacacaccag gatgctttgc agaagtttaa gcaagccaag aaggggctgc tgactctgac
     1321 agtgaggact cgcctgacaa cacccccttc actatgcagc cacctgtcac ctcctctgtg
     1381 ccgttccctg agctccagca catgtggtgc ccaggacagc agccccttct ccttggaaag
     1441 tccagcgtct cctgctagca ctgccaaacc caactacaga atcatggtgg aggtgtctct
     1501 gaagaaagag gcaggtgttg gcctggggat cggcctgtgc agcatcccct acttccagtg
     1561 catctcaggc atcttcgttc acacactgtc accaggatcc gtggcacatc ttgatggacg
     1621 gctgaggtgt ggtgatgaga ttgtggaaat caatgattct ccagtgcact gcctgactct
     1681 caatgaagtc tacacaatcc tgagccactg tgaccctggc ccagttccca tcatcgtaag
     1741 ccgacatccg gacccacagg tttctgaaca gcaactcaag gaagctgtgg ctcaggctgt
     1801 ggaaggcgtc aagtttggga aggacaggca ccagtggagc ttggaaggtg tcaaaaggct
     1861 ggagagcagc tggcatgggc ggcctacctt ggagaaagaa cgtgagaagc actcagcgcc
     1921 cccacatcga agggcccaga agatcatggt ccgatccagc agtgacagca gctacatgtc
     1981 tgggtcacca gggggaagtc cctgcagtgc aggtgcggag ccacagcctt ctgagaggga
     2041 aggcagcaca cacagtccca gcctgtcccc aggggaggag caagagccgt gcccaggggt
     2101 cccatccagg cctcagcagg agagcccacc ccttcctgag agcttggaaa gagagagcca
     2161 cccaccactg agactgaaga aatcttttga gattttggtg agaaagccga catcctccaa
     2221 acccaagcct ccacccagaa aatactttaa aaatgacagc gagcctcaga agaaactgga
     2281 ggagaaagag aaggtcacag acccttctgg gcacaccttg cccacctgca gccaggaaac
     2341 cagagagctg ctgccactgt tgctacagga agacactgca gggagagccc cctgcaccgc
     2401 tgcctgctgc ccaggacctg cagccagcac gcagacttca tcctccacag aaggagagtc
     2461 aaggaggagt gccagcccag agactccagc atccccagga aaacacccgc tgctgaagag
     2521 gcaggcacgg atggactata gctttgatat cactgctgaa gacccttggg ttagaatttc
     2581 cgactgcatc aaaaacttat ttagccccat catgagtgag aaccatagcc atacaccact
     2641 acagcccaac accagccttg gtgaagagga tgggacacag ggctgtccag aggggggcct
     2701 gtcaaaaatg gacgctgcca atggtgctcc cagagtttac aagtcagcag atggcagcac
     2761 tgtgaagaag gggcctccag tagccccaaa gccagcttgg tttcggcaga gcttgaaagg
     2821 tctgaggaat cgtgccccag accccagaag acccccggaa gtagcctcag ccattcagcc
     2881 tacaccagtt tctagggacc caccagggcc acagcctcag gcctcttcct ccatcaggca
     2941 gagaatcagc tcctttgaaa actttggctc ctcacaattg ccagacagag gagtccagag
     3001 actgagcctg cagcccagct ctggggagac caccaaattt ccaggaaagc aagatggagg
     3061 acgattttct ggtctcctgg gtcaaggggc tacagtaaca gctaagcaca gacagacaga
     3121 ggtagagtct atgtccacaa ccttccctaa ctcctcagag gtcagggacc caggtttgcc
     3181 tgagtctcct cccccaggtc agcgacccag cacaaaagct ttgtctccag accctctctt
     3241 gagactgttg actacacaat ccgaggatac tcaaggacca ggtctcaaga tgccaagtca
     3301 gcgggcacgg agcttccccc tgaccaggac ccagtcctgc gagacaaagc tgttggatga
     3361 aaaggccagt aagctttact ccatcagcag ccagctatca tctgctgtca tgaaatccct
     3421 gctgtgcctt ccatcttcag tctcttgtgg ccagatcacc tgcatcccca aggagagggt
     3481 gtctccaaag tcaccttgca acaacagctc agctgcagag ggttttggtg aagccatggc
     3541 ctctgacaca gggttctctc tcaacctttc agagctgaga gaatattcag aaggtctcac
     3601 agagcccggg gaaaccgagg acaggaacca ctgttcttct caggccggcc agtcggttat
     3661 ctccttgctg agtgcagaag aactggaaaa actcattgag gaagtgagag ttctagatga
     3721 agcaacattg aagcaattag acagcattca tgtcaccatc ttacacaagg aagaaggtgc
     3781 tggtcttgga ttcagcttgg caggaggggc agatctagaa aacaaggtga tcacggttca
     3841 cagagtgttt ccaaatgggc tggcttccca ggaaggcaca attcagaaag gcaacgaggt
     3901 tctttccatc aatggcaaat ctctcaaggg cgctacccac aatgatgccc tagctatcct
     3961 tcgccaagct cgggacccaa ggcaagctgt gattgtcacc aggaggacaa ctgtggaggc
     4021 cactcatgac ctgaactcct ctactgactc cgcagcctca gcttcagcag ccagtgacat
     4081 ttctgtagaa tctaaggagg ccactgtctg cacagtgaca ctggagaaga cctctgcagg
     4141 gctgggcttc agcctggagg gaggaaaggg ctccctgcat ggtgacaagc ctcttaccat
     4201 aaacaggatt ttcaaaggga cagaacaggg tgagatggtg cagccagggg atgagatctt
     4261 gcagctcgct ggcactgctg tgcaaggtct tacccggttt gaagcctgga atgtcatcaa
     4321 ggcattgcct gatggacctg tcactatagt catcagaagg accagcctcc agtgcaagca
     4381 gacaacagct tctgcagact cataggcagg cggccaatgc taagacaaag caggagctgg
     4441 aagctccagt aatcgctgat tctcagggtc tctgctgccc acctcaccca ggctggggaa
     4501 agcccaggtg tgcctctggt agctgctgct caggtttgga cctcctggca cactgcccat
     4561 caagagggct gttccaaatg tcaggacaga gtcacgcaga ggtggctgtt acgaaccacg
     4621 tcaactgtat atagacagct tagtgataat accctggtgc cgtaataaaa tggttgtatt
     4681 gcagtttccc aagaaacaaa tgacctgatt tggaaatccc ctagggacta tgaaagccac
     4741 cccatggcag tgcttttttt ttttttctct catgcatctc atgtcttgga ggggagctcc
     4801 ttactatcag ctcgagcagg tcaaggctgg gctggggtcc tgtgaagggt cactgcttgt
     4861 ggctctcccc agaggggctg gctgatgact ggggaagttt cttcacggct ggtgcttctg
     4921 caccatgccg attgattctg caccacactg cccagccaca ctacagtcag gtgcgggtgc
     4981 atcttttaaa tgttctgcct ttgaagactc ataacattgc tcctgtcaca ctcctgccga
     5041 gagcaggcaa acacctgcct gggtttaagg aaaggggata agttgttaga aacagctctg
     5101 tgagatgcag cctgccatga agaacacatt caaacacata gaagactttt tggttgggtc
     5161 gagagcctag aaggagtgga accagaagac agagggtatg agcataaaat aaaattattg
     5221 ttaatgtctt atctgtcacg tgtcaggaac cctgcttggt attagatgat agttattggt
     5281 gatcacagcc acttcaccaa tggcggtcct gcaccaatgt attggagggt actgagcctc
     5341 agaacaataa acagcttgtc aggctaagat gtggaagggc agaggtttag tcattccttc
     5401 agtgacatga gcaggcccag gagattgaaa acatggcaca tcagggaata aaaacaaaca
     5461 aacaaacaac tgctt
//
