LOCUS       NM_008358               1664 bp    mRNA    linear   ROD 11-APR-2023
DEFINITION  Mus musculus interleukin 15 receptor, alpha chain (Il15ra),
            transcript variant 1, mRNA.
ACCESSION   NM_008358
VERSION     NM_008358.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1664)
  AUTHORS   He Y, Ge L, Tong F, Zheng P, Yang J, Zhou J, Sun Z, Wang H, Yang S,
            Li Y and Yu Y.
  TITLE     Metabolic responses in the cortex and hippocampus induced by
            Il-15ralpha mutation
  JOURNAL   Mol Omics 18 (9), 865-872 (2022)
   PUBMED   35972394
  REMARK    GeneRIF: Metabolic responses in the cortex and hippocampus induced
            by Il-15ralpha mutation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1664)
  AUTHORS   Park JY, Won HY, DiPalma DT, Kim HK, Kim TH, Li C, Sato N, Hong C,
            Abraham N, Gress RE and Park JH.
  TITLE     In vivo availability of the cytokine IL-7 constrains the survival
            and homeostasis of peripheral iNKT cells
  JOURNAL   Cell Rep 38 (2), 110219 (2022)
   PUBMED   35021100
REFERENCE   3  (bases 1 to 1664)
  AUTHORS   Devocelle A, Lecru L, Ferlicot S, Bessede T, Candelier JJ,
            Giron-Michel J and Francois H.
  TITLE     IL-15 Prevents Renal Fibrosis by Inhibiting Collagen Synthesis: A
            New Pathway in Chronic Kidney Disease?
  JOURNAL   Int J Mol Sci 22 (21), 11698 (2021)
   PUBMED   34769128
  REMARK    GeneRIF: IL-15 Prevents Renal Fibrosis by Inhibiting Collagen
            Synthesis: A New Pathway in Chronic Kidney Disease?
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1664)
  AUTHORS   Ghilas S, Ambrosini M, Cancel JC, Brousse C, Masse M, Lelouard H,
            Dalod M and Crozat K.
  TITLE     Natural killer cells and dendritic epidermal gammadelta T cells
            orchestrate type 1 conventional DC spatiotemporal repositioning
            toward CD8+ T cells
  JOURNAL   iScience 24 (9), 103059 (2021)
   PUBMED   34568787
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1664)
  AUTHORS   Di Pilato M, Kfuri-Rubens R, Pruessmann JN, Ozga AJ, Messemaker M,
            Cadilha BL, Sivakumar R, Cianciaruso C, Warner RD, Marangoni F,
            Carrizosa E, Lesch S, Billingsley J, Perez-Ramos D, Zavala F,
            Rheinbay E, Luster AD, Gerner MY, Kobold S, Pittet MJ and Mempel
            TR.
  TITLE     CXCR6 positions cytotoxic T cells to receive critical survival
            signals in the tumor microenvironment
  JOURNAL   Cell 184 (17), 4512-4530 (2021)
   PUBMED   34343496
REFERENCE   6  (bases 1 to 1664)
  AUTHORS   Liu CC, Perussia B and Young JD.
  TITLE     The emerging role of IL-15 in NK-cell development
  JOURNAL   Immunol Today 21 (3), 113-116 (2000)
   PUBMED   10689297
  REMARK    Review article
REFERENCE   7  (bases 1 to 1664)
  AUTHORS   Malek TR, Porter BO and He YW.
  TITLE     Multiple gamma c-dependent cytokines regulate T-cell development
  JOURNAL   Immunol Today 20 (2), 71-76 (1999)
   PUBMED   10098325
  REMARK    Review article
REFERENCE   8  (bases 1 to 1664)
  AUTHORS   Lodolce JP, Boone DL, Chai S, Swain RE, Dassopoulos T, Trettin S
            and Ma A.
  TITLE     IL-15 receptor maintains lymphoid homeostasis by supporting
            lymphocyte homing and proliferation
  JOURNAL   Immunity 9 (5), 669-676 (1998)
   PUBMED   9846488
REFERENCE   9  (bases 1 to 1664)
  AUTHORS   Anderson DM, Kumaki S, Ahdieh M, Bertles J, Tometsko M, Loomis A,
            Giri J, Copeland NG, Gilbert DJ, Jenkins NA et al.
  TITLE     Functional characterization of the human interleukin-15 receptor
            alpha chain and close linkage of IL15RA and IL2RA genes
  JOURNAL   J Biol Chem 270 (50), 29862-29869 (1995)
   PUBMED   8530383
REFERENCE   10 (bases 1 to 1664)
  AUTHORS   Giri JG, Kumaki S, Ahdieh M, Friend DJ, Loomis A, Shanebeck K,
            DuBose R, Cosman D, Park LS and Anderson DM.
  TITLE     Identification and cloning of a novel IL-15 binding protein that is
            structurally related to the alpha chain of the IL-2 receptor
  JOURNAL   EMBO J 14 (15), 3654-3663 (1995)
   PUBMED   7641685
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL831794.6.
            
            [WARNING] On Apr 28, 2023 this sequence was replaced by
            NM_008358.3.
            
            On Oct 4, 2012 this sequence version replaced NM_008358.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189676.112157.1,
                                           SRR13862062.136304.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-233               AL831794.6         40604-40836         c
            234-428             AL831794.6         28090-28284         c
            429-521             AL831794.6         26443-26535         c
            522-719             AL831794.6         22938-23135         c
            720-752             AL831794.6         22420-22452         c
            753-828             AL831794.6         15902-15977         c
            829-1664            AL831794.6         12563-13398         c
FEATURES             Location/Qualifiers
     source          1..1664
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 8.97 cM"
     gene            1..1664
                     /gene="Il15ra"
                     /gene_synonym="IL-15RA"
                     /note="interleukin 15 receptor, alpha chain"
                     /db_xref="GeneID:16169"
                     /db_xref="MGI:MGI:104644"
     exon            1..233
                     /gene="Il15ra"
                     /gene_synonym="IL-15RA"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..928
                     /gene="Il15ra"
                     /gene_synonym="IL-15RA"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; interleukin-15 receptor subunit alpha;
                     IL-15R-alpha; IL-15 receptor subunit alpha"
                     /codon_start=1
                     /product="interleukin-15 receptor subunit alpha isoform 1
                     precursor"
                     /protein_id="NP_032384.1"
                     /db_xref="CCDS:CCDS15686.1"
                     /db_xref="GeneID:16169"
                     /db_xref="MGI:MGI:104644"
                     /translation="MASPQLRGYGVQAIPVLLLLLLLLLLPLRVTPGTTCPPPVSIEH
                     ADIRVKNYSVNSRERYVCNSGFKRKAGTSTLIECVINKNTNVAHWTTPSLKCIRDPSL
                     AHYSPVPTVVTPKVTSQPESPSPSAKEPEAFSPKSDTAMTTETAIMPGSRLTPSQTTS
                     AGTTGTGSHKSSRAPSLAATMTLEPTASTSLRITEISPHSSKMTKVAISTSVLLVGAG
                     VVMAFLAWYIKSRQPSQPCRVEVETMETVPMTVRASSKEDEDTGA"
     exon            234..428
                     /gene="Il15ra"
                     /gene_synonym="IL-15RA"
                     /inference="alignment:Splign:2.1.0"
     exon            429..521
                     /gene="Il15ra"
                     /gene_synonym="IL-15RA"
                     /inference="alignment:Splign:2.1.0"
     exon            522..719
                     /gene="Il15ra"
                     /gene_synonym="IL-15RA"
                     /inference="alignment:Splign:2.1.0"
     exon            720..752
                     /gene="Il15ra"
                     /gene_synonym="IL-15RA"
                     /inference="alignment:Splign:2.1.0"
     exon            753..828
                     /gene="Il15ra"
                     /gene_synonym="IL-15RA"
                     /inference="alignment:Splign:2.1.0"
     exon            829..1664
                     /gene="Il15ra"
                     /gene_synonym="IL-15RA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctctgcaat ccgggggcta aagcaaaagc gaaagcgaat actccttagc agcggtctgg
       61 tcctggagct gagctcgcca cctcccaggg accccagcct tgcgtcccgt tgggtcactg
      121 ctggggacaa ttggccatgg cctcgccgca gctccggggc tatggagtcc aggccattcc
      181 tgtgttgctg ctgctgctgt tgctactgtt gctcccgctg agggtgacgc cgggcaccac
      241 gtgtccacct cccgtatcta ttgagcatgc tgacatccgg gtcaagaatt acagtgtgaa
      301 ctccagggag aggtatgtct gtaactctgg ctttaagcgg aaagctggaa catccaccct
      361 gattgagtgt gtgatcaaca agaacacaaa tgttgcccac tggacaactc ccagcctcaa
      421 gtgcatcaga gacccctccc tagctcacta cagtccagtg ccaacagtag tgacaccaaa
      481 ggtgacctca cagccagaga gcccctcccc ctctgcaaaa gagccagaag ctttctctcc
      541 caaatcagat accgcaatga ccacagagac agctattatg cctggctcca ggctgacacc
      601 atcccaaaca acttctgcag gaactacagg gacaggcagt cacaagtcct cccgagcccc
      661 atctcttgca gcaacaatga ccttggagcc tacagcctcc acctccctca ggataacaga
      721 gatttctccc cacagttcca aaatgacgaa agtggccatc tctacatcgg tcctcttggt
      781 tggtgcaggg gttgtgatgg ctttcctggc ctggtacatc aaatcaaggc agccttctca
      841 gccgtgccgt gttgaggtgg aaaccatgga aacagtacca atgactgtga gggccagcag
      901 caaggaggat gaagacacag gagcctaacc acacgatttc agaaactcag ggagacctgc
      961 ccagctgatc ctgaagagaa gatacaaggg cagttagtcc agctgcgcct ggacacagga
     1021 gaaagcccaa tgtgataata gaggtctctg gtatgatctg ttttactgag cctgggtgcc
     1081 tcccatattc aggcctggat ccccggagtc cggaaggaca ccacctttct tcctggttca
     1141 tcacagaggc caacttccca gagtacaagc agcctgagct ctcctgggag tctccattaa
     1201 aagcctcgag ttccactcag agattaactc aaagcagctg atctgctaga ctctttttct
     1261 attccctact ctgacttgca gtttacagag attgacaagg ctcccattgt cttccaaggc
     1321 tcctctggca caggagatgt ctgtaaagaa gacagcaaca tttgagctcc tgaagacttg
     1381 gccctttgct gctttgcacc tattggagga gagcagagaa cagaagaaga gatactgagc
     1441 caatgaaccc tttcgtatag gattcatgac aaaaccaaac tcagtgacta tatatgtatg
     1501 tgtgtgtgtg tgtgtatgta aaagtgtata tttacatata catttatatt tatactttct
     1561 tttctattat atctacatat tgtatatgat ttatatttga aagtgctttg tgtagacaaa
     1621 ataaaatatc tattttcagt acaaaaagca ttaaaattat caac
//
