LOCUS       NM_008357               1256 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus interleukin 15 (Il15), transcript variant 1, mRNA.
ACCESSION   NM_008357
VERSION     NM_008357.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1256)
  AUTHORS   Osum,K.C., Becker,S.H., Krueger,P.D., Mitchell,J.S., Hong,S.W.,
            Magill,I.R. and Jenkins,M.K.
  TITLE     A minority of Th1 and Tfh effector cells express survival genes
            shared by memory cell progeny that require IL-7 or TCR signaling to
            persist
  JOURNAL   Cell Rep 44 (1), 115111 (2025)
   PUBMED   39723889
REFERENCE   2  (bases 1 to 1256)
  AUTHORS   Lin,F., Yin,S., Zhang,Z., Yu,Y., Fang,H., Liang,Z., Zhu,R.,
            Zhou,H., Li,J., Cao,K., Guo,W., Qin,S., Zhang,Y., Lu,C., Li,H.,
            Liu,S., Zhang,H., Ye,B., Lin,J., Li,Y., Kang,X., Xi,J.J. and
            Chen,P.R.
  TITLE     Multimodal targeting chimeras enable integrated immunotherapy
            leveraging tumor-immune microenvironment
  JOURNAL   Cell 187 (26), 7470-7491 (2024)
   PUBMED   39504957
REFERENCE   3  (bases 1 to 1256)
  AUTHORS   Cloutier,M., Variya,B., Akbari,S.A., Rexhepi,F., Ilangumaran,S. and
            Ramanathan,S.
  TITLE     Profibrogenic role of IL-15 through IL-15 receptor alpha-mediated
            trans-presentation in the carbon tetrachloride-induced liver
            fibrosis model
  JOURNAL   Front Immunol 15, 1404891 (2024)
   PUBMED   38919611
  REMARK    GeneRIF: Profibrogenic role of IL-15 through IL-15 receptor
            alpha-mediated trans-presentation in the carbon
            tetrachloride-induced liver fibrosis model.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1256)
  AUTHORS   Zekri,L., Hagelstein,I., Marklin,M., Klimovich,B., Christie,M.,
            Lindner,C., Kamereit,S., Prakash,N., Muller,S., Stotz,S.,
            Maurer,A., Greve,C., Schmied,B., Atar,D., Rammensee,H.G., Jung,G.
            and Salih,H.R.
  TITLE     Immunocytokines with target cell-restricted IL-15 activity for
            treatment of B cell malignancies
  JOURNAL   Sci Transl Med 16 (737), eadh1988 (2024)
   PUBMED   38446900
  REMARK    GeneRIF: Immunocytokines with target cell-restricted IL-15 activity
            for treatment of B cell malignancies.
REFERENCE   5  (bases 1 to 1256)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 1256)
  AUTHORS   Ye,W., Young,J.D. and Liu,C.C.
  TITLE     Interleukin-15 induces the expression of mRNAs of cytolytic
            mediators and augments cytotoxic activities in primary murine
            lymphocytes
  JOURNAL   Cell Immunol 174 (1), 54-62 (1996)
   PUBMED   8929454
REFERENCE   7  (bases 1 to 1256)
  AUTHORS   Bamford,R.N., Battiata,A.P. and Waldmann,T.A.
  TITLE     IL-15: the role of translational regulation in their expression
  JOURNAL   J Leukoc Biol 59 (4), 476-480 (1996)
   PUBMED   8613692
  REMARK    Review article
REFERENCE   8  (bases 1 to 1256)
  AUTHORS   Munger,W., DeJoy,S.Q., Jeyaseelan,R. Sr., Torley,L.W.,
            Grabstein,K.H., Eisenmann,J., Paxton,R., Cox,T., Wick,M.M. and
            Kerwar,S.S.
  TITLE     Studies evaluating the antitumor activity and toxicity of
            interleukin-15, a new T cell growth factor: comparison with
            interleukin-2
  JOURNAL   Cell Immunol 165 (2), 289-293 (1995)
   PUBMED   7553894
REFERENCE   9  (bases 1 to 1256)
  AUTHORS   Giri,J.G., Anderson,D.M., Kumaki,S., Park,L.S., Grabstein,K.H. and
            Cosman,D.
  TITLE     IL-15, a novel T cell growth factor that shares activities and
            receptor components with IL-2
  JOURNAL   J Leukoc Biol 57 (5), 763-766 (1995)
   PUBMED   7759955
  REMARK    Review article
REFERENCE   10 (bases 1 to 1256)
  AUTHORS   Anderson,D.M., Johnson,L., Glaccum,M.B., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A., Valentine,V., Kirstein,M.N.,
            Shapiro,D.N., Morris,S.W. et al.
  TITLE     Chromosomal assignment and genomic structure of Il15
  JOURNAL   Genomics 25 (3), 701-706 (1995)
   PUBMED   7759105
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156993.3.
            
            On Feb 2, 2022 this sequence version replaced NM_008357.2.
            
            Summary: This gene encodes a a pleiotropic cytokine of the
            interleukin family of proteins that plays important roles in the
            innate and adaptive cell homeostasis, as well as peripheral immune
            function. The encoded protein undergoes proteolytic processing to
            generate a mature cytokine that stimulates the proliferation of
            natural killer cells. The transgenic mice overexpressing the
            encoded protein exhibit an increase in the number of memory CD8+ T
            cells in a naive state and enhanced protection against bacterial
            infections. Mice lacking the encoded protein exhibit impaired
            protection against a strain of attenuated Mycobacterium. [provided
            by RefSeq, Aug 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U14332.1, AK155616.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-273               AC156993.3         90945-91217         c
            274-395             AC156993.3         68149-68270         c
            396-494             AC156993.3         34255-34353         c
            495-592             AC156993.3         33030-33127         c
            593-677             AC156993.3         31894-31978         c
            678-722             AC156993.3         26221-26265         c
            723-860             AC156993.3         23124-23261         c
            861-1256            AC156993.3         20284-20679         c
FEATURES             Location/Qualifiers
     source          1..1256
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 39.33 cM"
     gene            1..1256
                     /gene="Il15"
                     /gene_synonym="IL-15"
                     /note="interleukin 15"
                     /db_xref="GeneID:16168"
                     /db_xref="MGI:MGI:103014"
     exon            1..273
                     /gene="Il15"
                     /gene_synonym="IL-15"
                     /inference="alignment:Splign:2.1.0"
     exon            274..395
                     /gene="Il15"
                     /gene_synonym="IL-15"
                     /inference="alignment:Splign:2.1.0"
     exon            396..494
                     /gene="Il15"
                     /gene_synonym="IL-15"
                     /inference="alignment:Splign:2.1.0"
     CDS             483..971
                     /gene="Il15"
                     /gene_synonym="IL-15"
                     /codon_start=1
                     /product="interleukin-15 preproprotein"
                     /protein_id="NP_032383.1"
                     /db_xref="CCDS:CCDS40401.1"
                     /db_xref="GeneID:16168"
                     /db_xref="MGI:MGI:103014"
                     /translation="MKILKPYMRNTSISCYLCFLLNSHFLTEAGIHVFILGCVSVGLP
                     KTEANWIDVRYDLEKIESLIQSIHIDTTLYTDSDFHPSCKVTAMNCFLLELQVILHEY
                     SNMTLNETVRNVLYLANSTLSSNKNVAESGCKECEELEEKTFTEFLQSFIRIVQMFIN
                     TS"
     exon            495..592
                     /gene="Il15"
                     /gene_synonym="IL-15"
                     /inference="alignment:Splign:2.1.0"
     exon            593..677
                     /gene="Il15"
                     /gene_synonym="IL-15"
                     /inference="alignment:Splign:2.1.0"
     exon            678..722
                     /gene="Il15"
                     /gene_synonym="IL-15"
                     /inference="alignment:Splign:2.1.0"
     exon            723..860
                     /gene="Il15"
                     /gene_synonym="IL-15"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1256
                     /gene="Il15"
                     /gene_synonym="IL-15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1224..1229
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il15"
                     /gene_synonym="IL-15"
                     /note="hexamer: AATAAA"
     polyA_site      1256
                     /gene="Il15"
                     /gene_synonym="IL-15"
                     /note="major polyA site"
ORIGIN      
        1 agtggcactg tattcccctt ctgtccagcc actcttcccc agagttctct tcttcatcct
       61 cccccttgca gagtagggca gcttgcaggt cctcctgcaa gtctctccca attctctgcg
      121 cccaaaagac ttgcagtgca tctccttacg cgctgcaggg accttgccag ggcaggactg
      181 cccccgccca gttgcagagt tggacgaaga cgggatcctg ctgtgtttgg aaggctgagt
      241 tccacatcta acagctcaga gaggtcagga aagaatccac cttgacacat ggccctctgg
      301 ctcttcaaag cactgcctct tcatggtcct tgctggtgag gtccttaaga acacagaaac
      361 ccatgtcagc agataaccag cctacaggag gccaagaaga gttctggatg gatggcagct
      421 ggaagcccat cgccatagcc agctcatctt caacattgaa gctcttacct gggcattaag
      481 taatgaaaat tttgaaacca tatatgagga atacatccat ctcgtgctac ttgtgtttcc
      541 ttctaaacag tcacttttta actgaggctg gcattcatgt cttcattttg ggctgtgtca
      601 gtgtaggtct ccctaaaaca gaggccaact ggatagatgt aagatatgac ctggagaaaa
      661 ttgaaagcct tattcaatct attcatattg acaccacttt atacactgac agtgactttc
      721 atcccagttg caaagttact gcaatgaact gctttctcct ggaattgcag gttattttac
      781 atgagtacag taacatgact cttaatgaaa cagtaagaaa cgtgctctac cttgcaaaca
      841 gcactctgtc ttctaacaag aatgtagcag aatctggctg caaggaatgt gaggagctgg
      901 aggagaaaac cttcacagag tttttgcaaa gctttatacg cattgtccaa atgttcatca
      961 acacgtcctg actgcatgcg agcctcttcc gtgtttctgt tattaaggta cctccacctg
     1021 ctgctcagag gcagcacagc tccatgcatt tgaaatctgc tgggcaaact aagcttccta
     1081 acaaggagat aatgagccac ttggatcaca tgaaatcttg gaaatgaaga gaggaaaaga
     1141 gctcgtctca gacttatttt tgcttgctta tttttaattt attgcttcat ttgtacatat
     1201 ttgtaatata acagaagatg tggaataaag ttgtatggat attttatcaa ttgaaa
//
