LOCUS       NM_008356               2279 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus interleukin 13 receptor, alpha 2 (Il13ra2), transcript
            variant 1, mRNA.
ACCESSION   NM_008356 XM_006528709
VERSION     NM_008356.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2279)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2279)
  AUTHORS   Xu,W., Chao,R., Xie,X., Mao,Y., Chen,X., Chen,X. and Zhang,S.
  TITLE     IL13Ralpha2 as a crucial receptor for Chi3l1 in osteoclast
            differentiation and bone resorption through the MAPK/AKT pathway
  JOURNAL   Cell Commun Signal 22 (1), 81 (2024)
   PUBMED   38291404
  REMARK    GeneRIF: IL13Ralpha2 as a crucial receptor for Chi3l1 in osteoclast
            differentiation and bone resorption through the MAPK/AKT pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2279)
  AUTHORS   Bartolome,R.A., Martin-Regalado,A., Pintado-Berninches,L.,
            Robles,J., Ramirez-Gonzalez,M.A., Boukich,I., Sanchez-Gomez,P.,
            Balyasnikova,I.V. and Casal,J.I.
  TITLE     Schnurri-3 drives tumor growth and invasion in cancer cells
            expressing interleukin-13 receptor alpha 2
  JOURNAL   Cell Death Dis 14 (11), 742 (2023)
   PUBMED   37963919
  REMARK    GeneRIF: Schnurri-3 drives tumor growth and invasion in cancer
            cells expressing interleukin-13 receptor alpha 2.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2279)
  AUTHORS   Li,R., Wang,T., Marquardt,R.M., Lydon,J.P., Wu,S.P. and DeMayo,F.J.
  TITLE     TRIM28 modulates nuclear receptor signaling to regulate uterine
            function
  JOURNAL   Nat Commun 14 (1), 4605 (2023)
   PUBMED   37528140
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2279)
  AUTHORS   Xiao,S., Lu,Z., Steinhoff,M., Li,Y., Buhl,T., Fischer,M., Chen,W.,
            Cheng,W., Zhu,R., Yan,X., Yang,H., Liu,Y., Dou,Y., Wang,W., Wang,J.
            and Meng,J.
  TITLE     Innate immune regulates cutaneous sensory IL-13 receptor alpha 2 to
            promote atopic dermatitis
  JOURNAL   Brain Behav Immun 98, 28-39 (2021)
   PUBMED   34391816
  REMARK    GeneRIF: Innate immune regulates cutaneous sensory IL-13 receptor
            alpha 2 to promote atopic dermatitis.
REFERENCE   6  (bases 1 to 2279)
  AUTHORS   Chiaramonte,M.G., Mentink-Kane,M., Jacobson,B.A., Cheever,A.W.,
            Whitters,M.J., Goad,M.E., Wong,A., Collins,M., Donaldson,D.D.,
            Grusby,M.J. and Wynn,T.A.
  TITLE     Regulation and function of the interleukin 13 receptor alpha 2
            during a T helper cell type 2-dominant immune response
  JOURNAL   J Exp Med 197 (6), 687-701 (2003)
   PUBMED   12642601
  REMARK    GeneRIF: studies illustrate the central role played by the
            IL-13Ralpha2 in the down-regulation of a chronic and pathogenic
            Th2-mediated immune response
REFERENCE   7  (bases 1 to 2279)
  AUTHORS   Osawa,M., Miyoshi,S., Copeland,N.G., Gilbert,D.J., Jenkins,N.A.,
            Hiroyama,T., Motohashi,T., Nakamura,Y., Iwama,A. and Nakauchi,H.
  TITLE     Characterization of the mouse interleukin-13 receptor alpha1 gene
  JOURNAL   Immunogenetics 51 (11), 974-981 (2000)
   PUBMED   11003391
REFERENCE   8  (bases 1 to 2279)
  AUTHORS   Chiaramonte,M.G., Donaldson,D.D., Cheever,A.W. and Wynn,T.A.
  TITLE     An IL-13 inhibitor blocks the development of hepatic fibrosis
            during a T-helper type 2-dominated inflammatory response
  JOURNAL   J Clin Invest 104 (6), 777-785 (1999)
   PUBMED   10491413
  REMARK    GeneRIF: A soluble form of the IL-13 receptor alpha 2 inhibited
            IL-13 activity and the progression of liver fibrosis in
            schistosomiasis.
REFERENCE   9  (bases 1 to 2279)
  AUTHORS   Chiaramonte,M.G., Schopf,L.R., Neben,T.Y., Cheever,A.W.,
            Donaldson,D.D. and Wynn,T.A.
  TITLE     IL-13 is a key regulatory cytokine for Th2 cell-mediated pulmonary
            granuloma formation and IgE responses induced by Schistosoma
            mansoni eggs
  JOURNAL   J Immunol 162 (2), 920-930 (1999)
   PUBMED   9916716
  REMARK    GeneRIF: The IL-13 receptor alpha 2 can be used to inhibit type-2
            cytokine-mediated inflammation in the lung.
REFERENCE   10 (bases 1 to 2279)
  AUTHORS   Donaldson,D.D., Whitters,M.J., Fitz,L.J., Neben,T.Y., Finnerty,H.,
            Henderson,S.L., O'Hara,R.M. Jr., Beier,D.R., Turner,K.J., Wood,C.R.
            and Collins,M.
  TITLE     The murine IL-13 receptor alpha 2: molecular cloning,
            characterization, and comparison with murine IL-13 receptor alpha 1
  JOURNAL   J Immunol 161 (5), 2317-2324 (1998)
   PUBMED   9725226
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL807780.7, BX005200.8 and
            AL662932.10.
            
            On or before Apr 15, 2015 this sequence version replaced
            XM_006528709.1, NM_008356.3.
            
            Summary: This gene encodes a receptor protein that binds to
            interleukin 13 (IL-13) with very high affinity. The encoded protein
            acts as a decoy receptor, and does not elicit any signal upon the
            binding of IL-13. Mice lacking the encoded protein exhibit
            increased levels of serum immunoglobulins, immune-dependent
            production of interferon gamma and, increased bone marrow
            macrophage progenitor frequency. Macrophages lacking the encoded
            protein release less nitric oxide and IL-12 in response to
            lipopolysaccharide. Alternative splicing results in multiple
            transcript variants encoding different isoforms. [provided by
            RefSeq, Apr 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK089687.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-457               AL807780.7         34503-34959         c
            458-535             AL807780.7         13592-13669         c
            536-651             AL807780.7         11799-11914         c
            652-843             AL807780.7         9500-9691           c
            844-951             AL807780.7         6589-6696           c
            952-1060            AL807780.7         3639-3747           c
            1061-1075           AL807780.7         2001-2015           c
            1076-1212           BX005200.8         8329-8465           c
            1213-1366           BX005200.8         7244-7397           c
            1367-1487           BX005200.8         6555-6675           c
            1488-1672           BX005200.8         3071-3255           c
            1673-1712           BX005200.8         2001-2040           c
            1713-1818           AL662932.10        218635-218740       c
            1819-1963           AL662932.10        217186-217330       c
            1964-2079           AL662932.10        213416-213531       c
            2080-2279           AL662932.10        212450-212649       c
FEATURES             Location/Qualifiers
     source          1..2279
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 68.46 cM"
     gene            1..2279
                     /gene="Il13ra2"
                     /gene_synonym="CD213a2; IL-13R-alpha-2"
                     /note="interleukin 13 receptor, alpha 2"
                     /db_xref="GeneID:16165"
                     /db_xref="MGI:MGI:1277954"
     exon            1..457
                     /gene="Il13ra2"
                     /gene_synonym="CD213a2; IL-13R-alpha-2"
                     /inference="alignment:Splign:2.1.0"
     exon            458..535
                     /gene="Il13ra2"
                     /gene_synonym="CD213a2; IL-13R-alpha-2"
                     /inference="alignment:Splign:2.1.0"
     exon            536..651
                     /gene="Il13ra2"
                     /gene_synonym="CD213a2; IL-13R-alpha-2"
                     /inference="alignment:Splign:2.1.0"
     exon            652..843
                     /gene="Il13ra2"
                     /gene_synonym="CD213a2; IL-13R-alpha-2"
                     /inference="alignment:Splign:2.1.0"
     exon            844..951
                     /gene="Il13ra2"
                     /gene_synonym="CD213a2; IL-13R-alpha-2"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1060
                     /gene="Il13ra2"
                     /gene_synonym="CD213a2; IL-13R-alpha-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             985..2136
                     /gene="Il13ra2"
                     /gene_synonym="CD213a2; IL-13R-alpha-2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; interleukin-13 receptor subunit alpha-2"
                     /codon_start=1
                     /product="interleukin-13 receptor subunit alpha-2 isoform
                     1 precursor"
                     /protein_id="NP_032382.1"
                     /db_xref="CCDS:CCDS30460.1"
                     /db_xref="GeneID:16165"
                     /db_xref="MGI:MGI:1277954"
                     /translation="MAFVHIRCLCFILLCTITGYSLEIKVNPPQDFEILDPGLLGYLY
                     LQWKPPVVIEKFKGCTLEYELKYRNVDSDSWKTIITRNLIYKDGFDLNKGIEGKIRTH
                     LSEHCTNGSEVQSPWIEASYGISDEGSLETKIQDMKCIYYNWQYLVCSWKPGKTVYSD
                     TNYTMFFWYEGLDHALQCADYLQHDEKNVGCKLSNLDSSDYKDFFICVNGSSKLEPIR
                     SSYTVFQLQNIVKPLPPEFLHISVENSIDIRMKWSTPGGPIPPRCYTYEIVIREDDIS
                     WESATDKNDMKLKRRANESEDLCFFVRCKVNIYCADDGIWSEWSEEECWEGYTGPDSK
                     IIFIVPVCLFFIFLLLLLCLIVEKEEPEPTLSLHVDLNKEVCAYEDTLC"
     exon            1061..1212
                     /gene="Il13ra2"
                     /gene_synonym="CD213a2; IL-13R-alpha-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1366
                     /gene="Il13ra2"
                     /gene_synonym="CD213a2; IL-13R-alpha-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1487
                     /gene="Il13ra2"
                     /gene_synonym="CD213a2; IL-13R-alpha-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1672
                     /gene="Il13ra2"
                     /gene_synonym="CD213a2; IL-13R-alpha-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1818
                     /gene="Il13ra2"
                     /gene_synonym="CD213a2; IL-13R-alpha-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..1963
                     /gene="Il13ra2"
                     /gene_synonym="CD213a2; IL-13R-alpha-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2079
                     /gene="Il13ra2"
                     /gene_synonym="CD213a2; IL-13R-alpha-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2279
                     /gene="Il13ra2"
                     /gene_synonym="CD213a2; IL-13R-alpha-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2178..2183
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il13ra2"
                     /gene_synonym="CD213a2; IL-13R-alpha-2"
                     /note="hexamer: ATTAAA"
     polyA_site      2200
                     /gene="Il13ra2"
                     /gene_synonym="CD213a2; IL-13R-alpha-2"
                     /note="major polyA site"
     regulatory      2206..2211
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il13ra2"
                     /gene_synonym="CD213a2; IL-13R-alpha-2"
                     /note="hexamer: AATACA"
     polyA_site      2226
                     /gene="Il13ra2"
                     /gene_synonym="CD213a2; IL-13R-alpha-2"
ORIGIN      
        1 atgagaatca cagcaagacc tactgaccct cagctttctt ctgtaggact ggatcttcta
       61 cactagttct ttgggaattg tgctgtcttc atataaagac atattgcact agcgtgattt
      121 ccattttgtt ggctggttgt atgaagtata tatattttta aatgtattca ctgatgaata
      181 gtatttgtat catccattct gttttggaag aggagattac tatgaccagt ccacatgcca
      241 tgccagtcca caaacattct actatcttaa aattttaatt ttgtaaaaca aataagcatt
      301 tatttgagta attatccttt cacagatatc aggaagttag cagattagaa attctattct
      361 tgttagctga tttgtttcag ttcatattaa tagctctaca cagtgcttgt agagacaatt
      421 tgcaagaagt ttctggatcc cacgcatatt ttgaaagaga tcatacacag aagaaaacaa
      481 atgaaaatcc ggactgcttc cagaaaatag agatttccaa ttttctggag aaatgatttc
      541 atacatggag agaaagcttg cctttctgac ttacatgatt attttgatgt aaaggatctt
      601 ctttgtttca agacttaatt tcccggggct taaccctttg gccctcctaa ggacacagta
      661 tttacaatcc agtctttgaa agcatctgag gagtgtggag gaggaggagg aggaggagga
      721 ggagaagaag gaggaggaga agaggagagg aggagggaaa gatagaaaga gagagagaaa
      781 gattgcttgc tacccctgaa cagtgacctc tctcaagaca gtgctttgct cttcacgtat
      841 aaggaaggaa aacagtagag attcaattta gtgtctaatg tggaaaggag gacaaagagg
      901 tcttgtgata actgcctgtg ataatacatt tcttgagaaa ccatattatt gagtagagct
      961 ttcagcacac taaatcctgg agaaatggct tttgtgcata tcagatgctt gtgtttcatt
     1021 cttctttgta caataactgg ctattctttg gagataaaag ttaatcctcc tcaggatttt
     1081 gaaatattgg atcctggatt acttggttat ctctatttgc aatggaaacc tcctgtggtt
     1141 atagaaaaat ttaagggctg tacactagaa tatgagttaa aataccgaaa tgttgatagc
     1201 gacagctgga agactataat tactaggaat ctaatttaca aggatgggtt tgatcttaat
     1261 aaaggcattg aaggaaagat acgtacgcat ttgtcagagc attgtacaaa tggatcagaa
     1321 gtacaaagtc catggataga agcttcttat gggatatcag atgaaggaag tttggaaact
     1381 aaaattcagg acatgaagtg tatatattat aactggcagt atttggtctg ctcttggaaa
     1441 cctggcaaga cagtatattc tgataccaac tataccatgt ttttctggta tgagggcttg
     1501 gatcatgcct tacagtgtgc tgattacctc cagcatgatg aaaaaaatgt tggatgcaaa
     1561 ctgtccaact tggactcatc agactataaa gattttttta tctgtgttaa tggatcttca
     1621 aagttggaac ccatcagatc cagctataca gtttttcaac ttcaaaatat agttaaacca
     1681 ttgccaccag aattccttca tattagtgtg gagaattcca ttgatattag aatgaaatgg
     1741 agcacacctg gaggacccat tccaccaagg tgttacactt atgaaattgt gatccgagaa
     1801 gacgatattt cctgggagtc tgccacagac aaaaacgata tgaagttgaa gaggagagca
     1861 aatgaaagtg aagacctatg cttttttgta agatgtaagg tcaatatata ttgtgcagat
     1921 gatggaattt ggagcgaatg gagtgaagag gaatgttggg aaggttacac agggccagac
     1981 tcaaagatta ttttcatagt accagtttgt cttttcttta tattcctttt gttacttctt
     2041 tgccttattg tggagaagga agaacctgaa cccacattga gcctccatgt ggatctgaac
     2101 aaagaagtgt gtgcttatga agataccctc tgttaaacca ccaatttctt gacatagagc
     2161 cagccagcag gagtcatatt aaactcaatt tctcttaaaa tttcgaatac atcttcttga
     2221 aaatcagtgt ttgtcctaat agtgttgggt ttttgactaa agtgctggat atatatctc
//
