LOCUS       NM_133990               3734 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus interleukin 13 receptor, alpha 1 (Il13ra1), mRNA.
ACCESSION   NM_133990
VERSION     NM_133990.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3734)
  AUTHORS   Salomaa,T., Kummola,L., Gonzalez-Rodriguez,M.I., Hiihtola,L.,
            Jarvinen,T.A.H. and Junttila,I.S.
  TITLE     Low IL-13Ralpha1 expression on mast cells tunes them unresponsive
            to IL-13
  JOURNAL   J Leukoc Biol 114 (2), 187-194 (2023)
   PUBMED   37224625
  REMARK    GeneRIF: Low IL-13Ralpha1 expression on mast cells tunes them
            unresponsive to IL-13.
REFERENCE   2  (bases 1 to 3734)
  AUTHORS   Ricardo-Gonzalez,R.R., Kotas,M.E., O'Leary,C.E., Singh,K.,
            Damsky,W., Liao,C., Arouge,E., Tenvooren,I., Marquez,D.M.,
            Schroeder,A.W., Cohen,J.N., Fassett,M.S., Lee,J., Daniel,S.G.,
            Bittinger,K., Diaz,R.E., Fraser,J.S., Ali,N., Ansel,K.M.,
            Spitzer,M.H., Liang,H.E. and Locksley,R.M.
  TITLE     Innate type 2 immunity controls hair follicle commensalism by
            Demodex mites
  JOURNAL   Immunity 55 (10), 1891-1908 (2022)
   PUBMED   36044899
REFERENCE   3  (bases 1 to 3734)
  AUTHORS   Chen,Z., Flores Castro,D., Gupta,S., Phalke,S., Manni,M.,
            Rivera-Correa,J., Jessberger,R., Zaghouani,H., Giannopoulou,E.,
            Pannellini,T. and Pernis,A.B.
  TITLE     Interleukin-13 Receptor alpha1-Mediated Signaling Regulates
            Age-Associated/Autoimmune B Cell Expansion and Lupus Pathogenesis
  JOURNAL   Arthritis Rheumatol 74 (9), 1544-1555 (2022)
   PUBMED   35438841
  REMARK    GeneRIF: Interleukin-13 Receptor alpha1-Mediated Signaling
            Regulates Age-Associated/Autoimmune B Cell Expansion and Lupus
            Pathogenesis.
REFERENCE   4  (bases 1 to 3734)
  AUTHORS   Salomaa,T., Pemmari,T., Maatta,J., Kummola,L., Salonen,N.,
            Gonzalez-Rodriguez,M., Parviainen,L., Hiihtola,L., Vahatupa,M.,
            Jarvinen,T.A.H. and Junttila,I.S.
  TITLE     IL-13Ralpha1 Suppresses Tumor Progression in Two-Stage Skin
            Carcinogenesis Model by Regulating Regulatory T Cells
  JOURNAL   J Invest Dermatol 142 (6), 1565-1575 (2022)
   PUBMED   34808240
  REMARK    GeneRIF: IL-13Ralpha1 Suppresses Tumor Progression in Two-Stage
            Skin Carcinogenesis Model by Regulating Regulatory T Cells.
REFERENCE   5  (bases 1 to 3734)
  AUTHORS   Osawa,M., Miyoshi,S., Copeland,N.G., Gilbert,D.J., Jenkins,N.A.,
            Hiroyama,T., Motohashi,T., Nakamura,Y., Iwama,A. and Nakauchi,H.
  TITLE     Characterization of the mouse interleukin-13 receptor alpha1 gene
  JOURNAL   Immunogenetics 51 (11), 974-981 (2000)
   PUBMED   11003391
REFERENCE   6  (bases 1 to 3734)
  AUTHORS   Donaldson,D.D., Whitters,M.J., Fitz,L.J., Neben,T.Y., Finnerty,H.,
            Henderson,S.L., O'Hara,R.M. Jr., Beier,D.R., Turner,K.J., Wood,C.R.
            and Collins,M.
  TITLE     The murine IL-13 receptor alpha 2: molecular cloning,
            characterization, and comparison with murine IL-13 receptor alpha 1
  JOURNAL   J Immunol 161 (5), 2317-2324 (1998)
   PUBMED   9725226
REFERENCE   7  (bases 1 to 3734)
  AUTHORS   Gauchat,J.F., Schlagenhauf,E., Feng,N.P., Moser,R., Yamage,M.,
            Jeannin,P., Alouani,S., Elson,G., Notarangelo,L.D., Wells,T.,
            Eugster,H.P. and Bonnefoy,J.Y.
  TITLE     A novel 4-kb interleukin-13 receptor alpha mRNA expressed in human
            B, T, and endothelial cells encoding an alternate type-II
            interleukin-4/interleukin-13 receptor
  JOURNAL   Eur J Immunol 27 (4), 971-978 (1997)
   PUBMED   9130652
REFERENCE   8  (bases 1 to 3734)
  AUTHORS   Miloux,B., Laurent,P., Bonnin,O., Lupker,J., Caput,D., Vita,N. and
            Ferrara,P.
  TITLE     Cloning of the human IL-13R alpha1 chain and reconstitution with
            the IL4R alpha of a functional IL-4/IL-13 receptor complex
  JOURNAL   FEBS Lett 401 (2-3), 163-166 (1997)
   PUBMED   9013879
REFERENCE   9  (bases 1 to 3734)
  AUTHORS   Aman,M.J., Tayebi,N., Obiri,N.I., Puri,R.K., Modi,W.S. and
            Leonard,W.J.
  TITLE     cDNA cloning and characterization of the human interleukin 13
            receptor alpha chain
  JOURNAL   J Biol Chem 271 (46), 29265-29270 (1996)
   PUBMED   8910586
REFERENCE   10 (bases 1 to 3734)
  AUTHORS   Hilton,D.J., Zhang,J.G., Metcalf,D., Alexander,W.S., Nicola,N.A.
            and Willson,T.A.
  TITLE     Cloning and characterization of a binding subunit of the
            interleukin 13 receptor that is also a component of the interleukin
            4 receptor
  JOURNAL   Proc Natl Acad Sci U S A 93 (1), 497-501 (1996)
   PUBMED   8552669
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL672038.7, BC052425.1,
            AK082889.1 and CK334115.1.
            
            On May 8, 2015 this sequence version replaced NM_133990.4.
            
            Summary: This gene encodes a transmembrane protein that complexes
            with interleukin 4 receptor alpha (IL4RA) to form a functional
            receptor for interleukin-13. Signalling through this pathway
            mediates allergy response and occurs during bronchial asthma.
            [provided by RefSeq, May 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052425.1, AK154675.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AL672038.7         156663-156693
            32-1339             BC052425.1         1-1308
            1340-1340           AK082889.1         1281-1281
            1341-2574           BC052425.1         1310-2543
            2575-2575           CK334115.1         452-452
            2576-3734           BC052425.1         2545-3703
FEATURES             Location/Qualifiers
     source          1..3734
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 20.49 cM"
     gene            1..3734
                     /gene="Il13ra1"
                     /gene_synonym="CD213a1; IL-13R-alpha-1; IL-13r[a]; Il13ra;
                     NR4"
                     /note="interleukin 13 receptor, alpha 1"
                     /db_xref="GeneID:16164"
                     /db_xref="MGI:MGI:105052"
     exon            1..168
                     /gene="Il13ra1"
                     /gene_synonym="CD213a1; IL-13R-alpha-1; IL-13r[a]; Il13ra;
                     NR4"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1361
                     /gene="Il13ra1"
                     /gene_synonym="CD213a1; IL-13R-alpha-1; IL-13r[a]; Il13ra;
                     NR4"
                     /note="interleukin-13 receptor subunit alpha-1; IL-13R
                     subunit alpha-1; novel cytokine receptor 4; IL-13 receptor
                     subunit alpha-1; interleukin-13-binding protein"
                     /codon_start=1
                     /product="interleukin-13 receptor subunit alpha-1
                     precursor"
                     /protein_id="NP_598751.3"
                     /db_xref="CCDS:CCDS30057.1"
                     /db_xref="GeneID:16164"
                     /db_xref="MGI:MGI:105052"
                     /translation="MARPALLGELLVLLLWTATVGQVAAATEVQPPVTNLSVSVENLC
                     TIIWTWSPPEGASPNCTLRYFSHFDDQQDKKIAPETHRKEELPLDEKICLQVGSQCSA
                     NESEKPSPLVKKCISPPEGDPESAVTELKCIWHNLSYMKCSWLPGRNTSPDTHYTLYY
                     WYSSLEKSRQCENIYREGQHIACSFKLTKVEPSFEHQNVQIMVKDNAGKIRPSCKIVS
                     LTSYVKPDPPHIKHLLLKNGALLVQWKNPQNFRSRCLTYEVEVNNTQTDRHNILEVEE
                     DKCQNSESDRNMEGTSCFQLPGVLADAVYTVRVRVKTNKLCFDDNKLWSDWSEAQSIG
                     KEQNSTFYTTMLLTIPVFVAVAVIILLFYLKRLKIIIFPPIPDPGKIFKEMFGDQNDD
                     TLHWKKYDIYEKQSKEETDSVVLIENLKKAAP"
     exon            169..308
                     /gene="Il13ra1"
                     /gene_synonym="CD213a1; IL-13R-alpha-1; IL-13r[a]; Il13ra;
                     NR4"
                     /inference="alignment:Splign:2.1.0"
     exon            309..447
                     /gene="Il13ra1"
                     /gene_synonym="CD213a1; IL-13R-alpha-1; IL-13r[a]; Il13ra;
                     NR4"
                     /inference="alignment:Splign:2.1.0"
     exon            448..568
                     /gene="Il13ra1"
                     /gene_synonym="CD213a1; IL-13R-alpha-1; IL-13r[a]; Il13ra;
                     NR4"
                     /inference="alignment:Splign:2.1.0"
     exon            569..753
                     /gene="Il13ra1"
                     /gene_synonym="CD213a1; IL-13R-alpha-1; IL-13r[a]; Il13ra;
                     NR4"
                     /inference="alignment:Splign:2.1.0"
     exon            754..905
                     /gene="Il13ra1"
                     /gene_synonym="CD213a1; IL-13R-alpha-1; IL-13r[a]; Il13ra;
                     NR4"
                     /inference="alignment:Splign:2.1.0"
     exon            906..953
                     /gene="Il13ra1"
                     /gene_synonym="CD213a1; IL-13R-alpha-1; IL-13r[a]; Il13ra;
                     NR4"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1086
                     /gene="Il13ra1"
                     /gene_synonym="CD213a1; IL-13R-alpha-1; IL-13r[a]; Il13ra;
                     NR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1183
                     /gene="Il13ra1"
                     /gene_synonym="CD213a1; IL-13R-alpha-1; IL-13r[a]; Il13ra;
                     NR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1268
                     /gene="Il13ra1"
                     /gene_synonym="CD213a1; IL-13R-alpha-1; IL-13r[a]; Il13ra;
                     NR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..3717
                     /gene="Il13ra1"
                     /gene_synonym="CD213a1; IL-13R-alpha-1; IL-13r[a]; Il13ra;
                     NR4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1861..1866
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il13ra1"
                     /gene_synonym="CD213a1; IL-13R-alpha-1; IL-13r[a]; Il13ra;
                     NR4"
                     /note="hexamer: ATTAAA"
     polyA_site      1890
                     /gene="Il13ra1"
                     /gene_synonym="CD213a1; IL-13R-alpha-1; IL-13r[a]; Il13ra;
                     NR4"
     regulatory      3686..3691
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il13ra1"
                     /gene_synonym="CD213a1; IL-13R-alpha-1; IL-13r[a]; Il13ra;
                     NR4"
                     /note="hexamer: AATAAA"
     polyA_site      3717
                     /gene="Il13ra1"
                     /gene_synonym="CD213a1; IL-13R-alpha-1; IL-13r[a]; Il13ra;
                     NR4"
                     /note="major polyA site"
ORIGIN      
        1 gcggcggccg ggaagtggga gcaagaacag aggaggcgga gactgccgcg gctccagccg
       61 ggccacgctc cgaggcgagg ggctgcatgg cgcggccagc gctgctgggc gagctgttgg
      121 tgctgctact gtggaccgcc accgtgggcc aagttgccgc ggccacagaa gttcagccac
      181 ctgtgacgaa tttgagcgtc tctgtcgaaa atctctgcac gataatatgg acgtggagtc
      241 ctcctgaagg agccagtcca aattgcactc tcagatattt tagtcacttt gatgaccaac
      301 aggataagaa aattgctcca gaaactcatc gtaaagagga attacccctg gatgagaaaa
      361 tctgtctgca ggtgggctct cagtgtagtg ccaatgaaag tgagaagcct agccctttgg
      421 tgaaaaagtg catctcaccc cctgaaggtg atcctgagtc cgctgtgact gagctcaagt
      481 gcatttggca taacctgagc tatatgaagt gttcctggct ccctggaagg aatacaagcc
      541 ctgacacaca ctatactctg tactattggt acagcagcct ggagaaaagt cgtcaatgtg
      601 aaaacatcta tagagaaggt caacacattg cttgttcctt taaattgact aaagtggaac
      661 ctagttttga acatcagaac gttcaaataa tggtcaagga taatgctggg aaaattaggc
      721 catcctgcaa aatagtgtct ttaacttcct atgtgaaacc tgatcctcca catattaaac
      781 atcttctcct caaaaatggt gccttattag tgcagtggaa gaatccacaa aattttagaa
      841 gcagatgctt aacttatgaa gtggaggtca ataatactca aaccgaccga cataatattt
      901 tagaggttga agaggacaaa tgccagaatt ccgaatctga tagaaacatg gagggtacaa
      961 gttgtttcca actccctggt gttcttgccg acgctgtcta cacagtcaga gtaagagtca
     1021 aaacaaacaa gttatgcttt gatgacaaca aactgtggag tgattggagt gaagcacaga
     1081 gtataggtaa ggagcaaaac tccaccttct acaccaccat gttactcacc attccagtct
     1141 ttgtcgcagt ggcagtcata atcctccttt tttacctgaa aaggcttaag atcattatat
     1201 ttcctccaat tcctgatcct ggcaagattt ttaaagaaat gtttggagac cagaatgatg
     1261 ataccctgca ctggaagaag tatgacatct atgagaaaca atccaaagaa gaaacggatt
     1321 ctgtagtgct gatagaaaac ctgaagaaag cagctccttg atggggagaa gtgatttctt
     1381 tcttgccttc aatgtgaccc tgtgaagatt tattgcattc tccatttgtt atctggggac
     1441 ttgttaaata gaaactgaaa ctactcttga aaaacaggca gctcctaaga gccacaggtc
     1501 ttgatgtgac ttttgcattg aaaatccaaa ccaaaggagc tcttcaagaa aagcagagtt
     1561 cttctcgttc ttgttcaatc ctaaaagcag atgttttgcc aaatctccaa actagaggac
     1621 aaagacaagg ggacaatgac catcaattca tctaatcagg aattgtgatg gcttcctaag
     1681 gaatctctgc ttgctctgta ttctttatgt ggaataatat caagaaattt ttcttgtgag
     1741 gaaattcatt tggggtgtgt acactaatgc tgtactagat tcccacagaa catctagcaa
     1801 acaaaactga tacaatctgc tgcctattgt ttgaggaccc actgagtaat gtttgtggct
     1861 attaaaatgc attatcatta tccacttcaa tagcattttc ctctgctttg aaatttccag
     1921 aaatcatctt gggccaaggc aatgacacat acagaaaagt catgggcaac ttctccacca
     1981 aggctgattt atgttattgc tggtcttttt aggacaatgg atgcagaatg aggtagcatt
     2041 cgagttggaa ccaagaagac tctaatgatg tatgcccacc tttcatttct gctattcaag
     2101 ttttgactat gtatctagct tgtgcaaaac ccttaagtat gagggatagg acccccaccc
     2161 atgggtttac atatatttgg ggctcattat tttttagcat tttctttatc tccggatagc
     2221 catttcctgg acttttgaac ttcccatctt ctatgcttat gtcccactgt gcctgctccc
     2281 ccatcctctt tcttgtagcc ttttgactca gtggaatcga agatacaatt ttccttagac
     2341 tacctagtgg agcagggaat actctgcatc tcaggtaaaa aaatgagtac actgaacaat
     2401 atgtaattca tacgtatttt gcaacttacc tgtgagcctg caattatttg aggtttttga
     2461 gcaattggtg tttctatgtg ttttctaaat agagatgata tctttttttt tttcacttag
     2521 aatttagctc catttgcttg agagaggggg aaaaattcat atctgtttct ctttgtttgc
     2581 aaataagcct taggatggct gttttctatg ctgtaagtgg tcctgtcaat tctgtgtttt
     2641 attgagaggg agacaaatgg agctccaact atttactcac ttttgcatat attaggtttc
     2701 caattctatt ccattctcac aatataagca tatatatccc cattccaacc atttctgcaa
     2761 atttaaaaca gtgagaggta ccttccttct ctttctcata cacacagatc actagcaagg
     2821 actaaagaat tttatatcaa aattctccag gcatgtacca gttcgggtta ataaaatgat
     2881 gccacttgtg tcttttgttc ttaagcaggg aagataagag accctgctct ccacaggttg
     2941 gtacaaaggg gaaccttgct tctgtggtag tagaggagca ttgtgcctgg aatttcagga
     3001 actattggag cacggcacaa ttgatgcaca ggtatttcct cctggccctt ttgggtatca
     3061 gcttgcagct gggatacagg catcttagat attgcagttt ctcctgctat tcactagaaa
     3121 gaaggcttgg ctttcttgac tttcttgcat aagagtgaaa tactccttac ccagggtatc
     3181 atagttctaa gaatgaaagc accttaaatg ccttgcacag aaccaatttt ttttaactac
     3241 tggcctattt taatggtggt aaagagcatg ttttgaaatg ctgtggaaac catctatgct
     3301 gacagtcttg cagcatggga acaaagacat catattttgc ttcaaattct ctttcagtag
     3361 tacaatagca gggggaaagg ggacaggtaa caggagtacc tttgttttaa cagacaaaag
     3421 taatctccag gccttaggga ctcataaaga tatgagtaca ttgcttattg gaaacttgta
     3481 ggttcacata ttattttgac taaggtatat ggatttcccc ccacttacat aagtaaaccc
     3541 aacataagga ggaccattcc ttttctttca ttcagatgac ctttttctga atctgggcac
     3601 tgaagggatg cataaaataa tgttaatgtt ttcagtaatg tcttcaagta gaagactttc
     3661 tgttgaacta cttataagaa agtaaaataa atattgtctt tttgtatgtc acccaaaaaa
     3721 aaaaaaaaaa aaaa
//
