LOCUS       NM_008355               1217 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Mus musculus interleukin 13 (Il13), mRNA.
ACCESSION   NM_008355
VERSION     NM_008355.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1217)
  AUTHORS   Akama,Y., Park,E.J., Satoh-Takayama,N., Ito,A., Kawamoto,E.,
            Gaowa,A., Matsuo,E., Oikawa,S., Saito,M., Inoue,S., Akimoto,T.,
            Suzuki,K. and Shimaoka,M.
  TITLE     Roles of programmed death-1 and muscle innate lymphoid cell-derived
            interleukin 13 in sepsis-induced intensive care unit-acquired
            weakness
  JOURNAL   J Cachexia Sarcopenia Muscle 15 (5), 1999-2012 (2024)
   PUBMED   39016179
  REMARK    GeneRIF: Roles of programmed death-1 and muscle innate lymphoid
            cell-derived interleukin 13 in sepsis-induced intensive care
            unit-acquired weakness.
REFERENCE   2  (bases 1 to 1217)
  AUTHORS   Bessell,E., Finlay,R.E., James,L.K., Ludewig,B., Harris,N.L.,
            Krebs,P., Hepworth,M.R. and Dubey,L.K.
  TITLE     Stromal cell and B cell dialogue potentiates IL-33-enriched
            lymphoid niches to support eosinophil recruitment and function
            during type 2 immunity
  JOURNAL   Cell Rep 43 (8), 114620 (2024)
   PUBMED   39141517
REFERENCE   3  (bases 1 to 1217)
  AUTHORS   Donlan,A.N., Leslie,J.L., Simpson,M.E., Petri,W.A., Allen,J.E. and
            Petri,W.A.
  TITLE     IL-13 protects from Clostridioides difficile colitis
  JOURNAL   Anaerobe 88, 102860 (2024)
   PUBMED   38701912
  REMARK    GeneRIF: IL-13 protects from Clostridioides difficile colitis.
REFERENCE   4  (bases 1 to 1217)
  AUTHORS   Billipp,T.E., Fung,C., Webeck,L.M., Sargent,D.B., Gologorsky,M.B.,
            Chen,Z., McDaniel,M.M., Kasal,D.N., McGinty,J.W., Barrow,K.A.,
            Rich,L.M., Barilli,A., Sabat,M., Debley,J.S., Wu,C., Myers,R.,
            Howitt,M.R. and von Moltke,J.
  TITLE     Tuft cell-derived acetylcholine promotes epithelial chloride
            secretion and intestinal helminth clearance
  JOURNAL   Immunity 57 (6), 1243-1259 (2024)
   PUBMED   38744291
REFERENCE   5  (bases 1 to 1217)
  AUTHORS   Cespedes,N., Fellows,A.M., Donnelly,E.L., Kaylor,H.L., Coles,T.A.,
            Wild,R., Dobson,M., Schauer,J., Van de Water,J. and Luckhart,S.
  TITLE     Basophil-Derived IL-4 and IL-13 Protect Intestinal Barrier
            Integrity and Control Bacterial Translocation during Malaria
  JOURNAL   Immunohorizons 8 (5), 371-383 (2024)
   PUBMED   38780542
  REMARK    GeneRIF: Basophil-Derived IL-4 and IL-13 Protect Intestinal Barrier
            Integrity and Control Bacterial Translocation during Malaria.
REFERENCE   6  (bases 1 to 1217)
  AUTHORS   Zurawski,G. and de Vries,J.E.
  TITLE     Interleukin 13, an interleukin 4-like cytokine that acts on
            monocytes and B cells, but not on T cells
  JOURNAL   Immunol Today 15 (1), 19-26 (1994)
   PUBMED   7907877
  REMARK    Review article
REFERENCE   7  (bases 1 to 1217)
  AUTHORS   Doherty,T.M., Kastelein,R., Menon,S., Andrade,S. and Coffman,R.L.
  TITLE     Modulation of murine macrophage function by IL-13
  JOURNAL   J Immunol 151 (12), 7151-7160 (1993)
   PUBMED   7903102
REFERENCE   8  (bases 1 to 1217)
  AUTHORS   McKenzie,A.N., Li,X., Largaespada,D.A., Sato,A., Kaneda,A.,
            Zurawski,S.M., Doyle,E.L., Milatovich,A., Francke,U., Copeland,N.G.
            et al.
  TITLE     Structural comparison and chromosomal localization of the human and
            mouse IL-13 genes
  JOURNAL   J Immunol 150 (12), 5436-5444 (1993)
   PUBMED   8099936
REFERENCE   9  (bases 1 to 1217)
  AUTHORS   Minty,A., Chalon,P., Derocq,J.M., Dumont,X., Guillemot,J.C.,
            Kaghad,M., Labit,C., Leplatois,P., Liauzun,P., Miloux,B. et al.
  TITLE     Interleukin-13 is a new human lymphokine regulating inflammatory
            and immune responses
  JOURNAL   Nature 362 (6417), 248-250 (1993)
   PUBMED   8096327
REFERENCE   10 (bases 1 to 1217)
  AUTHORS   Brown,K.D., Zurawski,S.M., Mosmann,T.R. and Zurawski,G.
  TITLE     A family of small inducible proteins secreted by leukocytes are
            members of a new superfamily that includes leukocyte and
            fibroblast-derived inflammatory agents, growth factors, and
            indicators of various activation processes
  JOURNAL   J Immunol 142 (2), 679-687 (1989)
   PUBMED   2521353
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            M23504.1 and AA646049.1.
            
            On Apr 16, 2009 this sequence version replaced NM_008355.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M23504.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-950               M23504.1           2-951
            951-1205            M23504.1           953-1207
            1206-1217           AA646049.1         419-430
FEATURES             Location/Qualifiers
     source          1..1217
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 31.98 cM"
     gene            1..1217
                     /gene="Il13"
                     /gene_synonym="Il-13"
                     /note="interleukin 13"
                     /db_xref="GeneID:16163"
                     /db_xref="MGI:MGI:96541"
     exon            1..209
                     /gene="Il13"
                     /gene_synonym="Il-13"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..464
                     /gene="Il13"
                     /gene_synonym="Il-13"
                     /note="T-cell activation protein P600"
                     /codon_start=1
                     /product="interleukin-13 precursor"
                     /protein_id="NP_032381.1"
                     /db_xref="CCDS:CCDS24683.1"
                     /db_xref="GeneID:16163"
                     /db_xref="MGI:MGI:96541"
                     /translation="MALWVTAVLALACLGGLAAPGPVPRSVSLPLTLKELIEELSNIT
                     QDQTPLCNGSMVWSVDLAAGGFCVALDSLTNISNCNAIYRTQRILHGLCNRKAPTTVS
                     SLPDTKIEVAHFITKLLSYTKQLFRHGPF"
     exon            210..263
                     /gene="Il13"
                     /gene_synonym="Il-13"
                     /inference="alignment:Splign:2.1.0"
     exon            264..368
                     /gene="Il13"
                     /gene_synonym="Il-13"
                     /inference="alignment:Splign:2.1.0"
     exon            369..1206
                     /gene="Il13"
                     /gene_synonym="Il-13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1187..1192
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il13"
                     /gene_synonym="Il-13"
                     /note="hexamer: AATAAA"
     polyA_site      1206
                     /gene="Il13"
                     /gene_synonym="Il-13"
                     /note="major polyA site"
ORIGIN      
        1 acaagccagc agcctaggcc agcccacagt tctacagctc cctggttctc tcactggctc
       61 tgggcttcat ggcgctctgg gtgactgcag tcctggctct tgcttgcctt ggtggtctcg
      121 ccgccccagg gccggtgcca agatctgtgt ctctccctct gacccttaag gagcttattg
      181 aggagctgag caacatcaca caagaccaga ctcccctgtg caacggcagc atggtatgga
      241 gtgtggacct ggccgctggc gggttctgtg tagccctgga ttccctgacc aacatctcca
      301 attgcaatgc catctacagg acccagagga tattgcatgg cctctgtaac cgcaaggccc
      361 ccactacggt ctccagcctc cccgatacca aaatcgaagt agcccacttt ataacaaaac
      421 tgctcagcta cacaaagcaa ctgtttcgcc acggcccctt ctaatgagga gagaccatcc
      481 ctgggcatct cagctgtgga ctcattttcc tttctcacat cagactttgc tggggagagg
      541 cagggaggag ggttgaggag gaagggagat gcctcagctt tggcctcagc ctgcactgcc
      601 tgcctagtgc tcagggtctc agcctggcaa cacccccacc ccacccccac ccccgccgcc
      661 ccatcccatc cctacagaaa actgcagcaa gaccgtgagt ccagcctgtg gcctggtcca
      721 cacagggcaa ctgaggcagg cagcagcttg agcacatttc ttcttgatct tatttattat
      781 ggttgtgtgt tatttaaatg agtctgtcag tatcccggtg gggacatggt ttgctgccta
      841 tgccctgggg gctccagcat tgaagcagtg ggctctgggg tccctggcaa tattactgta
      901 tacataactc tgctacctca ctgtagcctc caggtctcac cccaggcagg agatgggagg
      961 ggaggccaga gcaacactcc tgtctgccac ggcagcaacc agccctcagc catgaaataa
     1021 cttattgttt tgttcttata tttaaagtat taaatagctt agcaaagagt taataatata
     1081 tggaagaatg gcctgttaca ctcaaggtga tgtgtagtga atggggggag ggtggtgggt
     1141 ttgtcactga acaaactttt cattgactgt caaactagaa accggaaata aagatggtga
     1201 cagataaaaa aaaaaaa
//
