LOCUS       NM_008354               2998 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus interleukin 12 receptor, beta 2 (Il12rb2), transcript
            variant 1, mRNA.
ACCESSION   NM_008354 XM_983347 XM_991219
VERSION     NM_008354.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2998)
  AUTHORS   Solaymani-Mohammadi,S.
  TITLE     The IL-21/IL-21R signaling axis regulates CD4+ T-cell
            responsiveness to IL-12 to promote bacterial-induced colitis
  JOURNAL   J Leukoc Biol 116 (4), 726-737 (2024)
   PUBMED   38498592
REFERENCE   2  (bases 1 to 2998)
  AUTHORS   Roy,T.A., Bubier,J.A., Dickson,P.E., Wilcox,T.D., Ndukum,J.,
            Clark,J.W., Sukoff Rizzo,S.J., Crabbe,J.C., Denegre,J.M.,
            Svenson,K.L., Braun,R.E., Kumar,V., Murray,S.A., White,J.K.,
            Philip,V.M. and Chesler,E.J.
  TITLE     Discovery and validation of genes driving drug-intake and related
            behavioral traits in mice
  JOURNAL   Genes Brain Behav 23 (1), e12875 (2024)
   PUBMED   38164795
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (bases 1 to 2998)
  AUTHORS   Andreadou,M., Ingelfinger,F., De Feo,D., Cramer,T.L.M., Tuzlak,S.,
            Friebel,E., Schreiner,B., Eede,P., Schneeberger,S., Geesdorf,M.,
            Ridder,F., Welsh,C.A., Power,L., Kirschenbaum,D., Tyagarajan,S.K.,
            Greter,M., Heppner,F.L., Mundt,S. and Becher,B.
  TITLE     IL-12 sensing in neurons induces neuroprotective CNS tissue
            adaptation and attenuates neuroinflammation in mice
  JOURNAL   Nat Neurosci 26 (10), 1701-1712 (2023)
   PUBMED   37749256
REFERENCE   4  (bases 1 to 2998)
  AUTHORS   Ma,L., Hostetler,A., Morgan,D.M., Maiorino,L., Sulkaj,I.,
            Whittaker,C.A., Neeser,A., Pires,I.S., Yousefpour,P., Gregory,J.,
            Qureshi,K., Dye,J., Abraham,W., Suh,H., Li,N., Love,J.C. and
            Irvine,D.J.
  TITLE     Vaccine-boosted CAR T crosstalk with host immunity to reject tumors
            with antigen heterogeneity
  JOURNAL   Cell 186 (15), 3148-3165 (2023)
   PUBMED   37413990
REFERENCE   5  (bases 1 to 2998)
  AUTHORS   Hildreth,A.D., Padilla,E.T., Tafti,R.Y., Legala,A.R. and
            O'Sullivan,T.E.
  TITLE     Sterile liver injury induces a protective tissue-resident cDC1-ILC1
            circuit through cDC1-intrinsic cGAS-STING-dependent IL-12
            production
  JOURNAL   Cell Rep 42 (2), 112141 (2023)
   PUBMED   36807146
REFERENCE   6  (bases 1 to 2998)
  AUTHORS   Wu,C., Wang,X., Gadina,M., O'Shea,J.J., Presky,D.H. and Magram,J.
  TITLE     IL-12 receptor beta 2 (IL-12R beta 2)-deficient mice are defective
            in IL-12-mediated signaling despite the presence of high affinity
            IL-12 binding sites
  JOURNAL   J Immunol 165 (11), 6221-6228 (2000)
   PUBMED   11086056
REFERENCE   7  (bases 1 to 2998)
  AUTHORS   Galbiati,F., Rogge,L. and Adorini,L.
  TITLE     IL-12 receptor regulation in IL-12-deficient BALB/c and C57BL/6
            mice
  JOURNAL   Eur J Immunol 30 (1), 29-37 (2000)
   PUBMED   10602024
REFERENCE   8  (bases 1 to 2998)
  AUTHORS   Himmelrich,H., Parra-Lopez,C., Tacchini-Cottier,F., Louis,J.A. and
            Launois,P.
  TITLE     The IL-4 rapidly produced in BALB/c mice after infection with
            Leishmania major down-regulates IL-12 receptor beta 2-chain
            expression on CD4+ T cells resulting in a state of unresponsiveness
            to IL-12
  JOURNAL   J Immunol 161 (11), 6156-6163 (1998)
   PUBMED   9834101
REFERENCE   9  (bases 1 to 2998)
  AUTHORS   Szabo,S.J., Dighe,A.S., Gubler,U. and Murphy,K.M.
  TITLE     Regulation of the interleukin (IL)-12R beta 2 subunit expression in
            developing T helper 1 (Th1) and Th2 cells
  JOURNAL   J Exp Med 185 (5), 817-824 (1997)
   PUBMED   9120387
REFERENCE   10 (bases 1 to 2998)
  AUTHORS   Presky,D.H., Yang,H., Minetti,L.J., Chua,A.O., Nabavi,N., Wu,C.Y.,
            Gately,M.K. and Gubler,U.
  TITLE     A functional interleukin 12 receptor complex is composed of two
            beta-type cytokine receptor subunits
  JOURNAL   Proc Natl Acad Sci U S A 93 (24), 14002-14007 (1996)
   PUBMED   8943050
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC130822.3.
            
            On Mar 19, 2018 this sequence version replaced NM_008354.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U64199.1, BC137745.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               AC130822.3         155095-155248       c
            155-264             AC130822.3         140935-141044       c
            265-591             AC130822.3         139553-139879       c
            592-706             AC130822.3         136736-136850       c
            707-900             AC130822.3         135642-135835       c
            901-1043            AC130822.3         133785-133927       c
            1044-1194           AC130822.3         130299-130449       c
            1195-1274           AC130822.3         115747-115826       c
            1275-1491           AC130822.3         95251-95467         c
            1492-1692           AC130822.3         88018-88218         c
            1693-1791           AC130822.3         82759-82857         c
            1792-1950           AC130822.3         82520-82678         c
            1951-2088           AC130822.3         77968-78105         c
            2089-2179           AC130822.3         77209-77299         c
            2180-2279           AC130822.3         74272-74371         c
            2280-2998           AC130822.3         71078-71796         c
FEATURES             Location/Qualifiers
     source          1..2998
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 30.81 cM"
     gene            1..2998
                     /gene="Il12rb2"
                     /gene_synonym="A930027I18Rik; Ifnm; IL-12RB2"
                     /note="interleukin 12 receptor, beta 2"
                     /db_xref="GeneID:16162"
                     /db_xref="MGI:MGI:1270861"
     exon            1..154
                     /gene="Il12rb2"
                     /gene_synonym="A930027I18Rik; Ifnm; IL-12RB2"
                     /inference="alignment:Splign:2.1.0"
     exon            155..264
                     /gene="Il12rb2"
                     /gene_synonym="A930027I18Rik; Ifnm; IL-12RB2"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..2813
                     /gene="Il12rb2"
                     /gene_synonym="A930027I18Rik; Ifnm; IL-12RB2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; interleukin-12 receptor subunit beta-2; IL-12R
                     subunit beta-2; IL-12 receptor subunit beta-2; interferon
                     response to microorganisms"
                     /codon_start=1
                     /product="interleukin-12 receptor subunit beta-2 isoform 1
                     precursor"
                     /protein_id="NP_032380.1"
                     /db_xref="CCDS:CCDS20220.1"
                     /db_xref="GeneID:16162"
                     /db_xref="MGI:MGI:1270861"
                     /translation="MAQTVRECSLALLFLFMWLLIKANIDVCKLGTVTVQPAPVIPLG
                     SAANISCSLNPKQGCSHYPSSNELILLKFVNDVLVENLHGKKVHDHTGHSSTFQVTNL
                     SLGMTLFVCKLNCSNSQKKPPVPVCGVEISVGVAPEPPQNISCVQEGENGTVACSWNS
                     GKVTYLKTNYTLQLSGPNNLTCQKQCFSDNRQNCNRLDLGINLSPDLAESRFIVRVTA
                     INDLGNSSSLPHTFTFLDIVIPLPPWDIRINFLNASGSRGTLQWEDEGQVVLNQLRYQ
                     PLNSTSWNMVNATNAKGKYDLRDLRPFTEYEFQISSKLHLSGGSWSNWSESLRTRTPE
                     EEPVGILDIWYMKQDIDYDRQQISLFWKSLNPSEARGKILHYQVTLQEVTKKTTLQNT
                     TRHTSWTRVIPRTGAWTASVSAANSKGASAPTHINIVDLCGTGLLAPHQVSAKSENMD
                     NILVTWQPPKKADSAVREYIVEWRALQPGSITKFPPHWLRIPPDNMSALISENIKPYI
                     CYEIRVHALSESQGGCSSIRGDSKHKAPVSGPHITAITEKKERLFISWTHIPFPEQRG
                     CILHYRIYWKERDSTAQPELCEIQYRRSQNSHPISSLQPRVTYVLWMTAVTAAGESPQ
                     GNEREFCPQGKANWKAFVISSICIAIITVGTFSIRYFRQKAFTLLSTLKPQWYSRTIP
                     DPANSTWVKKYPILEEKIQLPTDNLLMAWPTPEEPEPLIIHEVLYHMIPVVRQPYYFK
                     RGQGFQGYSTSKQDAMYIANPQATGTLTAETRQLVNLYKVLESRDPDSKLANLTSPLT
                     VTPVNYLPSHEGYLPSNIEDLSPHEADPTDSFDLEHQHISLSIFASSSLRPLIFGGER
                     LTLDRLKMGYDSLMSNEA"
     exon            265..591
                     /gene="Il12rb2"
                     /gene_synonym="A930027I18Rik; Ifnm; IL-12RB2"
                     /inference="alignment:Splign:2.1.0"
     exon            592..706
                     /gene="Il12rb2"
                     /gene_synonym="A930027I18Rik; Ifnm; IL-12RB2"
                     /inference="alignment:Splign:2.1.0"
     exon            707..900
                     /gene="Il12rb2"
                     /gene_synonym="A930027I18Rik; Ifnm; IL-12RB2"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1043
                     /gene="Il12rb2"
                     /gene_synonym="A930027I18Rik; Ifnm; IL-12RB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1194
                     /gene="Il12rb2"
                     /gene_synonym="A930027I18Rik; Ifnm; IL-12RB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1274
                     /gene="Il12rb2"
                     /gene_synonym="A930027I18Rik; Ifnm; IL-12RB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1491
                     /gene="Il12rb2"
                     /gene_synonym="A930027I18Rik; Ifnm; IL-12RB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1692
                     /gene="Il12rb2"
                     /gene_synonym="A930027I18Rik; Ifnm; IL-12RB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1791
                     /gene="Il12rb2"
                     /gene_synonym="A930027I18Rik; Ifnm; IL-12RB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1950
                     /gene="Il12rb2"
                     /gene_synonym="A930027I18Rik; Ifnm; IL-12RB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2088
                     /gene="Il12rb2"
                     /gene_synonym="A930027I18Rik; Ifnm; IL-12RB2"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..2179
                     /gene="Il12rb2"
                     /gene_synonym="A930027I18Rik; Ifnm; IL-12RB2"
                     /inference="alignment:Splign:2.1.0"
     exon            2180..2279
                     /gene="Il12rb2"
                     /gene_synonym="A930027I18Rik; Ifnm; IL-12RB2"
                     /inference="alignment:Splign:2.1.0"
     exon            2280..2998
                     /gene="Il12rb2"
                     /gene_synonym="A930027I18Rik; Ifnm; IL-12RB2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggacttcccc gagggccggg cacctctgcc tggacacttg tcatggccac tgcaccggag
       61 gtccacactg ccgcgtggac tccagcgatg gcgctgcgct aggctagcgg gtgccaggat
      121 ccctctctgc gtcctgtgcg cgggaagagc tctggagaac cagagttgca ttctggagtt
      181 gaagactcat ggcacagact gttagagaat gctcattggc acttcttttt ttgttcatgt
      241 ggctgctgat taaagcaaat atagatgtgt gcaagcttgg cactgtgacc gtccagcctg
      301 cccctgtgat tcctcttggg tcagctgcca atatttcctg ctccttgaat cccaagcaag
      361 gctgttcaca ttatcccagt tctaacgaat taatcctctt aaagtttgtc aatgatgtcc
      421 ttgttgaaaa tctccatggc aagaaagtcc atgaccacac tggtcactcc tccacttttc
      481 aagtcaccaa cctgtccctt ggtatgacct tgtttgtctg caagctaaac tgtagcaact
      541 ctcaaaagaa gccaccagtc ccagtatgtg gggtggagat ctcagttggt gttgctccag
      601 agccacctca aaacatatca tgtgtccagg aaggagaaaa tggaactgtg gcctgttcct
      661 ggaactctgg aaaagttact tatctgaaaa ccaattacac tttacagtta agtggaccaa
      721 acaatctgac ctgtcagaaa caatgttttt ctgacaatcg tcagaattgc aatcgcctgg
      781 atcttgggat caatctaagc cctgatttag ctgaatccag gttcatagtc cgtgttactg
      841 ccatcaacga tcttggaaat tcttcttcac ttccgcatac gttcacgttc ttggacatag
      901 tgatccctct tcctccgtgg gacatcagaa tcaactttct aaatgcttct gggagcagag
      961 gtacactgca gtgggaagat gaggggcaag tggtactcaa tcaactcaga tatcagcctc
     1021 ttaacagcac gtcctggaac atggtcaatg ctacaaatgc caaaggaaaa tatgacctgc
     1081 gagatctgag accgtttaca gaatatgaat ttcaaatctc ctctaagcta catctctctg
     1141 gaggaagttg gagtaattgg agtgagtcac tgagaacacg aacaccagag gaagagcctg
     1201 ttgggatatt agacatctgg tacatgaaac aagacatcga ctatgacaga cagcagatct
     1261 ctcttttctg gaagagtctg aatccatcag aggcaagggg gaagatcctc cactatcagg
     1321 tgacgttaca agaggtgaca aagaaaacaa cactgcagaa tactacaaga cacacctcct
     1381 ggaccagggt catcccccga actggggctt ggacggcatc agtgtctgca gccaactcaa
     1441 aaggcgcttc tgcacccact cacattaaca tagtggacct atgtggcact gggttgctgg
     1501 ctcctcacca ggtctctgca aagtcggaga acatggacaa cattctagtg acctggcagc
     1561 ctcctaagaa agctgattct gctgttcggg agtacatagt ggaatggaga gctctccaac
     1621 cagggagcat cacgaagttt cccccacact ggctgcggat ccccccggac aacatgtctg
     1681 ctctgatttc agagaacata aagccctata tctgttatga aatcagggtg catgcactgt
     1741 cagagagcca aggagggtgc agctccatcc ggggtgactc caagcacaaa gcaccagtga
     1801 gtggccctca cattactgcc atcacagaga aaaaggaacg ccttttcatt tcctggaccc
     1861 acattccatt cccggagcaa aggggctgca tcctccatta cagaatatac tggaaagaac
     1921 gagactcgac agcacaacct gagctctgcg aaattcagta ccgacgctct caaaactcac
     1981 atccaataag cagcctacag cccagggtga catatgtcct atggatgaca gctgtgacag
     2041 ctgctggtga aagtccccaa ggaaatgaaa gggaattttg tccacagggc aaagccaact
     2101 ggaaagcatt cgtgatatca agcatttgca tcgctatcat cacggtgggc acgttctcaa
     2161 ttcgttactt ccggcaaaag gcatttactc tcctgtctac tctcaaacct caatggtata
     2221 gcagaaccat tccagatcca gcaaacagca cttgggtaaa gaagtatccc attctggagg
     2281 agaagatcca gctacctacg gataatctcc tgatggcatg gcccactcct gaagagcctg
     2341 agcccctgat catccatgaa gtcctctacc acatgatccc agttgtcaga caaccatatt
     2401 acttcaaaag aggccaagga ttccaaggct actctacctc caagcaagat gcaatgtata
     2461 ttgccaatcc acaagctaca ggaactctca cagctgagac cagacaacta gtgaacctat
     2521 acaaggtgct agaaagcaga gaccctgact caaaactggc caacctgacc agccccttga
     2581 cagtcacccc agtgaactac cttcctagcc atgaaggcta tttaccctcc aacatagaag
     2641 atctgtcacc acatgaggct gacccaactg attcttttga cctggagcat caacatattt
     2701 ctctttccat ttttgcatca agttctctcc gcccactcat cttcggtggt gagcggctga
     2761 ctctagatcg gttaaagatg ggctatgact ccctcatgag taatgaggct tgatactaga
     2821 aagccaacgt acctcatttt atctgcccag ttcctactcc aaaggtctgt gacagtgaag
     2881 acaagccagc tgtctctgga taaaattagc ttcaccatag gtacttaagt cttatggata
     2941 aggtggcaat acaccaacac tgatatcata tagaaaggac cccaagatag tcatgctc
//
