LOCUS       NM_008353               4967 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus interleukin 12 receptor, beta 1 (Il12rb1), mRNA.
ACCESSION   NM_008353
VERSION     NM_008353.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4967)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4967)
  AUTHORS   Georgy,J., Arlt,Y., Moll,J.M., Ouzin,M., Weitz,H.T., Gremer,L.,
            Willbold,D., Grotzinger,J., Thives-Kurenbach,F., Scheller,J. and
            Floss,D.M.
  TITLE     Tryptophan (W) at position 37 of murine IL-12/IL-23 p40 is
            mandatory for binding to IL-12Rbeta1 and subsequent signal
            transduction
  JOURNAL   J Biol Chem 297 (5), 101295 (2021)
   PUBMED   34637790
  REMARK    GeneRIF: Tryptophan (W) at position 37 of murine IL-12/IL-23 p40 is
            mandatory for binding to IL-12Rbeta1 and subsequent signal
            transduction.
REFERENCE   3  (bases 1 to 4967)
  AUTHORS   Floss,D.M., Schonberg,M., Franke,M., Horstmeier,F.C.,
            Engelowski,E., Schneider,A., Rosenfeldt,E.M. and Scheller,J.
  TITLE     IL-6/IL-12 Cytokine Receptor Shuffling of Extra- and Intracellular
            Domains Reveals Canonical STAT Activation via Synthetic IL-35 and
            IL-39 Signaling
  JOURNAL   Sci Rep 7 (1), 15172 (2017)
   PUBMED   29123149
  REMARK    GeneRIF: In summary, the receptor shuffling approach highlights an
            interchangeable, modular domain structure among IL-6- and
            IL-12-type cytokine receptors and enabled synthetic IL-35 and IL-39
            signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4967)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   5  (bases 1 to 4967)
  AUTHORS   Ray,A.A., Fountain,J.J., Miller,H.E., Cooper,A.M. and Robinson,R.T.
  TITLE     IL12Rbeta1DeltaTM is a secreted product of il12rb1 that promotes
            control of extrapulmonary tuberculosis
  JOURNAL   Infect Immun 83 (2), 560-571 (2015)
   PUBMED   25404030
  REMARK    GeneRIF: the data support a model wherein IL12Rbeta1DeltaTM is a
            secreted product of il12rb1 that promotes resistance to M.
            tuberculosis infection by potentiating T(H) cells response to
            IL-12.
REFERENCE   6  (bases 1 to 4967)
  AUTHORS   Wu,C., Ferrante,J., Gately,M.K. and Magram,J.
  TITLE     Characterization of IL-12 receptor beta1 chain
            (IL-12Rbeta1)-deficient mice: IL-12Rbeta1 is an essential component
            of the functional mouse IL-12 receptor
  JOURNAL   J Immunol 159 (4), 1658-1665 (1997)
   PUBMED   9257825
REFERENCE   7  (bases 1 to 4967)
  AUTHORS   Vogel,L.A., Showe,L.C., Lester,T.L., McNutt,R.M., Van Cleave,V.H.
            and Metzger,D.W.
  TITLE     Direct binding of IL-12 to human and murine B lymphocytes
  JOURNAL   Int Immunol 8 (12), 1955-1962 (1996)
   PUBMED   8982780
REFERENCE   8  (bases 1 to 4967)
  AUTHORS   Presky,D.H., Yang,H., Minetti,L.J., Chua,A.O., Nabavi,N., Wu,C.Y.,
            Gately,M.K. and Gubler,U.
  TITLE     A functional interleukin 12 receptor complex is composed of two
            beta-type cytokine receptor subunits
  JOURNAL   Proc Natl Acad Sci U S A 93 (24), 14002-14007 (1996)
   PUBMED   8943050
REFERENCE   9  (bases 1 to 4967)
  AUTHORS   Chua,A.O., Wilkinson,V.L., Presky,D.H. and Gubler,U.
  TITLE     Cloning and characterization of a mouse IL-12 receptor-beta
            component
  JOURNAL   J Immunol 155 (9), 4286-4294 (1995)
   PUBMED   7594587
REFERENCE   10 (bases 1 to 4967)
  AUTHORS   Chua,A.O., Chizzonite,R., Desai,B.B., Truitt,T.P., Nunes,P.,
            Minetti,L.J., Warrier,R.R., Presky,D.H., Levine,J.F., Gately,M.K.
            et al.
  TITLE     Expression cloning of a human IL-12 receptor component. A new
            member of the cytokine receptor superfamily with strong homology to
            gp130
  JOURNAL   J Immunol 153 (1), 128-136 (1994)
   PUBMED   7911493
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162446.2.
            
            On Aug 30, 2022 this sequence version replaced NM_008353.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK137577.1, U23922.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               AC162446.2         160683-160830
            149-208             AC162446.2         162043-162102
            209-323             AC162446.2         162767-162881
            324-517             AC162446.2         163251-163444
            518-654             AC162446.2         164690-164826
            655-721             AC162446.2         165517-165583
            722-847             AC162446.2         165865-165990
            848-930             AC162446.2         166278-166360
            931-1168            AC162446.2         166649-166886
            1169-1336           AC162446.2         167914-168081
            1337-1471           AC162446.2         168645-168779
            1472-1627           AC162446.2         169096-169251
            1628-1762           AC162446.2         169424-169558
            1763-1859           AC162446.2         171537-171633
            1860-1941           AC162446.2         171894-171975
            1942-4967           AC162446.2         172727-175752
FEATURES             Location/Qualifiers
     source          1..4967
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.21 cM"
     gene            1..4967
                     /gene="Il12rb1"
                     /gene_synonym="CD212; IL-12R-beta-1; IL-12R[b]"
                     /note="interleukin 12 receptor, beta 1"
                     /db_xref="GeneID:16161"
                     /db_xref="MGI:MGI:104579"
     exon            1..148
                     /gene="Il12rb1"
                     /gene_synonym="CD212; IL-12R-beta-1; IL-12R[b]"
                     /inference="alignment:Splign:2.1.0"
     exon            149..208
                     /gene="Il12rb1"
                     /gene_synonym="CD212; IL-12R-beta-1; IL-12R[b]"
                     /inference="alignment:Splign:2.1.0"
     exon            209..323
                     /gene="Il12rb1"
                     /gene_synonym="CD212; IL-12R-beta-1; IL-12R[b]"
                     /inference="alignment:Splign:2.1.0"
     exon            324..517
                     /gene="Il12rb1"
                     /gene_synonym="CD212; IL-12R-beta-1; IL-12R[b]"
                     /inference="alignment:Splign:2.1.0"
     exon            518..654
                     /gene="Il12rb1"
                     /gene_synonym="CD212; IL-12R-beta-1; IL-12R[b]"
                     /inference="alignment:Splign:2.1.0"
     exon            655..721
                     /gene="Il12rb1"
                     /gene_synonym="CD212; IL-12R-beta-1; IL-12R[b]"
                     /inference="alignment:Splign:2.1.0"
     exon            722..847
                     /gene="Il12rb1"
                     /gene_synonym="CD212; IL-12R-beta-1; IL-12R[b]"
                     /inference="alignment:Splign:2.1.0"
     exon            848..930
                     /gene="Il12rb1"
                     /gene_synonym="CD212; IL-12R-beta-1; IL-12R[b]"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1168
                     /gene="Il12rb1"
                     /gene_synonym="CD212; IL-12R-beta-1; IL-12R[b]"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1336
                     /gene="Il12rb1"
                     /gene_synonym="CD212; IL-12R-beta-1; IL-12R[b]"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1471
                     /gene="Il12rb1"
                     /gene_synonym="CD212; IL-12R-beta-1; IL-12R[b]"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1627
                     /gene="Il12rb1"
                     /gene_synonym="CD212; IL-12R-beta-1; IL-12R[b]"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1762
                     /gene="Il12rb1"
                     /gene_synonym="CD212; IL-12R-beta-1; IL-12R[b]"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1859
                     /gene="Il12rb1"
                     /gene_synonym="CD212; IL-12R-beta-1; IL-12R[b]"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..1941
                     /gene="Il12rb1"
                     /gene_synonym="CD212; IL-12R-beta-1; IL-12R[b]"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..4967
                     /gene="Il12rb1"
                     /gene_synonym="CD212; IL-12R-beta-1; IL-12R[b]"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2817..2822
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il12rb1"
                     /gene_synonym="CD212; IL-12R-beta-1; IL-12R[b]"
                     /note="hexamer: AATAAA"
     polyA_site      2851
                     /gene="Il12rb1"
                     /gene_synonym="CD212; IL-12R-beta-1; IL-12R[b]"
                     /note="major polyA site"
     regulatory      4946..4951
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il12rb1"
                     /gene_synonym="CD212; IL-12R-beta-1; IL-12R[b]"
                     /note="hexamer: AATAAA"
     polyA_site      4967
                     /gene="Il12rb1"
                     /gene_synonym="CD212; IL-12R-beta-1; IL-12R[b]"
ORIGIN      
        1 agtgtgtttc tgagcgtgga caaggcggct gggccccttc agccctgcag aagttcctgg
       61 ggcctcacga ctcggctcct catggacatg atggggctgg cagggaccag caaacacatc
      121 accttcctcc tgctttgcca gctaggcgcc tcaggcccag gtgatggctg ctgcgttgag
      181 aagacatcgt tcccagaggg agcctcaggc tcacccttag gacccaggaa cttgagttgc
      241 tacagggttt ccaagacaga ctatgagtgc tcctggcagt atgatggccc tgaggacaat
      301 gtttctcacg tcctgtggtg ctgctttgtc cctccgaacc atacccacac cggccaggag
      361 cgctgccgct acttctcctc aggcccagac cgcactgtgc agttctggga acaggacggt
      421 atccctgtgc tgtccaaggt caacttctgg gtggagtctc ggcttgggaa ccgaaccatg
      481 aagtcccaga agatatccca gtacctgtac aactggacca agacgacccc tcccctggga
      541 cacatcaagg tgtcacaatc acaccggcag ttgcgaatgg actggaatgt gtctgaagag
      601 gccggtgctg aggtacagtt caggcgccgt atgcccacaa cgaattggac cttgggtgac
      661 tgcggacctc aggttaactc tggctcaggt gtgcttggtg acattcgtgg gagcatgtct
      721 gagtcctgcc tctgcccttc tgagaacatg gcccaagaga tccagatacg gaggaggagg
      781 cggctctcct caggagcccc tggaggtccc tggagtgatt ggagcatgcc tgtgtgtgtt
      841 ccacctgaag tccttcccca ggccaagatt aagttcttgg tggagcccct gaaccaaggt
      901 ggaaggaggc gtctaaccat gcaaggacag tcaccacagc tggcagtccc ggaaggctgc
      961 cgaggcaggc ctggtgcgca ggtgaagaag cacttggtgc tggtgcgcat gctgtcctgc
     1021 aggtgccagg ctcagacctc gaagaccgtg cccctgggca agaagctgaa cctctccggg
     1081 gccacctatg acctgaatgt gctcgccaaa actcgtttcg gtcgcagcac catccagaag
     1141 tggcaccttc ctgcccaaga gctcacagag acaagagccc tgaatgtcag cgtgggaggc
     1201 aacatgacat ccatgcagtg ggcagcccag gctcccggca ccacctactg ccttgagtgg
     1261 cagccatggt tccagcacag gaaccacaca cactgtaccc tgattgtacc agaagaagag
     1321 gatcctgcca agatggtgac acacagctgg agctctaaac ctaccctgga gcaggaggaa
     1381 tgttaccgca tcacagtgtt cgcctccaag aaccccaaga atcccatgct gtgggccaca
     1441 gtcctgtcca gttactactt tgggggtaac gcctcgagag ccggtactcc acgacacgtg
     1501 tcggtgagga accaaaccgg ggactcggtg tccgtggagt ggacggcgtc acagctgagc
     1561 acctgcccgg gggtcctgac gcaatacgtc gtgcgctgcg aggctgaaga cggcgcgtgg
     1621 gagtcagagt ggctcgtgcc acccactaaa acccaagtga cacttgacgg actgcgcagc
     1681 cgagtaatgt acaaggttca ggtgcgagcc gacactgcga ggctcccggg tgcctggagt
     1741 catccccagc gctttagctt tgaggtgcag atttcccgtt tatccatcat tttcgcgtct
     1801 ctgggaagct tcgccagcgt cctcctcgtg ggcagtctcg gatacattgg cttaaacagg
     1861 gccgcctggc acttgtgccc acccctgcct acaccctgtg gcagcactgc cgtggagttc
     1921 cctggcagcc agggcaagca ggcttggcag tggtgcaacc ctgaggactt cccggaggtg
     1981 ttgtacccgc gagatgcgct ggtggtcgag atgcccggag acagaggcga cgggacagag
     2041 tcgccccagg ccgcccctga gtgcgccctg gacacaaggc ggcccttgga gactcagagg
     2101 cagaggcagg tgcaggcact gtcagaggcc aggcgcctgg gcctggctag ggaggactgt
     2161 ccccgtggtg acctggccca cgtgacactc ccgctgctcc tgggaggtgt gacccaggga
     2221 gcctctgtac ttgacgatct ttggaggacc cataagactg cggagccggg accgcccact
     2281 ttggggcaag aggcctgact gttgcatctc cagcctgctc cctcctcagg agcccctaaa
     2341 ctgcaacagc tggtcataat ggctgtccta ttttatagat gtgattcttg aggcccagag
     2401 aaggtgactg tcttgcctga tgtcacacag cgtttgcagg acgcagaccc aggcctttct
     2461 cccggttctg tagcaccctt ctcttctccc acccactccc tccagcgcct atagccacac
     2521 cgcctgtgag gggaacatgg aaacctccaa gaaggggaaa gtgcttcatg cagctttgct
     2581 tggtatcctc agggcaaggc tggaccctat cactggtctg tttatttttg ggggggtcct
     2641 tccagtctga ggggacatgg tcagtcacag gctcagtttg cctccagcgt ccttggctgg
     2701 ggtcacagaa tgactctaga gcgtcataaa ttaggttacc taaaaagcag ggcctagaca
     2761 ttcacgggaa gtttatacgt ctggactcag tttccctatt agagtattgg gcacttaata
     2821 aatgggcctt cccagagact gagaaactaa atctggccgt cgtggtgcac gtctgtcatc
     2881 ccaataccca ggaggcagct gcagaaagat gagcttggac tgcaaagcga gtccgagggt
     2941 agcctgggct acatgagacc ctgtctggag gacagtgtgg acagtcacct agaattccga
     3001 gataagacct gggtagtaca gatagttgag gcgagaggcc cagctccctt cccatgtgct
     3061 cgcccgcccg tcaagaggac cctgggttcc ctcttttcct ggcgctacag ccacggtaaa
     3121 cgcgcgtccg taatgtctca ctttggccgc taggaggcag cagcgacgcg tgtcgcctcc
     3181 gcccgccctg cacatgaggc tcaaattgga cttttccagt ttgaactacc caaggtttga
     3241 gaaccctttt ataacaagag tatgcgaagc tagtagggcg aggcctccca gacctggaac
     3301 ctgcgttatc atagaagctt ctagctggcg aaggagccgt ggtctccggg tccagccaca
     3361 cagtggttac acaaatattt cggttatggt agcccgtttc cagtgctggg gtatgttggg
     3421 gttcctccag ggaccccggg aggttgaagc agaggacact tctacgcttg ggagaatttg
     3481 ccaacacacc tagagtctgc ctggactcgg gtggagaagg caagaccaga cctgggggtg
     3541 gagagtcagt caccagcatc cagccacgtg tggtggacaa actttccgtg gagtatattt
     3601 tgtgtccaac aggctccatc tggcttctgg ctaagggaaa gacgggtggg tggcggacag
     3661 agtgacagcc tagaatcccc cttaaggaag tgggggcgtg gctcagagtc agagaagctg
     3721 cctagaattt ccaaagtggg ctggggacgt ggctcgggga gcagagtaac aatttaggat
     3781 tcctatgtcg tggctccagg atgggatgat caacataatg ctaattgcct tgggtctgac
     3841 catcaccagt gcaaaacaca gttccttact gtgttccaga catcctgcgt gctcagcccc
     3901 tgtggcatgg gatgtctcac aggctactgc aggcaaacac ggatccagac atcacaccca
     3961 cacttttttt ttcctttttt tttttttttt ggtttttttt gagacagggt ttctctgtgt
     4021 agccctggct gtcctggaac tcactctgta gaccaggctg gcctcgaact cagaaatcca
     4081 cctgcctctg cctcccaagt gctgggatta aaggcgtgag ccaccacgcc tttttgttct
     4141 taagactcca ttctaagtta acttgccctt agagaggcat ggccccctcc cttgaggtct
     4201 gagaaaaatc acaaaatgtc cttggcagtt acaaaataga cacagcagct gcagctggct
     4261 ggtaacaaca aagtgggcta agaaaacata agtcattccc aggtcaaggt gctccttctt
     4321 gttgtatgct ccctctgtaa gctctgcccc acagttacct ggcaacaacc aggtaggtct
     4381 gattcactat taaaggggct gcttgccccc tcctctcttg ctctcttgct caccctctct
     4441 ccccattccg ttcccccact ctctccacat gctcatggct ggcctcttct tctctactct
     4501 ctccctctct ctgcctttct ctgcctctac tagcctctta actcccctcc ccatgccctg
     4561 aataagctct attctatact ctaccgtttt ggggctggtc cttcaggggg aagggaggcc
     4621 ttggcatagg cccactgaga cttccccttc tcccatacct gactacgtcc ccatagagga
     4681 tacccccatc tttatctttt tataaacaca tcaccctcct tgtggcttaa ccaggtgctt
     4741 gtaaaccaat tagcttaaag actaacacat ctgtaccctc ttatgtaatg ccaaggcttg
     4801 gaaaccccag tctcggtgtt tggtttgttg ttgttgtttg tttgtttgtt tgtttccccc
     4861 ctttagagac ccccttcact cagacctggg ggttcagtct ccttcctgtt ccatcaggaa
     4921 ggttggtggc ccgagcttga tcttcaataa aaaccctcat gcgctta
//
