LOCUS       NM_001303244            2505 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus interleukin 12b (Il12b), mRNA.
ACCESSION   NM_001303244 XM_006532306
VERSION     NM_001303244.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2505)
  AUTHORS   Delconte,R.B., Owyong,M., Santosa,E.K., Srpan,K., Sheppard,S.,
            McGuire,T.J., Abbasi,A., Diaz-Salazar,C., Chun,J., Rogatsky,I.,
            Hsu,K.C., Jordan,S., Merad,M. and Sun,J.C.
  TITLE     Fasting reshapes tissue-specific niches to improve NK cell-mediated
            anti-tumor immunity
  JOURNAL   Immunity 57 (8), 1923-1938 (2024)
   PUBMED   38878769
REFERENCE   2  (bases 1 to 2505)
  AUTHORS   Pan,H., Ji,Q., Zhao,M., Zheng,Z., Lu,X., Feng,Y., Gan,L., Ye,J.,
            Wan,J. and Ye,D.
  TITLE     IL-12p40 deletion reduces M1 macrophage polarization and alleviates
            cardiac remodeling via regulating Th17 cells differentiation, but
            not gammadeltaT 17 cells, in TAC mice
  JOURNAL   Eur J Pharmacol 974, 176602 (2024)
   PUBMED   38677538
  REMARK    GeneRIF: IL-12p40 deletion reduces M1 macrophage polarization and
            alleviates cardiac remodeling via regulating Th17 cells
            differentiation, but not gammadeltaT 17 cells, in TAC mice.
REFERENCE   3  (bases 1 to 2505)
  AUTHORS   Bridges,K., Pizzurro,G.A., Khunte,M., Chen,M., Salvador Rocha,E.,
            Alexander,A.F., Bass,V., Kellman,L.N., Baskaran,J. and
            Miller-Jensen,K.
  TITLE     Single-Cell Analysis Reveals a Subset of High IL-12p40-Secreting
            Dendritic Cells within Mouse Bone Marrow-Derived Macrophages
            Differentiated with M-CSF
  JOURNAL   J Immunol 212 (8), 1357-1365 (2024)
   PUBMED   38416039
REFERENCE   4  (bases 1 to 2505)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 2505)
  AUTHORS   Wang,J., Chang,C.Y., Yang,X., Zhou,F., Liu,J., Bargonetti,J.,
            Zhang,L., Xie,P., Feng,Z. and Hu,W.
  TITLE     p53 suppresses MHC class II presentation by intestinal epithelium
            to protect against radiation-induced gastrointestinal syndrome
  JOURNAL   Nat Commun 15 (1), 137 (2024)
   PUBMED   38167344
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2505)
  AUTHORS   Murphy,T.L., Cleveland,M.G., Kulesza,P., Magram,J. and Murphy,K.M.
  TITLE     Regulation of interleukin 12 p40 expression through an NF-kappa B
            half-site
  JOURNAL   Mol Cell Biol 15 (10), 5258-5267 (1995)
   PUBMED   7565674
REFERENCE   7  (bases 1 to 2505)
  AUTHORS   Heinzel,F.P., Rerko,R.M., Ahmed,F. and Pearlman,E.
  TITLE     Endogenous IL-12 is required for control of Th2 cytokine responses
            capable of exacerbating leishmaniasis in normally resistant mice
  JOURNAL   J Immunol 155 (2), 730-739 (1995)
   PUBMED   7608551
REFERENCE   8  (bases 1 to 2505)
  AUTHORS   Smith,T.J., Ducharme,L.A. and Weis,J.H.
  TITLE     Preferential expression of interleukin-12 or interleukin-4 by
            murine bone marrow mast cells derived in mast cell growth factor or
            interleukin-3
  JOURNAL   Eur J Immunol 24 (4), 822-826 (1994)
   PUBMED   7512032
REFERENCE   9  (bases 1 to 2505)
  AUTHORS   Schoenhaut,D.S., Chua,A.O., Wolitzky,A.G., Quinn,P.M., Dwyer,C.M.,
            McComas,W., Familletti,P.C., Gately,M.K. and Gubler,U.
  TITLE     Cloning and expression of murine IL-12
  JOURNAL   J Immunol 148 (11), 3433-3440 (1992)
   PUBMED   1350290
REFERENCE   10 (bases 1 to 2505)
  AUTHORS   Raich,N., Enver,T., Nakamoto,B., Josephson,B., Papayannopoulou,T.
            and Stamatoyannopoulos,G.
  TITLE     Autonomous developmental control of human embryonic globin gene
            switching in transgenic mice
  JOURNAL   Science 250 (4984), 1147-1149 (1990)
   PUBMED   2251502
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY154173.1, M86671.1 and
            AL669944.8.
            
            On Dec 23, 2014 this sequence version replaced XM_006532306.1.
            
            Summary: This gene encodes the beta subunit p40 of the Interleukin
            12 (IL-12) family of cytokines. Members of the IL-12 family form
            heterodimers consisting of heavy and light subunits linked by
            disulfide bonds. The product of this gene, p40, is a subunit of
            interleukins IL-12 and IL-23. [provided by RefSeq, Dec 2014].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK162981.1, M86671.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN02415128
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                BY154173.1         2-23
            23-1861             M86671.1           1-1839
            1862-2505           AL669944.8         7245-7888
FEATURES             Location/Qualifiers
     source          1..2505
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 25.94 cM"
     gene            1..2505
                     /gene="Il12b"
                     /gene_synonym="Il-12b; Il-12p40; Il12p40; p40"
                     /note="interleukin 12b"
                     /db_xref="GeneID:16160"
                     /db_xref="MGI:MGI:96540"
     exon            1..56
                     /gene="Il12b"
                     /gene_synonym="Il-12b; Il-12p40; Il12p40; p40"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..1064
                     /gene="Il12b"
                     /gene_synonym="Il-12b; Il-12p40; Il12p40; p40"
                     /note="interleukin-12 subunit beta; CLMF p40; IL-12
                     subunit p40; cytotoxic lymphocyte maturation factor 40 kDa
                     subunit; IL-23 subunit p40; IL-12 p40 subunit;
                     interleukin-12 p40 subunit"
                     /codon_start=1
                     /product="interleukin-12 subunit beta precursor"
                     /protein_id="NP_001290173.1"
                     /db_xref="CCDS:CCDS24563.1"
                     /db_xref="GeneID:16160"
                     /db_xref="MGI:MGI:96540"
                     /translation="MCPQKLTISWFAIVLLVSPLMAMWELEKDVYVVEVDWTPDAPGE
                     TVNLTCDTPEEDDITWTSDQRHGVIGSGKTLTITVKEFLDAGQYTCHKGGETLSHSHL
                     LLHKKENGIWSTEILKNFKNKTFLKCEAPNYSGRFTCSWLVQRNMDLKFNIKSSSSSP
                     DSRAVTCGMASLSAEKVTLDQRDYEKYSVSCQEDVTCPTAEETLPIELALEARQQNKY
                     ENYSTSFFIRDIIKPDPPKNLQMKPLKNSQVEVSWEYPDSWSTPHSYFSLKFFVRIQR
                     KKEKMKETEEGCNQKGAFLVEKTSTEVQCKGGNVCVQAQDRYYNSSCSKWACVPCRVR
                     S"
     exon            57..144
                     /gene="Il12b"
                     /gene_synonym="Il-12b; Il-12p40; Il12p40; p40"
                     /inference="alignment:Splign:2.1.0"
     exon            145..411
                     /gene="Il12b"
                     /gene_synonym="Il-12b; Il-12p40; Il12p40; p40"
                     /inference="alignment:Splign:2.1.0"
     exon            412..529
                     /gene="Il12b"
                     /gene_synonym="Il-12b; Il-12p40; Il12p40; p40"
                     /inference="alignment:Splign:2.1.0"
     exon            530..747
                     /gene="Il12b"
                     /gene_synonym="Il-12b; Il-12p40; Il12p40; p40"
                     /inference="alignment:Splign:2.1.0"
     exon            748..926
                     /gene="Il12b"
                     /gene_synonym="Il-12b; Il-12p40; Il12p40; p40"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1051
                     /gene="Il12b"
                     /gene_synonym="Il-12b; Il-12p40; Il12p40; p40"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..2505
                     /gene="Il12b"
                     /gene_synonym="Il-12b; Il-12p40; Il12p40; p40"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaaggaaca gtgggtgtcc aggcacatca gaccaggcag ctcgcagcaa agcaagatgt
       61 gtcctcagaa gctaaccatc tcctggtttg ccatcgtttt gctggtgtct ccactcatgg
      121 ccatgtggga gctggagaaa gacgtttatg ttgtagaggt ggactggact cccgatgccc
      181 ctggagaaac agtgaacctc acctgtgaca cgcctgaaga agatgacatc acctggacct
      241 cagaccagag acatggagtc ataggctctg gaaagaccct gaccatcact gtcaaagagt
      301 ttctagatgc tggccagtac acctgccaca aaggaggcga gactctgagc cactcacatc
      361 tgctgctcca caagaaggaa aatggaattt ggtccactga aattttaaaa aatttcaaaa
      421 acaagacttt cctgaagtgt gaagcaccaa attactccgg acggttcacg tgctcatggc
      481 tggtgcaaag aaacatggac ttgaagttca acatcaagag cagtagcagt tcccctgact
      541 ctcgggcagt gacatgtgga atggcgtctc tgtctgcaga gaaggtcaca ctggaccaaa
      601 gggactatga gaagtattca gtgtcctgcc aggaggatgt cacctgccca actgccgagg
      661 agaccctgcc cattgaactg gcgttggaag cacggcagca gaataaatat gagaactaca
      721 gcaccagctt cttcatcagg gacatcatca aaccagaccc gcccaagaac ttgcagatga
      781 agcctttgaa gaactcacag gtggaggtca gctgggagta ccctgactcc tggagcactc
      841 cccattccta cttctccctc aagttctttg ttcgaatcca gcgcaagaaa gaaaagatga
      901 aggagacaga ggaggggtgt aaccagaaag gtgcgttcct cgtagagaag acatctaccg
      961 aagtccaatg caaaggcggg aatgtctgcg tgcaagctca ggatcgctat tacaattcct
     1021 catgcagcaa gtgggcatgt gttccctgca gggtccgatc ctaggatgca acgttggaaa
     1081 ggaaagaaaa gtggaagaca ttaaggaaga aaaatttaaa ctcaggatgg aagagtcccc
     1141 caaaagctgt cttctgcttg gttggctttt tccagttttc ctaagttcat catgacacct
     1201 ttgctgattt ctacatgtaa atgttaaatg cccgcagagc cagggagcta atgtatgcat
     1261 agatattcta gcattccact tggccttatg ctgttgaaat atttaagtaa tttatgtatt
     1321 tattaattta tttctgcatt tcacatttgt ataccaagat gtattgaata tttcatgtgc
     1381 tcgtggcctg atccactggg accaggccct attatgcaaa ttgtgagctt gttatcttct
     1441 tcaacagctc ttcaatcagg gctgcgtagg tacattagct tttgtgacaa ccaataagaa
     1501 cataatattc tgacacaagc agtgttacat atttgtgacc agtaaagaca taggtggtat
     1561 ttggagacat gaagaagctg taaagttgac tctgaagagt ttagcactag tttcaacacc
     1621 aagaaagact ttttagaagt gatattgata agaaaccagg gccttcttta gaagggtacc
     1681 taaatttaaa agaattttga aaggctgggt atcggtggta tatgctttta attccagcac
     1741 tcaggagacc aaggcaggca gatctctgtg agtttgagga cagcctggtg tacagaggga
     1801 gttccagcac agccagtgcc acacagaaat tctgtctcaa aaacaattaa aaaaaaaaaa
     1861 actagaaatt ggaatccagg tttgggtctg tagctcagac ggcagtgtgc ttgtctaaca
     1921 ttcatgagga gctggctttg gtccccagca ctgcataaac taagtatgtt ggtacatgcc
     1981 ttaattctag cactggggcg agagaggcag agaactcaca agttcaatgt catccttagc
     2041 tacacaacaa ggccaggctg gactgcatga tagcgtgata taatatctca aaaagaaagg
     2101 aaggaaatag gggtggggag agtcggttgc ttaccttctt ggcaggcctc acatcccaca
     2161 ctcataagac acaggagcag agacatcctg gctgtctgga agaacagaag cttttggaat
     2221 ttgagggaaa atatagtgta gctgtgacaa aagggcataa aatccagggt gacttaatcg
     2281 ccacacaaat ggatgcaaag aaaaccatcc aggttcgcca tgtcatcagc ctgagtgatc
     2341 ctaaggtaca gatatgacca gacaagttcc atcgtgccat gaagatacta cggctacctc
     2401 aggacacaat ggccacactc cttgtagtga cttgcgtatg tttttcatgt gttggtttat
     2461 ttgtttatgc tttctgagat gaaataaata aaaactcttc tttgc
//
