LOCUS       NM_010550               1935 bp    mRNA    linear   ROD 08-APR-2024
DEFINITION  Mus musculus interleukin 11 receptor subunit alpha 2 (Il11ra2),
            transcript variant 1, mRNA.
ACCESSION   NM_010550
VERSION     NM_010550.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1935)
  AUTHORS   Chim,S.M., Kuek,V., Chow,S.T., Lim,B.S., Tickner,J., Zhao,J.,
            Chung,R., Su,Y.W., Zhang,G., Erber,W., Xian,C.J., Rosen,V. and
            Xu,J.
  TITLE     EGFL7 is expressed in bone microenvironment and promotes
            angiogenesis via ERK, STAT3, and integrin signaling cascades
  JOURNAL   J Cell Physiol 230 (1), 82-94 (2015)
   PUBMED   24909139
REFERENCE   2  (bases 1 to 1935)
  AUTHORS   Zhang,S., Kong,S., Wang,B., Cheng,X., Chen,Y., Wu,W., Wang,Q.,
            Shi,J., Zhang,Y., Wang,S., Lu,J., Lydon,J.P., DeMayo,F., Pear,W.S.,
            Han,H., Lin,H., Li,L., Wang,H., Wang,Y.L., Li,B., Chen,Q., Duan,E.
            and Wang,H.
  TITLE     Uterine Rbpj is required for embryonic-uterine orientation and
            decidual remodeling via Notch pathway-independent and -dependent
            mechanisms
  JOURNAL   Cell Res 24 (8), 925-942 (2014)
   PUBMED   24971735
REFERENCE   3  (bases 1 to 1935)
  AUTHORS   Chen,W., Sivaprasad,U., Tabata,Y., Gibson,A.M., Stier,M.T.,
            Finkelman,F.D. and Hershey,G.K.
  TITLE     IL-13R alpha 2 membrane and soluble isoforms differ in humans and
            mice
  JOURNAL   J Immunol 183 (12), 7870-7876 (2009)
   PUBMED   20007572
  REMARK    GeneRIF: Unlike humans, discrete transcripts encoding soluble and
            membrane forms of mouse IL-13Ralpha2 are both generated by
            alternative splicing.
REFERENCE   4  (bases 1 to 1935)
  AUTHORS   Yamada,A., Miyazaki,T., Lu,L.M., Ono,M., Ito,M.R., Terada,M.,
            Mori,S., Hata,K., Nozaki,Y., Nakatsuru,S., Nakamura,Y., Onji,M. and
            Nose,M.
  TITLE     Genetic basis of tissue specificity of vasculitis in MRL/lpr mice
  JOURNAL   Arthritis Rheum 48 (5), 1445-1451 (2003)
   PUBMED   12746919
REFERENCE   5  (bases 1 to 1935)
  AUTHORS   Li,R., Hartley,L. and Robb,L.
  TITLE     Cloning of rat interleukin 11 and interleukin 11 receptor alpha
            chain and analysis of their expression in rat uterus in the
            peri-implantation period
  JOURNAL   Reproduction 122 (4), 593-600 (2001)
   PUBMED   11570967
REFERENCE   6  (bases 1 to 1935)
  AUTHORS   Robb,L., Hilton,D.J., Willson,T.A. and Begley,C.G.
  TITLE     Structural analysis of the gene encoding the murine interleukin-11
            receptor alpha-chain and a related locus
  JOURNAL   J Biol Chem 271 (23), 13754-13761 (1996)
   PUBMED   8662802
REFERENCE   7  (bases 1 to 1935)
  AUTHORS   Neuhaus,H., Bettenhausen,B., Bilinski,P., Simon-Chazottes,D.,
            Guenet,J.L. and Gossler,A.
  TITLE     Etl2, a novel putative type-I cytokine receptor expressed during
            mouse embryogenesis at high levels in skin and cells with
            skeletogenic potential
  JOURNAL   Dev Biol 166 (2), 531-542 (1994)
   PUBMED   7813775
REFERENCE   8  (bases 1 to 1935)
  AUTHORS   Korn,R., Schoor,M., Neuhaus,H., Henseling,U., Soininen,R.,
            Zachgo,J. and Gossler,A.
  TITLE     Enhancer trap integrations in mouse embryonic stem cells give rise
            to staining patterns in chimaeric embryos with a high frequency and
            detect endogenous genes
  JOURNAL   Mech Dev 39 (1-2), 95-109 (1992)
   PUBMED   1283314
REFERENCE   9  (bases 1 to 1935)
  AUTHORS   Walther,C., Guenet,J.L., Simon,D., Deutsch,U., Jostes,B.,
            Goulding,M.D., Plachov,D., Balling,R. and Gruss,P.
  TITLE     Pax: a murine multigene family of paired box-containing genes
  JOURNAL   Genomics 11 (2), 424-434 (1991)
   PUBMED   1685142
REFERENCE   10 (bases 1 to 1935)
  AUTHORS   O'Kane,C.J. and Gehring,W.J.
  TITLE     Detection in situ of genomic regulatory elements in Drosophila
  JOURNAL   Proc Natl Acad Sci U S A 84 (24), 9123-9127 (1987)
   PUBMED   2827169
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX548253.32.
            
            On Apr 5, 2022 this sequence version replaced NM_010550.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR5189676.76553.1, SRR13422601.1330474.1
                                    [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMN00849374,
                                    SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               BX548253.32        80496-80605         c
            111-282             BX548253.32        77750-77921         c
            283-382             BX548253.32        76655-76754         c
            383-443             BX548253.32        76451-76511         c
            444-613             BX548253.32        75456-75625         c
            614-728             BX548253.32        75213-75327         c
            729-761             BX548253.32        75027-75059         c
            762-928             BX548253.32        74782-74948         c
            929-1092            BX548253.32        74062-74225         c
            1093-1234           BX548253.32        72744-72885         c
            1235-1360           BX548253.32        72273-72398         c
            1361-1457           BX548253.32        72079-72175         c
            1458-1540           BX548253.32        71769-71851         c
            1541-1935           BX548253.32        70862-71256         c
FEATURES             Location/Qualifiers
     source          1..1935
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 22.73 cM"
     gene            1..1935
                     /gene="Il11ra2"
                     /gene_synonym="Etl-2; Etl2; Il11ra-ps1"
                     /note="interleukin 11 receptor subunit alpha 2"
                     /db_xref="GeneID:16158"
                     /db_xref="MGI:MGI:109123"
     exon            1..110
                     /gene="Il11ra2"
                     /gene_synonym="Etl-2; Etl2; Il11ra-ps1"
                     /inference="alignment:Splign:2.1.0"
     exon            111..282
                     /gene="Il11ra2"
                     /gene_synonym="Etl-2; Etl2; Il11ra-ps1"
                     /inference="alignment:Splign:2.1.0"
     CDS             283..1581
                     /gene="Il11ra2"
                     /gene_synonym="Etl-2; Etl2; Il11ra-ps1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; IL-11RB; IL-11RA2; IL-11R-beta; IL-11R-alpha-2;
                     IL-11R subunit beta; IL-11R subunit alpha-2; IL-11
                     receptor subunit beta; IL-11 receptor subunit alpha-2;
                     interleukin-11 receptor subunit beta; interleukin 11
                     receptor, alpha chain 2"
                     /codon_start=1
                     /product="interleukin-11 receptor subunit alpha-2 isoform
                     1 precursor"
                     /protein_id="NP_034680.3"
                     /db_xref="CCDS:CCDS38735.1"
                     /db_xref="GeneID:16158"
                     /db_xref="MGI:MGI:109123"
                     /translation="MSSSCSGLTRVLVAVATALVSSSSPCPQAWGPPGVQYGQPGRPV
                     MLCCPGVSAGTPVSWFRDGDSRLLQGPDSGLGHRLVLAQVDSPDEGTYVCQTLDGVSG
                     GMVTLKLGFPPARPEVSCQAVDYENFSCTWSPGQVSGLPTRYLTSYRKKTLPGAESQR
                     ESPSTGPWPCPQDPLEASRCVVHGAEFWSEYRINVTEVNPLGASTCLLDVRLQSILRP
                     DPPQGLRVESVPGYPRRLHASWTYPASWRRQPHFLLKFRLQYRPAQHPAWSTVEPIGL
                     EEVITDTVAGLPHAVRVSARDFLDAGTWSAWSPEAWGTPSTGLLQDEIPDWSQGHGQQ
                     LEAVVAQEDSLAPARPSLQPDPRPLDHRDPLEQVAVLASLGIFSCLGLAVGALALGLW
                     LRLRRSGKEGPQKPGLLAPMIPVEKLPGIPNLQRTPENFS"
     exon            283..382
                     /gene="Il11ra2"
                     /gene_synonym="Etl-2; Etl2; Il11ra-ps1"
                     /inference="alignment:Splign:2.1.0"
     exon            383..443
                     /gene="Il11ra2"
                     /gene_synonym="Etl-2; Etl2; Il11ra-ps1"
                     /inference="alignment:Splign:2.1.0"
     exon            444..613
                     /gene="Il11ra2"
                     /gene_synonym="Etl-2; Etl2; Il11ra-ps1"
                     /inference="alignment:Splign:2.1.0"
     exon            614..728
                     /gene="Il11ra2"
                     /gene_synonym="Etl-2; Etl2; Il11ra-ps1"
                     /inference="alignment:Splign:2.1.0"
     exon            729..761
                     /gene="Il11ra2"
                     /gene_synonym="Etl-2; Etl2; Il11ra-ps1"
                     /inference="alignment:Splign:2.1.0"
     exon            762..928
                     /gene="Il11ra2"
                     /gene_synonym="Etl-2; Etl2; Il11ra-ps1"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1092
                     /gene="Il11ra2"
                     /gene_synonym="Etl-2; Etl2; Il11ra-ps1"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1234
                     /gene="Il11ra2"
                     /gene_synonym="Etl-2; Etl2; Il11ra-ps1"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1360
                     /gene="Il11ra2"
                     /gene_synonym="Etl-2; Etl2; Il11ra-ps1"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1457
                     /gene="Il11ra2"
                     /gene_synonym="Etl-2; Etl2; Il11ra-ps1"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1540
                     /gene="Il11ra2"
                     /gene_synonym="Etl-2; Etl2; Il11ra-ps1"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1935
                     /gene="Il11ra2"
                     /gene_synonym="Etl-2; Etl2; Il11ra-ps1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccccccgcc tggggtcagg gctggacagg gaggagaagc gagctccttg caagacgagt
       61 tggggacgag atagctagtg accctggcct tggctgaccc gaaagaggcc tggagacatc
      121 tgtcctcaaa ggattgtcca cttccggtga ctccctgctg ctgataatag ggcccatgtt
      181 tcccagaagg cccgaggtta tcccaagact gcttctctcc cttcacctcc catggcttca
      241 ttcctgaaga gcctgtgatc acttagggtc agaaatagac ggatgagcag cagctgctca
      301 gggctgacca gggtcctggt ggccgtggct acagccctgg tgtcttcctc ctccccctgc
      361 ccccaagctt ggggtcctcc aggggtccag tatggacaac ctggcaggcc cgtgatgctg
      421 tgctgccccg gagtgagtgc tgggactcca gtgtcctggt ttcgggatgg agattcaagg
      481 ctgctccagg gacctgactc tgggttagga cacagactgg tcttggccca ggtggacagc
      541 cctgatgaag gcacttatgt ctgccagacc ctggatggtg tatcaggggg catggtgacc
      601 ctgaagctgg gctttccccc agcacgtcct gaagtctctt gccaagcggt agactatgaa
      661 aacttctcct gtacttggag tccaggccag gtcagcggtt tgcccacccg ctaccttact
      721 tcctacagga agaagacgct gccaggagct gagagtcaga gggaaagtcc atccaccggg
      781 ccttggccgt gtccacagga ccctctggag gcctcccgat gtgtggtcca tggggcagag
      841 ttctggagtg agtaccggat caatgtgacc gaggtgaacc cactgggtgc cagcacgtgc
      901 ctactggatg tgagattaca gagcatcttg cgtcccgatc caccccaagg actgcgggtg
      961 gaatccgtac ctggttaccc aagacgcctg catgccagct ggacataccc tgcctcctgg
     1021 cgtcgccaac cccactttct gctcaagttc cggttgcaat accgaccagc acagcatcca
     1081 gcctggtcca cggtggagcc cattggcttg gaggaagtga taacagatac tgtggctggg
     1141 ctgccccacg cggtacgagt cagtgccagg gactttctgg atgctggcac ctggagcgcc
     1201 tggagcccag aggcctgggg tactcctagc actggtctcc tgcaggatga gatacctgat
     1261 tggagccagg gacatggaca gcagctagag gcagtagtag ctcaggagga cagcctggct
     1321 cctgcaaggc cttccttgca gccagaccca aggccacttg atcacaggga tcccttggag
     1381 caagtagctg tgttagcatc tctgggaatc ttctcttgcc ttggcctggc tgttggagcc
     1441 ctggcactgg ggctctggct gaggctgaga cggagtggga aggaaggacc gcaaaaacct
     1501 gggctcttgg cacccatgat cccggtggaa aagcttccag gaattccaaa cctgcagagg
     1561 accccagaga acttcagctg atttcatctg taacccggtc agacttgggt ggttaaaagg
     1621 acaggcagaa agaggcgggg cagtggatcc ctgtggatgg aggtctcagc tggaagtctg
     1681 agctcttttc tttgacacct atactccaaa cttgctgccg gctgaaggct gtctggactt
     1741 ctgatgtcct gaggtggaag tccacctgag gaatgtgtac agaagtctgt gttcctgtga
     1801 tcgtgtgtgt atgtgagaca gggagcaaaa gttctctgca tgtgtgtaca catgattgga
     1861 gagtgtgtgc ggtcttgggc ttggcccttc tggggagtgt gaagagttga aataaaagag
     1921 acggaagttt ttgga
//
