LOCUS       NM_001163401            1761 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Mus musculus interleukin 11 receptor subunit alpha 1 (Il11ra1),
            transcript variant 2, mRNA.
ACCESSION   NM_001163401
VERSION     NM_001163401.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1761)
  AUTHORS   Huber,A., Allam,A.H., Dijkstra,C., Thiem,S., Huynh,J., Poh,A.R.,
            Konecnik,J., Jacob,S.P., Busuttil,R., Liao,Y., Chisanga,D., Shi,W.,
            Alorro,M.G., Forrow,S., Tauriello,D.V.F., Batlle,E.,
            Boussioutas,A., Williams,D.S., Buchert,M., Ernst,M. and
            Eissmann,M.F.
  TITLE     Mutant TP53 switches therapeutic vulnerability during gastric
            cancer progression within interleukin-6 family cytokines
  JOURNAL   Cell Rep 43 (8), 114616 (2024)
   PUBMED   39128004
REFERENCE   2  (bases 1 to 1761)
  AUTHORS   Zhang,Z.G., Zhu,H.M. and Hua,H.K.
  TITLE     Inhibiting IL11RA to mitigate hepatic metastasis in skin cutaneous
            melanoma: Comprehensive insights from in vitro and in vivo
            investigations
  JOURNAL   Skin Res Technol 30 (3), e13618 (2024)
   PUBMED   38468436
  REMARK    GeneRIF: Inhibiting IL11RA to mitigate hepatic metastasis in skin
            cutaneous melanoma: Comprehensive insights from in vitro and in
            vivo investigations.
REFERENCE   3  (bases 1 to 1761)
  AUTHORS   Ng,B., Xie,C., Su,L., Kuthubudeen,F.F., Kwek,X.Y., Yeong,D.,
            Pua,C.J., Cook,S.A. and Lim,W.W.
  TITLE     IL11 (Interleukin-11) Causes Emphysematous Lung Disease in a Mouse
            Model of Marfan Syndrome
  JOURNAL   Arterioscler Thromb Vasc Biol 43 (5), 739-754 (2023)
   PUBMED   36924234
REFERENCE   4  (bases 1 to 1761)
  AUTHORS   Nishina,T., Deguchi,Y., Kawauchi,M., Xiyu,C., Yamazaki,S.,
            Mikami,T. and Nakano,H.
  TITLE     Interleukin 11 confers resistance to dextran sulfate sodium-induced
            colitis in mice
  JOURNAL   iScience 26 (2), 105934 (2023)
   PUBMED   36685040
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1761)
  AUTHORS   Widjaja,A.A., Viswanathan,S., Shekeran,S.G., Adami,E., Lim,W.W.,
            Chothani,S., Tan,J., Goh,J.W.T., Chen,H.M., Lim,S.Y.,
            Boustany-Kari,C.M., Hawkins,J., Petretto,E., Hubner,N., Schafer,S.,
            Coffman,T.M. and Cook,S.A.
  TITLE     Targeting endogenous kidney regeneration using anti-IL11 therapy in
            acute and chronic models of kidney disease
  JOURNAL   Nat Commun 13 (1), 7497 (2022)
   PUBMED   36470928
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1761)
  AUTHORS   Robb,L., Hilton,D.J., Willson,T.A. and Begley,C.G.
  TITLE     Structural analysis of the gene encoding the murine interleukin-11
            receptor alpha-chain and a related locus
  JOURNAL   J Biol Chem 271 (23), 13754-13761 (1996)
   PUBMED   8662802
REFERENCE   7  (bases 1 to 1761)
  AUTHORS   Nandurkar,H.H., Hilton,D.J., Nathan,P., Willson,T., Nicola,N. and
            Begley,C.G.
  TITLE     The human IL-11 receptor requires gp130 for signalling:
            demonstration by molecular cloning of the receptor
  JOURNAL   Oncogene 12 (3), 585-593 (1996)
   PUBMED   8637716
REFERENCE   8  (bases 1 to 1761)
  AUTHORS   Van Leuven,F., Stas,L., Hilliker,C., Miyake,Y., Bilinski,P. and
            Gossler,A.
  TITLE     Molecular cloning and characterization of the human interleukin-11
            receptor alpha-chain gene, IL11RA, located on chromosome 9p13
  JOURNAL   Genomics 31 (1), 65-70 (1996)
   PUBMED   8808281
REFERENCE   9  (bases 1 to 1761)
  AUTHORS   Neuhaus,H., Bettenhausen,B., Bilinski,P., Simon-Chazottes,D.,
            Guenet,J.L. and Gossler,A.
  TITLE     Etl2, a novel putative type-I cytokine receptor expressed during
            mouse embryogenesis at high levels in skin and cells with
            skeletogenic potential
  JOURNAL   Dev Biol 166 (2), 531-542 (1994)
   PUBMED   7813775
REFERENCE   10 (bases 1 to 1761)
  AUTHORS   Hilton,D.J., Hilton,A.A., Raicevic,A., Rakar,S., Harrison-Smith,M.,
            Gough,N.M., Begley,C.G., Metcalf,D., Nicola,N.A. and Willson,T.A.
  TITLE     Cloning of a murine IL-11 receptor alpha-chain; requirement for
            gp130 for high affinity binding and signal transduction
  JOURNAL   EMBO J 13 (20), 4765-4775 (1994)
   PUBMED   7957045
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY777524.1, AK159559.1 and AK146742.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 3. Variants 1-3 all encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146742.1, AK159559.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                BY777524.1         1-66
            67-1323             AK159559.1         2-1258
            1324-1761           AK146742.1         1277-1714
FEATURES             Location/Qualifiers
     source          1..1761
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 21.94 cM"
     gene            1..1761
                     /gene="Il11ra1"
                     /gene_synonym="GP130; Il-11ra; Il11ra; Il11ra2; NR1"
                     /note="interleukin 11 receptor subunit alpha 1"
                     /db_xref="GeneID:16157"
                     /db_xref="MGI:MGI:107426"
     exon            1..109
                     /gene="Il11ra1"
                     /gene_synonym="GP130; Il-11ra; Il11ra; Il11ra2; NR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..1408
                     /gene="Il11ra1"
                     /gene_synonym="GP130; Il-11ra; Il11ra; Il11ra2; NR1"
                     /note="interleukin 11 receptor, alpha chain 2; NR-1;
                     etl-2; IL-11RA1; IL-11R-alpha-1; IL-11R subunit alpha-1;
                     novel cytokine receptor 1; enhancer trap locus homolog 2;
                     IL-11 receptor subunit alpha-1; Il-11ra-alpha; locus 2;
                     interleukin 11 receptor, alpha chain 1"
                     /codon_start=1
                     /product="interleukin-11 receptor subunit alpha-1
                     precursor"
                     /protein_id="NP_001156873.1"
                     /db_xref="CCDS:CCDS18071.1"
                     /db_xref="GeneID:16157"
                     /db_xref="MGI:MGI:107426"
                     /translation="MSSSCSGLTRVLVAVATALVSSSSPCPQAWGPPGVQYGQPGRPV
                     MLCCPGVSAGTPVSWFRDGDSRLLQGPDSGLGHRLVLAQVDSPDEGTYVCQTLDGVSG
                     GMVTLKLGFPPARPEVSCQAVDYENFSCTWSPGQVSGLPTRYLTSYRKKTLPGAESQR
                     ESPSTGPWPCPQDPLEASRCVVHGAEFWSEYRINVTEVNPLGASTCLLDVRLQSILRP
                     DPPQGLRVESVPGYPRRLHASWTYPASWRRQPHFLLKFRLQYRPAQHPAWSTVEPIGL
                     EEVITDAVAGLPHAVRVSARDFLDAGTWSAWSPEAWGTPSTGPLQDEIPDWSQGHGQQ
                     LEAVVAQEDSPAPARPSLQPDPRPLDHRDPLEQVAVLASLGIFSCLGLAVGALALGLW
                     LRLRRSGKDGPQKPGLLAPMIPVEKLPGIPNLQRTPENFS"
     exon            110..209
                     /gene="Il11ra1"
                     /gene_synonym="GP130; Il-11ra; Il11ra; Il11ra2; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            210..270
                     /gene="Il11ra1"
                     /gene_synonym="GP130; Il-11ra; Il11ra; Il11ra2; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            271..440
                     /gene="Il11ra1"
                     /gene_synonym="GP130; Il-11ra; Il11ra; Il11ra2; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            441..555
                     /gene="Il11ra1"
                     /gene_synonym="GP130; Il-11ra; Il11ra; Il11ra2; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            556..588
                     /gene="Il11ra1"
                     /gene_synonym="GP130; Il-11ra; Il11ra; Il11ra2; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            589..755
                     /gene="Il11ra1"
                     /gene_synonym="GP130; Il-11ra; Il11ra; Il11ra2; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            756..919
                     /gene="Il11ra1"
                     /gene_synonym="GP130; Il-11ra; Il11ra; Il11ra2; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1061
                     /gene="Il11ra1"
                     /gene_synonym="GP130; Il-11ra; Il11ra; Il11ra2; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1187
                     /gene="Il11ra1"
                     /gene_synonym="GP130; Il-11ra; Il11ra; Il11ra2; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1284
                     /gene="Il11ra1"
                     /gene_synonym="GP130; Il-11ra; Il11ra; Il11ra2; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1367
                     /gene="Il11ra1"
                     /gene_synonym="GP130; Il-11ra; Il11ra; Il11ra2; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1761
                     /gene="Il11ra1"
                     /gene_synonym="GP130; Il-11ra; Il11ra; Il11ra2; NR1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tattggcgct gggaggagcc gcccccactg cctgcgctca gcactggagg gagcagaggc
       61 cggggcagag ggtgagggcg gagggcgctg gcggcggctg ccgcagaaga tgagcagcag
      121 ctgctcaggg ctgaccaggg tcctggtggc cgtggctaca gccctggtgt cttcctcctc
      181 cccctgcccc caagcttggg gtcctccagg ggtccagtat ggacaacctg gcaggcccgt
      241 gatgctgtgc tgccccggag tgagtgctgg gactccagtg tcctggtttc gggatggaga
      301 ttcaaggctg ctccagggac ctgactctgg gttaggacac agactggtct tggcccaggt
      361 ggacagccct gatgaaggca cttatgtctg ccagaccctg gatggtgtat cagggggcat
      421 ggtgaccctg aagctgggct ttcccccagc acgtcctgaa gtctcctgcc aagcggtaga
      481 ctatgaaaac ttctcctgta cttggagtcc aggccaggtc agcggtttgc ccacccgcta
      541 ccttacttcc tacaggaaga agacgctgcc aggagctgag agtcagaggg aaagtccatc
      601 caccgggcct tggccgtgtc cacaggaccc tctggaggcc tcccgatgtg tggtccatgg
      661 ggcagagttc tggagtgagt accggatcaa tgtgaccgag gtgaacccac tgggtgccag
      721 cacgtgccta ctggatgtga gattacagag catcttgcgt cctgatccac cccaaggact
      781 gcgggtggaa tccgtacctg gttacccgag acgcctgcat gccagctgga cataccctgc
      841 ctcctggcgt cgccaacccc actttctgct caagttccgg ttgcaatacc gaccagcaca
      901 gcatccagcc tggtccacgg tggagcccat tggcttggag gaagtgataa cagatgctgt
      961 ggctgggctg ccacacgcgg tacgagtcag tgccagggac tttctggatg ctggcacctg
     1021 gagcgcctgg agcccagagg cctggggtac tcctagcact ggtcccctgc aggatgagat
     1081 acctgattgg agccagggac acggacagca gctagaggca gtagtagctc aggaggacag
     1141 cccggctcct gcaaggcctt ccttgcagcc ggacccaagg ccacttgatc acagggaccc
     1201 cttggagcaa gtagctgtgt tagcgtctct gggaatcttc tcttgccttg gcctggctgt
     1261 tggagctctg gcactggggc tctggctgag gctgagacgg agtgggaagg atggaccgca
     1321 aaaacctggg ctcttggcac ccatgatccc ggtggaaaag cttccaggaa ttccaaacct
     1381 gcagaggacc ccagagaact tcagctgatt tcatctgtaa cccggtcaga cttgggtggt
     1441 taaaaggaca ggcagaaaga ggcggggcag tggatccctg tggatggagg tctcagctga
     1501 aagtctgagc tcttttcttt gacacctata ctccaaactt gctgccggct gaaggctgtc
     1561 tggacttccg atgtcctgag gtggaagtcc acctgaggaa tgtgtacaga agtctgtgtt
     1621 cctgtgatcg tgtgtgtatg tgagacaggg agcaaaagtt ctctgcatgt gtgtacagat
     1681 gattggagag tgtgtgcggt cttgggcttg gcccttctgg gaagtgtgaa gagttgaaat
     1741 aaaagagacg gaagtttttg g
//
