LOCUS       NM_008350               1951 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Mus musculus interleukin 11 (Il11), transcript variant 1, mRNA.
ACCESSION   NM_008350 XR_105070 XR_107862
VERSION     NM_008350.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1951)
  AUTHORS   Ng,B., Huang,K.Y., Pua,C.J., Viswanathan,S., Lim,W.W.,
            Kuthubudeen,F.F., Liu,Y.N., Hii,A.A., George,B.L., Widjaja,A.A.,
            Petretto,E. and Cook,S.A.
  TITLE     Interleukin-11 causes alveolar type 2 cell dysfunction and prevents
            alveolar regeneration
  JOURNAL   Nat Commun 15 (1), 8530 (2024)
   PUBMED   39358385
  REMARK    GeneRIF: Interleukin-11 causes alveolar type 2 cell dysfunction and
            prevents alveolar regeneration.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1951)
  AUTHORS   Liang,P., Ness,J., Rapp,J., Boneva,S., Schwammle,M., Jung,M.,
            Schlunck,G., Agostini,H. and Bucher,F.
  TITLE     Characterization of the angiomodulatory effects of Interleukin 11
            cis- and trans-signaling in the retina
  JOURNAL   J Neuroinflammation 21 (1), 230 (2024)
   PUBMED   39294742
  REMARK    GeneRIF: Characterization of the angiomodulatory effects of
            Interleukin 11 cis- and trans-signaling in the retina.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1951)
  AUTHORS   Huber,A., Allam,A.H., Dijkstra,C., Thiem,S., Huynh,J., Poh,A.R.,
            Konecnik,J., Jacob,S.P., Busuttil,R., Liao,Y., Chisanga,D., Shi,W.,
            Alorro,M.G., Forrow,S., Tauriello,D.V.F., Batlle,E.,
            Boussioutas,A., Williams,D.S., Buchert,M., Ernst,M. and
            Eissmann,M.F.
  TITLE     Mutant TP53 switches therapeutic vulnerability during gastric
            cancer progression within interleukin-6 family cytokines
  JOURNAL   Cell Rep 43 (8), 114616 (2024)
   PUBMED   39128004
REFERENCE   4  (bases 1 to 1951)
  AUTHORS   Widjaja,A.A., Lim,W.W., Viswanathan,S., Chothani,S., Corden,B.,
            Dasan,C.M., Goh,J.W.T., Lim,R., Singh,B.K., Tan,J., Pua,C.J.,
            Lim,S.Y., Adami,E., Schafer,S., George,B.L., Sweeney,M., Xie,C.,
            Tripathi,M., Sims,N.A., Hubner,N., Petretto,E., Withers,D.J.,
            Ho,L., Gil,J., Carling,D. and Cook,S.A.
  TITLE     Inhibition of IL-11 signalling extends mammalian healthspan and
            lifespan
  JOURNAL   Nature 632 (8023), 157-165 (2024)
   PUBMED   39020175
  REMARK    GeneRIF: Inhibition of IL-11 signalling extends mammalian
            healthspan and lifespan.
REFERENCE   5  (bases 1 to 1951)
  AUTHORS   Cho,W.J., Pulimamidi,V.K., Mittal,S.K. and Chauhan,S.K.
  TITLE     Mesenchymal stromal cells protect tissues from Th1 immune responses
            via IL-11 secretion
  JOURNAL   FASEB J 38 (10), e23683 (2024)
   PUBMED   38758184
  REMARK    GeneRIF: Mesenchymal stromal cells protect tissues from Th1 immune
            responses via IL-11 secretion.
REFERENCE   6  (bases 1 to 1951)
  AUTHORS   Wang,X.Y., Fuhrer,D.K., Marshall,M.S. and Yang,Y.C.
  TITLE     Interleukin-11 induces complex formation of Grb2, Fyn, and JAK2 in
            3T3L1 cells
  JOURNAL   J Biol Chem 270 (47), 27999-28002 (1995)
   PUBMED   7499280
REFERENCE   7  (bases 1 to 1951)
  AUTHORS   Yin,T. and Yang,Y.C.
  TITLE     Mitogen-activated protein kinases and ribosomal S6 protein kinases
            are involved in signaling pathways shared by interleukin-11,
            interleukin-6, leukemia inhibitory factor, and oncostatin M in
            mouse 3T3-L1 cells
  JOURNAL   J Biol Chem 269 (5), 3731-3738 (1994)
   PUBMED   7508917
REFERENCE   8  (bases 1 to 1951)
  AUTHORS   Tsuji,K., Lyman,S.D., Sudo,T., Clark,S.C. and Ogawa,M.
  TITLE     Enhancement of murine hematopoiesis by synergistic interactions
            between steel factor (ligand for c-kit), interleukin-11, and other
            early acting factors in culture
  JOURNAL   Blood 79 (11), 2855-2860 (1992)
   PUBMED   1375116
REFERENCE   9  (bases 1 to 1951)
  AUTHORS   Quesniaux,V.F.
  TITLE     Interleukins 9, 10, 11 and 12 and kit ligand: a brief overview
  JOURNAL   Res Immunol 143 (4), 385-400 (1992)
   PUBMED   1381512
  REMARK    Review article
REFERENCE   10 (bases 1 to 1951)
  AUTHORS   Paul,S.R., Bennett,F., Calvetti,J.A., Kelleher,K., Wood,C.R.,
            O'Hara,R.M. Jr., Leary,A.C., Sibley,B., Clark,S.C., Williams,D.A.
            et al.
  TITLE     Molecular cloning of a cDNA encoding interleukin 11, a stromal
            cell-derived lymphopoietic and hematopoietic cytokine
  JOURNAL   Proc Natl Acad Sci U S A 87 (19), 7512-7516 (1990)
   PUBMED   2145578
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162034.6.
            
            On Sep 30, 2022 this sequence version replaced NM_008350.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U03421.1, SRR13948564.4358671.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               AC162034.6         122475-122638       c
            165-337             AC162034.6         120820-120992       c
            338-424             AC162034.6         120625-120711       c
            425-586             AC162034.6         120373-120534       c
            587-1951            AC162034.6         116868-118232       c
FEATURES             Location/Qualifiers
     source          1..1951
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 2.76 cM"
     gene            1..1951
                     /gene="Il11"
                     /gene_synonym="IL-11"
                     /note="interleukin 11"
                     /db_xref="GeneID:16156"
                     /db_xref="MGI:MGI:107613"
     exon            1..164
                     /gene="Il11"
                     /gene_synonym="IL-11"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..757
                     /gene="Il11"
                     /gene_synonym="IL-11"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="interleukin-11 isoform 1 precursor"
                     /protein_id="NP_032376.1"
                     /db_xref="CCDS:CCDS39740.1"
                     /db_xref="GeneID:16156"
                     /db_xref="MGI:MGI:107613"
                     /translation="MNCVCRLVLVVLSLWPDRVVAPGPPAGSPRVSSDPRADLDSAVL
                     LTRSLLADTRQLAAQMRDKFPADGDHSLDSLPTLAMSAGTLGSLQLPGVLTRLRVDLM
                     SYLRHVQWLRRAGGPSLKTLEPELGALQARLERLLRRLQLLMSRLALPQAAPDQPVIP
                     LGPPASAWGSIRAAHAILGGLHLTLDWAVRGLLLLKTRL"
     exon            165..337
                     /gene="Il11"
                     /gene_synonym="IL-11"
                     /inference="alignment:Splign:2.1.0"
     exon            338..424
                     /gene="Il11"
                     /gene_synonym="IL-11"
                     /inference="alignment:Splign:2.1.0"
     exon            425..586
                     /gene="Il11"
                     /gene_synonym="IL-11"
                     /inference="alignment:Splign:2.1.0"
     exon            587..1951
                     /gene="Il11"
                     /gene_synonym="IL-11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1927..1932
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il11"
                     /gene_synonym="IL-11"
                     /note="hexamer: AATAAA"
     polyA_site      1951
                     /gene="Il11"
                     /gene_synonym="IL-11"
                     /note="major polyA site"
ORIGIN      
        1 actgcctggc ccttgctgct cacactcaca aacctcccct ccccaggccg aggcccagct
       61 gaccccctgg gtcccccggc agcggacagg gaagggttaa agcccccccc cccggctccc
      121 tgccccctgc cctggggaac ccctggcctg tggggacatg aactgtgttt gtcgcctggt
      181 cctggtggtg ctgagcctct ggccagatag agtcgttgcc cctgggccac cagctggctc
      241 ccctcgagtc tcttcagacc ctcgagcaga tctggacagc gctgttctcc taacccgatc
      301 cctcctggca gacacacggc aactagctgc acagatgaga gacaaattcc cagctgacgg
      361 agatcacagt ctggactccc tgcccacctt ggccatgagc gctgggacat tgggatcttt
      421 gcagcttcct ggtgtgctga caaggcttcg agtagacttg atgtcctacc tccggcatgt
      481 acaatggctg cgccgtgcag gtggtccttc cctaaagact ctggagccag agctgggtgc
      541 cctgcaagcc cgactggaac ggctactccg ccgtttacag ctcttgatgt ctcgcctggc
      601 cttgccccag gcagccccag accaacctgt gatccccctg ggccctcctg cctcagcctg
      661 gggaagcatc cgggcagctc atgccatcct aggagggctg cacctgacct tggactgggc
      721 cgtgcggggc ctgctgttgt taaagactcg actgtgactc gggactgaaa accaccatcg
      781 ataccgccct ttaaaaccag atcttattta tttatttatt ttggtacttg gaggggggca
      841 tgatgatcag gggcatgcca caccccaaac aaccgcccca cacccagcta gacagtcttt
      901 ccagtagacc tgggtgaggg ggatcacctg tggcttattt atacttattt atttaaacaa
      961 ttggggggtg ggtgggtgca tctgagaccc tgaagagcag ggaactgaga tcctgggttc
     1021 tggggtctct atgaaatctg ttcacagtgt cttcctcact tcctacatta tttattaaac
     1081 gattactttt tatattaaga ggaggaagga gggaagccgg gcgtggtggc gcatgccttt
     1141 aatcccagca ctcgggaggc agaggcaggc agatttctga gttcgaggcc agcctggtct
     1201 aagagtgagt tcgtgagttc caggacagcc agggctacac agagaaaccc tgtctcgaaa
     1261 aaccaaaaaa aaaaaaaaaa aaaaagagga ggaaggaggg ggaaaaagga agcctggggt
     1321 tttataccaa aatgtgagtt tttttttgtg agtcagagaa gtgagaggat ttaaatacat
     1381 atctatttag aggttattag caggagtatg ccgaaaggat cggagtctaa actggtaccc
     1441 tagcatttca aaggtcctca acagatactt aacaaaaagt tccagagcat caccttataa
     1501 ctaatagcac ctgtatggta cagagctgta aggtacaagg ttttttgttt cagcaaaatt
     1561 cacgatgacc aatgggaaac aatctaggct ttctgggggg cgggcagggg atggatgaat
     1621 aaagctaggg atacatccgc atgatgaagt tctagctcgc caaccataaa aaggcaagtt
     1681 ccaggcgaag actgctttag atattgaacg tctctgcgac ccaggagcag cagatggtag
     1741 aactactctc cctatacatg agtatggact gtttggtttt tcaaaatgga aacaccatga
     1801 tgttgacgat agctgcctca gggctgaaaa caagcaatgg cacagtgggt gactgttact
     1861 gtttgtgttt gcattttcca gagttttcac catgactgta ttttgcagga cacatttata
     1921 aacattaata aacactattt ttagaatggc a
//
