LOCUS       NM_001412484            1932 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Mus musculus interleukin 11 (Il11), transcript variant 5, mRNA.
ACCESSION   NM_001412484 XM_030242164
VERSION     NM_001412484.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1932)
  AUTHORS   Ng,B., Huang,K.Y., Pua,C.J., Viswanathan,S., Lim,W.W.,
            Kuthubudeen,F.F., Liu,Y.N., Hii,A.A., George,B.L., Widjaja,A.A.,
            Petretto,E. and Cook,S.A.
  TITLE     Interleukin-11 causes alveolar type 2 cell dysfunction and prevents
            alveolar regeneration
  JOURNAL   Nat Commun 15 (1), 8530 (2024)
   PUBMED   39358385
  REMARK    GeneRIF: Interleukin-11 causes alveolar type 2 cell dysfunction and
            prevents alveolar regeneration.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1932)
  AUTHORS   Liang,P., Ness,J., Rapp,J., Boneva,S., Schwammle,M., Jung,M.,
            Schlunck,G., Agostini,H. and Bucher,F.
  TITLE     Characterization of the angiomodulatory effects of Interleukin 11
            cis- and trans-signaling in the retina
  JOURNAL   J Neuroinflammation 21 (1), 230 (2024)
   PUBMED   39294742
  REMARK    GeneRIF: Characterization of the angiomodulatory effects of
            Interleukin 11 cis- and trans-signaling in the retina.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1932)
  AUTHORS   Huber,A., Allam,A.H., Dijkstra,C., Thiem,S., Huynh,J., Poh,A.R.,
            Konecnik,J., Jacob,S.P., Busuttil,R., Liao,Y., Chisanga,D., Shi,W.,
            Alorro,M.G., Forrow,S., Tauriello,D.V.F., Batlle,E.,
            Boussioutas,A., Williams,D.S., Buchert,M., Ernst,M. and
            Eissmann,M.F.
  TITLE     Mutant TP53 switches therapeutic vulnerability during gastric
            cancer progression within interleukin-6 family cytokines
  JOURNAL   Cell Rep 43 (8), 114616 (2024)
   PUBMED   39128004
REFERENCE   4  (bases 1 to 1932)
  AUTHORS   Widjaja,A.A., Lim,W.W., Viswanathan,S., Chothani,S., Corden,B.,
            Dasan,C.M., Goh,J.W.T., Lim,R., Singh,B.K., Tan,J., Pua,C.J.,
            Lim,S.Y., Adami,E., Schafer,S., George,B.L., Sweeney,M., Xie,C.,
            Tripathi,M., Sims,N.A., Hubner,N., Petretto,E., Withers,D.J.,
            Ho,L., Gil,J., Carling,D. and Cook,S.A.
  TITLE     Inhibition of IL-11 signalling extends mammalian healthspan and
            lifespan
  JOURNAL   Nature 632 (8023), 157-165 (2024)
   PUBMED   39020175
  REMARK    GeneRIF: Inhibition of IL-11 signalling extends mammalian
            healthspan and lifespan.
REFERENCE   5  (bases 1 to 1932)
  AUTHORS   Cho,W.J., Pulimamidi,V.K., Mittal,S.K. and Chauhan,S.K.
  TITLE     Mesenchymal stromal cells protect tissues from Th1 immune responses
            via IL-11 secretion
  JOURNAL   FASEB J 38 (10), e23683 (2024)
   PUBMED   38758184
  REMARK    GeneRIF: Mesenchymal stromal cells protect tissues from Th1 immune
            responses via IL-11 secretion.
REFERENCE   6  (bases 1 to 1932)
  AUTHORS   Wang,X.Y., Fuhrer,D.K., Marshall,M.S. and Yang,Y.C.
  TITLE     Interleukin-11 induces complex formation of Grb2, Fyn, and JAK2 in
            3T3L1 cells
  JOURNAL   J Biol Chem 270 (47), 27999-28002 (1995)
   PUBMED   7499280
REFERENCE   7  (bases 1 to 1932)
  AUTHORS   Yin,T. and Yang,Y.C.
  TITLE     Mitogen-activated protein kinases and ribosomal S6 protein kinases
            are involved in signaling pathways shared by interleukin-11,
            interleukin-6, leukemia inhibitory factor, and oncostatin M in
            mouse 3T3-L1 cells
  JOURNAL   J Biol Chem 269 (5), 3731-3738 (1994)
   PUBMED   7508917
REFERENCE   8  (bases 1 to 1932)
  AUTHORS   Tsuji,K., Lyman,S.D., Sudo,T., Clark,S.C. and Ogawa,M.
  TITLE     Enhancement of murine hematopoiesis by synergistic interactions
            between steel factor (ligand for c-kit), interleukin-11, and other
            early acting factors in culture
  JOURNAL   Blood 79 (11), 2855-2860 (1992)
   PUBMED   1375116
REFERENCE   9  (bases 1 to 1932)
  AUTHORS   Quesniaux,V.F.
  TITLE     Interleukins 9, 10, 11 and 12 and kit ligand: a brief overview
  JOURNAL   Res Immunol 143 (4), 385-400 (1992)
   PUBMED   1381512
  REMARK    Review article
REFERENCE   10 (bases 1 to 1932)
  AUTHORS   Paul,S.R., Bennett,F., Calvetti,J.A., Kelleher,K., Wood,C.R.,
            O'Hara,R.M. Jr., Leary,A.C., Sibley,B., Clark,S.C., Williams,D.A.
            et al.
  TITLE     Molecular cloning of a cDNA encoding interleukin 11, a stromal
            cell-derived lymphopoietic and hematopoietic cytokine
  JOURNAL   Proc Natl Acad Sci U S A 87 (19), 7512-7516 (1990)
   PUBMED   2145578
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162034.6.
            
            On Sep 30, 2022 this sequence version replaced XM_030242164.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253012.7660231.1,
                                           SRR17253013.2677658.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               AC162034.6         121359-121503       c
            146-318             AC162034.6         120820-120992       c
            319-405             AC162034.6         120625-120711       c
            406-567             AC162034.6         120373-120534       c
            568-1932            AC162034.6         116868-118232       c
FEATURES             Location/Qualifiers
     source          1..1932
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 2.76 cM"
     gene            1..1932
                     /gene="Il11"
                     /gene_synonym="IL-11"
                     /note="interleukin 11"
                     /db_xref="GeneID:16156"
                     /db_xref="MGI:MGI:107613"
     exon            1..145
                     /gene="Il11"
                     /gene_synonym="IL-11"
                     /inference="alignment:Splign:2.1.0"
     exon            146..318
                     /gene="Il11"
                     /gene_synonym="IL-11"
                     /inference="alignment:Splign:2.1.0"
     CDS             316..738
                     /gene="Il11"
                     /gene_synonym="IL-11"
                     /note="isoform 2 is encoded by transcript variant 5"
                     /codon_start=1
                     /product="interleukin-11 isoform 2"
                     /protein_id="NP_001399413.1"
                     /db_xref="GeneID:16156"
                     /db_xref="MGI:MGI:107613"
                     /translation="MRDKFPADGDHSLDSLPTLAMSAGTLGSLQLPGVLTRLRVDLMS
                     YLRHVQWLRRAGGPSLKTLEPELGALQARLERLLRRLQLLMSRLALPQAAPDQPVIPL
                     GPPASAWGSIRAAHAILGGLHLTLDWAVRGLLLLKTRL"
     exon            319..405
                     /gene="Il11"
                     /gene_synonym="IL-11"
                     /inference="alignment:Splign:2.1.0"
     exon            406..567
                     /gene="Il11"
                     /gene_synonym="IL-11"
                     /inference="alignment:Splign:2.1.0"
     exon            568..1932
                     /gene="Il11"
                     /gene_synonym="IL-11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1908..1913
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il11"
                     /gene_synonym="IL-11"
                     /note="hexamer: AATAAA"
     polyA_site      1932
                     /gene="Il11"
                     /gene_synonym="IL-11"
                     /note="major polyA site"
ORIGIN      
        1 gacgcccggc ccgtctaccc gccccgggcc gcgtctgctc cgacgggcgg ggcagccaga
       61 gccagggagg gagagggaag cccgcccggg ctcgggcttt gcgacctgcc ccggggcgcc
      121 ccaccctgag actcaagacc tccaggtgtt tgtcgcctgg tcctggtggt gctgagcctc
      181 tggccagata gagtcgttgc ccctgggcca ccagctggct cccctcgagt ctcttcagac
      241 cctcgagcag atctggacag cgctgttctc ctaacccgat ccctcctggc agacacacgg
      301 caactagctg cacagatgag agacaaattc ccagctgacg gagatcacag tctggactcc
      361 ctgcccacct tggccatgag cgctgggaca ttgggatctt tgcagcttcc tggtgtgctg
      421 acaaggcttc gagtagactt gatgtcctac ctccggcatg tacaatggct gcgccgtgca
      481 ggtggtcctt ccctaaagac tctggagcca gagctgggtg ccctgcaagc ccgactggaa
      541 cggctactcc gccgtttaca gctcttgatg tctcgcctgg ccttgcccca ggcagcccca
      601 gaccaacctg tgatccccct gggccctcct gcctcagcct ggggaagcat ccgggcagct
      661 catgccatcc taggagggct gcacctgacc ttggactggg ccgtgcgggg cctgctgttg
      721 ttaaagactc gactgtgact cgggactgaa aaccaccatc gataccgccc tttaaaacca
      781 gatcttattt atttatttat tttggtactt ggaggggggc atgatgatca ggggcatgcc
      841 acaccccaaa caaccgcccc acacccagct agacagtctt tccagtagac ctgggtgagg
      901 gggatcacct gtggcttatt tatacttatt tatttaaaca attggggggt gggtgggtgc
      961 atctgagacc ctgaagagca gggaactgag atcctgggtt ctggggtctc tatgaaatct
     1021 gttcacagtg tcttcctcac ttcctacatt atttattaaa cgattacttt ttatattaag
     1081 aggaggaagg agggaagccg ggcgtggtgg cgcatgcctt taatcccagc actcgggagg
     1141 cagaggcagg cagatttctg agttcgaggc cagcctggtc taagagtgag ttcgtgagtt
     1201 ccaggacagc cagggctaca cagagaaacc ctgtctcgaa aaaccaaaaa aaaaaaaaaa
     1261 aaaaaagagg aggaaggagg gggaaaaagg aagcctgggg ttttatacca aaatgtgagt
     1321 ttttttttgt gagtcagaga agtgagagga tttaaataca tatctattta gaggttatta
     1381 gcaggagtat gccgaaagga tcggagtcta aactggtacc ctagcatttc aaaggtcctc
     1441 aacagatact taacaaaaag ttccagagca tcaccttata actaatagca cctgtatggt
     1501 acagagctgt aaggtacaag gttttttgtt tcagcaaaat tcacgatgac caatgggaaa
     1561 caatctaggc tttctggggg gcgggcaggg gatggatgaa taaagctagg gatacatccg
     1621 catgatgaag ttctagctcg ccaaccataa aaaggcaagt tccaggcgaa gactgcttta
     1681 gatattgaac gtctctgcga cccaggagca gcagatggta gaactactct ccctatacat
     1741 gagtatggac tgtttggttt ttcaaaatgg aaacaccatg atgttgacga tagctgcctc
     1801 agggctgaaa acaagcaatg gcacagtggg tgactgttac tgtttgtgtt tgcattttcc
     1861 agagttttca ccatgactgt attttgcagg acacatttat aaacattaat aaacactatt
     1921 tttagaatgg ca
//
