LOCUS       NM_001290423            1852 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Mus musculus interleukin 11 (Il11), transcript variant 2, mRNA.
ACCESSION   NM_001290423 XM_006539562
VERSION     NM_001290423.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1852)
  AUTHORS   Ng,B., Huang,K.Y., Pua,C.J., Viswanathan,S., Lim,W.W.,
            Kuthubudeen,F.F., Liu,Y.N., Hii,A.A., George,B.L., Widjaja,A.A.,
            Petretto,E. and Cook,S.A.
  TITLE     Interleukin-11 causes alveolar type 2 cell dysfunction and prevents
            alveolar regeneration
  JOURNAL   Nat Commun 15 (1), 8530 (2024)
   PUBMED   39358385
  REMARK    GeneRIF: Interleukin-11 causes alveolar type 2 cell dysfunction and
            prevents alveolar regeneration.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1852)
  AUTHORS   Liang,P., Ness,J., Rapp,J., Boneva,S., Schwammle,M., Jung,M.,
            Schlunck,G., Agostini,H. and Bucher,F.
  TITLE     Characterization of the angiomodulatory effects of Interleukin 11
            cis- and trans-signaling in the retina
  JOURNAL   J Neuroinflammation 21 (1), 230 (2024)
   PUBMED   39294742
  REMARK    GeneRIF: Characterization of the angiomodulatory effects of
            Interleukin 11 cis- and trans-signaling in the retina.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1852)
  AUTHORS   Huber,A., Allam,A.H., Dijkstra,C., Thiem,S., Huynh,J., Poh,A.R.,
            Konecnik,J., Jacob,S.P., Busuttil,R., Liao,Y., Chisanga,D., Shi,W.,
            Alorro,M.G., Forrow,S., Tauriello,D.V.F., Batlle,E.,
            Boussioutas,A., Williams,D.S., Buchert,M., Ernst,M. and
            Eissmann,M.F.
  TITLE     Mutant TP53 switches therapeutic vulnerability during gastric
            cancer progression within interleukin-6 family cytokines
  JOURNAL   Cell Rep 43 (8), 114616 (2024)
   PUBMED   39128004
REFERENCE   4  (bases 1 to 1852)
  AUTHORS   Widjaja,A.A., Lim,W.W., Viswanathan,S., Chothani,S., Corden,B.,
            Dasan,C.M., Goh,J.W.T., Lim,R., Singh,B.K., Tan,J., Pua,C.J.,
            Lim,S.Y., Adami,E., Schafer,S., George,B.L., Sweeney,M., Xie,C.,
            Tripathi,M., Sims,N.A., Hubner,N., Petretto,E., Withers,D.J.,
            Ho,L., Gil,J., Carling,D. and Cook,S.A.
  TITLE     Inhibition of IL-11 signalling extends mammalian healthspan and
            lifespan
  JOURNAL   Nature 632 (8023), 157-165 (2024)
   PUBMED   39020175
  REMARK    GeneRIF: Inhibition of IL-11 signalling extends mammalian
            healthspan and lifespan.
REFERENCE   5  (bases 1 to 1852)
  AUTHORS   Cho,W.J., Pulimamidi,V.K., Mittal,S.K. and Chauhan,S.K.
  TITLE     Mesenchymal stromal cells protect tissues from Th1 immune responses
            via IL-11 secretion
  JOURNAL   FASEB J 38 (10), e23683 (2024)
   PUBMED   38758184
  REMARK    GeneRIF: Mesenchymal stromal cells protect tissues from Th1 immune
            responses via IL-11 secretion.
REFERENCE   6  (bases 1 to 1852)
  AUTHORS   Wang,X.Y., Fuhrer,D.K., Marshall,M.S. and Yang,Y.C.
  TITLE     Interleukin-11 induces complex formation of Grb2, Fyn, and JAK2 in
            3T3L1 cells
  JOURNAL   J Biol Chem 270 (47), 27999-28002 (1995)
   PUBMED   7499280
REFERENCE   7  (bases 1 to 1852)
  AUTHORS   Yin,T. and Yang,Y.C.
  TITLE     Mitogen-activated protein kinases and ribosomal S6 protein kinases
            are involved in signaling pathways shared by interleukin-11,
            interleukin-6, leukemia inhibitory factor, and oncostatin M in
            mouse 3T3-L1 cells
  JOURNAL   J Biol Chem 269 (5), 3731-3738 (1994)
   PUBMED   7508917
REFERENCE   8  (bases 1 to 1852)
  AUTHORS   Tsuji,K., Lyman,S.D., Sudo,T., Clark,S.C. and Ogawa,M.
  TITLE     Enhancement of murine hematopoiesis by synergistic interactions
            between steel factor (ligand for c-kit), interleukin-11, and other
            early acting factors in culture
  JOURNAL   Blood 79 (11), 2855-2860 (1992)
   PUBMED   1375116
REFERENCE   9  (bases 1 to 1852)
  AUTHORS   Quesniaux,V.F.
  TITLE     Interleukins 9, 10, 11 and 12 and kit ligand: a brief overview
  JOURNAL   Res Immunol 143 (4), 385-400 (1992)
   PUBMED   1381512
  REMARK    Review article
REFERENCE   10 (bases 1 to 1852)
  AUTHORS   Paul,S.R., Bennett,F., Calvetti,J.A., Kelleher,K., Wood,C.R.,
            O'Hara,R.M. Jr., Leary,A.C., Sibley,B., Clark,S.C., Williams,D.A.
            et al.
  TITLE     Molecular cloning of a cDNA encoding interleukin 11, a stromal
            cell-derived lymphopoietic and hematopoietic cytokine
  JOURNAL   Proc Natl Acad Sci U S A 87 (19), 7512-7516 (1990)
   PUBMED   2145578
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162034.6.
            
            On Sep 30, 2022 this sequence version replaced NM_001290423.1.
            
            Transcript Variant: This variant (2) contains an alternate first
            exon compared to variant 1. The resulting isoform (2) is shorter at
            the N-terminus compared to isoform 1. Variants 2-5 all encode the
            same isoform (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132897.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                AC162034.6         127290-127354       c
            66-238              AC162034.6         120820-120992       c
            239-325             AC162034.6         120625-120711       c
            326-487             AC162034.6         120373-120534       c
            488-1852            AC162034.6         116868-118232       c
FEATURES             Location/Qualifiers
     source          1..1852
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 2.76 cM"
     gene            1..1852
                     /gene="Il11"
                     /gene_synonym="IL-11"
                     /note="interleukin 11"
                     /db_xref="GeneID:16156"
                     /db_xref="MGI:MGI:107613"
     exon            1..65
                     /gene="Il11"
                     /gene_synonym="IL-11"
                     /inference="alignment:Splign:2.1.0"
     exon            66..238
                     /gene="Il11"
                     /gene_synonym="IL-11"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..658
                     /gene="Il11"
                     /gene_synonym="IL-11"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="interleukin-11 isoform 2"
                     /protein_id="NP_001277352.1"
                     /db_xref="CCDS:CCDS71881.1"
                     /db_xref="GeneID:16156"
                     /db_xref="MGI:MGI:107613"
                     /translation="MRDKFPADGDHSLDSLPTLAMSAGTLGSLQLPGVLTRLRVDLMS
                     YLRHVQWLRRAGGPSLKTLEPELGALQARLERLLRRLQLLMSRLALPQAAPDQPVIPL
                     GPPASAWGSIRAAHAILGGLHLTLDWAVRGLLLLKTRL"
     exon            239..325
                     /gene="Il11"
                     /gene_synonym="IL-11"
                     /inference="alignment:Splign:2.1.0"
     exon            326..487
                     /gene="Il11"
                     /gene_synonym="IL-11"
                     /inference="alignment:Splign:2.1.0"
     exon            488..1852
                     /gene="Il11"
                     /gene_synonym="IL-11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1828..1833
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il11"
                     /gene_synonym="IL-11"
                     /note="hexamer: AATAAA"
     polyA_site      1852
                     /gene="Il11"
                     /gene_synonym="IL-11"
                     /note="major polyA site"
ORIGIN      
        1 acaagaaggg gtgacctggt cccatcaatt ctatctagga agtagctcct tacttaggag
       61 aagaggtgtt tgtcgcctgg tcctggtggt gctgagcctc tggccagata gagtcgttgc
      121 ccctgggcca ccagctggct cccctcgagt ctcttcagac cctcgagcag atctggacag
      181 cgctgttctc ctaacccgat ccctcctggc agacacacgg caactagctg cacagatgag
      241 agacaaattc ccagctgacg gagatcacag tctggactcc ctgcccacct tggccatgag
      301 cgctgggaca ttgggatctt tgcagcttcc tggtgtgctg acaaggcttc gagtagactt
      361 gatgtcctac ctccggcatg tacaatggct gcgccgtgca ggtggtcctt ccctaaagac
      421 tctggagcca gagctgggtg ccctgcaagc ccgactggaa cggctactcc gccgtttaca
      481 gctcttgatg tctcgcctgg ccttgcccca ggcagcccca gaccaacctg tgatccccct
      541 gggccctcct gcctcagcct ggggaagcat ccgggcagct catgccatcc taggagggct
      601 gcacctgacc ttggactggg ccgtgcgggg cctgctgttg ttaaagactc gactgtgact
      661 cgggactgaa aaccaccatc gataccgccc tttaaaacca gatcttattt atttatttat
      721 tttggtactt ggaggggggc atgatgatca ggggcatgcc acaccccaaa caaccgcccc
      781 acacccagct agacagtctt tccagtagac ctgggtgagg gggatcacct gtggcttatt
      841 tatacttatt tatttaaaca attggggggt gggtgggtgc atctgagacc ctgaagagca
      901 gggaactgag atcctgggtt ctggggtctc tatgaaatct gttcacagtg tcttcctcac
      961 ttcctacatt atttattaaa cgattacttt ttatattaag aggaggaagg agggaagccg
     1021 ggcgtggtgg cgcatgcctt taatcccagc actcgggagg cagaggcagg cagatttctg
     1081 agttcgaggc cagcctggtc taagagtgag ttcgtgagtt ccaggacagc cagggctaca
     1141 cagagaaacc ctgtctcgaa aaaccaaaaa aaaaaaaaaa aaaaaagagg aggaaggagg
     1201 gggaaaaagg aagcctgggg ttttatacca aaatgtgagt ttttttttgt gagtcagaga
     1261 agtgagagga tttaaataca tatctattta gaggttatta gcaggagtat gccgaaagga
     1321 tcggagtcta aactggtacc ctagcatttc aaaggtcctc aacagatact taacaaaaag
     1381 ttccagagca tcaccttata actaatagca cctgtatggt acagagctgt aaggtacaag
     1441 gttttttgtt tcagcaaaat tcacgatgac caatgggaaa caatctaggc tttctggggg
     1501 gcgggcaggg gatggatgaa taaagctagg gatacatccg catgatgaag ttctagctcg
     1561 ccaaccataa aaaggcaagt tccaggcgaa gactgcttta gatattgaac gtctctgcga
     1621 cccaggagca gcagatggta gaactactct ccctatacat gagtatggac tgtttggttt
     1681 ttcaaaatgg aaacaccatg atgttgacga tagctgcctc agggctgaaa acaagcaatg
     1741 gcacagtggg tgactgttac tgtttgtgtt tgcattttcc agagttttca ccatgactgt
     1801 attttgcagg acacatttat aaacattaat aaacactatt tttagaatgg ca
//
