LOCUS       NM_008349               1803 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus interleukin 10 receptor, beta (Il10rb), transcript
            variant 1, mRNA.
ACCESSION   NM_008349
VERSION     NM_008349.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1803)
  AUTHORS   Volk-Draper,L., Athaiya,S., Espinosa Gonzalez,M., Bhattarai,N.,
            Wilber,A. and Ran,S.
  TITLE     Tumor microenvironment restricts IL-10 induced multipotent
            progenitors to myeloid-lymphatic phenotype
  JOURNAL   PLoS One 19 (4), e0298465 (2024)
   PUBMED   38640116
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1803)
  AUTHORS   York,A.G., Skadow,M.H., Oh,J., Qu,R., Zhou,Q.D., Hsieh,W.Y.,
            Mowel,W.K., Brewer,J.R., Kaffe,E., Williams,K.J., Kluger,Y.,
            Smale,S.T., Crawford,J.M., Bensinger,S.J. and Flavell,R.A.
  TITLE     IL-10 constrains sphingolipid metabolism to limit inflammation
  JOURNAL   Nature 627 (8004), 628-635 (2024)
   PUBMED   38383790
REFERENCE   3  (bases 1 to 1803)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1803)
  AUTHORS   Brockmann,L., Tran,A., Huang,Y., Edwards,M., Ronda,C., Wang,H.H.
            and Ivanov,I.I.
  TITLE     Intestinal microbiota-specific Th17 cells possess regulatory
            properties and suppress effector T cells via c-MAF and IL-10
  JOURNAL   Immunity 56 (12), 2719-2735 (2023)
   PUBMED   38039966
REFERENCE   5  (bases 1 to 1803)
  AUTHORS   So,L., Obata-Ninomiya,K., Hu,A., Muir,V.S., Takamori,A., Song,J.,
            Buckner,J.H., Savan,R. and Ziegler,S.F.
  TITLE     Regulatory T cells suppress CD4+ effector T cell activation by
            controlling protein synthesis
  JOURNAL   J Exp Med 220 (3) (2023)
   PUBMED   36598533
REFERENCE   6  (bases 1 to 1803)
  AUTHORS   Lewis,K., Li,C., Perrin,M.H., Blount,A., Kunitake,K., Donaldson,C.,
            Vaughan,J., Reyes,T.M., Gulyas,J., Fischer,W., Bilezikjian,L.,
            Rivier,J., Sawchenko,P.E. and Vale,W.W.
  TITLE     Identification of urocortin III, an additional member of the
            corticotropin-releasing factor (CRF) family with high affinity for
            the CRF2 receptor
  JOURNAL   Proc Natl Acad Sci U S A 98 (13), 7570-7575 (2001)
   PUBMED   11416224
REFERENCE   7  (bases 1 to 1803)
  AUTHORS   Spencer,S.D., Di Marco,F., Hooley,J., Pitts-Meek,S., Bauer,M.,
            Ryan,A.M., Sordat,B., Gibbs,V.C. and Aguet,M.
  TITLE     The orphan receptor CRF2-4 is an essential subunit of the
            interleukin 10 receptor
  JOURNAL   J Exp Med 187 (4), 571-578 (1998)
   PUBMED   9463407
REFERENCE   8  (bases 1 to 1803)
  AUTHORS   Gibbs,V.C. and Pennica,D.
  TITLE     CRF2-4: isolation of cDNA clones encoding the human and mouse
            proteins
  JOURNAL   Gene 186 (1), 97-101 (1997)
   PUBMED   9047351
REFERENCE   9  (bases 1 to 1803)
  AUTHORS   Cheng,S., Lutfalla,G., Uze,G., Chumakov,I.M. and Gardiner,K.
  TITLE     GART, SON, IFNAR, and CRF2-4 genes cluster on human chromosome 21
            and mouse chromosome 16
  JOURNAL   Mamm Genome 4 (6), 338-342 (1993)
   PUBMED   8318737
REFERENCE   10 (bases 1 to 1803)
  AUTHORS   Cheng,S.V., Nadeau,J.H., Tanzi,R.E., Watkins,P.C., Jagadesh,J.,
            Taylor,B.A., Haines,J.L., Sacchi,N. and Gusella,J.F.
  TITLE     Comparative mapping of DNA markers from the familial Alzheimer
            disease and Down syndrome regions of human chromosome 21 to mouse
            chromosomes 16 and 17
  JOURNAL   Proc Natl Acad Sci U S A 85 (16), 6032-6036 (1988)
   PUBMED   2901095
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC152503.5.
            
            On Apr 19, 2022 this sequence version replaced NM_008349.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK134042.1, AF440787.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                AC152503.5         182221-182315
            96-219              AC152503.5         183561-183684
            220-377             AC152503.5         187826-187983
            378-544             AC152503.5         190556-190722
            545-692             AC152503.5         195275-195422
            693-850             AC152503.5         197676-197833
            851-1803            AC152503.5         200821-201773
FEATURES             Location/Qualifiers
     source          1..1803
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 52.87 cM"
     gene            1..1803
                     /gene="Il10rb"
                     /gene_synonym="6620401D04Rik; CRF2-4; Crfb4; D16H21S58;
                     D21S58h; IL-10R2; Il10r2"
                     /note="interleukin 10 receptor, beta"
                     /db_xref="GeneID:16155"
                     /db_xref="MGI:MGI:109380"
     exon            1..95
                     /gene="Il10rb"
                     /gene_synonym="6620401D04Rik; CRF2-4; Crfb4; D16H21S58;
                     D21S58h; IL-10R2; Il10r2"
                     /inference="alignment:Splign:2.1.0"
     exon            96..219
                     /gene="Il10rb"
                     /gene_synonym="6620401D04Rik; CRF2-4; Crfb4; D16H21S58;
                     D21S58h; IL-10R2; Il10r2"
                     /inference="alignment:Splign:2.1.0"
     exon            220..377
                     /gene="Il10rb"
                     /gene_synonym="6620401D04Rik; CRF2-4; Crfb4; D16H21S58;
                     D21S58h; IL-10R2; Il10r2"
                     /inference="alignment:Splign:2.1.0"
     exon            378..544
                     /gene="Il10rb"
                     /gene_synonym="6620401D04Rik; CRF2-4; Crfb4; D16H21S58;
                     D21S58h; IL-10R2; Il10r2"
                     /inference="alignment:Splign:2.1.0"
     exon            545..692
                     /gene="Il10rb"
                     /gene_synonym="6620401D04Rik; CRF2-4; Crfb4; D16H21S58;
                     D21S58h; IL-10R2; Il10r2"
                     /inference="alignment:Splign:2.1.0"
     exon            693..850
                     /gene="Il10rb"
                     /gene_synonym="6620401D04Rik; CRF2-4; Crfb4; D16H21S58;
                     D21S58h; IL-10R2; Il10r2"
                     /inference="alignment:Splign:2.1.0"
     exon            851..1803
                     /gene="Il10rb"
                     /gene_synonym="6620401D04Rik; CRF2-4; Crfb4; D16H21S58;
                     D21S58h; IL-10R2; Il10r2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1793..1798
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il10rb"
                     /gene_synonym="6620401D04Rik; CRF2-4; Crfb4; D16H21S58;
                     D21S58h; IL-10R2; Il10r2"
                     /note="hexamer: AAGAAA"
     polyA_site      1803
                     /gene="Il10rb"
                     /gene_synonym="6620401D04Rik; CRF2-4; Crfb4; D16H21S58;
                     D21S58h; IL-10R2; Il10r2"
                     /note="major polyA site"
ORIGIN      
        1 ggaaagggcg cgggcggccg cggggctgcc gcacggggcc atgtcctggg cgccgagcgt
       61 ggcgggctgg ctgggtggct tccttctggt gccagctcta ggaatgattc caccccctga
      121 gaaggtcaga atgaattcag ttaatttcaa gaacattcta cagtgggagg tacctgcttt
      181 ccccaaaacg aacctgactt tcacagctca gtatgaaagt tacaggtctt tccaagatca
      241 ctgcaagcgc actgcctcga ctcagtgcga cttctctcat ctttctaaat acggagacta
      301 cactgtgaga gtcagggctg aattggcgga tgaacattcg gagtgggtca atgtcacctt
      361 ctgccccgtg gaagacacca tcattggacc tcctgagatg cagatagaat cccttgctga
      421 gtctttacac ctgcgtttct cagccccaca aattgagaat gagcctgaga cgtggacctt
      481 gaagaacatt tatgactcat gggcttacag agtgcaatac tggaaaaatg ggactaatga
      541 gaagtttcaa gttgtgtctc cgtacgactc tgaggtcctc cggaacctgg agccgtggac
      601 aacttactgc attcaagttc aagggtttct tctcgaccag aacagaacag gagagtggag
      661 tgaacccatc tgtgaacgga caggcaatga cgaaataacc ccttcctgga ttgtggccat
      721 catcctcata gtctccgtcc tggtggtctt cctcttcctc ctgggctgct ttgtcgtgct
      781 gtggctcatt tataagaaga ccaagcatac cttccgttct gggacgtctc ttccacagca
      841 cctgaaggag tttctgggcc acccccatca cagcacgttt ctgctgttct ccttccctcc
      901 ccccgaggag gccgaggtgt tcgacaaact aagcatcatc agcgaagagt ctgaaggcag
      961 caagcagagt cctgaagaca actgtgcctc agagcccccg tctgatccag ggcctcggga
     1021 gctggagtcc aaggatgaag ctccctcacc tccacacgat gaccccaaac tgctcacgtc
     1081 gacctcagaa gtatgaccag agagccacct gaaaaaactc caaatctaga acttcctgat
     1141 gctgcactgg tacacacaac caaagagcta ggttttaaac actctacttg ggaatttgct
     1201 gccatataaa gactaataat ttagggactg agggtgtagc tcagtgacta gagctcttac
     1261 ttggcacaca tgaagtccta gcttcgatcc ccaacaccat ataaaccagg gatgggggca
     1321 cctacctata agcccagcac tttggaggta gaggcaggag gatcacagtc atcttgaact
     1381 atacagggag ttcaaggcca agctggacta gagaccctgt ctaagagaga gagagagaaa
     1441 ctttaataat tattttttat ggccactgaa tgtaatttga gccctttgtg ctcactaaaa
     1501 caaggatcac atttaacttg tgacaaacaa aaatatttta aatggggggg gggggcatgg
     1561 aaacactatg aaattataag aatgcctata gaccacccgc atctcaaaag tggttggccc
     1621 catgcgggac agacatgaac attttggatt cccaaggagc aaagagattt ccttccttac
     1681 ctgtgtgttt tgtattaata ttagtgttct gtaaatattc tatatttgta tatttgtgtt
     1741 agcctacttc ctgctgttgt aacgaaattc ctggcgtaaa caatttaaaa ggaagaaagg
     1801 aaa
//
