LOCUS       NM_001405059            1596 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus interleukin 10 receptor, beta (Il10rb), transcript
            variant 3, mRNA.
ACCESSION   NM_001405059
VERSION     NM_001405059.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1596)
  AUTHORS   Volk-Draper,L., Athaiya,S., Espinosa Gonzalez,M., Bhattarai,N.,
            Wilber,A. and Ran,S.
  TITLE     Tumor microenvironment restricts IL-10 induced multipotent
            progenitors to myeloid-lymphatic phenotype
  JOURNAL   PLoS One 19 (4), e0298465 (2024)
   PUBMED   38640116
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1596)
  AUTHORS   York,A.G., Skadow,M.H., Oh,J., Qu,R., Zhou,Q.D., Hsieh,W.Y.,
            Mowel,W.K., Brewer,J.R., Kaffe,E., Williams,K.J., Kluger,Y.,
            Smale,S.T., Crawford,J.M., Bensinger,S.J. and Flavell,R.A.
  TITLE     IL-10 constrains sphingolipid metabolism to limit inflammation
  JOURNAL   Nature 627 (8004), 628-635 (2024)
   PUBMED   38383790
REFERENCE   3  (bases 1 to 1596)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1596)
  AUTHORS   Brockmann,L., Tran,A., Huang,Y., Edwards,M., Ronda,C., Wang,H.H.
            and Ivanov,I.I.
  TITLE     Intestinal microbiota-specific Th17 cells possess regulatory
            properties and suppress effector T cells via c-MAF and IL-10
  JOURNAL   Immunity 56 (12), 2719-2735 (2023)
   PUBMED   38039966
REFERENCE   5  (bases 1 to 1596)
  AUTHORS   So,L., Obata-Ninomiya,K., Hu,A., Muir,V.S., Takamori,A., Song,J.,
            Buckner,J.H., Savan,R. and Ziegler,S.F.
  TITLE     Regulatory T cells suppress CD4+ effector T cell activation by
            controlling protein synthesis
  JOURNAL   J Exp Med 220 (3) (2023)
   PUBMED   36598533
REFERENCE   6  (bases 1 to 1596)
  AUTHORS   Lewis,K., Li,C., Perrin,M.H., Blount,A., Kunitake,K., Donaldson,C.,
            Vaughan,J., Reyes,T.M., Gulyas,J., Fischer,W., Bilezikjian,L.,
            Rivier,J., Sawchenko,P.E. and Vale,W.W.
  TITLE     Identification of urocortin III, an additional member of the
            corticotropin-releasing factor (CRF) family with high affinity for
            the CRF2 receptor
  JOURNAL   Proc Natl Acad Sci U S A 98 (13), 7570-7575 (2001)
   PUBMED   11416224
REFERENCE   7  (bases 1 to 1596)
  AUTHORS   Spencer,S.D., Di Marco,F., Hooley,J., Pitts-Meek,S., Bauer,M.,
            Ryan,A.M., Sordat,B., Gibbs,V.C. and Aguet,M.
  TITLE     The orphan receptor CRF2-4 is an essential subunit of the
            interleukin 10 receptor
  JOURNAL   J Exp Med 187 (4), 571-578 (1998)
   PUBMED   9463407
REFERENCE   8  (bases 1 to 1596)
  AUTHORS   Gibbs,V.C. and Pennica,D.
  TITLE     CRF2-4: isolation of cDNA clones encoding the human and mouse
            proteins
  JOURNAL   Gene 186 (1), 97-101 (1997)
   PUBMED   9047351
REFERENCE   9  (bases 1 to 1596)
  AUTHORS   Cheng,S., Lutfalla,G., Uze,G., Chumakov,I.M. and Gardiner,K.
  TITLE     GART, SON, IFNAR, and CRF2-4 genes cluster on human chromosome 21
            and mouse chromosome 16
  JOURNAL   Mamm Genome 4 (6), 338-342 (1993)
   PUBMED   8318737
REFERENCE   10 (bases 1 to 1596)
  AUTHORS   Cheng,S.V., Nadeau,J.H., Tanzi,R.E., Watkins,P.C., Jagadesh,J.,
            Taylor,B.A., Haines,J.L., Sacchi,N. and Gusella,J.F.
  TITLE     Comparative mapping of DNA markers from the familial Alzheimer
            disease and Down syndrome regions of human chromosome 21 to mouse
            chromosomes 16 and 17
  JOURNAL   Proc Natl Acad Sci U S A 85 (16), 6032-6036 (1988)
   PUBMED   2901095
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC152503.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK040938.1, SRR7345562.1463881.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                AC152503.5         182221-182315
            96-219              AC152503.5         183561-183684
            220-377             AC152503.5         187826-187983
            378-544             AC152503.5         190556-190722
            545-1596            AC152503.5         195275-196326
FEATURES             Location/Qualifiers
     source          1..1596
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 52.87 cM"
     gene            1..1596
                     /gene="Il10rb"
                     /gene_synonym="6620401D04Rik; CRF2-4; Crfb4; D16H21S58;
                     D21S58h; IL-10R2; Il10r2"
                     /note="interleukin 10 receptor, beta"
                     /db_xref="GeneID:16155"
                     /db_xref="MGI:MGI:109380"
     exon            1..95
                     /gene="Il10rb"
                     /gene_synonym="6620401D04Rik; CRF2-4; Crfb4; D16H21S58;
                     D21S58h; IL-10R2; Il10r2"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..700
                     /gene="Il10rb"
                     /gene_synonym="6620401D04Rik; CRF2-4; Crfb4; D16H21S58;
                     D21S58h; IL-10R2; Il10r2"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; interleukin-10 receptor subunit beta; cytokine
                     receptor family II, member 4; interleukin 10 receptor 2;
                     IL-10RB; IL-10R subunit 2; IL-10R subunit beta; IL-10
                     receptor subunit beta; interleukin-10 receptor subunit 2;
                     cytokine receptor class-II member 4; cytokine receptor
                     family 2 member 4"
                     /codon_start=1
                     /product="interleukin-10 receptor subunit beta isoform 3
                     precursor"
                     /protein_id="NP_001391988.1"
                     /db_xref="GeneID:16155"
                     /db_xref="MGI:MGI:109380"
                     /translation="MSWAPSVAGWLGGFLLVPALGMIPPPEKVRMNSVNFKNILQWEV
                     PAFPKTNLTFTAQYESYRSFQDHCKRTASTQCDFSHLSKYGDYTVRVRAELADEHSEW
                     VNVTFCPVEDTIIGPPEMQIESLAESLHLRFSAPQIENEPETWTLKNIYDSWAYRVQY
                     WKNGTNEKFQVVSPYDSEVLRNLEPWTTYCIQVQGFLLDQNRTGEWSEPICERTGNDG
                     E"
     exon            96..219
                     /gene="Il10rb"
                     /gene_synonym="6620401D04Rik; CRF2-4; Crfb4; D16H21S58;
                     D21S58h; IL-10R2; Il10r2"
                     /inference="alignment:Splign:2.1.0"
     exon            220..377
                     /gene="Il10rb"
                     /gene_synonym="6620401D04Rik; CRF2-4; Crfb4; D16H21S58;
                     D21S58h; IL-10R2; Il10r2"
                     /inference="alignment:Splign:2.1.0"
     exon            378..544
                     /gene="Il10rb"
                     /gene_synonym="6620401D04Rik; CRF2-4; Crfb4; D16H21S58;
                     D21S58h; IL-10R2; Il10r2"
                     /inference="alignment:Splign:2.1.0"
     exon            545..1596
                     /gene="Il10rb"
                     /gene_synonym="6620401D04Rik; CRF2-4; Crfb4; D16H21S58;
                     D21S58h; IL-10R2; Il10r2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1541..1546
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il10rb"
                     /gene_synonym="6620401D04Rik; CRF2-4; Crfb4; D16H21S58;
                     D21S58h; IL-10R2; Il10r2"
                     /note="hexamer: AATAAA"
     regulatory      1562..1567
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il10rb"
                     /gene_synonym="6620401D04Rik; CRF2-4; Crfb4; D16H21S58;
                     D21S58h; IL-10R2; Il10r2"
                     /note="hexamer: AATAAA"
     polyA_site      1573
                     /gene="Il10rb"
                     /gene_synonym="6620401D04Rik; CRF2-4; Crfb4; D16H21S58;
                     D21S58h; IL-10R2; Il10r2"
     polyA_site      1596
                     /gene="Il10rb"
                     /gene_synonym="6620401D04Rik; CRF2-4; Crfb4; D16H21S58;
                     D21S58h; IL-10R2; Il10r2"
                     /note="major polyA site"
ORIGIN      
        1 ggaaagggcg cgggcggccg cggggctgcc gcacggggcc atgtcctggg cgccgagcgt
       61 ggcgggctgg ctgggtggct tccttctggt gccagctcta ggaatgattc caccccctga
      121 gaaggtcaga atgaattcag ttaatttcaa gaacattcta cagtgggagg tacctgcttt
      181 ccccaaaacg aacctgactt tcacagctca gtatgaaagt tacaggtctt tccaagatca
      241 ctgcaagcgc actgcctcga ctcagtgcga cttctctcat ctttctaaat acggagacta
      301 cactgtgaga gtcagggctg aattggcgga tgaacattcg gagtgggtca atgtcacctt
      361 ctgccccgtg gaagacacca tcattggacc tcctgagatg cagatagaat cccttgctga
      421 gtctttacac ctgcgtttct cagccccaca aattgagaat gagcctgaga cgtggacctt
      481 gaagaacatt tatgactcat gggcttacag agtgcaatac tggaaaaatg ggactaatga
      541 gaagtttcaa gttgtgtctc cgtacgactc tgaggtcctc cggaacctgg agccgtggac
      601 aacttactgc attcaagttc aagggtttct tctcgaccag aacagaacag gagagtggag
      661 tgaacccatc tgtgaacgga caggcaatga cggtgagtag agacggggac agcctgtcac
      721 tgcctgctca gagctccgtg ggccctagac accatggcag tcagctccaa ctgcaccaca
      781 ggtcagagat cagccttctc cttgtctgca tggtctccag accctgcttc atgctccaaa
      841 caaggtgccc tatgctgagg acgctggctc tctctcgcca gtccagggcg ctgcaggatg
      901 cctcgatgaa tctaccttta ctatgctcta ttgtccttcc agctctctga agtaggttaa
      961 ttggttctca catggatacc cagcagagac tgagcctggc cacatcttgt ttttccttcc
     1021 ctgcatctcc agttttgacg acacataatg actgggaagg gggagcttgg aaaacatcag
     1081 tgacctcaga tagtaccatt acgtactgag accccttgta aaacgtggtc caggatacag
     1141 tggtctacca gggtgttctc cacactgtgt gttaacagaa tagtagttta gggtatggtt
     1201 cagtgatcta tcatgtgcat ccctggattc taccccacag aacaacattc tgtctcctga
     1261 caggatccaa acatttttat tttaaaaaaa gaaatagaaa agctgtttga caaactccca
     1321 tttttcaggg atttttaaaa tctcatttag acatcccagg gattcagaaa aggaagaccc
     1381 caaggttctt ccgactgccc agagtcacct ggctagtgga ggacaaagat ggaactgagg
     1441 acaagctggt atatctccag atcacatctt taactctctg cctacggact aattccaaag
     1501 atagcctgac gcgtcctgat ccttaaaaca aaaataaaaa aataaaacgt ggtctgccaa
     1561 taataaagtc aaacagatct acagccaggg gaataa
//
