LOCUS       NM_008348               3509 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus interleukin 10 receptor, alpha (Il10ra), transcript
            variant 1, mRNA.
ACCESSION   NM_008348
VERSION     NM_008348.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3509)
  AUTHORS   Hajam,I.A., Tsai,C.M., Gonzalez,C., Caldera,J.R., Lazaro Diez,M.,
            Du,X., Aralar,A., Lin,B., Duong,W. and Liu,G.Y.
  TITLE     Pathobiont-induced suppressive immune imprints thwart T cell
            vaccine responses
  JOURNAL   Nat Commun 15 (1), 10335 (2024)
   PUBMED   39681568
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3509)
  AUTHORS   He,K., Xiao,H., MacDonald,W.A., Mehta,I., Kishore,A., Vincent,A.,
            Xu,Z., Ray,A., Chen,W., Weaver,C.T., Lambrecht,B.N., Das,J. and
            Poholek,A.C.
  TITLE     Spatial microniches of IL-2 combine with IL-10 to drive lung
            migratory TH2 cells in response to inhaled allergen
  JOURNAL   Nat Immunol 25 (11), 2124-2139 (2024)
   PUBMED   39394532
REFERENCE   3  (bases 1 to 3509)
  AUTHORS   Bravo,M., Dileepan,T., Dolan,M., Hildebrand,J., Wolford,J.,
            Hanson,I.D., Hamilton,S.E., Frosch,A.E. and Burrack,K.S.
  TITLE     IL-15 Complex-Induced IL-10 Enhances Plasmodium-specific CD4+ T
            Follicular Helper Differentiation and Antibody Production
  JOURNAL   J Immunol 212 (6), 992-1001 (2024)
   PUBMED   38305633
REFERENCE   4  (bases 1 to 3509)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 3509)
  AUTHORS   Horn,K.J., Fulte,S., Yang,M., Lorenz,B.P. and Clark,S.E.
  TITLE     Neutrophil responsiveness to IL-10 impairs clearance of
            Streptococcus pneumoniae from the lungs
  JOURNAL   J Leukoc Biol 115 (1), 4-15 (2024)
   PUBMED   37381945
REFERENCE   6  (bases 1 to 3509)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   7  (bases 1 to 3509)
  AUTHORS   Wydner,K.S., Kim,Y., Csiszar,K., Boyd,C.D. and Passmore,H.C.
  TITLE     An intron capture strategy used to identify and map a lysyl
            oxidase-like gene on chromosome 9 in the mouse
  JOURNAL   Genomics 40 (2), 342-345 (1997)
   PUBMED   9119402
REFERENCE   8  (bases 1 to 3509)
  AUTHORS   Jones,J.M., Meisler,M.H. and Isom,L.L.
  TITLE     Scn2b, a voltage-gated sodium channel beta2 gene on mouse
            chromosome 9
  JOURNAL   Genomics 34 (2), 258-259 (1996)
   PUBMED   8661062
REFERENCE   9  (bases 1 to 3509)
  AUTHORS   Liu,Y., Wei,S.H., Ho,A.S., de Waal Malefyt,R. and Moore,K.W.
  TITLE     Expression cloning and characterization of a human IL-10 receptor
  JOURNAL   J Immunol 152 (4), 1821-1829 (1994)
   PUBMED   8120391
REFERENCE   10 (bases 1 to 3509)
  AUTHORS   Ho,A.S., Liu,Y., Khan,T.A., Hsu,D.H., Bazan,J.F. and Moore,K.W.
  TITLE     A receptor for interleukin 10 is related to interferon receptors
  JOURNAL   Proc Natl Acad Sci U S A 90 (23), 11267-11271 (1993)
   PUBMED   8248239
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK149899.1, AK159566.1 and BY691362.1.
            
            On May 7, 2016 this sequence version replaced NM_008348.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK153120.1, AK150524.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AK149899.1         2-13
            13-3496             AK159566.1         7-3490
            3497-3509           BY691362.1         406-418
FEATURES             Location/Qualifiers
     source          1..3509
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 24.84 cM"
     gene            1..3509
                     /gene="Il10ra"
                     /gene_synonym="CDw210; CDw210a; IL-10R1; IL-10RA; Il10r;
                     mIL-10R"
                     /note="interleukin 10 receptor, alpha"
                     /db_xref="GeneID:16154"
                     /db_xref="MGI:MGI:96538"
     exon            1..144
                     /gene="Il10ra"
                     /gene_synonym="CDw210; CDw210a; IL-10R1; IL-10RA; Il10r;
                     mIL-10R"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1805
                     /gene="Il10ra"
                     /gene_synonym="CDw210; CDw210a; IL-10R1; IL-10RA; Il10r;
                     mIL-10R"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; interleukin-10 receptor subunit alpha; IL-10R
                     subunit 1; IL-10R subunit alpha; IL-10 receptor subunit
                     alpha; interleukin-10 receptor subunit 1"
                     /codon_start=1
                     /product="interleukin-10 receptor subunit alpha isoform 1
                     precursor"
                     /protein_id="NP_032374.1"
                     /db_xref="CCDS:CCDS23131.1"
                     /db_xref="GeneID:16154"
                     /db_xref="MGI:MGI:96538"
                     /translation="MLSRLLPFLVTISSLSLEFIAYGTELPSPSYVWFEARFFQHILH
                     WKPIPNQSESTYYEVALKQYGNSTWNDIHICRKAQALSCDLTTFTLDLYHRSYGYRAR
                     VRAVDNSQYSNWTTTETRFTVDEVILTVDSVTLKAMDGIIYGTIHPPRPTITPAGDEY
                     EQVFKDLRVYKISIRKFSELKNATKRVKQETFTLTVPIGVRKFCVKVLPRLESRINKA
                     EWSEEQCLLITTEQYFTVTNLSILVISMLLFCGILVCLVLQWYIRHPGKLPTVLVFKK
                     PHDFFPANPLCPETPDAIHIVDLEVFPKVSLELRDSVLHGSTDSGFGSGKPSLQTEES
                     QFLLPGSHPQIQGTLGKEESPGLQATCGDNTDSGICLQEPGLHSSMGPAWKQQLGYTH
                     QDQDDSDVNLVQNSPGQPKYTQDASALGHVCLLEPKAPEEKDQVMVTFQGYQKQTRWK
                     AEAAGPAECLDEEIPLTDAFDPELGVHLQDDLAWPPPALAAGYLKQESQGMASAPPGT
                     PSRQWNQLTEEWSLLGVVSCEDLSIESWRFAHKLDPLDCGAAPGGLLDSLGSNLVTLP
                     LISSLQVEE"
     exon            145..265
                     /gene="Il10ra"
                     /gene_synonym="CDw210; CDw210a; IL-10R1; IL-10RA; Il10r;
                     mIL-10R"
                     /inference="alignment:Splign:2.1.0"
     exon            266..453
                     /gene="Il10ra"
                     /gene_synonym="CDw210; CDw210a; IL-10R1; IL-10RA; Il10r;
                     mIL-10R"
                     /inference="alignment:Splign:2.1.0"
     exon            454..620
                     /gene="Il10ra"
                     /gene_synonym="CDw210; CDw210a; IL-10R1; IL-10RA; Il10r;
                     mIL-10R"
                     /inference="alignment:Splign:2.1.0"
     exon            621..774
                     /gene="Il10ra"
                     /gene_synonym="CDw210; CDw210a; IL-10R1; IL-10RA; Il10r;
                     mIL-10R"
                     /inference="alignment:Splign:2.1.0"
     exon            775..893
                     /gene="Il10ra"
                     /gene_synonym="CDw210; CDw210a; IL-10R1; IL-10RA; Il10r;
                     mIL-10R"
                     /inference="alignment:Splign:2.1.0"
     exon            894..3498
                     /gene="Il10ra"
                     /gene_synonym="CDw210; CDw210a; IL-10R1; IL-10RA; Il10r;
                     mIL-10R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3473..3478
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Il10ra"
                     /gene_synonym="CDw210; CDw210a; IL-10R1; IL-10RA; Il10r;
                     mIL-10R"
                     /note="hexamer: AATAAA"
     polyA_site      3498
                     /gene="Il10ra"
                     /gene_synonym="CDw210; CDw210a; IL-10R1; IL-10RA; Il10r;
                     mIL-10R"
                     /note="major polyA site"
ORIGIN      
        1 agtcttcagt tctcaggacg ccgccggccg gaggcgtaaa ggccggctcc agtggacgat
       61 gccgctgtgc gcccaggatg ttgtcgcgtt tgctcccatt cctcgtcacg atctccagcc
      121 tgagcctaga attcattgca tacgggacag aactgccaag cccttcctat gtgtggtttg
      181 aagccagatt tttccagcac atcctccact ggaaacctat cccaaaccag tctgagagca
      241 cctactatga agtggccctc aaacagtacg gaaactcaac ctggaatgac atccatatct
      301 gtagaaaggc tcaggcattg tcctgtgatc tcacaacgtt caccctggat ctgtatcacc
      361 gaagctatgg ctaccgggcc agagtccggg cagtggacaa cagtcagtac tccaactgga
      421 ccaccactga gactcgcttc acagtggatg aagtgattct gacagtggat agcgtgactc
      481 tgaaagcaat ggacggcatc atctatggga caatccatcc ccccaggccc acgataaccc
      541 ctgcagggga tgagtacgaa caagtcttca aggatctccg agtttacaag atttccatcc
      601 ggaagttctc agaactaaag aatgcaacca agagagtgaa acaggaaacc ttcaccctca
      661 cggtccccat aggggtgaga aagttttgtg tcaaggtgct gccccgcttg gaatcccgaa
      721 ttaacaaggc agagtggtcg gaggagcagt gtttacttat cacgacggag cagtatttca
      781 ctgtgaccaa cctgagcatc ttagtcatat ctatgctgct attctgtgga atcctggtct
      841 gtctggttct ccagtggtac atccggcacc cggggaagtt gcctacagtc ctggtcttca
      901 agaagcctca cgacttcttc ccagccaacc ctctctgccc agaaactccc gatgccattc
      961 acatcgtgga cctggaggtt ttcccaaagg tgtcactaga gctgagagac tcagtcctgc
     1021 atggcagcac cgacagtggc tttggcagtg gtaaaccatc acttcagact gaagagtccc
     1081 aattcctcct ccctggctcc cacccccaga tacaggggac tctgggaaaa gaagagtctc
     1141 cagggctaca ggccacctgt ggggacaaca cggacagtgg gatctgcctg caggagcccg
     1201 gcttacactc cagcatgggg cccgcctgga agcagcagct tggatatacc catcaggacc
     1261 aggatgacag tgacgttaac ctagtccaga actctccagg gcagcctaag tacacacagg
     1321 atgcatctgc cttgggccat gtctgtctcc tagaacctaa agcccctgag gagaaagacc
     1381 aagtcatggt gacattccag ggctaccaga aacagaccag atggaaggca gaggcagcag
     1441 gcccagcaga atgcttggac gaagagattc ccttgacaga tgcctttgat cctgaacttg
     1501 gggtacacct gcaggatgat ttggcttggc ctccaccagc tctggccgca ggttatttga
     1561 aacaggagtc tcaagggatg gcttctgctc caccagggac accaagtaga cagtggaatc
     1621 aactgaccga agagtggtca ctcctgggtg tggttagctg tgaagatcta agcatagaaa
     1681 gttggaggtt tgcccataaa cttgaccctc tggactgtgg ggcagcccct ggtggcctcc
     1741 tggatagcct tggctctaac ctggtcaccc tgccgttgat ctccagcctg caggtagaag
     1801 aatgacagcg gctaagagtt atttgtattc cagccatgcc tgctcccctc cctgtacctg
     1861 ggaggctcag gagtcaaaga aatatgtggg tccttttctg cagacctact gtgaccagct
     1921 agccaggctc cacggggcaa ggaaaggcca tcttgataca cgagtgtcag gtacatgaga
     1981 ggttgtggct agtctgctga gtgagggtct gtagatacca gcagagctga gcaggattga
     2041 cagagacctc ctcatgcctc agggctggct cctacactgg aaggacctgt gtttgggtgt
     2101 aacctcaggg ctttctggat gtggtaagac tgtaggtctg aagtcagctg agcctggatg
     2161 tctgcggagg tgttggagtg gctagcctgc tacaggataa agggaaggct caagagatag
     2221 aagggcagag catgagccag gtttaatttt gtcctgtaga gatggtcccc agccaggatg
     2281 ggttacttgt ggctgggaga tcttggggta tacaccaccc tgaatgatca gccagtcaat
     2341 tcagagctgt gtggcaaaag ggactgagac ccagaatttc tgttcctctt gtgaggtgtc
     2401 tctgctaccc atctgcagac agacatcttc atctttttac tatggctgtg tcccctgaat
     2461 taccagcagt ggccaagcca ttactccctg ctgctcactg ttgtgacgtc agaccagacc
     2521 agacgctgtc tgtctgtgtt agtacactac cctttaggtg gcctttgggc ttgagcactg
     2581 gcccaggctt aggacttatg tctgcttttg ctgctaatct ctaactgcag acccagagaa
     2641 cagggtgctg ggctgacacc tccgtgttca gctgtgtgac ctccgaccag cagcttcctc
     2701 aggggactaa aataatgact aggtcattca gaagtccctc atgctgaatg ttaaccaagg
     2761 tgcccctggg gtgatagttt aggtcctgcc aacctctggg ttggaaggaa gtggactacg
     2821 gaagccatct gtccccctgg ggagcttcca cctcatgcca gtgtttcaga gatcttgtgg
     2881 gagcctaggg ccttgtgcca agggagctgc tagtccctgg ggtctagggc tggtccctgc
     2941 ctccctatac tgcgtttgag acctgtcttc aaatggaggc agtttgcagc ccctaagcaa
     3001 ggatgctgag agaagcagca aggctgctga tccctgagcc cagagtttct ctgaagcttt
     3061 ccaaatacag actgtgtgac ggggtgaggc cagccatgaa ctttggcatc ctgccgagaa
     3121 ggtcatgacc ctaatctggt acgagagctc cttctggaac tgggcaagct ctttgagacc
     3181 cccctgggaa cctttattta tttatttgct cacttattta ttgaggaagc agcgtggcac
     3241 aggcgcaagg ctctgggtct ctcaggaggt ctagatttgc ctgccctgtt tctagctgtg
     3301 tgaccttggg caagtcacgt ttcctcgtgg agcctcagtt ttcctgtctg tatgcaaagc
     3361 ttggaaattg aaatgtacct gacgtgctcc atccctagga gtgctgagtc ccactgagaa
     3421 agcgggcaca gacgcctcaa atggaaccac aagtggtgtg tgttttcatc ctaataaaaa
     3481 gtcaggtgtt ttgtggaaaa aaaaaaaaa
//
