LOCUS       NM_010548               1306 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus interleukin 10 (Il10), mRNA.
ACCESSION   NM_010548
VERSION     NM_010548.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1306)
  AUTHORS   Hajam,I.A., Tsai,C.M., Gonzalez,C., Caldera,J.R., Lazaro Diez,M.,
            Du,X., Aralar,A., Lin,B., Duong,W. and Liu,G.Y.
  TITLE     Pathobiont-induced suppressive immune imprints thwart T cell
            vaccine responses
  JOURNAL   Nat Commun 15 (1), 10335 (2024)
   PUBMED   39681568
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1306)
  AUTHORS   Rabani,S., Gunes,E.G., Gunes,M., Pellegrino,B., Lampert,B.,
            David,K., Pillai,R., Li,A., Becker-Herman,S., Rosen,S.T. and
            Shachar,I.
  TITLE     CD84 as a therapeutic target for breaking immune tolerance in
            triple-negative breast cancer
  JOURNAL   Cell Rep 43 (11), 114920 (2024)
   PUBMED   39466774
REFERENCE   3  (bases 1 to 1306)
  AUTHORS   Mao,Y., Meng,Y., Zou,K., Qin,N., Wang,Y., Yan,J., Chen,P.,
            Cheng,Y., Shi,W., Zhou,C., Chen,H., Sheng,J., Liu,X., Pan,J. and
            Huang,H.
  TITLE     Advanced paternal age exacerbates neuroinflammation in offspring
            via m6A modification-mediated intergenerational inheritance
  JOURNAL   J Neuroinflammation 21 (1), 249 (2024)
   PUBMED   39367406
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1306)
  AUTHORS   Saraiva,M., Christensen,J.R., Tsytsykova,A.V., Goldfeld,A.E.,
            Ley,S.C., Kioussis,D. and O'Garra,A.
  TITLE     Identification of a macrophage-specific chromatin signature in the
            IL-10 locus
  JOURNAL   J Immunol 175 (2), 1041-1046 (2005)
   PUBMED   16002704
  REMARK    GeneRIF: Production of IL-10 by primary mouse bone marrow-derived
            macrophages stimulated through pattern recognition receptors is
            associated with chromatin remodeling of the IL-10 locus.
REFERENCE   5  (bases 1 to 1306)
  AUTHORS   Ghildyal,N., McNeil,H.P., Stechschulte,S., Austen,K.F.,
            Silberstein,D., Gurish,M.F., Somerville,L.L. and Stevens,R.L.
  TITLE     IL-10 induces transcription of the gene for mouse mast cell
            protease-1, a serine protease preferentially expressed in mucosal
            mast cells of Trichinella spiralis-infected mice
  JOURNAL   J Immunol 149 (6), 2123-2129 (1992)
   PUBMED   1517575
REFERENCE   6  (bases 1 to 1306)
  AUTHORS   Kim,J.M., Brannan,C.I., Copeland,N.G., Jenkins,N.A., Khan,T.A. and
            Moore,K.W.
  TITLE     Structure of the mouse IL-10 gene and chromosomal localization of
            the mouse and human genes
  JOURNAL   J Immunol 148 (11), 3618-3623 (1992)
   PUBMED   1350294
REFERENCE   7  (bases 1 to 1306)
  AUTHORS   Quesniaux,V.F.
  TITLE     Interleukins 9, 10, 11 and 12 and kit ligand: a brief overview
  JOURNAL   Res Immunol 143 (4), 385-400 (1992)
   PUBMED   1381512
  REMARK    Review article
REFERENCE   8  (bases 1 to 1306)
  AUTHORS   Vieira,P., de Waal-Malefyt,R., Dang,M.N., Johnson,K.E.,
            Kastelein,R., Fiorentino,D.F., deVries,J.E., Roncarolo,M.G.,
            Mosmann,T.R. and Moore,K.W.
  TITLE     Isolation and expression of human cytokine synthesis inhibitory
            factor cDNA clones: homology to Epstein-Barr virus open reading
            frame BCRFI
  JOURNAL   Proc Natl Acad Sci U S A 88 (4), 1172-1176 (1991)
   PUBMED   1847510
REFERENCE   9  (bases 1 to 1306)
  AUTHORS   Moore,K.W., Vieira,P., Fiorentino,D.F., Trounstine,M.L., Khan,T.A.
            and Mosmann,T.R.
  TITLE     Homology of cytokine synthesis inhibitory factor (IL-10) to the
            Epstein-Barr virus gene BCRFI
  JOURNAL   Science 248 (4960), 1230-1234 (1990)
   PUBMED   2161559
  REMARK    Erratum:[Science 1990 Oct 26;250(4980):494]
REFERENCE   10 (bases 1 to 1306)
  AUTHORS   Fiorentino,D.F., Bond,M.W. and Mosmann,T.R.
  TITLE     Two types of mouse T helper cell. IV. Th2 clones secrete a factor
            that inhibits cytokine production by Th1 clones
  JOURNAL   J Exp Med 170 (6), 2081-2095 (1989)
   PUBMED   2531194
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK152344.1 and AL513351.26.
            
            On Mar 26, 2010 this sequence version replaced NM_010548.1.
            
            Summary: This gene encodes an anti-inflammatory cytokine that is a
            member of the class-2 cytokine family. The encoded protein is
            secreted by cells of both the innate and adaptive immune systems
            and is crucial for limiting the immune response to a broad range of
            pathogens. It also has been shown to suppress autoimmune responses.
            This protein mediates it's immunosuppressive signal through a
            specific interleukin 10 receptor complex. Aberrant functioning of
            this gene is associated with numerous immune disorders including
            graft-versus-host disease, and increased susceptibility to HIV-1
            infection and rheumatoid arthritis. [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK152344.1, M37897.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-403               AK152344.1         2-404
            404-404             AL513351.26        121057-121057       c
            405-1306            AK152344.1         406-1307
FEATURES             Location/Qualifiers
     source          1..1306
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 56.89 cM"
     gene            1..1306
                     /gene="Il10"
                     /gene_synonym="CSIF; If2a; Il-10"
                     /note="interleukin 10"
                     /db_xref="GeneID:16153"
                     /db_xref="MGI:MGI:96537"
     exon            1..232
                     /gene="Il10"
                     /gene_synonym="CSIF; If2a; Il-10"
                     /inference="alignment:Splign:2.1.0"
     exon            233..292
                     /gene="Il10"
                     /gene_synonym="CSIF; If2a; Il-10"
                     /inference="alignment:Splign:2.1.0"
     exon            293..445
                     /gene="Il10"
                     /gene_synonym="CSIF; If2a; Il-10"
                     /inference="alignment:Splign:2.1.0"
     exon            446..511
                     /gene="Il10"
                     /gene_synonym="CSIF; If2a; Il-10"
                     /inference="alignment:Splign:2.1.0"
     exon            512..1306
                     /gene="Il10"
                     /gene_synonym="CSIF; If2a; Il-10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acatttagag acttgctctt gcactaccaa agccacaagg cagccttgca gaaaagagag
       61 ctccatcatg cctggctcag cactgctatg ctgcctgctc ttactgactg gcatgaggat
      121 cagcaggggc cagtacagcc gggaagacaa taactgcacc cacttcccag tcggccagag
      181 ccacatgctc ctagagctgc ggactgcctt cagccaggtg aagactttct ttcaaacaaa
      241 ggaccagctg gacaacatac tgctaaccga ctccttaatg caggacttta agggttactt
      301 gggttgccaa gccttatcgg aaatgatcca gttttacctg gtagaagtga tgccccaggc
      361 agagaagcat ggcccagaaa tcaaggagca tttgaattcc ctgggtgaga agctgaagac
      421 cctcaggatg cggctgaggc gctgtcatcg atttctcccc tgtgaaaata agagcaaggc
      481 agtggagcag gtgaagagtg attttaataa gctccaagac caaggtgtct acaaggccat
      541 gaatgaattt gacatcttca tcaactgcat agaagcatac atgatgatca aaatgaaaag
      601 ctaaaacacc tgcagtgtgt attgagtctg ctggactcca ggacctagac agagctctct
      661 aaatctgatc cagggatctt agctaacgga aacaactcct tggaaaacct cgtttgtacc
      721 tctctccgaa atatttatta cctctgatac ctcagttccc attctattta ttcactgagc
      781 ttctctgtga actatttaga aagaagccca atattataat tttacagtat ttattatttt
      841 taacctgtgt ttaagctgtt tccattgggg acactttata gtatttaaag ggagattata
      901 ttatatgatg ggaggggttc ttccttggga agcaattgaa gcttctattc taaggctggc
      961 cacacttgag agctgcaggg ccctttgcta tggtgtcctt tcaattgctc tcatccctga
     1021 gttcagagct cctaagagag ttgtgaagaa actcatgggt cttgggaaga gaaaccaggg
     1081 agatcctttg atgatcattc ctgcagcagc tcagagggtt cccctactgt catcccccag
     1141 ccgcttcatc cctgaaaact gtggccagtt tgttatttat aaccacctaa aattagttct
     1201 aatagaactc atttttaact agaagtaatg caattcctct gggaatggtg tattgtttgt
     1261 ctgcctttgt agcagactct aattttgaat aaatggatct tattcg
//
