LOCUS       NM_001418763            4571 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus IKAROS family zinc finger 5 (Ikzf5), transcript
            variant 4, mRNA.
ACCESSION   NM_001418763 XM_006508122
VERSION     NM_001418763.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4571)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4571)
  AUTHORS   Nakata,H., Hashimoto,T. and Yoshiki,A.
  TITLE     Quick validation of genetic quality for conditional alleles in mice
  JOURNAL   Genes Cells 26 (4), 240-245 (2021)
   PUBMED   33540482
REFERENCE   3  (bases 1 to 4571)
  AUTHORS   Kasowitz,S.D., Ma,J., Anderson,S.J., Leu,N.A., Xu,Y., Gregory,B.D.,
            Schultz,R.M. and Wang,P.J.
  TITLE     Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and
            splicing during mouse oocyte development
  JOURNAL   PLoS Genet 14 (5), e1007412 (2018)
   PUBMED   29799838
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4571)
  AUTHORS   Martin-Ibanez,R., Pardo,M., Giralt,A., Miguez,A., Guardia,I.,
            Marion-Poll,L., Herranz,C., Esgleas,M., Garcia-Diaz Barriga,G.,
            Edel,M.J., Vicario-Abejon,C., Alberch,J., Girault,J.A., Chan,S.,
            Kastner,P. and Canals,J.M.
  TITLE     Helios expression coordinates the development of a subset of
            striatopallidal medium spiny neurons
  JOURNAL   Development 144 (8), 1566-1577 (2017)
   PUBMED   28289129
REFERENCE   5  (bases 1 to 4571)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 4571)
  AUTHORS   Alsio,J.M., Tarchini,B., Cayouette,M. and Livesey,F.J.
  TITLE     Ikaros promotes early-born neuronal fates in the cerebral cortex
  JOURNAL   Proc Natl Acad Sci U S A 110 (8), E716-E725 (2013)
   PUBMED   23382203
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):E3088. doi:
            10.1073/pnas.1508413112.. PMID: 25976099]
REFERENCE   7  (bases 1 to 4571)
  AUTHORS   Yeung,F., Chung,E., Guess,M.G., Bell,M.L. and Leinwand,L.A.
  TITLE     Myh7b/miR-499 gene expression is transcriptionally regulated by
            MRFs and Eos
  JOURNAL   Nucleic Acids Res 40 (15), 7303-7318 (2012)
   PUBMED   22638570
REFERENCE   8  (bases 1 to 4571)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   9  (bases 1 to 4571)
  AUTHORS   Elliott,J., Jolicoeur,C., Ramamurthy,V. and Cayouette,M.
  TITLE     Ikaros confers early temporal competence to mouse retinal
            progenitor cells
  JOURNAL   Neuron 60 (1), 26-39 (2008)
   PUBMED   18940586
REFERENCE   10 (bases 1 to 4571)
  AUTHORS   Mattar,P., Britz,O., Johannes,C., Nieto,M., Ma,L., Rebeyka,A.,
            Klenin,N., Polleux,F., Guillemot,F. and Schuurmans,C.
  TITLE     A screen for downstream effectors of Neurogenin2 in the embryonic
            neocortex
  JOURNAL   Dev Biol 273 (2), 373-389 (2004)
   PUBMED   15328020
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156606.12.
            
            On Mar 23, 2023 this sequence version replaced XM_006508122.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422597.520089.1,
                                           SRR7652917.691285.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               AC156606.12        137955-138082       c
            129-276             AC156606.12        136499-136646       c
            277-459             AC156606.12        124237-124419       c
            460-642             AC156606.12        121323-121505       c
            643-4571            AC156606.12        116220-120148       c
FEATURES             Location/Qualifiers
     source          1..4571
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 73.98 cM"
     gene            1..4571
                     /gene="Ikzf5"
                     /gene_synonym="2610034F18Rik; PEGASUS; Zfpn1a5"
                     /note="IKAROS family zinc finger 5"
                     /db_xref="GeneID:67143"
                     /db_xref="MGI:MGI:1914393"
     exon            1..128
                     /gene="Ikzf5"
                     /gene_synonym="2610034F18Rik; PEGASUS; Zfpn1a5"
                     /inference="alignment:Splign:2.1.0"
     exon            129..276
                     /gene="Ikzf5"
                     /gene_synonym="2610034F18Rik; PEGASUS; Zfpn1a5"
                     /inference="alignment:Splign:2.1.0"
     exon            277..459
                     /gene="Ikzf5"
                     /gene_synonym="2610034F18Rik; PEGASUS; Zfpn1a5"
                     /inference="alignment:Splign:2.1.0"
     CDS             327..1586
                     /gene="Ikzf5"
                     /gene_synonym="2610034F18Rik; PEGASUS; Zfpn1a5"
                     /note="isoform 1 is encoded by transcript variant 4; zinc
                     finger protein, subfamily 1A, 5; zinc finger protein
                     Pegasus; ikaros family zinc finger protein 5"
                     /codon_start=1
                     /product="zinc finger protein Pegasus isoform 1"
                     /protein_id="NP_001405692.1"
                     /db_xref="GeneID:67143"
                     /db_xref="MGI:MGI:1914393"
                     /translation="MGEKKPEPLDFVKDFQEYLTQQTHHVNMISGSVSGDKEAETLQG
                     AGTDGDQNGLDHPSVEVSLDENSGMLVDGFERTFDGKLKCRYCNYASKGTARLIEHIR
                     IHTGEKPHRCHLCPFASAYERHLEAHMRSHTGEKPYKCELCSFRCSDRSNLSHHRRRK
                     HKMVPIKGTRSSLSSKKMWGVLQKKTSNLGYSRRALINLSPPSMVVQKPDYLNDFTHE
                     IPNIQTDSYEAMAKTTPTGGLPRDPQELMVDNPLNQLSTLAGQLSSLPPENQNPASPD
                     VDACPDEKPFMIQQPSAQAVVSAVSASIPQSSSPTSPEPRPSHSQRNYSPVAGPSSEP
                     SAHTSTPSIGNSQPSTPAPTLPVQDPQLLHHCQHCDVYFADNVLYTVHMGCHGYDSPF
                     QCNVCGCKCKDKYDFACHFARGQHNQH"
     exon            460..642
                     /gene="Ikzf5"
                     /gene_synonym="2610034F18Rik; PEGASUS; Zfpn1a5"
                     /inference="alignment:Splign:2.1.0"
     exon            643..4571
                     /gene="Ikzf5"
                     /gene_synonym="2610034F18Rik; PEGASUS; Zfpn1a5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2838..2843
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ikzf5"
                     /gene_synonym="2610034F18Rik; PEGASUS; Zfpn1a5"
                     /note="hexamer: AATAAA"
     polyA_site      2857
                     /gene="Ikzf5"
                     /gene_synonym="2610034F18Rik; PEGASUS; Zfpn1a5"
     regulatory      4550..4555
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ikzf5"
                     /gene_synonym="2610034F18Rik; PEGASUS; Zfpn1a5"
                     /note="hexamer: AATAAA"
     polyA_site      4571
                     /gene="Ikzf5"
                     /gene_synonym="2610034F18Rik; PEGASUS; Zfpn1a5"
                     /note="major polyA site"
ORIGIN      
        1 gggaagggag cggagacaca acaaatatgg cggctacagc tgcgacgctg acgaacgctg
       61 aggcggtggc ggtggcggcg acggcagtga aaagggctgt ggggattcct cggtgcggtt
      121 gtcaggagac ttcttgtggc ttttgaattt tagttgaaat tccctccatg gccttttgga
      181 cgcctttgtt gtatctccag agtaaatttc aattattcaa catttcagca gtgttgccgt
      241 ggaaagtaaa aagtggagct aaattggggt gaacagatat aacagacttt caacttaaag
      301 aaagaaagaa aaaaaaaagc accaagatgg gtgaaaagaa accagagcct ttggactttg
      361 taaaagattt ccaggaatac ctgacccagc agacgcatca tgtgaacatg atttcgggat
      421 cagttagtgg ggacaaagaa gcagagactc ttcagggagc tggaacagat ggcgatcaga
      481 atggccttga tcacccgtct gttgaagttt ccctggatga aaactcagga atgttagtag
      541 acgggtttga gaggaccttc gatgggaagc tcaagtgtcg gtactgcaac tatgccagca
      601 aaggaacggc caggctcatt gagcacatca ggatccacac aggcgagaag cctcacaggt
      661 gtcacttatg tccatttgca tctgcttacg agcgccacct ggaagcccat atgcgctctc
      721 acactgggga aaaaccatac aaatgtgaat tgtgctcctt ccgctgcagt gaccgaagta
      781 acctgtccca ccatcgaagg cgcaaacata aaatggtacc aattaaaggt accaggtctt
      841 ccttaagcag caagaaaatg tggggggttt tacaaaagaa aacaagcaat ctggggtata
      901 gcagaagagc actaatcaac ttaagtccac cttccatggt ggtccagaaa ccagactacc
      961 ttaatgattt tacacacgaa atcccaaata ttcagactga ctcctatgaa gctatggcta
     1021 aaactacacc aactggtggc ctgccaaggg acccccaaga actcatggtt gacaaccctt
     1081 tgaatcagct ctctacttta gcaggacagt tgtccagctt gccaccagaa aaccaaaacc
     1141 ctgcctctcc tgatgtagat gcctgccctg atgaaaagcc tttcatgatt cagcaaccct
     1201 ctgcccaagc agttgtctct gctgtgtcag caagtattcc tcagagctcc tcccccacaa
     1261 gtccggaacc gcggccatcg catagtcaga ggaactacag tccagtggca gggcccagca
     1321 gtgaaccaag tgcccacacc agtactccca gcataggaaa cagccagcca agcactccag
     1381 ctccaaccct gccggtgcag gatcctcagc ttctacacca ctgccagcac tgtgacgtgt
     1441 actttgcaga caacgtcctt tacactgtcc acatggggtg ccatgggtat gacagcccct
     1501 ttcagtgtaa cgtatgtggg tgcaaatgta aagacaagta cgattttgcc tgtcattttg
     1561 caagagggca acacaaccag cactgaacac aatcaacatt gttctcactt ggtttggcct
     1621 tttgggagtt tgtagtttgg tttttagttt gatcatccct aataaggtat atgctaattt
     1681 aaaatttata cattctagtc tataaaatag aagtttgata gtgaaaaagg gttttgttaa
     1741 cttttcataa aagtctggtc agggttattt atgcattaga tagttagatg cattgctgtc
     1801 tttttcattt acacctatga gagttaaagt acagttgtaa tcagtttcct acacttgtcc
     1861 ataaggattc ccagggttat ctgtactcct gatgcttcag gatatacatt acagctaatg
     1921 ttctttctgc catatgtcaa aatggcacac ttctcataaa atcttttata acatttcagt
     1981 gtttatagac aaactgcctt taagtttgct cctaattaaa atactatttt cattcacata
     2041 acttaagttg aattagtttc attacaacca aaaccagtag ttatttcagt gtaataaata
     2101 tttctcttca aggagaagca taaaacagtt ctttcaaatt taaattataa aatgaaaatc
     2161 ttggaagttg aaatttgggg ctaaattgaa aattgtgttt ggtatttgag atatctgttc
     2221 atttaatgtg taaacatgtt agtttttagc ttttcattta tatatgtatt tatatatttt
     2281 gagtattatt ttaaagccac aggtaaatat actagagtgc tagatgcctt ttttcaatct
     2341 gatctttcat gtaaattctg cattcacctg ttactggtgt caggtaagat tgacagccac
     2401 actgattatt ttattcttcc cagtctttga tgaccaaaga ggaagtgagc gcatcatccc
     2461 actgagatgc ttccagagcc tccgaggctc ctttcctgcc ctctgtgcat aattgcccgt
     2521 aatgtccacg aagggttggt ctagaaaccc agagacgtaa taagtgagga aacagctaca
     2581 aacccagagc atgcccagac agagcctcct tgcctctcca gagcagagca ggccatggaa
     2641 agtcctccct gtgagtcttt atggacagag acggtgggat cgtcaccaca gtgggaaagg
     2701 ataaatagag ttattatgaa gcacatttaa atgtgtcatt taacttactt agaattagag
     2761 tggttcattt tatataggaa gccattattt ttgtattgtg taataagtag cttactctga
     2821 agagagcctg gcaaaacaat aaaacattgt cacttactat tggtttctgt gtaccttgca
     2881 aatttttcat ttttatttgg ttaatagctt gaaaatattc tcaattggct tcttaaagaa
     2941 ataccctgtc aagcatttat taaccaaaaa atagcctctt acagtaaata agagggaact
     3001 atgagagtgt ctacccgtga agccccaagt gccctggtaa tggacctgct ctccctccct
     3061 gtgctggaaa gccattccga gggtgcctgt gcgtacacag ccagtcttgg ctcctcccaa
     3121 ctgcactgtt aaagcgcagc cccgaagaca ctttctagtg attttggtct gttgcttaaa
     3181 tcatttacta gattagtttt agggcaacac tttccaaata cataacttga ctgttgtgct
     3241 tatcagctgc cagaaagaaa caggttattg ttgggaaacc ttgctgtttt taaagtttga
     3301 ttcaattaaa agcaatactt ccaaatagac agtgaaaact tcccaaaaga ggaagaagcc
     3361 cagtgtactg ccgcacatct gtagtcccag ctgcttgaag cagaggcggg aagagtgcta
     3421 gagcccagga ggtccctgcc aggccgggca acactgcaag acacagtctc aaaggccaag
     3481 cagccgaaag ggctctcctc acagccagct ttatcacctc tacgttctgg gccaaacagt
     3541 gacatgggca ttttggtttt cctaacaact aacgatgaat gttctgaagg tacatttcat
     3601 tttaaatacg gaaaaaactt ttcataatta cagacaagaa ggaaaaaccc ccgattttcc
     3661 aataatataa agagcacagt tggtcttcca aaggtgtcca tgtgtgaagc tacaagtact
     3721 tcgaaatgca ctaaaatttt gaagcaaatc taccttagga acttttttga aattgtactt
     3781 ttaaaggttt aggcttttgc ttaaatattc tgagttaaat tctgtactag gaaagatgtt
     3841 ggattctttc cttaaatact aaataagttc ctcatcttat ttttaatcaa atgttttata
     3901 gaaatgagtt gagaaaagtt gaccatgcac tatttatagt actttgccat aacaggcaat
     3961 gttctaaaac taaatttatt tttgtttagt gaacatgagt ttagattttt aaagttggta
     4021 atttatctcc actaatattt ttttaaagaa actgtgaaga gattaacaga ataattttat
     4081 ttcagatttt actaatgtag tgtgtagcta caacttgaca ttcaagtgaa gactagactt
     4141 ctgttttgaa atttttccat caggtagttt cagtggtttc attttagaaa tgtgtttgca
     4201 gatgtttgac aaagggaata ttactaaaaa agaaaagcaa aaaaaaaaaa aacttatcaa
     4261 atgaagaatt gttagaaaaa tttaaattcc ctgctaaaga catttttgtt agtcttaggg
     4321 ggtaggtatt tgctttctag aacttgtttt tgttgatagt atttgctttc tagaacttgt
     4381 ttttgttgat agctggatgt atggaacctg ttttctatgc gaggtgcaag tcttgcacta
     4441 cagttgtaag atatattata ttgtttaggg atcaagaaag caatctatgc tgaagtaact
     4501 atagtatgta gttcctattg tgaataatgc tttgcttttg taatgtatta ataaaaagta
     4561 acactttcta a
//
