LOCUS       NM_011772               5152 bp    mRNA    linear   ROD 21-AUG-2023
DEFINITION  Mus musculus IKAROS family zinc finger 4 (Ikzf4), transcript
            variant 1, mRNA.
ACCESSION   NM_011772 NM_175689 XM_978666 XM_991405
VERSION     NM_011772.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5152)
  AUTHORS   Polak K, Marchal P, Taroni C, Ebel C, Kirstetter P, Kastner P and
            Chan S.
  TITLE     CD4+ regulatory T cells lacking Helios and Eos
  JOURNAL   Biochem Biophys Res Commun 674, 83-89 (2023)
   PUBMED   37413709
  REMARK    GeneRIF: CD4[+] regulatory T cells lacking Helios and Eos.
REFERENCE   2  (bases 1 to 5152)
  AUTHORS   Javed A, Santos-Franca PL, Mattar P, Cui A, Kassem F and Cayouette
            M.
  TITLE     Ikaros family proteins redundantly regulate temporal patterning in
            the developing mouse retina
  JOURNAL   Development 150 (2) (2023)
   PUBMED   36537580
REFERENCE   3  (bases 1 to 5152)
  AUTHORS   Gokhale AS, Gangaplara A, Lopez-Occasio M, Thornton AM and Shevach
            EM.
  TITLE     Selective deletion of Eos (Ikzf4) in T-regulatory cells leads to
            loss of suppressive function and development of systemic
            autoimmunity
  JOURNAL   J Autoimmun 105, 102300 (2019)
   PUBMED   31296356
  REMARK    GeneRIF: Eos (lkzf4) appears to play an essential role in multiple
            aspects of Treg suppressor function.
            Erratum:[J Autoimmun. 2020 Nov;114:102544. PMID: 32981806]
REFERENCE   4  (bases 1 to 5152)
  AUTHORS   Yang HY, Barbi J, Wu CY, Zheng Y, Vignali PD, Wu X, Tao JH, Park
            BV, Bandara S, Novack L, Ni X, Yang X, Chang KY, Wu RC, Zhang J,
            Yang CW, Pardoll DM, Li H and Pan F.
  TITLE     MicroRNA-17 Modulates Regulatory T Cell Function by Targeting
            Co-regulators of the Foxp3 Transcription Factor
  JOURNAL   Immunity 45 (1), 83-93 (2016)
   PUBMED   27438767
  REMARK    GeneRIF: this study reports that IL-6 actively suppressed Eos mRNA
            and protein expression through miR-17
REFERENCE   5  (bases 1 to 5152)
  AUTHORS   Arenzana TL, Schjerven H and Smale ST.
  TITLE     Regulation of gene expression dynamics during developmental
            transitions by the Ikaros transcription factor
  JOURNAL   Genes Dev 29 (17), 1801-1816 (2015)
   PUBMED   26314708
  REMARK    GeneRIF: Ikaros may not be a conventional activator or repressor of
            defined sets of genes, but may sharpen the dynamic range of gene
            expression changes during developmental transitions
REFERENCE   6  (bases 1 to 5152)
  AUTHORS   Elliott J, Jolicoeur C, Ramamurthy V and Cayouette M.
  TITLE     Ikaros confers early temporal competence to mouse retinal
            progenitor cells
  JOURNAL   Neuron 60 (1), 26-39 (2008)
   PUBMED   18940586
REFERENCE   7  (bases 1 to 5152)
  AUTHORS   Hu R, Sharma SM, Bronisz A, Srinivasan R, Sankar U and Ostrowski
            MC.
  TITLE     Eos, MITF, and PU.1 recruit corepressors to osteoclast-specific
            genes in committed myeloid progenitors
  JOURNAL   Mol Cell Biol 27 (11), 4018-4027 (2007)
   PUBMED   17403896
  REMARK    GeneRIF: Data suggest that Eos, MITF, and PU.1 recruit corepressors
            to osteoclast-specific genes in committed myeloid progenitor cells.
REFERENCE   8  (bases 1 to 5152)
  AUTHORS   Jensen P, Magdaleno S, Lehman KM, Rice DS, Lavallie ER,
            Collins-Racie L, McCoy JM and Curran T.
  TITLE     A neurogenomics approach to gene expression analysis in the
            developing brain
  JOURNAL   Brain Res Mol Brain Res 132 (2), 116-127 (2004)
   PUBMED   15582152
REFERENCE   9  (bases 1 to 5152)
  AUTHORS   Perdomo J and Crossley M.
  TITLE     The Ikaros family protein Eos associates with C-terminal-binding
            protein corepressors
  JOURNAL   Eur J Biochem 269 (23), 5885-5892 (2002)
   PUBMED   12444977
REFERENCE   10 (bases 1 to 5152)
  AUTHORS   Honma Y, Kiyosawa H, Mori T, Oguri A, Nikaido T, Kanazawa K, Tojo
            M, Takeda J, Tanno Y, Yokoya S, Kawabata I, Ikeda H and Wanaka A.
  TITLE     Eos: a novel member of the Ikaros gene family expressed
            predominantly in the developing nervous system
  JOURNAL   FEBS Lett 447 (1), 76-80 (1999)
   PUBMED   10218586
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117232.3, AK089522.1 and BU058596.1.
            
            [WARNING] On Jan 17, 2024 this sequence was replaced by
            NM_011772.4.
            
            On Dec 1, 2017 this sequence version replaced NM_011772.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EE663597.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-167               AC117232.3         131403-131569       c
            168-1617            AK089522.1         2-1451
            1618-4942           AC117232.3         116629-119953       c
            4943-5152           BU058596.1         323-532
FEATURES             Location/Qualifiers
     source          1..5152
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 77.11 cM"
     gene            1..5152
                     /gene="Ikzf4"
                     /gene_synonym="A630026H08Rik; Eos; Zfpn1a4; Znfn1a4"
                     /note="IKAROS family zinc finger 4"
                     /db_xref="GeneID:22781"
                     /db_xref="MGI:MGI:1343139"
     exon            1..273
                     /gene="Ikzf4"
                     /gene_synonym="A630026H08Rik; Eos; Zfpn1a4; Znfn1a4"
                     /inference="alignment:Splign:2.1.0"
     exon            274..367
                     /gene="Ikzf4"
                     /gene_synonym="A630026H08Rik; Eos; Zfpn1a4; Znfn1a4"
                     /inference="alignment:Splign:2.1.0"
     exon            368..472
                     /gene="Ikzf4"
                     /gene_synonym="A630026H08Rik; Eos; Zfpn1a4; Znfn1a4"
                     /inference="alignment:Splign:2.1.0"
     exon            473..733
                     /gene="Ikzf4"
                     /gene_synonym="A630026H08Rik; Eos; Zfpn1a4; Znfn1a4"
                     /inference="alignment:Splign:2.1.0"
     exon            734..901
                     /gene="Ikzf4"
                     /gene_synonym="A630026H08Rik; Eos; Zfpn1a4; Znfn1a4"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1051
                     /gene="Ikzf4"
                     /gene_synonym="A630026H08Rik; Eos; Zfpn1a4; Znfn1a4"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1183
                     /gene="Ikzf4"
                     /gene_synonym="A630026H08Rik; Eos; Zfpn1a4; Znfn1a4"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..5152
                     /gene="Ikzf4"
                     /gene_synonym="A630026H08Rik; Eos; Zfpn1a4; Znfn1a4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acacacgagg ctctcagcac atacaccctg ggctgagcgg ttctgccggc tgcagccgtg
       61 ggcccctgct caccgtgcgg ctgccactgc ctgcgaaatg acggcggttc ccctcacttc
      121 caggaatcca cgcttcctgg aaggtgagtg gctgggctca cccctgcctg ccaccgagac
      181 gcagacatgc acacaccacc cgcactccct cgccgtttcc aaggcggcgg ccgcgttcgc
      241 accccagggt ctcaccggca agggaaggat aatctggaga gggagctctc aggagggtgt
      301 gctccggatt tcttgcctca ggcccaggac tccaaccatt ttataatgga atctttattt
      361 tgtgaaagta gcggggactc atctctggag aaggagttcc ttggggcccc agtggggccc
      421 tcggtgagca ccccaaacag ccaacactct tcacccagcc gctcgctcag tgccaactcc
      481 atcaaggtgg agatgtacag cgatgaggag tcgagcagac tgctggggcc ggatgaacgg
      541 ctcctggata aggatgacag tgtgattgtg gaagactcat tgtcagagcc cttaggctac
      601 tgcgatggaa gtgggccaga gcctcactcc cctggcggca tccggctacc caacggcaag
      661 ctcaagtgcg acgtctgcgg catggtctgc attgggccca atgtgctcat ggtacacaag
      721 cgcagccaca ctggggagag gcccttccac tgtaatcagt gtggtgcctc cttcacacag
      781 aagggcaatc tgcttcgcca catcaagctg cactcggggg agaagccctt caagtgcccc
      841 ttctgcaact atgcctgccg ccggcgtgac gcactcactg gccacctccg cacacactca
      901 gtctcctccc ccaccgtggg caaaccctac aagtgcaact actgtggccg gagctacaaa
      961 cagcaaagta ccctggagga gcacaaggag aggtgccaca actacctaca gagtctcagc
     1021 actgatgccc aagctctgac tggccagcca ggtgatgaaa tccgtgacct ggagatggtg
     1081 cctgactcaa tgctgcaccc atcgactgaa cggccaactt tcattgatcg tttggccaac
     1141 agcctcacca aacgcaagcg ttccacccca cagaagtttg taggtgaaaa gcagatgcgc
     1201 ttcagcctct cagaccttcc ctatgatgtg aatgccagcg gtggctatga aaaggacgta
     1261 gagttggtgg cacaccatgg cctggagcct ggctttggag ggtctctagc ctttgtgggt
     1321 acagagcatc tgcgtcccct ccgcctccca cccaccaact gcatctcaga actcacacct
     1381 gtcatcagct ctgtgtacac ccaaatgcag cccatcccca gccgactgga gcttccaggg
     1441 tcccgagaag caggtgaggg accggaggac ctgggagatg gaggtcccct cctttatcgg
     1501 gcccgaggct ctctgactga ccctggggca tcccccagca atggctgcca ggactccaca
     1561 gatacagaga gcaaccacga agaccggatt ggtggggtgg tatcccttcc tcagggtccc
     1621 ccaccccaac ctcctcccac catagtggtg ggccggcaca gtcccgccta tgccaaagag
     1681 gaccccaaac cacaggaggg gttactgcgg ggcaccccag gcccctccaa ggaagtgctt
     1741 cgggtggtgg gtgagagtgg tgagccagtg aaggccttta agtgtgaaca ctgccgcatc
     1801 ctctttctgg accacgtcat gttcaccatc cacatgggct gccacggctt cagagaccct
     1861 tttgagtgta acatctgtgg ttatcacagc caggatcggt atgagttctc ttcccacatc
     1921 gtccgggggg aacataaggt gggctagaga cctctttccc cacagcctgc tctcagcccg
     1981 gcccccaccc tactgcccta cctacagggg tctagcccaa ttcctgttac accctaagga
     2041 gttttgcgtt gtagccccac ccactggccg cctcacttca cacttgactc caaccgtctt
     2101 tgcctgttcc cttctaccct gaccgatttg agcatttcga caagacaagt ctcttgctta
     2161 tatttctcct tctaacctct ctccccggca catttgcttt ttaaattgac tttaacttgg
     2221 ccttttctta gtttactgca atctctggcc actccttcat tcttctgccc atggctccct
     2281 tctgctctaa gcctagattt ttttttattt tattattatt attattatta ttacttgtgt
     2341 gtgtgtgtgg atcccacatc ctccaacagc tccaggggtt ggaagctcct ctctgtgcta
     2401 agagacgttg ggcttcttgc tttaatcctc acccttattt atctgaccct tcacttttga
     2461 tgctgatacc tcccaacggc cccaccttag ctctgtggca ttattatctc ctctctggga
     2521 cctttcagcc cggcactcca tacctctcgt gcccactcac tttaggcagc ttgcactatt
     2581 cttaaatgaa tgaagaattt cctcatttgc aggtaggagg ggctgtagaa actctcccca
     2641 ggcactgtgg actgagggtc ctcttgacct cacctgggaa tccgagctcc ctaaagacta
     2701 cattcaggac ctccctctag gatgtgatac cacccttccc tctccctggc tcacccctca
     2761 acaccactct ggtctcaact cgccactctt gtcagttggt ggcttttctc tccttggaat
     2821 gcccccattt tatattctca ggggctaagg ctagacctgc taccctttct ctgacacaca
     2881 gagagagctg caggtaccta gctgagaacc agggcatggg aagggggatg ggtagaactc
     2941 tctcctccac ctttcaaaca cttacactcc agtgaccttc ctaggctctc agggactcct
     3001 tctgtcccca tattatgaga aaccagcggg ttgctgctcg atgaccaggg gtctctcaac
     3061 cctgtcagtc acgctgcctt tttcctccct tccagcagga ctcgccgtct cgtccccagg
     3121 ctcctgggcc ctgttatgat caatggcagg gagaaagggg atgtctcttt tctctctgcc
     3181 aattttcagt ataaccaaaa aaactgtccc aggatgaact acacgtatgt gcccgtcaac
     3241 cattccaccc ttgtcccagc aagaatggga cggacacagc tgggagtcac ctccactgcc
     3301 ctttccatac ttagctccag acacagggca ggagaggcag tcttctctgg tggttgcaga
     3361 cactctggct attcggataa tcgaggattc gtgagaccat gcaggaggag gcatagctcc
     3421 attgcaggtg gaagtctctc tctctaaaga gttccctgcc agggccacaa ccatcccact
     3481 ctctgcttct ttgagattca aaccaaagga tgttttttct atatttaaag aaaaggaaaa
     3541 aaaaagaaaa gaaaaaaaaa aaaaaccaaa cacaacacct cataagttat agtcttggtc
     3601 ttcaccctcc ctttctcttc ccttccgtcc atcttccttc ccacgtgccc tttctttatc
     3661 tcttctgcct ctccctactt tcctcactcc ctgttaggga cgttgagagg cacgagaaag
     3721 ggtgggctag atcagatcct gggactgggg ctcttaagca ttccgaagag agtcgacttt
     3781 ctcctatcgg gagaagggta gtggggtgaa aaccactctt ttctcttctt ccttcggccc
     3841 tggcactgct tcccaaaagg accagattgg cagagagcag ctctgtgggg ctgttcttcc
     3901 ctgacaatgt agcaataagc aggtgctgcc aaaggcaaga gaatgaggtc tgagctctga
     3961 aaggagtggt cccgagacaa gggaagggtc gccacaacag agccttggca ctaattcctt
     4021 cttgggctgg cacacagctg aggttactgt ctgggcttct cctcaaccat tctggttgtg
     4081 agctcccatt agacccgctc ccacctcttc tgtgtctgcc ctgtattcga ggacacctca
     4141 gaaggactta gtccctctga ggcgctagag ccttagagtg ccccacccct ccctttgttt
     4201 agtcagtctt agcacctgtg acctcccagg aacacaaagg actatgctcc tccgaggcta
     4261 tgctaacgcc catgagagca gaggtggaag ggacaagacc aggtgctagg gaggaggggg
     4321 catggcgtct ctctccagcc caccactgca ctttaaccag ggtcttaggt acaaaatgct
     4381 acttttcagg gccttccagc tctggaacct caaacatcct catgctctct cccagatcct
     4441 tttgcataaa aaaaaacaaa acaaaaaaac caacaacaaa aaaagtaaag aaaaagaaga
     4501 aaacaacaac aaaaaacaaa atgccaaaat ccacacagag aaaagaggtg ttctctctct
     4561 ctcttttttt tattactctt aaaaaaacaa caccacaaaa aagtggaggg aagggagaga
     4621 atttctaaat agacactttt ccagaccttt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     4681 gtgtgtatgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtca gtgtccaagc
     4741 tgcaagtgga attttataat acttctggca gcttctttcc ttgtgtatat aatatatata
     4801 tatttttaat cagaaattat gaagatcaaa aatagaataa acacagaagc aagtgcaata
     4861 ccacctctcc ttctccccag agttcctctg tagcctgttc ggtgtcccct ttggcccttg
     4921 acccttgacc ttgtctctct tcctctggtt cctgacctat tctccccttc cctcttttta
     4981 aagagttttt ctcttttctc aaagggggtt aaaccagctt ttgagactta ctgcaaagca
     5041 ttttgtatat gtaacatact gtaagtaaat atttgtgtaa tggagaaata ctactgtaag
     5101 ttttgtactg tactggctga aggtctgtta taaataaaca cgagtaattt aa
//
