LOCUS       NM_011771               4098 bp    mRNA    linear   ROD 18-FEB-2025
DEFINITION  Mus musculus IKAROS family zinc finger 3 (Ikzf3), mRNA.
ACCESSION   NM_011771 XM_283022 XM_903035 XM_903037 XM_903038 XM_903039
            XM_915425 XM_923689 XM_923696 XM_923700 XM_923704 XM_983715
            XM_983788 XM_983820 XM_983864 XM_983905
VERSION     NM_011771.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4098)
  AUTHORS   Leonard,M.R., Jones,D.M., Read,K.A., Pokhrel,S., Tuazon,J.A.,
            Warren,R.T., Yount,J.S. and Oestreich,K.J.
  TITLE     Aiolos promotes CXCR3 expression on Th1 cells via positive
            regulation of IFN-gamma/STAT1 signaling
  JOURNAL   JCI Insight 10 (1), e180287 (2024)
   PUBMED   39560988
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4098)
  AUTHORS   Jones,D.M., Tuazon,J.A., Read,K.A., Leonard,M.R., Pokhrel,S.,
            Sreekumar,B.K., Warren,R.T., Yount,J.S., Collins,P.L. and
            Oestreich,K.J.
  TITLE     Cytotoxic Programming of CD4+ T Cells Is Regulated by Opposing
            Actions of the Related Transcription Factors Eos and Aiolos
  JOURNAL   J Immunol 212 (7), 1129-1141 (2024)
   PUBMED   38363226
  REMARK    GeneRIF: Cytotoxic Programming of CD4+ T Cells Is Regulated by
            Opposing Actions of the Related Transcription Factors Eos and
            Aiolos.
REFERENCE   3  (bases 1 to 4098)
  AUTHORS   Rodrigues de Oliveira,B., Iansavitchous,J., Rysan,H., Wang,W.C.,
            Sams,M.P., Knight,D., Xu,L.S., Jeong,J., Qu,T.P., Zorzi,A.P. and
            DeKoter,R.P.
  TITLE     IKZF3/Aiolos H195Y mutation identified in a mouse model of B cell
            leukemia results in altered DNA binding and altered STAT5-dependent
            gene expression
  JOURNAL   Gene 900, 148131 (2024)
   PUBMED   38216003
  REMARK    GeneRIF: IKZF3/Aiolos H195Y mutation identified in a mouse model of
            B cell leukemia results in altered DNA binding and altered
            STAT5-dependent gene expression.
REFERENCE   4  (bases 1 to 4098)
  AUTHORS   Herr,L.A., Fiala,G.J., Sagar, Schaffer,A.M., Hummel,J.F.,
            Zintchenko,M., Raute,K., Velasco Cardenas,R.M., Heizmann,B.,
            Ebert,K., Fehrenbach,K., Janowska,I., Chan,S., Tanriver,Y.,
            Minguet,S. and Schamel,W.W.
  TITLE     Kidins220 and Aiolos promote thymic iNKT cell development by
            reducing TCR signals
  JOURNAL   Sci Adv 10 (11), eadj2802 (2024)
   PUBMED   38489359
  REMARK    GeneRIF: Kidins220 and Aiolos promote thymic iNKT cell development
            by reducing TCR signals.
REFERENCE   5  (bases 1 to 4098)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 4098)
  AUTHORS   Hosokawa,Y., Maeda,Y., Takahashi,Ei., Suzuki,M. and Seto,M.
  TITLE     Human aiolos, an ikaros-related zinc finger DNA binding protein:
            cDNA cloning, tissue expression pattern, and chromosomal mapping
  JOURNAL   Genomics 61 (3), 326-329 (1999)
   PUBMED   10552935
REFERENCE   7  (bases 1 to 4098)
  AUTHORS   Kim,J., Sif,S., Jones,B., Jackson,A., Koipally,J., Heller,E.,
            Winandy,S., Viel,A., Sawyer,A., Ikeda,T., Kingston,R. and
            Georgopoulos,K.
  TITLE     Ikaros DNA-binding proteins direct formation of chromatin
            remodeling complexes in lymphocytes
  JOURNAL   Immunity 10 (3), 345-355 (1999)
   PUBMED   10204490
REFERENCE   8  (bases 1 to 4098)
  AUTHORS   Wang,J.H., Avitahl,N., Cariappa,A., Friedrich,C., Ikeda,T.,
            Renold,A., Andrikopoulos,K., Liang,L., Pillai,S., Morgan,B.A. and
            Georgopoulos,K.
  TITLE     Aiolos regulates B cell activation and maturation to effector state
  JOURNAL   Immunity 9 (4), 543-553 (1998)
   PUBMED   9806640
REFERENCE   9  (bases 1 to 4098)
  AUTHORS   Kelley,C.M., Ikeda,T., Koipally,J., Avitahl,N., Wu,L.,
            Georgopoulos,K. and Morgan,B.A.
  TITLE     Helios, a novel dimerization partner of Ikaros expressed in the
            earliest hematopoietic progenitors
  JOURNAL   Curr Biol 8 (9), 508-515 (1998)
   PUBMED   9560339
REFERENCE   10 (bases 1 to 4098)
  AUTHORS   Morgan,B., Sun,L., Avitahl,N., Andrikopoulos,K., Ikeda,T.,
            Gonzales,E., Wu,P., Neben,S. and Georgopoulos,K.
  TITLE     Aiolos, a lymphoid restricted transcription factor that interacts
            with Ikaros to regulate lymphocyte differentiation
  JOURNAL   EMBO J 16 (8), 2004-2013 (1997)
   PUBMED   9155026
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK036657.1, AF001293.1, AI549961.1, AK038043.1, AI019346.1 and
            BE457553.1.
            
            On or before Aug 30, 2006 this sequence version replaced
            XM_915425.2, XM_923689.2, XM_923696.2, XM_923700.2, XM_923704.2,
            XM_283022.5, XM_903035.2, XM_903037.2, XM_903038.2, XM_903039.2,
            XM_983788.1, XM_983715.1, XM_983820.1, XM_983864.1, XM_983905.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849388
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-342               AK036657.1         2-343
            343-620             AF001293.1         62-339
            621-702             AI549961.1         367-448
            703-1235            AF001293.1         422-954
            1236-3501           AK038043.1         1699-3964
            3502-3627           AI019346.1         164-289
            3628-3899           AK038043.1         4091-4362
            3900-4098           BE457553.1         231-429
FEATURES             Location/Qualifiers
     source          1..4098
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 61.75 cM"
     gene            1..4098
                     /gene="Ikzf3"
                     /gene_synonym="5830411O07Rik; Aiolos; Zfpn1a3; Znfn1a3"
                     /note="IKAROS family zinc finger 3"
                     /db_xref="GeneID:22780"
                     /db_xref="MGI:MGI:1342542"
     exon            1..288
                     /gene="Ikzf3"
                     /gene_synonym="5830411O07Rik; Aiolos; Zfpn1a3; Znfn1a3"
                     /inference="alignment:Splign:2.1.0"
     CDS             282..1805
                     /gene="Ikzf3"
                     /gene_synonym="5830411O07Rik; Aiolos; Zfpn1a3; Znfn1a3"
                     /note="ikaros family zinc finger protein 3; zinc finger
                     protein, subfamily 1A, 3 (Aiolos)"
                     /codon_start=1
                     /product="zinc finger protein Aiolos"
                     /protein_id="NP_035901.1"
                     /db_xref="CCDS:CCDS25352.1"
                     /db_xref="GeneID:22780"
                     /db_xref="MGI:MGI:1342542"
                     /translation="MEDIQPTVELKSTEEQPLPTESPDALNDYSLPKPHEIENVDSRE
                     APANEDEDAGEDSMKVKDEYSDRDENIMKPEPMGDAEESEMPYSYAREYSDYESIKLE
                     RHVPYDNSRPTGGKMNCDVCGLSCISFNVLMVHKRSHTGERPFQCNQCGASFTQKGNL
                     LRHIKLHTGEKPFKCHLCNYACQRRDALTGHLRTHSVEKPYKCEFCGRSYKQRSSLEE
                     HKERCRAFLQNPDLGDAASVEARHIKAEMGSERALVLDRLASNVAKRKSSMPQKFIGE
                     KRHCFDANYNPGYMYEKENEMMQTRMMDQAINNAISYLGAEALRPLVQTPPAPTSEMV
                     PVISSVYPIALTRADMPNGAPQEMEKKRILLPEKILPSERGLSPNNSAQDSTDTDSNH
                     EDRQHLYQQSHVVLPQARNGMPLLKEVPRSFELLKPPPICLRDSIKVINKEGEVMDVF
                     RCDHCHVLFLDYVMFTIHMGCHGFRDPFECNMCGYRSHDRYEFSSHIARGEHRAMLK"
     exon            289..342
                     /gene="Ikzf3"
                     /gene_synonym="5830411O07Rik; Aiolos; Zfpn1a3; Znfn1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            343..444
                     /gene="Ikzf3"
                     /gene_synonym="5830411O07Rik; Aiolos; Zfpn1a3; Znfn1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            445..702
                     /gene="Ikzf3"
                     /gene_synonym="5830411O07Rik; Aiolos; Zfpn1a3; Znfn1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            703..870
                     /gene="Ikzf3"
                     /gene_synonym="5830411O07Rik; Aiolos; Zfpn1a3; Znfn1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            871..987
                     /gene="Ikzf3"
                     /gene_synonym="5830411O07Rik; Aiolos; Zfpn1a3; Znfn1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1104
                     /gene="Ikzf3"
                     /gene_synonym="5830411O07Rik; Aiolos; Zfpn1a3; Znfn1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..4098
                     /gene="Ikzf3"
                     /gene_synonym="5830411O07Rik; Aiolos; Zfpn1a3; Znfn1a3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3479..3484
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ikzf3"
                     /gene_synonym="5830411O07Rik; Aiolos; Zfpn1a3; Znfn1a3"
                     /note="hexamer: AATATA"
     polyA_site      3506
                     /gene="Ikzf3"
                     /gene_synonym="5830411O07Rik; Aiolos; Zfpn1a3; Znfn1a3"
                     /note="major polyA site"
     regulatory      3865..3870
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ikzf3"
                     /gene_synonym="5830411O07Rik; Aiolos; Zfpn1a3; Znfn1a3"
                     /note="hexamer: ATTAAA"
     polyA_site      3893
                     /gene="Ikzf3"
                     /gene_synonym="5830411O07Rik; Aiolos; Zfpn1a3; Znfn1a3"
                     /note="major polyA site"
ORIGIN      
        1 ttccacgcga tcagggttcc tcaggcttga cattcaaaag tgggtgcgga acccgcggca
       61 ctcggagcgt gctttaaagc ggccgccagc cagcgccgct ctaacctcgc gccccggctg
      121 ccggcggctc ccgccctgca tctgcgccga cgcgaccgag cgatcccggg gcctccctgc
      181 gcccggaatc tcccgccagc cgcgcgggtc cccacggcag cagcacgtgg agcggccgcg
      241 gagcctgagc gacagctgca gcccgcgcgg cccgcggcga catggaagat atacaaccga
      301 ctgtggagct gaaaagcacg gaggagcagc ctctgcccac agagagccca gacgctctga
      361 atgactacag cttgcccaaa cctcatgaga tagaaaacgt ggacagtaga gaagccccag
      421 ccaatgaaga cgaagatgca ggagaagatt cgatgaaagt gaaagatgaa tacagcgaca
      481 gagatgagaa cattatgaag ccggagccca tgggagatgc agaagagagt gaaatgcctt
      541 acagctatgc aagagaatac agcgactatg aaagcattaa gctggagaga cacgtgccct
      601 atgacaacag cagaccaacc ggtgggaaga tgaactgcga cgtgtgcggg ttatcctgca
      661 ttagcttcaa cgtcttgatg gttcataagc gaagccatac cggcgaacgc ccgttccagt
      721 gtaatcagtg cggggcatct tttactcaga aaggtaacct cctccgtcat attaaactgc
      781 acacggggga aaaacctttt aagtgtcacc tctgcaacta cgcatgccaa aggagagatg
      841 cgctcacggg acaccttagg acacattctg tggagaagcc gtacaagtgt gagttctgcg
      901 gaagaagcta caagcagaga agctccctgg aggagcacaa ggaacgctgc cgagcttttc
      961 ttcagaaccc tgacctgggg gacgctgcaa gtgtggaggc aagacacatc aaagccgaga
     1021 tgggaagtga gagagctctc gtcctggaca gattagcaag caatgtggct aagcgaaaaa
     1081 gctcgatgcc tcagaaattc atcggtgaga agcggcactg cttcgatgcc aactacaatc
     1141 ccggctacat gtacgagaag gagaacgaga tgatgcagac ccggatgatg gaccaagcca
     1201 tcaataacgc catcagctat ctaggggctg aagcccttcg ccccttagtc cagactccgc
     1261 ctgctcccac ctctgagatg gtcccagtca tcagcagtgt gtaccccata gcacttactc
     1321 gggccgatat gcccaatggg gccccgcagg agatggaaaa gaaacggatc ctcctgccag
     1381 agaagatctt gccttctgaa cgaggtctgt cccccaataa cagtgcccag gactccacag
     1441 acaccgacag caaccacgag gatcgccaac atctctacca gcaaagccac gtggtcctcc
     1501 cccaggcccg caatgggatg cctcttctga aggaggtccc tcgctctttt gaactcctca
     1561 agccccctcc catctgcctg agggactcca tcaaagtgat caacaaagaa ggggaggtga
     1621 tggatgtgtt tcgatgtgac cactgccacg tcctcttcct agattatgtg atgttcacca
     1681 tccacatggg gtgccatggt ttccgtgatc cctttgagtg taacatgtgt ggctatcgaa
     1741 gccacgatcg ctatgagttc tcctctcaca tcgccagagg agagcacaga gccatgttga
     1801 agtgagcatc tgtcctcaat gcgagggtca acattgtttt ttaaagctga tggtagcctt
     1861 atccagtaga ctgaactcaa acccacagtc ccacccagtt ctgttagctc tcaatcatgt
     1921 ccacatgaac agtcagggaa ataactgtct tcattcagaa actgtttgca gagctatcat
     1981 gttactctgt gaaacctccc ttcccatcag ttgagtttga tgggatttaa aagccaaaga
     2041 agtatctggt tcattatctt ttgtagcaat agacagccat ctactggagc tcccggccaa
     2101 ttggaacagt cctccgtggg ccgcaggagt cattcactgg aatacagcag ccatatgtgg
     2161 aaaagccctt tgatcctatg cccagatcca cacagcggaa gagccgccca gctgcccttg
     2221 ctcttgggca ccaacacaag gcagaagcct tagcgtgtag tccccctccc ttcacgttct
     2281 aacagcaagg aagaggtggc cgtacagtaa ggacctgctg atagtaatgg aagaccctat
     2341 tcttggagca tcaacccact tcctatcaaa caaaactgaa gccacctgag caaggaccct
     2401 tctcctttac ctacggtcac aagggtgaac ctcagatgat ttggcctgag ccagaccctg
     2461 atcctcctgc ctccgtctgg aggaaaattc tactccagaa gaactgatgc gtttaaatat
     2521 tgggtatcat tgaaaccgca gagtcatgca ccgaggggtg gtatttgtct cctttgattg
     2581 ggattggtag agcaagtggt ggggacatag tttaagggta cagtgcctgc caggtacaac
     2641 caccacacca gggggcaaag agggaagaaa gaaaatggag ggaagagagg ttggctgagt
     2701 agagcgtgta aggttgactg gttggcaacc cttgtcacct tggtggagta ctggctgaaa
     2761 ccccaaagaa catttgaaaa gtgatttttg gcaaaggagc caaaatgtgc tgcttagttc
     2821 cccaccacct cccaccccac aggcgtgaga tcagggacag aaccacagat gttctctcag
     2881 gacggtgtga catcacactc tcctgggtta gaaatgcatg gtttttatta tattactcta
     2941 ttttcaaaac agggtctcct ggtgccccgg caagcctcaa actcattgct ggctgaagct
     3001 gcccagcact ctgagcctcc tgcctcagcc tacagagtgc tgggttgaga gggttatcag
     3061 caccgtggtg ttgggcttct gctgtcctaa agaggagctg ccacatccca ctgagagtct
     3121 gggaaggctg atcttgttct gtagatagac caggtagtca cctttgtcac acaggcacca
     3181 agacatcaag attcttggaa aaatgctcca taaacaagca ctggaatcga ggccaccaac
     3241 cgtgcttgcc aagctcatat ttgcaactaa ttggttaact ctaaaagaca aatggcctca
     3301 accataaaat aagagtagca tccaaaccct cttgatggtc acttctggct ttgatacatg
     3361 attattcaat agccacaggt tttttgcttt tgtttttgtt tttttaactt cttgatgtgt
     3421 gggcattaag cagacaagtc tgcgtgtgag aatgtgtttc atatgtcttt gatgtgaaaa
     3481 tatagttgtg ttaagttttt ccttcagcta ctgagtcatg accatgaagg aggcgatgag
     3541 gggggactaa ggacaggaag ggttttgatc atgcagtcgt gtatacacga gctggcatct
     3601 gcagcagccg tgtacacacg agctggcatc tacagcttct tgccggagcc cttttcttcc
     3661 tttcctttta aaagaacttg tgttagggaa aaataagttc tgcttacagg gacggcttca
     3721 tggagcctat ttacaaatta agagcttagc ttttatgaac atttctgcca gagccaggaa
     3781 tcccaaattc ccggtatgtt agcattttcc ttctaagggg cttatggatt cggctcttac
     3841 tcattcatgt atacgatgcc agtaattaaa acattcctcc tcaaacacac aaatagctta
     3901 gcctgccttg tagcatggtg tctgtctcag ggtaaggggg gtgggttatg agattccgtg
     3961 gcaacaattc tgtggcaaca atcccgtgtc agcttaaggg ctaggtgtct tcagcacatc
     4021 tctgcatctc agcagaatcg gatgtgagct gcaccacatt gttcatgccc actgtgaaag
     4081 aggacctgcc tagtctag
//
