LOCUS       NM_001402850            9354 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus IKAROS family zinc finger 2 (Ikzf2), transcript
            variant 1, mRNA.
ACCESSION   NM_001402850 XM_006495965
VERSION     NM_001402850.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9354)
  AUTHORS   Ballasch,I., Lopez-Molina,L., Galan-Ganga,M., Sancho-Balsells,A.,
            Rodriguez-Navarro,I., Borras-Pernas,S., Rabadan,M.A., Chen,W.,
            Pasto-Pellicer,C., Flotta,F., Maoyu,W., Fernandez-Irigoyen,J.,
            Santamaria,E., Aguilar,R., Dobano,C., Egri,N., Hernandez,C.,
            Alfonso,M., Juan,M., Alberch,J., Del Toro,D., Arranz,B.,
            Canals,J.M. and Giralt,A.
  TITLE     Alterations of the IKZF1-IKZF2 tandem in immune cells of
            schizophrenia patients regulate associated phenotypes
  JOURNAL   J Neuroinflammation 21 (1), 326 (2024)
   PUBMED   39695786
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9354)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 9354)
  AUTHORS   Polak,K., Marchal,P., Taroni,C., Ebel,C., Kirstetter,P., Kastner,P.
            and Chan,S.
  TITLE     CD4+ regulatory T cells lacking Helios and Eos
  JOURNAL   Biochem Biophys Res Commun 674, 83-89 (2023)
   PUBMED   37413709
  REMARK    GeneRIF: CD4[+] regulatory T cells lacking Helios and Eos.
REFERENCE   4  (bases 1 to 9354)
  AUTHORS   Li,S., He,S., Lu,Y., Jia,S. and Liu,Z.
  TITLE     Epistatic genetic interactions between Insm1 and Ikzf2 during
            cochlear outer hair cell development
  JOURNAL   Cell Rep 42 (5), 112504 (2023)
   PUBMED   37171961
  REMARK    GeneRIF: Epistatic genetic interactions between Insm1 and Ikzf2
            during cochlear outer hair cell development.
REFERENCE   5  (bases 1 to 9354)
  AUTHORS   Bi,Z., Li,X., Ren,M., Gu,Y., Zhu,T., Li,S., Wang,G., Sun,S., Sun,Y.
            and Liu,Z.
  TITLE     Development and transdifferentiation into inner hair cells require
            Tbx2
  JOURNAL   Natl Sci Rev 9 (12), nwac156 (2022)
   PUBMED   36687561
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9354)
  AUTHORS   Zhang,Z., Swindle,C.S., Bates,J.T., Ko,R., Cotta,C.V. and Klug,C.A.
  TITLE     Expression of a non-DNA-binding isoform of Helios induces T-cell
            lymphoma in mice
  JOURNAL   Blood 109 (5), 2190-2197 (2007)
   PUBMED   17110463
  REMARK    GeneRIF: results demonstrate a vital function for Helios in
            maintaining normal homeostasis of developing T cells and formally
            show that non-DNA-binding isoforms of Helios are lymphomagenic if
            aberrantly expressed within the T-cell lineage
REFERENCE   7  (bases 1 to 9354)
  AUTHORS   Dovat,S., Montecino-Rodriguez,E., Schuman,V., Teitell,M.A.,
            Dorshkind,K. and Smale,S.T.
  TITLE     Transgenic expression of Helios in B lineage cells alters B cell
            properties and promotes lymphomagenesis
  JOURNAL   J Immunol 175 (6), 3508-3515 (2005)
   PUBMED   16148093
  REMARK    GeneRIF: silencing of Helios is critical for normal B cell function
REFERENCE   8  (bases 1 to 9354)
  AUTHORS   Xu,H., Wakabayashi,Y., Okano,H., Saito,Y., Miyazawa,T. and
            Kominami,R.
  TITLE     Genetic mapping and allelic loss analysis in mouse thymic lymphomas
            of Helios and Aiolos belonging to the Ikaros gene family
  JOURNAL   Jpn J Cancer Res 92 (1), 36-41 (2001)
   PUBMED   11173542
REFERENCE   9  (bases 1 to 9354)
  AUTHORS   Kelley,C.M., Ikeda,T., Koipally,J., Avitahl,N., Wu,L.,
            Georgopoulos,K. and Morgan,B.A.
  TITLE     Helios, a novel dimerization partner of Ikaros expressed in the
            earliest hematopoietic progenitors
  JOURNAL   Curr Biol 8 (9), 508-515 (1998)
   PUBMED   9560339
REFERENCE   10 (bases 1 to 9354)
  AUTHORS   Hahm,K., Cobb,B.S., McCarty,A.S., Brown,K.E., Klug,C.A., Lee,R.,
            Akashi,K., Weissman,I.L., Fisher,A.G. and Smale,S.T.
  TITLE     Helios, a T cell-restricted Ikaros family member that
            quantitatively associates with Ikaros at centromeric
            heterochromatin
  JOURNAL   Genes Dev 12 (6), 782-796 (1998)
   PUBMED   9512513
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC101737.6.
            
            On Mar 23, 2022 this sequence version replaced XM_006495965.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219380.11793.1,
                                           SRR17784646.1132620.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-210               AC101737.6         226973-227182       c
            211-259             AC101737.6         224056-224104       c
            260-367             AC101737.6         223142-223249       c
            368-634             AC101737.6         117713-117979       c
            635-802             AC101737.6         110425-110592       c
            803-940             AC101737.6         88531-88668         c
            941-1084            AC101737.6         82159-82302         c
            1085-9354           AC101737.6         71155-79424         c
FEATURES             Location/Qualifiers
     source          1..9354
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 34.9 cM"
     gene            1..9354
                     /gene="Ikzf2"
                     /gene_synonym="A730095J18Rik; Helios; Zfpn1a2; Znfn1a2"
                     /note="IKAROS family zinc finger 2"
                     /db_xref="GeneID:22779"
                     /db_xref="MGI:MGI:1342541"
     exon            1..210
                     /gene="Ikzf2"
                     /gene_synonym="A730095J18Rik; Helios; Zfpn1a2; Znfn1a2"
                     /inference="alignment:Splign:2.1.0"
     exon            211..259
                     /gene="Ikzf2"
                     /gene_synonym="A730095J18Rik; Helios; Zfpn1a2; Znfn1a2"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..1809
                     /gene="Ikzf2"
                     /gene_synonym="A730095J18Rik; Helios; Zfpn1a2; Znfn1a2"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein Helios; ikaros family zinc finger protein
                     2; zinc finger protein, subfamily 1A, 2 (Helios)"
                     /codon_start=1
                     /product="zinc finger protein Helios isoform 1"
                     /protein_id="NP_001389779.1"
                     /db_xref="GeneID:22779"
                     /db_xref="MGI:MGI:1342541"
                     /translation="METDAIDGYITSGDNELSPEGEHANMAIDLTSSTPNGQHASPSH
                     MTSTNSVKLEMQSDEECDRQPLSREDEIRGHDEGSSLEEPLIESSEVADNRKVQDLQG
                     EGGIRLPNGKLKCDVCGMVCIGPNVLMVHKRSHTGERPFHCNQCGASFTQKGNLLRHI
                     KLHSGEKPFKCPFCSYACRRRDALTGHLRTHSVGKPHKCNYCGRSYKQRSSLEEHKER
                     CHNYLQNVSMEAAGQVMSHHVPPMEDCKEQEPIMDNNISLVPFERPAVIEKLTANMGK
                     RKSSTPQKFVGEKLMRFSYPDIHFDMNLTYEKEAELMQSHMMDQAINNAITYLGAEAL
                     HPLMQHAPSTIAEVAPVISSAYSQVYHPNRIERPISRETSDSHENNMDGPISLIRPKS
                     RPQEREASPSNSCLDSTDSESSHDDRQSYQGNPALNPKRKQSPAYMKEDVKALDATKA
                     PKGSLKDIYKVFNGEGEQIRAFKCEHCRVLFLDHVMYTIHMGCHGYRDPLECNICGYR
                     SQDRYEFSSHIVRGEHTFH"
     exon            260..367
                     /gene="Ikzf2"
                     /gene_synonym="A730095J18Rik; Helios; Zfpn1a2; Znfn1a2"
                     /inference="alignment:Splign:2.1.0"
     exon            368..634
                     /gene="Ikzf2"
                     /gene_synonym="A730095J18Rik; Helios; Zfpn1a2; Znfn1a2"
                     /inference="alignment:Splign:2.1.0"
     exon            635..802
                     /gene="Ikzf2"
                     /gene_synonym="A730095J18Rik; Helios; Zfpn1a2; Znfn1a2"
                     /inference="alignment:Splign:2.1.0"
     exon            803..940
                     /gene="Ikzf2"
                     /gene_synonym="A730095J18Rik; Helios; Zfpn1a2; Znfn1a2"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1084
                     /gene="Ikzf2"
                     /gene_synonym="A730095J18Rik; Helios; Zfpn1a2; Znfn1a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..9354
                     /gene="Ikzf2"
                     /gene_synonym="A730095J18Rik; Helios; Zfpn1a2; Znfn1a2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9336..9341
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ikzf2"
                     /gene_synonym="A730095J18Rik; Helios; Zfpn1a2; Znfn1a2"
                     /note="hexamer: AATAAA"
     polyA_site      9354
                     /gene="Ikzf2"
                     /gene_synonym="A730095J18Rik; Helios; Zfpn1a2; Znfn1a2"
                     /note="major polyA site"
ORIGIN      
        1 gggctaaccc tgctcctcgc tgaagatgga ggaagtaaaa acaggattac ccttagctac
       61 agatccactg ccttagtttc caccaccaac tgcagtgcac aaacacacgt taggcacagg
      121 aaagaaagaa agagagagag ggagaggaca cactaacagt aaacacaaac aaaagggtga
      181 tgggattatt ttactgcatg cactgctgag cactgcactt tgactatgga aacagacgca
      241 attgatggct atataacatc aggtgacaat gagctttcac ccgaagggga acacgccaat
      301 atggccattg acctcacctc aagcacaccc aatggacagc acgcctcgcc aagtcacatg
      361 acaagcacaa attctgtaaa gctggaaatg cagagtgatg aagagtgtga caggcagccc
      421 ctgagccgtg aggatgagat caggggccac gatgagggga gcagcctaga agaaccccta
      481 attgagagca gcgaggtggc cgacaacagg aaagtccagg accttcaagg cgagggagga
      541 atccggcttc cgaatggtaa actgaaatgt gacgtctgtg gcatggtttg cattgggccc
      601 aatgtgctta tggtacataa aaggagtcac actggtgagc ggcccttcca ctgtaaccag
      661 tgcggagctt cttttaccca gaagggcaac cttctgagac acataaagtt acactctgga
      721 gagaagccct tcaaatgtcc tttctgtagc tatgcttgta gaagaaggga cgctctcaca
      781 ggacacctca ggacccattc tgtgggtaaa cctcacaagt gtaactactg tggccgaagc
      841 tacaagcagc gcagctcact ggaggaacac aaggaacgct gtcacaacta tctccagaat
      901 gtcagcatgg aggctgccgg gcaggtcatg agtcaccatg taccgcctat ggaagattgt
      961 aaggaacaag agcctatcat ggacaacaat atttctctgg tgccttttga gagacctgct
     1021 gtcatagaga agctcacggc aaatatggga aagcgcaaaa gctccactcc tcagaagttt
     1081 gtgggggaaa agcttatgcg attcagctac ccagatattc attttgatat gaacttaaca
     1141 tatgagaagg aggctgagct gatgcagtct catatgatgg accaagccat caacaatgca
     1201 atcacctacc ttggagctga ggcccttcac cctctgatgc agcatgcacc aagcacaatc
     1261 gctgaggtgg ccccagttat aagctcagct tattctcagg tctatcatcc aaacaggata
     1321 gaaagaccca ttagcaggga aacatctgat agtcacgaaa acaacatgga tggccccatc
     1381 tctctcatca gaccaaagag tcgaccccag gaaagagagg cctcgcccag caatagctgc
     1441 ctcgattcta ctgactcaga aagtagccat gatgaccgcc agtcctacca aggaaaccct
     1501 gccttaaatc ccaagaggaa acaaagccca gcttacatga aggaggatgt caaggctttg
     1561 gatgctacca aggcccccaa gggctctctg aaggacatct ataaggtttt caatggagaa
     1621 ggagaacaga taagggcctt caagtgtgag cactgccgag tcctttttct agaccatgtc
     1681 atgtacacca ttcacatggg ttgccatggc taccgggacc cactggaatg caacatctgt
     1741 ggctacagaa gccaggaccg ctacgaattt tcatcacaca ttgttcgagg ggagcacaca
     1801 ttccactagg ccttttcatt ccaaagggga cccctatgaa gaactgcaca tgaagaaata
     1861 ctgcacttac agtcccacct tccctcggat ggcgacatgc tgtcttctgg atgctgtcac
     1921 tgtctataat tcttattttg tggacaaaat gtcatttgct ctgcctaact acaatgagga
     1981 agaaacaaaa gaaaagggat gggatgttca atgataactt ggcttgttta tttcgtgagc
     2041 atttaaagca gttcattgca gccatgcatc cttgttaagg cctatcataa tttaggagat
     2101 cattcagttc atagaggttc atccaagaga ttctgatctg ccattcatat tcaggattgt
     2161 gatagaaggc aggaaagttg agagttttct gggtaggatg cttggcaatt taaaatggtc
     2221 taagtcattt tactctcaaa gaagtttcaa aatgtaaacc gattttattt tctgttcgtt
     2281 agagatcatg gaacacaaaa acaatgttat tttccataac tactaggatg agttgaattg
     2341 ttgtgggttc tgtgtttacc tcccctacgg aatttataat tgagtatgtt ttacactgta
     2401 tcatatagca aaaattttaa actacaggta gtcaagggcc gctacgatac atctgaggtc
     2461 ctttgatctt atttttctaa acttggcgca ctgtttttcc atagttttga tgactggcat
     2521 tttatagaca ccctggcagc cttactttta acacctgtaa caaatagtat tttttatgta
     2581 gttttcagaa taacatatgg tctcaagagt gggtaagagg cagtcagtaa tttccaggaa
     2641 gaattctgct tttcacaatt tgagattttt ttttaagctg taatatgatg gcagcttagt
     2701 atacatgttt gcttctaaag gtgtgtttac gatcgtcact ttatcagcat tcaatcagtg
     2761 ttaacaagtc agcagaaaag tgtaattagg cgaacagtag ggggaattcc cactctaaga
     2821 acccttttct ggtatttctc ttcaagctgt gaccactcag tgttctgtcc acagtccatt
     2881 cctctttgac tcttggaata gaaggtctta aaaagccttg ctagcagttg cttcttttaa
     2941 aatcttggag caactgttaa ttggacctga aagtggtaac ttgaaccctg gaaggtcttt
     3001 tatttactag ggctatttat tccactattt cttcagtaat aagagttact acctttgctg
     3061 gagacaaaag ggaacttctt tgttacctga ataacatagt gcaggtcaaa caaacaagca
     3121 aaaagttttc tttcagcctt cccggagttg agaatgtgac catctttagg agaaggtccc
     3181 gcactttaaa aataaaaaca aaaaatccaa ctctagagtt ccttatcaga aatgaatctc
     3241 aaccccttag tcaagaattt tctgtcgtct cttaatttgc acgtgagaaa tacttccata
     3301 tctcatgctc aggttttaat ctgatctttg tgagttctca attgtttttt tttttttttt
     3361 tctttttctt ttctgaactt gacttgcatt tgtgggtagg attggagcac actgttatca
     3421 aggcattcgg gggaatcaac ttggcagaca taacttgctg cttgtgtttg aggaaaacaa
     3481 acctgaccat aactggatta tttgacagtc atttgtaaat gctgagaggt ctgctgtgtg
     3541 gtaacacatc gctgctccaa cagtcccttg agtgacatgc ccaaaccatg tcactgcact
     3601 ttgccttggg aagtaccacg actggagaag tacccacgga tgagcagtgt gctccgaact
     3661 cgctttgcag gtttctgtct gatcatttaa ggaacttctt agctcttcca tagccagagc
     3721 gaggtagttc tgacttgcct cttttactaa tccttatctt agttctttct ggagaaatat
     3781 ccaactggtt ccttaacatg taagagaatg caccaaacca gagctatatc aaatgccaat
     3841 tgttggtttt gttttttttt ttttggcggg gggggggggg ggggttgtat cccttggtac
     3901 attttaaaaa catagcttcc tcggggatga aacatctcat catgccttcc ctatccccac
     3961 ttaccctaca cactctggaa tcacagtgaa aaggatattt atttctgaat gaggtaaata
     4021 agtttaaggc tcctgacttc tttgttttaa ctgcaacttg aggaagcatc tggatgtctg
     4081 tcagtgtgtc cctttcggct ctttgtgaac acctgcaggc atctgctatc tcttccttct
     4141 ctctgctagc acctgctcta ttaacaatca tgtacctacc tgccctggga tgacactgaa
     4201 tttaggtgta ctggaagagt tgtgtccttc ccctacgaag gtggtaccga tgtgctctgc
     4261 ctttctgatc ccattttatt ggaaaacctg atgtactcaa aggcgtgaac tataagggta
     4321 gattggctgt acatatgcac ttagcctttt ctttcttttt cagctgcatg gcacaagata
     4381 cagaaaaaaa agtagatagc tctgctgtga cagggacaaa tggggacaag ctgaattcaa
     4441 gatttgtggg ttacgataaa ctttgtggac atagtgctgt ctgagggacc ctcaatgact
     4501 gtatttgcct ctttttcacc aaagagaata ggagacatgg tagcacctaa aaataggtat
     4561 gaaggccaga taccaaataa atcaaattta cataaccgtt acaagaccag tttatttagg
     4621 tgacatttta cagttgagag agaatttgag gggcacgaaa atgggttatc ctctgtgttt
     4681 tccagtttgt caggaattta tcagatggct ctgccctaat tttgcccaga tttttttttt
     4741 tttatcacca gttccttctg gagaaacatg ctgcgtctct atagtagtga ttgattgctt
     4801 gttataaagg ctttttagaa cagtgagagc cgccagccca atgagcggta gagggaagtg
     4861 tgaaacactg tcattcaaac attccgttaa taattctctg gataaaatgg ggatgtgagg
     4921 gccaaccatt aagatttaga atgaagttgg ctgcctggct ggcatacata caggtcagtg
     4981 tttgaatgca gtacagtttg catgcacatg catattgcac attcttttaa tgaaaattca
     5041 cagaaaagaa gcaattagca ttgccagttg tattacaaaa gcttagagtt agaagtacag
     5101 tacagttact acgccagcag ttgggtctaa ttcagcaggt tgtattaaga aagccccatg
     5161 ttgtcagtgt gtctttaagg ctaatggcaa tttaaatcac aaatctccat tgtctgcatc
     5221 cagaaaaaca aacaaagcaa ggcaaaaaac aatgaaacaa tgaaaagata ttgagttgac
     5281 tggagaatat ttgaagaaat atagattttt tttgtgagag gaagaagttg caggaagtaa
     5341 tttagcaacc ttggcttgtg tttgtgcttc tctgacccag ttgcacacct cacaagtttg
     5401 gtctttccaa accttcatct tctctcctaa atgacaagtt agggtagaaa gattcatgga
     5461 agaggctgga gaggacaagg agagctgtct gcccctagat tcaggactgc gccttacact
     5521 gtccaagtca cctgccacat actgtcttag ccttgaaatt gtagattggt ggtgatcgtc
     5581 agttgtactt catgttattt taataactac tgtctgtata attattctac agcaaaagct
     5641 cccccaaatc caaaagggga aaaaagtgag ggatgaattg aaactttgta tatataaaag
     5701 ttattttata aatgttttag tcttccagtt tctgcaaaat aattaaaata tacagtaact
     5761 ggtctcttaa accctgaact taatgtatta aatacttata aaattttata ttggtgcctt
     5821 ttaaaaatgc attgagagtg ttggttagct ctttagctct accacacttt tactgtgtat
     5881 tttttaagaa aaaaaaaaat cacataaaat ctaagtactc tctaattcac ctttgtgttc
     5941 ttagaagaag aagaaaaaaa ctgctaaaag aatttccaga cttttagctg agctggcaaa
     6001 agtgacaaaa aaaaaaaaaa aaaaaacaaa ctttgaaacc agattttaat ctttttagct
     6061 tgatgatatt tctggacatt attctatggt agaggcaaaa tagaaggtag actcacatat
     6121 cagcaatgaa ttggattatg ctatatgttt tgatttcttc ttgaggaaga atatgttttg
     6181 catcacacag gggtttcttt gtataatttg gagtcagtaa ttacagtatt gctttgcttt
     6241 gttttaaata cccgactgat gttactctag tcttgggtct tctgtctctt ctgtcttcta
     6301 acctgtggtt gttttgtgaa atggcgtggg aatgcagatc attgtctcct cttgaacaag
     6361 acaaagctca gcacactagt cccgtgactg gtctccaaaa tgtcatctca gatgtgtagt
     6421 ctggggtcgt ctgtcacttc taaggggtgt cttcaactat gacagctttt taaaaacgag
     6481 ctgctggctg ggtaaagcag acatcatatg accaagaagc tgtgatacgc tagtgtttcc
     6541 ttctgtcatc gtgttgtact cttaggccaa ataatgacac cttgactgtt tttacattta
     6601 ctacagaaac ctaaactttt ggaattttca aaggttttta tgtaatgttc tatttcacag
     6661 cggtttcctt ttctcttgct gtactgagtc tgtgagtatt ttttttttca gatgcactct
     6721 tggaaataag ttctgaattc tgtttatggc gtttctctcg cttgacactc cgtgtataga
     6781 tgttctgtat aagtttgtta tgaatccacc tttctcatgt atggacagtg agaagtacat
     6841 gaacaactag tttcctaaga tgacttttat attatgaatt aatatgaaat ttacaggtca
     6901 tgtgcacctt aagtgcagaa tcaaaacttc ctataggtcc acataagcag ttctcagtga
     6961 accgggcctt cagtttacct caagtgacat gtagtaagga aagcccggga acatggaggt
     7021 cactctctgc agcacagtgc acttagtagc atgttgctga atctcagtta cagaaaatgg
     7081 atatttaaag gaacacactg gaaggatgca agggattgag ggactgctga tattttcgtt
     7141 gttgctgttg ctttgtgctt ttcaaaaagt tgttcaaatt atggaactgt gatctaaaaa
     7201 cggtttgaca gtggagcacc agagaggatg tccaccactc acttgccctt cggtacgact
     7261 aagctctgag tttgcgtctt caactctacc ttcctctccc ctcctcatcc ctactctgtc
     7321 tgtggccctc ctctcggtgt catttcctct tggtggctct cttgacactc ctactagtta
     7381 ggaggtcaac tctgaacttc tgactcatta aatcttaatt tttgtctcag tggttttagt
     7441 tagctgtgta gtctgctggc gtatttttat acccacgtgt agttttatat ttttaaagcg
     7501 tggttgagtt gacatggtgc actccgtagt ccttattttg cttcactctc aagtaggagg
     7561 cacctaacgt gactccagaa attctgtaat cagagtatcc gtctggctcc tttgtgcttg
     7621 gattttgatt tgtttggctt tcttcttaaa tacaaatcat acaagagtag actttccccc
     7681 caccatagag gataaaaatg taaagcaaag agtcttaact ttctcccaac cggggggcgg
     7741 ggcgagtgct gtcccacttc tgcagtgatg ttccaggctc agaggggtct ccagacccca
     7801 ggcttgcctg tcatcgggtc tcttcgaccc tgttatttgc agctttggga tggtttcttt
     7861 tgctatggag tttaacagct cttctttttt ccataaaagt gcaatacccc tcttgaagtc
     7921 ttaaaaacta tggtaatttt cttcttttct ttctctgaca tttgtctcat tagccaatga
     7981 tgaaaagaaa tctttggaaa ttctaacatg tcataggaca taggcaaata tggaaaccac
     8041 tctgctatga aaagttgaaa aaaaaaacgt attaacaaac gactcctctg actttctaga
     8101 aacttcgttt agactaaatt ttctttgaaa tcatgaatga aagtttatcc tgaggctgaa
     8161 atataatttt tctcccactc ttgtctaatg ctcttaagtt aaataactaa tatttaatgt
     8221 tttcatttct ctcattttgg aaaataaata tcaaagcact taggtcaggt ttaaatcaat
     8281 attacctgtt ggaaaaaaat ttttttacat atttaaagca gacctgtttc aatgcagatg
     8341 gagaagtatc ttttgtatta ttcatattta tatgtagtgt gttcttttct ttttttaata
     8401 cctgtgtttc tgtagtaaga ctgctgtaat gtaaatacac gttttattaa aaagtaacat
     8461 ttctttggca tttcttttga tggcacatac tgtattttta cagtatatgt cttggctact
     8521 taactttttt ttctttaata ataccaaagg taattagact attttaagga ctaattgctt
     8581 gacagtttct agactacttt gattttttta gaagaaaaaa gaaaaaagga taaaaaaaag
     8641 tcaaaccagt gaacctcatt ttttcaaact aataatttgg ggaaataaaa actattgttt
     8701 aaaaagaaat atatataaat atatatataa atatctgtaa aattaaaatc ccagaccttg
     8761 tatgtcaggt ttgctcagtg taatgtaggg tttttttttg ttttgttttt gtttttgttt
     8821 ttaaaggctc aaatacctca gaaaatgggg tttactatgg aaatactgcg acagtctctg
     8881 cagctgtgtg agctgtcatt ctgctgcata ctgattggga gacctccact aaacagtttt
     8941 atcactgcag actaaaatgt gggacttgta ttttctttgt ttttaatgca cacacgtgca
     9001 tgctctgtgc gtgtatgtgg gtaccgtgta tatgtgtgtg agtgttgtat atgcatgtgt
     9061 gaatgtgtgt gtgtgtgcgt gcttgtgtgt gtgtgtgcgt gcttgtgtgt gtgtgtgtgt
     9121 gtgtgtgtgt gtgtacaact gaagaagctg caaaaacttt gtaatacttt gtgaaagggt
     9181 tatattataa aggtttgtac tgtctgagtg cacagctact ggaataaact tagccaatct
     9241 caggaacaag catataattt gtccaagatt tatttcttct cagaagtgta agtgcagttt
     9301 ttaattctgt atattattta atattttacc aataaaataa acttctgaca gaaa
//
