LOCUS       NM_001404501            5217 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus IKAROS family zinc finger 1 (Ikzf1), transcript
            variant 18, mRNA.
ACCESSION   NM_001404501
VERSION     NM_001404501.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5217)
  AUTHORS   Ballasch,I., Lopez-Molina,L., Galan-Ganga,M., Sancho-Balsells,A.,
            Rodriguez-Navarro,I., Borras-Pernas,S., Rabadan,M.A., Chen,W.,
            Pasto-Pellicer,C., Flotta,F., Maoyu,W., Fernandez-Irigoyen,J.,
            Santamaria,E., Aguilar,R., Dobano,C., Egri,N., Hernandez,C.,
            Alfonso,M., Juan,M., Alberch,J., Del Toro,D., Arranz,B.,
            Canals,J.M. and Giralt,A.
  TITLE     Alterations of the IKZF1-IKZF2 tandem in immune cells of
            schizophrenia patients regulate associated phenotypes
  JOURNAL   J Neuroinflammation 21 (1), 326 (2024)
   PUBMED   39695786
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5217)
  AUTHORS   Ichiyama,K., Long,J., Kobayashi,Y., Horita,Y., Kinoshita,T.,
            Nakamura,Y., Kominami,C., Georgopoulos,K. and Sakaguchi,S.
  TITLE     Transcription factor Ikzf1 associates with Foxp3 to repress gene
            expression in Treg cells and limit autoimmunity and anti-tumor
            immunity
  JOURNAL   Immunity 57 (9), 2043-2060 (2024)
   PUBMED   39111316
REFERENCE   3  (bases 1 to 5217)
  AUTHORS   Hu,X., Wang,J., Yang,K., Fan,H., Wu,J., Ren,J., Han,G., Li,J.,
            Xue,Z., Liu,X. and Lv,X.
  TITLE     The GWAS SNP rs80207740 modulates erythrocyte traits via
            allele-specific binding of IKZF1 and targeting XPO7 gene
  JOURNAL   FASEB J 38 (10), e23666 (2024)
   PUBMED   38780091
  REMARK    GeneRIF: The GWAS SNP rs80207740 modulates erythrocyte traits via
            allele-specific binding of IKZF1 and targeting XPO7 gene.
REFERENCE   4  (bases 1 to 5217)
  AUTHORS   Thomas,R.M., Pahl,M.C., Wang,L., Grant,S.F.A., Hancock,W.W. and
            Wells,A.D.
  TITLE     Foxp3 depends on Ikaros for control of regulatory T cell gene
            expression and function
  JOURNAL   Elife 12, 91392 (2024)
   PUBMED   38655862
  REMARK    GeneRIF: Foxp3 depends on Ikaros for control of regulatory T cell
            gene expression and function.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5217)
  AUTHORS   Guo,P., Lim,R.C., Rajawasam,K., Trinh,T., Sun,H. and Zhang,H.
  TITLE     A methylation-phosphorylation switch controls EZH2 stability and
            hematopoiesis
  JOURNAL   Elife 13, e86168 (2024)
   PUBMED   38346162
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5217)
  AUTHORS   Winandy,S., Wu,P. and Georgopoulos,K.
  TITLE     A dominant mutation in the Ikaros gene leads to rapid development
            of leukemia and lymphoma
  JOURNAL   Cell 83 (2), 289-299 (1995)
   PUBMED   7585946
REFERENCE   7  (bases 1 to 5217)
  AUTHORS   Hahm,K., Ernst,P., Lo,K., Kim,G.S., Turck,C. and Smale,S.T.
  TITLE     The lymphoid transcription factor LyF-1 is encoded by specific,
            alternatively spliced mRNAs derived from the Ikaros gene
  JOURNAL   Mol Cell Biol 14 (11), 7111-7123 (1994)
   PUBMED   7935426
REFERENCE   8  (bases 1 to 5217)
  AUTHORS   Georgopoulos,K., Bigby,M., Wang,J.H., Molnar,A., Wu,P., Winandy,S.
            and Sharpe,A.
  TITLE     The Ikaros gene is required for the development of all lymphoid
            lineages
  JOURNAL   Cell 79 (1), 143-156 (1994)
   PUBMED   7923373
REFERENCE   9  (bases 1 to 5217)
  AUTHORS   Georgopoulos,K., Moore,D.D. and Derfler,B.
  TITLE     Ikaros, an early lymphoid-specific transcription factor and a
            putative mediator for T cell commitment
  JOURNAL   Science 258 (5083), 808-812 (1992)
   PUBMED   1439790
REFERENCE   10 (bases 1 to 5217)
  AUTHORS   Holm,H.H., Juul,N., Torp-Pedersen,S., Fredfeldt,K.E., Steven,K.,
            Hald,T., Larsen,S. and Hansen,U.
  TITLE     Bladder tumor staging by transurethral ultrasonic scanning
  JOURNAL   Eur Urol 15 (1-2), 31-33 (1988)
   PUBMED   3063539
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL596450.8.
            
            Summary: The protein encoded by this gene belongs to a family of
            transcription factors that are characterized by a set of four
            DNA-binding zinc fingers at the N-terminus and two C-terminal zinc
            fingers involved in protein dimerization. It is regulated by both
            epigenetic and transcription factors. This protein is a
            transcriptional regulator of hematopoietic cell development and
            homeostasis. In addition, it is required to confer temporal
            competence to retinal progenitor cells during embryogenesis,
            demonstrating an essential function in nervous system development.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Sep 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422600.1763633.1,
                                           SRR13422597.481770.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-168               AL596450.8         150422-150589       c
            169-306             AL596450.8         136117-136254       c
            307-360             AL596450.8         135330-135383       c
            361-480             AL596450.8         127684-127803       c
            481-741             AL596450.8         87017-87277         c
            742-909             AL596450.8         81414-81581         c
            910-1032            AL596450.8         77271-77393         c
            1033-1167           AL596450.8         74235-74369         c
            1168-5217           AL596450.8         62658-66707         c
FEATURES             Location/Qualifiers
     source          1..5217
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 7.02 cM"
     gene            1..5217
                     /gene="Ikzf1"
                     /gene_synonym="5832432G11Rik; hlk-1; Ikaros; LyF-1;
                     mKIAA4227; Zfpn1a1; Znfn1a1"
                     /note="IKAROS family zinc finger 1"
                     /db_xref="GeneID:22778"
                     /db_xref="MGI:MGI:1342540"
     exon            1..168
                     /gene="Ikzf1"
                     /gene_synonym="5832432G11Rik; hlk-1; Ikaros; LyF-1;
                     mKIAA4227; Zfpn1a1; Znfn1a1"
                     /inference="alignment:Splign:2.1.0"
     exon            169..306
                     /gene="Ikzf1"
                     /gene_synonym="5832432G11Rik; hlk-1; Ikaros; LyF-1;
                     mKIAA4227; Zfpn1a1; Znfn1a1"
                     /inference="alignment:Splign:2.1.0"
     exon            307..360
                     /gene="Ikzf1"
                     /gene_synonym="5832432G11Rik; hlk-1; Ikaros; LyF-1;
                     mKIAA4227; Zfpn1a1; Znfn1a1"
                     /inference="alignment:Splign:2.1.0"
     CDS             321..1868
                     /gene="Ikzf1"
                     /gene_synonym="5832432G11Rik; hlk-1; Ikaros; LyF-1;
                     mKIAA4227; Zfpn1a1; Znfn1a1"
                     /note="isoform 1 is encoded by transcript variant 18;
                     DNA-binding protein Ikaros; ikaros family zinc finger
                     protein 1; lymphoid transcription factor LyF-1; zinc
                     finger protein, subfamily 1A, 1 (Ikaros)"
                     /codon_start=1
                     /product="DNA-binding protein Ikaros isoform 1"
                     /protein_id="NP_001391430.1"
                     /db_xref="GeneID:22778"
                     /db_xref="MGI:MGI:1342540"
                     /translation="MDVDEGQDMSQVSGKESPPVSDTPDEGDEPMPVPEDLSTTSGAQ
                     QNSKSDRGMASNVKVETQSDEENGRACEMNGEECAEDLRMLDASGEKMNGSHRDQGSS
                     ALSGVGGIRLPNGKLKCDICGIVCIGPNVLMVHKRSHTGERPFQCNQCGASFTQKGNL
                     LRHIKLHSGEKPFKCHLCNYACRRRDALTGHLRTHSVGKPHKCGYCGRSYKQRSSLEE
                     HKERCHNYLESMGLPGMYPVIKEETNHNEMAEDLCKIGAERSLVLDRLASNVAKRKSS
                     MPQKFLGDKCLSDMPYDSANYEKEDMMTSHVMDQAINNAINYLGAESLRPLVQTPPGS
                     SEVVPVISSMYQLHKPPSDGPPRSNHSAQDAVDNLLLLSKAKSVSSEREASPSNSCQD
                     STDTESNAEEQRSGLIYLTNHINPHARNGLALKEEQRAYEVLRAASENSQDAFRVVST
                     SGEQLKVYKCEHCRVLFLDHVMYTIHMGCHGFRDPFECNMCGYHSQDRYEFSSHITRG
                     EHRYHLS"
     exon            361..480
                     /gene="Ikzf1"
                     /gene_synonym="5832432G11Rik; hlk-1; Ikaros; LyF-1;
                     mKIAA4227; Zfpn1a1; Znfn1a1"
                     /inference="alignment:Splign:2.1.0"
     exon            481..741
                     /gene="Ikzf1"
                     /gene_synonym="5832432G11Rik; hlk-1; Ikaros; LyF-1;
                     mKIAA4227; Zfpn1a1; Znfn1a1"
                     /inference="alignment:Splign:2.1.0"
     exon            742..909
                     /gene="Ikzf1"
                     /gene_synonym="5832432G11Rik; hlk-1; Ikaros; LyF-1;
                     mKIAA4227; Zfpn1a1; Znfn1a1"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1032
                     /gene="Ikzf1"
                     /gene_synonym="5832432G11Rik; hlk-1; Ikaros; LyF-1;
                     mKIAA4227; Zfpn1a1; Znfn1a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1167
                     /gene="Ikzf1"
                     /gene_synonym="5832432G11Rik; hlk-1; Ikaros; LyF-1;
                     mKIAA4227; Zfpn1a1; Znfn1a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..5217
                     /gene="Ikzf1"
                     /gene_synonym="5832432G11Rik; hlk-1; Ikaros; LyF-1;
                     mKIAA4227; Zfpn1a1; Znfn1a1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4310..4315
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ikzf1"
                     /gene_synonym="5832432G11Rik; hlk-1; Ikaros; LyF-1;
                     mKIAA4227; Zfpn1a1; Znfn1a1"
                     /note="hexamer: ATTAAA"
     polyA_site      4334
                     /gene="Ikzf1"
                     /gene_synonym="5832432G11Rik; hlk-1; Ikaros; LyF-1;
                     mKIAA4227; Zfpn1a1; Znfn1a1"
                     /note="major polyA site"
     polyA_site      4394
                     /gene="Ikzf1"
                     /gene_synonym="5832432G11Rik; hlk-1; Ikaros; LyF-1;
                     mKIAA4227; Zfpn1a1; Znfn1a1"
                     /note="major polyA site"
     regulatory      5000..5005
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ikzf1"
                     /gene_synonym="5832432G11Rik; hlk-1; Ikaros; LyF-1;
                     mKIAA4227; Zfpn1a1; Znfn1a1"
                     /note="hexamer: GATAAA"
     polyA_site      5033
                     /gene="Ikzf1"
                     /gene_synonym="5832432G11Rik; hlk-1; Ikaros; LyF-1;
                     mKIAA4227; Zfpn1a1; Znfn1a1"
     regulatory      5080..5085
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ikzf1"
                     /gene_synonym="5832432G11Rik; hlk-1; Ikaros; LyF-1;
                     mKIAA4227; Zfpn1a1; Znfn1a1"
                     /note="hexamer: ATTAAA"
     polyA_site      5108
                     /gene="Ikzf1"
                     /gene_synonym="5832432G11Rik; hlk-1; Ikaros; LyF-1;
                     mKIAA4227; Zfpn1a1; Znfn1a1"
     regulatory      5201..5206
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ikzf1"
                     /gene_synonym="5832432G11Rik; hlk-1; Ikaros; LyF-1;
                     mKIAA4227; Zfpn1a1; Znfn1a1"
                     /note="hexamer: AATACA"
     polyA_site      5217
                     /gene="Ikzf1"
                     /gene_synonym="5832432G11Rik; hlk-1; Ikaros; LyF-1;
                     mKIAA4227; Zfpn1a1; Znfn1a1"
ORIGIN      
        1 gcagtcctgt ctctacgcag gcactccgtg cctgacacgc cagggagagg tctgcggcgc
       61 cgtggagcat ggtgtaggat tgccttgctc ccacctctgt ccatagaccc cttccacgct
      121 ggcgtgtgca cacaggccgg gatggaaggc gccatcctaa cttcttctgt ccctccctga
      181 tatttgtggt agtctgtgta cagtttatgg agcactcacc tggcccacta taaggcagcc
      241 ttttcctatg ggtgttttca attcaaacca agatgaggag ccagccacag gcctgcaaag
      301 caggagataa cctgaagaca atggatgtcg atgagggtca agacatgtcc caagtttcag
      361 gaaaggagag ccccccagtc agtgacactc cagatgaagg ggatgagccc atgcctgtcc
      421 ctgaggacct gtccactacc tctggagcac agcagaactc caagagtgat cgaggcatgg
      481 ccagtaatgt taaagtagag actcagagtg atgaagagaa tgggcgtgcc tgtgaaatga
      541 atggggaaga atgtgcagag gatttacgaa tgcttgatgc ctcgggagag aaaatgaatg
      601 gctcccacag ggaccaaggc agctcggctt tgtcaggagt tggaggcatt cgacttccta
      661 acggaaaact aaagtgtgat atctgtggga tcgtttgcat cgggcccaat gtgctcatgg
      721 ttcacaaaag aagtcatact ggtgaacggc ctttccagtg caaccagtgt ggggcctcct
      781 ttacccagaa aggcaacctc ctgcggcaca tcaagctgca ctcgggtgag aagcccttca
      841 aatgccatct ttgcaactat gcctgccgcc ggagggacgc cctcaccggc cacctgagga
      901 cgcactccgt tggtaagcct cacaaatgtg gatattgtgg ccggagctat aaacagcgaa
      961 gctctttaga ggagcataaa gagcgatgcc acaactactt ggaaagcatg ggccttccgg
     1021 gcatgtaccc agtcattaag gaagaaacta accacaacga gatggcagaa gacctgtgca
     1081 agataggagc agagaggtcc cttgtcctgg acaggctggc aagcaatgtc gccaaacgta
     1141 agagctctat gcctcagaaa tttcttggag acaagtgcct gtcagacatg ccctatgaca
     1201 gtgccaacta tgagaaggag gatatgatga catcccacgt gatggaccag gccatcaaca
     1261 atgccatcaa ctacctgggg gctgagtccc tgcgcccatt ggtgcagaca ccccccggta
     1321 gctccgaggt ggtgccagtc atcagctcca tgtaccagct gcacaagccc ccctcagatg
     1381 gccccccacg gtccaaccat tcagcacagg acgccgtgga taacttgctg ctgctgtcca
     1441 aggccaagtc tgtgtcatcg gagcgagagg cctccccgag caacagctgc caagactcca
     1501 cagatacaga gagcaacgcg gaggaacagc gcagcggcct tatctaccta accaaccaca
     1561 tcaacccgca tgcacgcaat gggctggctc tcaaggagga gcagcgcgcc tacgaggtgc
     1621 tgagggcggc ctcagagaac tcgcaggatg ccttccgtgt ggtcagcacg agtggcgagc
     1681 agctgaaggt gtacaagtgc gaacactgcc gcgtgctctt cctggatcac gtcatgtata
     1741 ccattcacat gggctgccat ggctttcggg atccctttga gtgtaacatg tgtggttatc
     1801 acagccagga caggtacgag ttctcatccc atatcacgcg gggggagcat cgttaccacc
     1861 tgagctaaac ccagccaggc cccactgaag cacaaagata gctggttatg cctccttccc
     1921 ggcagctgga cccacagcgg acaatgttgg gagtggattt gcaggcagca tttgttcttt
     1981 tatgttggtt gtttggcgtt tgatttgcgt tggaagataa gtttttaatg ttagtgacag
     2041 gattgcattg catcaggaac attcacaaca tccatccttc tagccagttt tgttcactgg
     2101 tagctgaggt ttcccggata tgtggcttcc taacactctc cccacccacc ccacccccca
     2161 aaacagagcc tgaatcttca tgaagtgaat aaaacaatta tccaagaagg agtaaggtgg
     2221 atcttgccct aagcagagtt tatgccacaa agattctcca aatcccccaa gacagcacag
     2281 ccactggggt tgagccatct cagggagctc tgcaggtgag ccagaggacc agatataagg
     2341 cagctgggga ggagcaggga catcagcctg tgcagagacc aaggccaaag gttgaacttt
     2401 gaaagactat taagtcatat attgtatggc aatatggtgt ctggacaagt tgtgcaatgt
     2461 gctgaaggga agggattgga gagccttgaa gactcttctt catttgcctg atcaacccga
     2521 cctccagagg gtttgttgcc cagtaagacg agctcagtgc tcttgtgatc atttttctct
     2581 tatcgtttcc atgccgttga tggccctgaa gctcatcact gcattttaga acccaatcct
     2641 gaaattggga cctttttttt aaacttctga tactgtaaaa cttcttggaa gccaaagctt
     2701 tcttccaagc cccatcctca gttatcctgg ttcctgttct tccccgagct gatagtacca
     2761 ggacctgtta ttccacaaaa gcacaggcat ccgtcacttc aattcaatcc ctgttcagat
     2821 tatagatatg gactttgcta tcttgataaa tgtcttctct atgttatttt gtctgaaaaa
     2881 cctataaaac cattattaag aatgaccatt tttagatgga agaaatgagc ccagcatctc
     2941 agtggctaaa acacaaaata tccatgcttt taaacaaaat tgttaaatat tccgaagctc
     3001 tctagtataa acaccaagta gcatgtgttt tcacataaag aagacagggg ccatgcaacc
     3061 tttatcaagt ggaggtatta gaatgttgta atgtttggag acacagtgtg accagtacag
     3121 gttcccagag aggaatgccc accatatcac agaaaggtag aggtgggatc tggtatagcc
     3181 agaccaagac agggatgtca cgctgaagcc aagtcagtta gctgaagatt ctcaacagga
     3241 aggcctctct taagagtcag taatagggtt gttaccatcc accacctcaa caaaacaaaa
     3301 agcttataat tgtaaatgtt tacagcactg tcttcgcaga aactttctga ggtgattcca
     3361 aagaactaga ggggagatgg tctataacag ctcttgaagt aaacgaggtt cttagtctca
     3421 gctctcctga catatagggc ttgatcatta ctggtaggga ttgttctgtg aattgcttac
     3481 tactacccct ggtctctccc cagtagatgc caggaacatt ctagctgata cctaactgtc
     3541 ttcccaggtg ttcgagggag caaaccactg atctaaactc taaacgctga agtacgcagg
     3601 ttttctaaaa atgacaagcc cttgaaacct ttcccagtag gcagcctcga gctggacttg
     3661 tgtctttgga atgctgatga attctataga tcagcattgc aaatacactt caaatacgtc
     3721 tgagttcaag tgcagggact gagttcacca aggtgtgaaa tgtgctcaaa aagttcaaaa
     3781 gtgtgtgttt ctttgtttct aaaacattgt ggcatctttt tcatttgttt ctaaaacttt
     3841 ttttttagaa acaaatgaag cacttggaaa gtgaaagtaa aattacaaat ataaggattt
     3901 acactgaaga gagaaaaatt ttaggaacta tagctgtgaa aagattttgt tcaaaaggca
     3961 ggctagcctt acccaaattc atatatggca ggtgtcaacc tcccaagctt acagttagca
     4021 ggcagctttt gctcactcat ccttagccat gagagccatt aagtgtggtc caagaaagat
     4081 ggctccaaac cctacccccg acccaccagt ggtattcaga gattaaagca gaattgtaaa
     4141 tagtggcttc aggagctctt ttttagaatg ctttgcccct tcctctcact gcctttttta
     4201 gccaatataa atgtcaattt gcacaccttt tgttgtggtt ttatattgta acagcatttt
     4261 tttgaaacta ttgtatttaa gataaggttt catattatgt ccacaagtaa ttaaattatg
     4321 tttgaaggtg gctatatgct gtatcagaag ttgatgatgt ttttctttag ctggtaaagg
     4381 agggttttgc atgacctcac tgtttgttct gtggtttgtt ctgttgtatg atgtgtgtct
     4441 tgagttttgc tgtgtgatga agtgcgctga gattccagtg ccctcaagtt gtgttttaag
     4501 tagctatcag aggcaagagg gttcctaaga gcaggttgac ctgttggcga cagatggcaa
     4561 tcaccatttc tcattccttc ttctccctgt taccccagct tcctgtccca ggtcccttct
     4621 gtgattctta ccttagtgtg catgtgtgtc tgtcctggtg agagtcagga gcatcgatat
     4681 gttatcattg cattatcacc aagggcacgc acagcctagc acctgttgct tcagataccg
     4741 tcacactctg tttccaattt agatacaacc acataataaa atgttagagt cttcaatggg
     4801 aagcagaggt gcttgttata aagatggggg cttatgcttg tgtcacattt tgtgttcttt
     4861 tcttcttttg tttggtttta acttaattgt gacccttgta acatcatctt gccaaaaaaa
     4921 aaaaaaaagt tgaactggat ttatgtagac atgtcaagac gtactatcta tttctttgtc
     4981 agttatagca ataagagtgg ataaactcta aaatccagat ctcccacaat gaacatccgt
     5041 gttctttcta tgatttttct ttctttatgg tgagccacaa ttaaacttga gatgtacagc
     5101 cacccaaacc caggaagctc atgtgcatct ggtgctatgg cactcactgt gaataagtgt
     5161 gaccagatat taatatgcaa tattgtttcc aatcctttct aatacatttt ttcatga
//
