LOCUS       NM_001404490            5170 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus IKAROS family zinc finger 1 (Ikzf1), transcript
            variant 7, mRNA.
ACCESSION   NM_001404490 XM_011243702
VERSION     NM_001404490.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5170)
  AUTHORS   Ballasch,I., Lopez-Molina,L., Galan-Ganga,M., Sancho-Balsells,A.,
            Rodriguez-Navarro,I., Borras-Pernas,S., Rabadan,M.A., Chen,W.,
            Pasto-Pellicer,C., Flotta,F., Maoyu,W., Fernandez-Irigoyen,J.,
            Santamaria,E., Aguilar,R., Dobano,C., Egri,N., Hernandez,C.,
            Alfonso,M., Juan,M., Alberch,J., Del Toro,D., Arranz,B.,
            Canals,J.M. and Giralt,A.
  TITLE     Alterations of the IKZF1-IKZF2 tandem in immune cells of
            schizophrenia patients regulate associated phenotypes
  JOURNAL   J Neuroinflammation 21 (1), 326 (2024)
   PUBMED   39695786
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5170)
  AUTHORS   Ichiyama,K., Long,J., Kobayashi,Y., Horita,Y., Kinoshita,T.,
            Nakamura,Y., Kominami,C., Georgopoulos,K. and Sakaguchi,S.
  TITLE     Transcription factor Ikzf1 associates with Foxp3 to repress gene
            expression in Treg cells and limit autoimmunity and anti-tumor
            immunity
  JOURNAL   Immunity 57 (9), 2043-2060 (2024)
   PUBMED   39111316
REFERENCE   3  (bases 1 to 5170)
  AUTHORS   Hu,X., Wang,J., Yang,K., Fan,H., Wu,J., Ren,J., Han,G., Li,J.,
            Xue,Z., Liu,X. and Lv,X.
  TITLE     The GWAS SNP rs80207740 modulates erythrocyte traits via
            allele-specific binding of IKZF1 and targeting XPO7 gene
  JOURNAL   FASEB J 38 (10), e23666 (2024)
   PUBMED   38780091
  REMARK    GeneRIF: The GWAS SNP rs80207740 modulates erythrocyte traits via
            allele-specific binding of IKZF1 and targeting XPO7 gene.
REFERENCE   4  (bases 1 to 5170)
  AUTHORS   Thomas,R.M., Pahl,M.C., Wang,L., Grant,S.F.A., Hancock,W.W. and
            Wells,A.D.
  TITLE     Foxp3 depends on Ikaros for control of regulatory T cell gene
            expression and function
  JOURNAL   Elife 12, 91392 (2024)
   PUBMED   38655862
  REMARK    GeneRIF: Foxp3 depends on Ikaros for control of regulatory T cell
            gene expression and function.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5170)
  AUTHORS   Guo,P., Lim,R.C., Rajawasam,K., Trinh,T., Sun,H. and Zhang,H.
  TITLE     A methylation-phosphorylation switch controls EZH2 stability and
            hematopoiesis
  JOURNAL   Elife 13, e86168 (2024)
   PUBMED   38346162
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5170)
  AUTHORS   Winandy,S., Wu,P. and Georgopoulos,K.
  TITLE     A dominant mutation in the Ikaros gene leads to rapid development
            of leukemia and lymphoma
  JOURNAL   Cell 83 (2), 289-299 (1995)
   PUBMED   7585946
REFERENCE   7  (bases 1 to 5170)
  AUTHORS   Hahm,K., Ernst,P., Lo,K., Kim,G.S., Turck,C. and Smale,S.T.
  TITLE     The lymphoid transcription factor LyF-1 is encoded by specific,
            alternatively spliced mRNAs derived from the Ikaros gene
  JOURNAL   Mol Cell Biol 14 (11), 7111-7123 (1994)
   PUBMED   7935426
REFERENCE   8  (bases 1 to 5170)
  AUTHORS   Georgopoulos,K., Bigby,M., Wang,J.H., Molnar,A., Wu,P., Winandy,S.
            and Sharpe,A.
  TITLE     The Ikaros gene is required for the development of all lymphoid
            lineages
  JOURNAL   Cell 79 (1), 143-156 (1994)
   PUBMED   7923373
REFERENCE   9  (bases 1 to 5170)
  AUTHORS   Georgopoulos,K., Moore,D.D. and Derfler,B.
  TITLE     Ikaros, an early lymphoid-specific transcription factor and a
            putative mediator for T cell commitment
  JOURNAL   Science 258 (5083), 808-812 (1992)
   PUBMED   1439790
REFERENCE   10 (bases 1 to 5170)
  AUTHORS   Holm,H.H., Juul,N., Torp-Pedersen,S., Fredfeldt,K.E., Steven,K.,
            Hald,T., Larsen,S. and Hansen,U.
  TITLE     Bladder tumor staging by transurethral ultrasonic scanning
  JOURNAL   Eur Urol 15 (1-2), 31-33 (1988)
   PUBMED   3063539
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL596450.8.
            
            On Apr 12, 2022 this sequence version replaced XM_011243702.2.
            
            Summary: The protein encoded by this gene belongs to a family of
            transcription factors that are characterized by a set of four
            DNA-binding zinc fingers at the N-terminus and two C-terminal zinc
            fingers involved in protein dimerization. It is regulated by both
            epigenetic and transcription factors. This protein is a
            transcriptional regulator of hematopoietic cell development and
            homeostasis. In addition, it is required to confer temporal
            competence to retinal progenitor cells during embryogenesis,
            demonstrating an essential function in nervous system development.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Sep 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422589.513148.1,
                                           SRR13422598.1499785.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-199               AL596450.8         150391-150589       c
            200-253             AL596450.8         135330-135383       c
            254-373             AL596450.8         127684-127803       c
            374-433             AL596450.8         94579-94638         c
            434-694             AL596450.8         87017-87277         c
            695-862             AL596450.8         81414-81581         c
            863-985             AL596450.8         77271-77393         c
            986-1120            AL596450.8         74235-74369         c
            1121-5170           AL596450.8         62658-66707         c
FEATURES             Location/Qualifiers
     source          1..5170
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 7.02 cM"
     gene            1..5170
                     /gene="Ikzf1"
                     /gene_synonym="5832432G11Rik; hlk-1; Ikaros; LyF-1;
                     mKIAA4227; Zfpn1a1; Znfn1a1"
                     /note="IKAROS family zinc finger 1"
                     /db_xref="GeneID:22778"
                     /db_xref="MGI:MGI:1342540"
     exon            1..199
                     /gene="Ikzf1"
                     /gene_synonym="5832432G11Rik; hlk-1; Ikaros; LyF-1;
                     mKIAA4227; Zfpn1a1; Znfn1a1"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..1821
                     /gene="Ikzf1"
                     /gene_synonym="5832432G11Rik; hlk-1; Ikaros; LyF-1;
                     mKIAA4227; Zfpn1a1; Znfn1a1"
                     /note="isoform 5 is encoded by transcript variant 7;
                     DNA-binding protein Ikaros; ikaros family zinc finger
                     protein 1; lymphoid transcription factor LyF-1; zinc
                     finger protein, subfamily 1A, 1 (Ikaros)"
                     /codon_start=1
                     /product="DNA-binding protein Ikaros isoform 5"
                     /protein_id="NP_001391419.1"
                     /db_xref="GeneID:22778"
                     /db_xref="MGI:MGI:1342540"
                     /translation="MEGAILTSSVSRWEGRDARDNLKTMDVDEGQDMSQVSGKESPPV
                     SDTPDEGDEPMPVPEDLSTTSGAQQNSKSDRGMVAYGADGFRDFHAIIPKSFSPSNVK
                     VETQSDEENGRACEMNGEECAEDLRMLDASGEKMNGSHRDQGSSALSGVGGIRLPNGK
                     LKCDICGIVCIGPNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHSGEKPFK
                     CHLCNYACRRRDALTGHLRTHSVGKPHKCGYCGRSYKQRSSLEEHKERCHNYLESMGL
                     PGMYPVIKEETNHNEMAEDLCKIGAERSLVLDRLASNVAKRKSSMPQKFLGDKCLSDM
                     PYDSANYEKEDMMTSHVMDQAINNAINYLGAESLRPLVQTPPGSSEVVPVISSMYQLH
                     KPPSDGPPRSNHSAQDAVDNLLLLSKAKSVSSEREASPSNSCQDSTDTESNAEEQRSG
                     LIYLTNHINPHARNGLALKEEQRAYEVLRAASENSQDAFRVVSTSGEQLKVYKCEHCR
                     VLFLDHVMYTIHMGCHGFRDPFECNMCGYHSQDRYEFSSHITRGEHRYHLS"
     exon            200..253
                     /gene="Ikzf1"
                     /gene_synonym="5832432G11Rik; hlk-1; Ikaros; LyF-1;
                     mKIAA4227; Zfpn1a1; Znfn1a1"
                     /inference="alignment:Splign:2.1.0"
     exon            254..373
                     /gene="Ikzf1"
                     /gene_synonym="5832432G11Rik; hlk-1; Ikaros; LyF-1;
                     mKIAA4227; Zfpn1a1; Znfn1a1"
                     /inference="alignment:Splign:2.1.0"
     exon            374..433
                     /gene="Ikzf1"
                     /gene_synonym="5832432G11Rik; hlk-1; Ikaros; LyF-1;
                     mKIAA4227; Zfpn1a1; Znfn1a1"
                     /inference="alignment:Splign:2.1.0"
     exon            434..694
                     /gene="Ikzf1"
                     /gene_synonym="5832432G11Rik; hlk-1; Ikaros; LyF-1;
                     mKIAA4227; Zfpn1a1; Znfn1a1"
                     /inference="alignment:Splign:2.1.0"
     exon            695..862
                     /gene="Ikzf1"
                     /gene_synonym="5832432G11Rik; hlk-1; Ikaros; LyF-1;
                     mKIAA4227; Zfpn1a1; Znfn1a1"
                     /inference="alignment:Splign:2.1.0"
     exon            863..985
                     /gene="Ikzf1"
                     /gene_synonym="5832432G11Rik; hlk-1; Ikaros; LyF-1;
                     mKIAA4227; Zfpn1a1; Znfn1a1"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1120
                     /gene="Ikzf1"
                     /gene_synonym="5832432G11Rik; hlk-1; Ikaros; LyF-1;
                     mKIAA4227; Zfpn1a1; Znfn1a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..5170
                     /gene="Ikzf1"
                     /gene_synonym="5832432G11Rik; hlk-1; Ikaros; LyF-1;
                     mKIAA4227; Zfpn1a1; Znfn1a1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4263..4268
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ikzf1"
                     /gene_synonym="5832432G11Rik; hlk-1; Ikaros; LyF-1;
                     mKIAA4227; Zfpn1a1; Znfn1a1"
                     /note="hexamer: ATTAAA"
     polyA_site      4287
                     /gene="Ikzf1"
                     /gene_synonym="5832432G11Rik; hlk-1; Ikaros; LyF-1;
                     mKIAA4227; Zfpn1a1; Znfn1a1"
                     /note="major polyA site"
     polyA_site      4347
                     /gene="Ikzf1"
                     /gene_synonym="5832432G11Rik; hlk-1; Ikaros; LyF-1;
                     mKIAA4227; Zfpn1a1; Znfn1a1"
                     /note="major polyA site"
     regulatory      4953..4958
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ikzf1"
                     /gene_synonym="5832432G11Rik; hlk-1; Ikaros; LyF-1;
                     mKIAA4227; Zfpn1a1; Znfn1a1"
                     /note="hexamer: GATAAA"
     polyA_site      4986
                     /gene="Ikzf1"
                     /gene_synonym="5832432G11Rik; hlk-1; Ikaros; LyF-1;
                     mKIAA4227; Zfpn1a1; Znfn1a1"
     regulatory      5033..5038
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ikzf1"
                     /gene_synonym="5832432G11Rik; hlk-1; Ikaros; LyF-1;
                     mKIAA4227; Zfpn1a1; Znfn1a1"
                     /note="hexamer: ATTAAA"
     polyA_site      5061
                     /gene="Ikzf1"
                     /gene_synonym="5832432G11Rik; hlk-1; Ikaros; LyF-1;
                     mKIAA4227; Zfpn1a1; Znfn1a1"
     regulatory      5154..5159
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ikzf1"
                     /gene_synonym="5832432G11Rik; hlk-1; Ikaros; LyF-1;
                     mKIAA4227; Zfpn1a1; Znfn1a1"
                     /note="hexamer: AATACA"
     polyA_site      5170
                     /gene="Ikzf1"
                     /gene_synonym="5832432G11Rik; hlk-1; Ikaros; LyF-1;
                     mKIAA4227; Zfpn1a1; Znfn1a1"
ORIGIN      
        1 gcagtcctgt ctctacgcag gcactccgtg cctgacacgc cagggagagg tctgcggcgc
       61 cgtggagcat ggtgtaggat tgccttgctc ccacctctgt ccatagaccc cttccacgct
      121 ggcgtgtgca cacaggccgg gatggaaggc gccatcctaa cttcttctgt gagcaggtgg
      181 gagggaagag acgcgagaga taacctgaag acaatggatg tcgatgaggg tcaagacatg
      241 tcccaagttt caggaaagga gagcccccca gtcagtgaca ctccagatga aggggatgag
      301 cccatgcctg tccctgagga cctgtccact acctctggag cacagcagaa ctccaagagt
      361 gatcgaggca tggttgcata tggggctgat ggctttaggg attttcatgc aataattccc
      421 aaatctttct ctcccagtaa tgttaaagta gagactcaga gtgatgaaga gaatgggcgt
      481 gcctgtgaaa tgaatgggga agaatgtgca gaggatttac gaatgcttga tgcctcggga
      541 gagaaaatga atggctccca cagggaccaa ggcagctcgg ctttgtcagg agttggaggc
      601 attcgacttc ctaacggaaa actaaagtgt gatatctgtg ggatcgtttg catcgggccc
      661 aatgtgctca tggttcacaa aagaagtcat actggtgaac ggcctttcca gtgcaaccag
      721 tgtggggcct cctttaccca gaaaggcaac ctcctgcggc acatcaagct gcactcgggt
      781 gagaagccct tcaaatgcca tctttgcaac tatgcctgcc gccggaggga cgccctcacc
      841 ggccacctga ggacgcactc cgttggtaag cctcacaaat gtggatattg tggccggagc
      901 tataaacagc gaagctcttt agaggagcat aaagagcgat gccacaacta cttggaaagc
      961 atgggccttc cgggcatgta cccagtcatt aaggaagaaa ctaaccacaa cgagatggca
     1021 gaagacctgt gcaagatagg agcagagagg tcccttgtcc tggacaggct ggcaagcaat
     1081 gtcgccaaac gtaagagctc tatgcctcag aaatttcttg gagacaagtg cctgtcagac
     1141 atgccctatg acagtgccaa ctatgagaag gaggatatga tgacatccca cgtgatggac
     1201 caggccatca acaatgccat caactacctg ggggctgagt ccctgcgccc attggtgcag
     1261 acaccccccg gtagctccga ggtggtgcca gtcatcagct ccatgtacca gctgcacaag
     1321 cccccctcag atggcccccc acggtccaac cattcagcac aggacgccgt ggataacttg
     1381 ctgctgctgt ccaaggccaa gtctgtgtca tcggagcgag aggcctcccc gagcaacagc
     1441 tgccaagact ccacagatac agagagcaac gcggaggaac agcgcagcgg ccttatctac
     1501 ctaaccaacc acatcaaccc gcatgcacgc aatgggctgg ctctcaagga ggagcagcgc
     1561 gcctacgagg tgctgagggc ggcctcagag aactcgcagg atgccttccg tgtggtcagc
     1621 acgagtggcg agcagctgaa ggtgtacaag tgcgaacact gccgcgtgct cttcctggat
     1681 cacgtcatgt ataccattca catgggctgc catggctttc gggatccctt tgagtgtaac
     1741 atgtgtggtt atcacagcca ggacaggtac gagttctcat cccatatcac gcggggggag
     1801 catcgttacc acctgagcta aacccagcca ggccccactg aagcacaaag atagctggtt
     1861 atgcctcctt cccggcagct ggacccacag cggacaatgt tgggagtgga tttgcaggca
     1921 gcatttgttc ttttatgttg gttgtttggc gtttgatttg cgttggaaga taagttttta
     1981 atgttagtga caggattgca ttgcatcagg aacattcaca acatccatcc ttctagccag
     2041 ttttgttcac tggtagctga ggtttcccgg atatgtggct tcctaacact ctccccaccc
     2101 accccacccc ccaaaacaga gcctgaatct tcatgaagtg aataaaacaa ttatccaaga
     2161 aggagtaagg tggatcttgc cctaagcaga gtttatgcca caaagattct ccaaatcccc
     2221 caagacagca cagccactgg ggttgagcca tctcagggag ctctgcaggt gagccagagg
     2281 accagatata aggcagctgg ggaggagcag ggacatcagc ctgtgcagag accaaggcca
     2341 aaggttgaac tttgaaagac tattaagtca tatattgtat ggcaatatgg tgtctggaca
     2401 agttgtgcaa tgtgctgaag ggaagggatt ggagagcctt gaagactctt cttcatttgc
     2461 ctgatcaacc cgacctccag agggtttgtt gcccagtaag acgagctcag tgctcttgtg
     2521 atcatttttc tcttatcgtt tccatgccgt tgatggccct gaagctcatc actgcatttt
     2581 agaacccaat cctgaaattg ggaccttttt tttaaacttc tgatactgta aaacttcttg
     2641 gaagccaaag ctttcttcca agccccatcc tcagttatcc tggttcctgt tcttccccga
     2701 gctgatagta ccaggacctg ttattccaca aaagcacagg catccgtcac ttcaattcaa
     2761 tccctgttca gattatagat atggactttg ctatcttgat aaatgtcttc tctatgttat
     2821 tttgtctgaa aaacctataa aaccattatt aagaatgacc atttttagat ggaagaaatg
     2881 agcccagcat ctcagtggct aaaacacaaa atatccatgc ttttaaacaa aattgttaaa
     2941 tattccgaag ctctctagta taaacaccaa gtagcatgtg ttttcacata aagaagacag
     3001 gggccatgca acctttatca agtggaggta ttagaatgtt gtaatgtttg gagacacagt
     3061 gtgaccagta caggttccca gagaggaatg cccaccatat cacagaaagg tagaggtggg
     3121 atctggtata gccagaccaa gacagggatg tcacgctgaa gccaagtcag ttagctgaag
     3181 attctcaaca ggaaggcctc tcttaagagt cagtaatagg gttgttacca tccaccacct
     3241 caacaaaaca aaaagcttat aattgtaaat gtttacagca ctgtcttcgc agaaactttc
     3301 tgaggtgatt ccaaagaact agaggggaga tggtctataa cagctcttga agtaaacgag
     3361 gttcttagtc tcagctctcc tgacatatag ggcttgatca ttactggtag ggattgttct
     3421 gtgaattgct tactactacc cctggtctct ccccagtaga tgccaggaac attctagctg
     3481 atacctaact gtcttcccag gtgttcgagg gagcaaacca ctgatctaaa ctctaaacgc
     3541 tgaagtacgc aggttttcta aaaatgacaa gcccttgaaa cctttcccag taggcagcct
     3601 cgagctggac ttgtgtcttt ggaatgctga tgaattctat agatcagcat tgcaaataca
     3661 cttcaaatac gtctgagttc aagtgcaggg actgagttca ccaaggtgtg aaatgtgctc
     3721 aaaaagttca aaagtgtgtg tttctttgtt tctaaaacat tgtggcatct ttttcatttg
     3781 tttctaaaac ttttttttta gaaacaaatg aagcacttgg aaagtgaaag taaaattaca
     3841 aatataagga tttacactga agagagaaaa attttaggaa ctatagctgt gaaaagattt
     3901 tgttcaaaag gcaggctagc cttacccaaa ttcatatatg gcaggtgtca acctcccaag
     3961 cttacagtta gcaggcagct tttgctcact catccttagc catgagagcc attaagtgtg
     4021 gtccaagaaa gatggctcca aaccctaccc ccgacccacc agtggtattc agagattaaa
     4081 gcagaattgt aaatagtggc ttcaggagct cttttttaga atgctttgcc ccttcctctc
     4141 actgcctttt ttagccaata taaatgtcaa tttgcacacc ttttgttgtg gttttatatt
     4201 gtaacagcat ttttttgaaa ctattgtatt taagataagg tttcatatta tgtccacaag
     4261 taattaaatt atgtttgaag gtggctatat gctgtatcag aagttgatga tgtttttctt
     4321 tagctggtaa aggagggttt tgcatgacct cactgtttgt tctgtggttt gttctgttgt
     4381 atgatgtgtg tcttgagttt tgctgtgtga tgaagtgcgc tgagattcca gtgccctcaa
     4441 gttgtgtttt aagtagctat cagaggcaag agggttccta agagcaggtt gacctgttgg
     4501 cgacagatgg caatcaccat ttctcattcc ttcttctccc tgttacccca gcttcctgtc
     4561 ccaggtccct tctgtgattc ttaccttagt gtgcatgtgt gtctgtcctg gtgagagtca
     4621 ggagcatcga tatgttatca ttgcattatc accaagggca cgcacagcct agcacctgtt
     4681 gcttcagata ccgtcacact ctgtttccaa tttagataca accacataat aaaatgttag
     4741 agtcttcaat gggaagcaga ggtgcttgtt ataaagatgg gggcttatgc ttgtgtcaca
     4801 ttttgtgttc ttttcttctt ttgtttggtt ttaacttaat tgtgaccctt gtaacatcat
     4861 cttgccaaaa aaaaaaaaaa agttgaactg gatttatgta gacatgtcaa gacgtactat
     4921 ctatttcttt gtcagttata gcaataagag tggataaact ctaaaatcca gatctcccac
     4981 aatgaacatc cgtgttcttt ctatgatttt tctttcttta tggtgagcca caattaaact
     5041 tgagatgtac agccacccaa acccaggaag ctcatgtgca tctggtgcta tggcactcac
     5101 tgtgaataag tgtgaccaga tattaatatg caatattgtt tccaatcctt tctaatacat
     5161 tttttcatga
//
