LOCUS       NP_001391419             559 aa            linear   ROD 26-MAR-2025
DEFINITION  DNA-binding protein Ikaros isoform 5 [Mus musculus].
ACCESSION   NP_001391419 XP_011242004
VERSION     NP_001391419.1
DBSOURCE    REFSEQ: accession NM_001404490.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 559)
  AUTHORS   Ballasch,I., Lopez-Molina,L., Galan-Ganga,M., Sancho-Balsells,A.,
            Rodriguez-Navarro,I., Borras-Pernas,S., Rabadan,M.A., Chen,W.,
            Pasto-Pellicer,C., Flotta,F., Maoyu,W., Fernandez-Irigoyen,J.,
            Santamaria,E., Aguilar,R., Dobano,C., Egri,N., Hernandez,C.,
            Alfonso,M., Juan,M., Alberch,J., Del Toro,D., Arranz,B.,
            Canals,J.M. and Giralt,A.
  TITLE     Alterations of the IKZF1-IKZF2 tandem in immune cells of
            schizophrenia patients regulate associated phenotypes
  JOURNAL   J Neuroinflammation 21 (1), 326 (2024)
   PUBMED   39695786
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 559)
  AUTHORS   Ichiyama,K., Long,J., Kobayashi,Y., Horita,Y., Kinoshita,T.,
            Nakamura,Y., Kominami,C., Georgopoulos,K. and Sakaguchi,S.
  TITLE     Transcription factor Ikzf1 associates with Foxp3 to repress gene
            expression in Treg cells and limit autoimmunity and anti-tumor
            immunity
  JOURNAL   Immunity 57 (9), 2043-2060 (2024)
   PUBMED   39111316
REFERENCE   3  (residues 1 to 559)
  AUTHORS   Fedl,A.S., Tagoh,H., Gruenbacher,S., Sun,Q., Schenk,R.L.,
            Froussios,K., Jaritz,M., Busslinger,M. and Schwickert,T.A.
  TITLE     Transcriptional function of E2A, Ebf1, Pax5, Ikaros and Aiolos
            analyzed by in vivo acute protein degradation in early B cell
            development
  JOURNAL   Nat Immunol 25 (9), 1663-1677 (2024)
   PUBMED   39179932
  REMARK    Erratum:[Nat Immunol. 2025 Mar 21. doi: 10.1038/s41590-025-02139-1.
            PMID: 40119193]
REFERENCE   4  (residues 1 to 559)
  AUTHORS   Hu,X., Wang,J., Yang,K., Fan,H., Wu,J., Ren,J., Han,G., Li,J.,
            Xue,Z., Liu,X. and Lv,X.
  TITLE     The GWAS SNP rs80207740 modulates erythrocyte traits via
            allele-specific binding of IKZF1 and targeting XPO7 gene
  JOURNAL   FASEB J 38 (10), e23666 (2024)
   PUBMED   38780091
  REMARK    GeneRIF: The GWAS SNP rs80207740 modulates erythrocyte traits via
            allele-specific binding of IKZF1 and targeting XPO7 gene.
REFERENCE   5  (residues 1 to 559)
  AUTHORS   Thomas,R.M., Pahl,M.C., Wang,L., Grant,S.F.A., Hancock,W.W. and
            Wells,A.D.
  TITLE     Foxp3 depends on Ikaros for control of regulatory T cell gene
            expression and function
  JOURNAL   Elife 12, 91392 (2024)
   PUBMED   38655862
  REMARK    GeneRIF: Foxp3 depends on Ikaros for control of regulatory T cell
            gene expression and function.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 559)
  AUTHORS   Winandy,S., Wu,P. and Georgopoulos,K.
  TITLE     A dominant mutation in the Ikaros gene leads to rapid development
            of leukemia and lymphoma
  JOURNAL   Cell 83 (2), 289-299 (1995)
   PUBMED   7585946
REFERENCE   7  (residues 1 to 559)
  AUTHORS   Hahm,K., Ernst,P., Lo,K., Kim,G.S., Turck,C. and Smale,S.T.
  TITLE     The lymphoid transcription factor LyF-1 is encoded by specific,
            alternatively spliced mRNAs derived from the Ikaros gene
  JOURNAL   Mol Cell Biol 14 (11), 7111-7123 (1994)
   PUBMED   7935426
REFERENCE   8  (residues 1 to 559)
  AUTHORS   Georgopoulos,K., Bigby,M., Wang,J.H., Molnar,A., Wu,P., Winandy,S.
            and Sharpe,A.
  TITLE     The Ikaros gene is required for the development of all lymphoid
            lineages
  JOURNAL   Cell 79 (1), 143-156 (1994)
   PUBMED   7923373
REFERENCE   9  (residues 1 to 559)
  AUTHORS   Georgopoulos,K., Moore,D.D. and Derfler,B.
  TITLE     Ikaros, an early lymphoid-specific transcription factor and a
            putative mediator for T cell commitment
  JOURNAL   Science 258 (5083), 808-812 (1992)
   PUBMED   1439790
REFERENCE   10 (residues 1 to 559)
  AUTHORS   Holm,H.H., Juul,N., Torp-Pedersen,S., Fredfeldt,K.E., Steven,K.,
            Hald,T., Larsen,S. and Hansen,U.
  TITLE     Bladder tumor staging by transurethral ultrasonic scanning
  JOURNAL   Eur Urol 15 (1-2), 31-33 (1988)
   PUBMED   3063539
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL596450.8.
            
            On Apr 12, 2022 this sequence version replaced XP_011242004.1.
            
            Summary: The protein encoded by this gene belongs to a family of
            transcription factors that are characterized by a set of four
            DNA-binding zinc fingers at the N-terminus and two C-terminal zinc
            fingers involved in protein dimerization. It is regulated by both
            epigenetic and transcription factors. This protein is a
            transcriptional regulator of hematopoietic cell development and
            homeostasis. In addition, it is required to confer temporal
            competence to retinal progenitor cells during embryogenesis,
            demonstrating an essential function in nervous system development.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Sep 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422589.513148.1,
                                           SRR13422598.1499785.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..559
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 7.02 cM"
     Protein         1..559
                     /product="DNA-binding protein Ikaros isoform 5"
                     /note="DNA-binding protein Ikaros; ikaros family zinc
                     finger protein 1; lymphoid transcription factor LyF-1;
                     zinc finger protein, subfamily 1A, 1 (Ikaros)"
                     /calculated_mol_wt=61953
     Region          163..183
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(168,170,172,174..175,178..179,182,196,198,202..203,
                     206..207,210,224,226,228,230..231,234..235,238)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          176..200
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          187..>535
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          191..211
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          203..228
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          219..239
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          247..268
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..559
                     /gene="Ikzf1"
                     /gene_synonym="5832432G11Rik; hlk-1; Ikaros; LyF-1;
                     mKIAA4227; Zfpn1a1; Znfn1a1"
                     /coded_by="NM_001404490.1:142..1821"
                     /note="isoform 5 is encoded by transcript variant 7"
                     /db_xref="GeneID:22778"
                     /db_xref="MGI:MGI:1342540"
ORIGIN      
        1 megailtssv srwegrdard nlktmdvdeg qdmsqvsgke sppvsdtpde gdepmpvped
       61 lsttsgaqqn sksdrgmvay gadgfrdfha iipksfspsn vkvetqsdee ngracemnge
      121 ecaedlrmld asgekmngsh rdqgssalsg vggirlpngk lkcdicgivc igpnvlmvhk
      181 rshtgerpfq cnqcgasftq kgnllrhikl hsgekpfkch lcnyacrrrd altghlrths
      241 vgkphkcgyc grsykqrssl eehkerchny lesmglpgmy pvikeetnhn emaedlckig
      301 aerslvldrl asnvakrkss mpqkflgdkc lsdmpydsan yekedmmtsh vmdqainnai
      361 nylgaeslrp lvqtppgsse vvpvissmyq lhkppsdgpp rsnhsaqdav dnllllskak
      421 svssereasp snscqdstdt esnaeeqrsg liyltnhinp harnglalke eqrayevlra
      481 asensqdafr vvstsgeqlk vykcehcrvl fldhvmytih mgchgfrdpf ecnmcgyhsq
      541 dryefsshit rgehryhls
//
