LOCUS       NM_010547               6814 bp    mRNA    linear   ROD 04-OCT-2024
DEFINITION  Mus musculus inhibitor of kappaB kinase gamma (Ikbkg), transcript
            variant 1, mRNA.
ACCESSION   NM_010547
VERSION     NM_010547.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6814)
  AUTHORS   Tsesmelis,M., Buttner,U.F.G., Gerstenlauer,M., Manfras,U.,
            Tsesmelis,K., Du,Z., Sperb,N., Weissinger,S.E., Moller,P.,
            Barth,T.F.E., Maier,H.J., Chan,L.K. and Wirth,T.
  TITLE     NEMO/NF-kappaB signaling functions as a double-edged sword in PanIN
            formation versus progression to pancreatic cancer
  JOURNAL   Mol Cancer 23 (1), 103 (2024)
   PUBMED   38755681
  REMARK    GeneRIF: NEMO/NF-kappaB signaling functions as a double-edged sword
            in PanIN formation versus progression to pancreatic cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6814)
  AUTHORS   Harding,O., Holzer,E., Riley,J.F., Martens,S. and Holzbaur,E.L.F.
  TITLE     Damaged mitochondria recruit the effector NEMO to activate
            NF-kappaB signaling
  JOURNAL   Mol Cell 83 (17), 3188-3204 (2023)
   PUBMED   37683611
  REMARK    GeneRIF: Damaged mitochondria recruit the effector NEMO to activate
            NF-kappaB signaling.
REFERENCE   3  (bases 1 to 6814)
  AUTHORS   Tang,X., Weng,R., Guo,G., Wei,J., Wu,X., Chen,B., Liu,S., Zhong,Z.
            and Chen,X.
  TITLE     USP10 regulates macrophage inflammation responses via stabilizing
            NEMO in LPS-induced sepsis
  JOURNAL   Inflamm Res 72 (8), 1621-1632 (2023)
   PUBMED   37436447
  REMARK    GeneRIF: USP10 regulates macrophage inflammation responses via
            stabilizing NEMO in LPS-induced sepsis.
REFERENCE   4  (bases 1 to 6814)
  AUTHORS   Vucur,M., Ghallab,A., Schneider,A.T., Adili,A., Cheng,M.,
            Castoldi,M., Singer,M.T., Buttner,V., Keysberg,L.S., Kusgens,L.,
            Kohlhepp,M., Gorg,B., Gallage,S., Barragan Avila,J.E., Unger,K.,
            Kordes,C., Leblond,A.L., Albrecht,W., Loosen,S.H., Lohr,C.,
            Jordens,M.S., Babler,A., Hayat,S., Schumacher,D., Koenen,M.T.,
            Govaere,O., Boekschoten,M.V., Jors,S., Villacorta-Martin,C.,
            Mazzaferro,V., Llovet,J.M., Weiskirchen,R., Kather,J.N.,
            Starlinger,P., Trauner,M., Luedde,M., Heij,L.R., Neumann,U.P.,
            Keitel,V., Bode,J.G., Schneider,R.K., Tacke,F., Levkau,B.,
            Lammers,T., Fluegen,G., Alexandrov,T., Collins,A.L., Nelson,G.,
            Oakley,F., Mann,D.A., Roderburg,C., Longerich,T., Weber,A.,
            Villanueva,A., Samson,A.L., Murphy,J.M., Kramann,R., Geisler,F.,
            Costa,I.G., Hengstler,J.G., Heikenwalder,M. and Luedde,T.
  TITLE     Sublethal necroptosis signaling promotes inflammation and liver
            cancer
  JOURNAL   Immunity 56 (7), 1578-1595 (2023)
   PUBMED   37329888
REFERENCE   5  (bases 1 to 6814)
  AUTHORS   Koerner,L., Schmiel,M., Yang,T.P., Peifer,M., Buettner,R. and
            Pasparakis,M.
  TITLE     NEMO- and RelA-dependent NF-kappaB signaling promotes small cell
            lung cancer
  JOURNAL   Cell Death Differ 30 (4), 938-951 (2023)
   PUBMED   36653597
  REMARK    GeneRIF: NEMO- and RelA-dependent NF-kappaB signaling promotes
            small cell lung cancer.
REFERENCE   6  (bases 1 to 6814)
  AUTHORS   Maniatis,T.
  TITLE     A ubiquitin ligase complex essential for the NF-kappaB,
            Wnt/Wingless, and Hedgehog signaling pathways
  JOURNAL   Genes Dev 13 (5), 505-510 (1999)
   PUBMED   10072378
  REMARK    Review article
REFERENCE   7  (bases 1 to 6814)
  AUTHORS   Li,Y., Kang,J., Friedman,J., Tarassishin,L., Ye,J., Kovalenko,A.,
            Wallach,D. and Horwitz,M.S.
  TITLE     Identification of a cell protein (FIP-3) as a modulator of
            NF-kappaB activity and as a target of an adenovirus inhibitor of
            tumor necrosis factor alpha-induced apoptosis
  JOURNAL   Proc Natl Acad Sci U S A 96 (3), 1042-1047 (1999)
   PUBMED   9927690
REFERENCE   8  (bases 1 to 6814)
  AUTHORS   Mercurio,F., Murray,B.W., Shevchenko,A., Bennett,B.L., Young,D.B.,
            Li,J.W., Pascual,G., Motiwala,A., Zhu,H., Mann,M. and Manning,A.M.
  TITLE     IkappaB kinase (IKK)-associated protein 1, a common component of
            the heterogeneous IKK complex
  JOURNAL   Mol Cell Biol 19 (2), 1526-1538 (1999)
   PUBMED   9891086
REFERENCE   9  (bases 1 to 6814)
  AUTHORS   Yamaoka,S., Courtois,G., Bessia,C., Whiteside,S.T., Weil,R.,
            Agou,F., Kirk,H.E., Kay,R.J. and Israel,A.
  TITLE     Complementation cloning of NEMO, a component of the IkappaB kinase
            complex essential for NF-kappaB activation
  JOURNAL   Cell 93 (7), 1231-1240 (1998)
   PUBMED   9657155
REFERENCE   10 (bases 1 to 6814)
  AUTHORS   Verma,I.M., Stevenson,J.K., Schwarz,E.M., Van Antwerp,D. and
            Miyamoto,S.
  TITLE     Rel/NF-kappa B/I kappa B family: intimate tales of association and
            dissociation
  JOURNAL   Genes Dev 9 (22), 2723-2735 (1995)
   PUBMED   7590248
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY768708.1, AY112937.1 and AL669976.11.
            
            On May 30, 2009 this sequence version replaced NM_010547.1.
            
            Transcript Variant: This variant (1) differs in the 5' UTR and
            coding sequence compared to variant 3. The resulting isoform (1) is
            shorter at the N-terminus compared to isoform 3. Variants 1 and 6
            both encode the same isoform.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154095.1, SRR10223969.19833.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               BY768708.1         11-174
            165-2142            AY112937.1         269-2246
            2143-6814           AL669976.11        28310-32981
FEATURES             Location/Qualifiers
     source          1..6814
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 38.0 cM"
     gene            1..6814
                     /gene="Ikbkg"
                     /gene_synonym="1110037D23Rik; IKK[g]; NEMO"
                     /note="inhibitor of kappaB kinase gamma"
                     /db_xref="GeneID:16151"
                     /db_xref="MGI:MGI:1338074"
     exon            1..141
                     /gene="Ikbkg"
                     /gene_synonym="1110037D23Rik; IKK[g]; NEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            142..343
                     /gene="Ikbkg"
                     /gene_synonym="1110037D23Rik; IKK[g]; NEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            344..555
                     /gene="Ikbkg"
                     /gene_synonym="1110037D23Rik; IKK[g]; NEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            556..674
                     /gene="Ikbkg"
                     /gene_synonym="1110037D23Rik; IKK[g]; NEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            675..827
                     /gene="Ikbkg"
                     /gene_synonym="1110037D23Rik; IKK[g]; NEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            828..903
                     /gene="Ikbkg"
                     /gene_synonym="1110037D23Rik; IKK[g]; NEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1047
                     /gene="Ikbkg"
                     /gene_synonym="1110037D23Rik; IKK[g]; NEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1190
                     /gene="Ikbkg"
                     /gene_synonym="1110037D23Rik; IKK[g]; NEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1252
                     /gene="Ikbkg"
                     /gene_synonym="1110037D23Rik; IKK[g]; NEMO"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..6814
                     /gene="Ikbkg"
                     /gene_synonym="1110037D23Rik; IKK[g]; NEMO"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3304..3309
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ikbkg"
                     /gene_synonym="1110037D23Rik; IKK[g]; NEMO"
                     /note="hexamer: AATAAA"
     polyA_site      3326
                     /gene="Ikbkg"
                     /gene_synonym="1110037D23Rik; IKK[g]; NEMO"
     regulatory      4537..4542
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ikbkg"
                     /gene_synonym="1110037D23Rik; IKK[g]; NEMO"
                     /note="hexamer: AATAAA"
     polyA_site      4561
                     /gene="Ikbkg"
                     /gene_synonym="1110037D23Rik; IKK[g]; NEMO"
                     /note="major polyA site"
ORIGIN      
        1 ggaagccgga agtggagttt tccactgcag agaagggaag ggtgaccgcc tgactaggac
       61 tttctaggag ctccggttct gtcggagcgg tcggatccct ctgctcctgc cctcttcact
      121 tctggccgac tctgctgaca gacactgtcc tgttggatga acaagcaccc ctggaagaac
      181 cagctgagtg agatggtgca gcccagtggt ggcccagcag aggaccagga catgctgggt
      241 gaagaatctt ctctggggaa gcctgcaatg ctacatctgc cttcagagca gggtactcct
      301 gagaccctcc agcgctgcct ggaagagaat caagagctcc gagacgctat ccggcagagc
      361 aatcagatgc tgagggaacg ctgtgaggag ctgctgcatt tccaggtcag ccagcgggag
      421 gagaaggagt tccttatgtg caaattccag gaagcccgga agctggtgga gagactgagc
      481 ttggagaagc ttgatcttcg gagtcagagg gaacaggcct taaaggagtt ggagcaactg
      541 aagaaatgcc aacagcagat ggctgaggac aaggcctctg tgaaagctca ggtgacatca
      601 ttgctcggag aactccagga gagccagagc cgtttggagg ctgccaccaa ggatcggcaa
      661 gctttagagg gaaggattcg agcagttagt gagcaggtca gacagctgga gagtgagcgg
      721 gaggtgctac agcagcagca cagcgtccag gtggaccagc tgcgtatgca gaaccagagc
      781 gtggaggctg ccttgcgaat ggagcggcag gctgcttcag aggagaagcg gaagctggct
      841 cagttgcagg cagcctatca ccagctcttc caagactacg acagccacat taagagcagc
      901 aagggcatgc agctggaaga tctgaggcaa cagctccagc aagctgagga ggccctggta
      961 gccaaacagg aattgattga taagctgaaa gaggaggctg agcagcacaa gattgtgatg
     1021 gagactgtgc cagtcttgaa ggcccaggcg gatatctaca aggctgactt ccaagctgag
     1081 aggcatgccc gggagaagct ggtggagaag aaggagtatt tgcaggagca gctggagcag
     1141 ctgcagcgcg agttcaacaa gctgaaagtt ggctgccatg agtcagccag gattgaggat
     1201 atgaggaagc ggcatgtaga gactccccag cctcctttac tccctgctcc agctcaccac
     1261 tcctttcatt tggccttgtc caaccagcgg aggagccctc ctgaagaacc tcctgacttc
     1321 tgttgtccga agtgccagta tcaggctcct gatatggaca ctctacagat acatgtcatg
     1381 gagtgcatag agtaggagca gcagatgcaa ggccacttgc agtactatgt cctgatctgt
     1441 gtgacttgtg ctttcctgtt ttacctgcat agtccacact taagggcttg ctttagccct
     1501 ttggtccccc atttagggta gacagcccca ttcagggctt ttttttttct gtgtgcctga
     1561 tccagtttgc ctctggtggc ttcttccctc ttctcccata gtcctaggga gtctagaatg
     1621 gaggccaggg gctcttaggg agcatccctt ctccaagcag gtctgggtac agcttttctt
     1681 ctctccaact ggtacctttc ttgccggtga actgcaggct ctcctcccag ggcatgtggc
     1741 acttgggtct ataacatgtg ttacctctgg tagacatgtg gaaagtattc tgtccttttg
     1801 ttactgtaat taatggtgta gtgaaagtac ttgtacactg atctgtgtgt acctttagga
     1861 cagatgctta gatgtgacat tggatccttg ccctggagga ggtgggcaga cctttggatt
     1921 tttgccatct ctaagatata ccattcttta ctaaagaatt tgcttaagtg tctttttctg
     1981 gggcatgtgg gcccttttta attcctctga tgtaacttgg attttcataa ttcctaccca
     2041 tttttctgtt gggacattgc catttgttct tgggctttgt agagcttttt gattatcagt
     2101 caggttggtt ttgactatta cagaagtgca ccccttgttc cacattgatt gttagtgttt
     2161 tggggcctag aagctgtttt atactcctac ttacccattc tttactccta gttttttgac
     2221 tttggaatta tgactgcttt gtcaacagaa aggtatttca catgtatgct ttcctttttc
     2281 tagccccagt gtgctcttgt ttttgccaag cacattgtta ccttctgtga atggtggtgg
     2341 ccatagttca tcacactcct ggagtttgtg atcacatgtt cttcaccagc caaaatgtcc
     2401 tagggaacca tttagcagtg actgactgat cacagaaaag ggaacacttc acttgttttg
     2461 caaggttcta gacattttgt gggaccttac cgtcattggt attagacctg cagttctagt
     2521 aaaggaaagg aagttgtagt tgagaaagca ataaatatgc cttgctcatt ccttaggtct
     2581 aaatccttcc tgccctcctg taagctttca tggttctgag tggtatctgt gaatccatcc
     2641 cgggggcttt tatttacatg gtttctttcc cattaagagt gagaaggcta agtagaattc
     2701 agattataaa aaaggattta aaaagtaatc ctgagctggg ggctttctcg gaattttcag
     2761 gggatgcaga gtaagttttc catttcctaa ttcccaggta tctatcagaa agatctttag
     2821 gaaaatgtta aaggaacaaa caagttcttt gcttatgtgt tttcatttaa atacctaatc
     2881 tataattttc ctttaggaat actattggtt taggttgagt ccagttttgt ggtggtatat
     2941 atcacttttc tatagctgct ttaaaatttt tcctaaactt ggaagagcaa gaacaacaac
     3001 aacaacaaca acaacaacaa atcactcttt cctgtctgga agccacatat taagtttttt
     3061 ctggaggctg tgagaatcaa ttccaggcat tctcttaact ttcagtggtt tgtggtagtc
     3121 cttggtgttg cttggctcat agacccatca ctccagtttc tggttctagg gccttgtggt
     3181 ttcttcctct cttctgtctc ataaggaaac catgttgtgc atgtggggtc tatttgatta
     3241 gattaaggag gatctccagt tcaagaccct taactcattc cacctaccaa gatcctttcc
     3301 ccaaataaag tcttgttctc acattatggg ggtttgggct tatataaccc ggagtatgga
     3361 tatcatcaga acctgagtaa atgcagccca aaggcagggc ctttaaagcc ttgtaattct
     3421 gctagagaga cctggtctct agggtgatga ccagtagtct tcagagtttg aaggcagacc
     3481 cttgtcagtg cttgatgctg ttagtagggt cagtgggaat gattgggaaa ggcaggttgg
     3541 ctatagtagg agagagctgt tgggctgcct gcagtggctg catgagcttc acgcttcttg
     3601 gataaacaga gatgcatagg tgcatttctg accagtactt tatcctgaaa gggtcccaga
     3661 aagcaggtgt gacccaggtt acacagtagg aagcttgaaa acatgggctt catgcactgg
     3721 tcaagacaaa tctgagggtg gcacaaggta atggttggga cctagtaccc ttctagaagg
     3781 tgggagccct tgccaccgac ttaccctgca gtatggtgta tgattaaccg tacatcaaag
     3841 atttgagatt ctaccatctt tttgacatga gacatgctct tttcttttgc agaattactt
     3901 aagctagaac tggaaaaagt ggtcgttcca ttcccctcag gaattagtct acttgctttt
     3961 gcacaaattt tatgtggcct ctggcagaca acttttagat ccatacagct agaagcatgc
     4021 cctttccaga agacctgttc tggaatagat agtgcttctt atgtatgctc tcttcctgtt
     4081 ggcccatgcc caagagaaaa ccagagagcc agtaagacag tacagagtgc ttcacctact
     4141 gaagtaataa acgataaggc agattgtagg taggaatgat atctaaaaag gaacaattgc
     4201 agccctgtgt gtgacaccct caggcaaggt aaggcctacc ttttagtgtt tcccctttca
     4261 aggtgggagt ttggagagat gaacaagcac tttggaagca tccccagccc tctttacctg
     4321 acaacagttt ggtcctcaca gtgactgctt cattggagtg cctctccagt gttatggcac
     4381 catcatctgt taccacccaa ggctgtgatg aaataagata caacatatcc gatgacacag
     4441 gcctgcatgg ctagcatctt gaacatttta ttacatgaac attctctgta cgatggtata
     4501 aaaaggcccg aggattaaat tatgtataaa atatgaaata aagaagtaag actttcaagc
     4561 atgcactctg tcctcccttg ttggatgtag gggtaggatt gccagtaaca aaggttttct
     4621 ttgctatttc tatctcttta attcccctgt attacatagg aagtagctgt tacacacagc
     4681 tctgaggttt cttctgccta tggctgagga aagctcatta ttgacacaac agagtggtga
     4741 aaggggccaa gtcaactaat ttggggcttg aatttcctgt ggttgcagca acaaagtacc
     4801 acacgttagg gagcttaggc aacagatttc ctctccctgt taaggatggc aggcatctga
     4861 gaagtgggtt cctcataagg gataacccat tccagtgccc ctctccagtg tgtggcaggt
     4921 cccagaaatt cttagttttc tctagttgta cctgcatctc tgcctctgcc acttttgtca
     4981 catggccatc ttgtgtttcc tttttataag cacaccagtg ttgtatacag gtgggtattt
     5041 ggaaacatgg aagcattttg ttcagtatct agtgacagtg atggaaagag atgatttgca
     5101 gagaaggtca gagcagcatg agggtcttag gtatggagct gcagccaaca ttatggacat
     5161 ggaagagagg gattgctgga cttttggttt cctgcctggg tacctggaca atctatctac
     5221 cattgggagg actaggtaac agtggaagtt agttatgaga gaagttgttt gatgttcaat
     5281 tctgatctag ccaggctcag tgtgagatgt cctgggtccc ttcatcttgc cttgactgtt
     5341 aggtgcagtt tcatattgaa actgcaggct cttttttatc cattgctact ggcaaccagt
     5401 gtgatctggt aaatctgttt ccactttgct tagtgctctc cactgatttt ctgttacttg
     5461 agacctaaac tccatcttca gccttgtgtt gatctaatgt catgtcaact tctctaaaag
     5521 ctcagccaat tctacactgg ccttctattc ctttcctcaa accacttagc actttttttt
     5581 tttaaatttt tttagattta tttatttatt tattatatgt aagtacactg tagttgtctt
     5641 cagacactcc agaaaaggag tcagatcttg ttacggatgg ttgtgagcca ccatgtggtt
     5701 gctgggattt gaactccaga cctttggaag agcagtaggg tgctcttacc cactgagcca
     5761 tctcaccagc ccagcacttc tgtttcttaa ggctgttgct cctgttgtct cctttgctga
     5821 gaaagttctg ttccctaatt tgtactgttg actacttttt gtcatccata taagtgtaaa
     5881 caaaagttct ttcatctgat ctcttcatcc taaatcatac taccctgttt taactcacat
     5941 tactaccact gaccttttct agtgtttttt tcttttctac cactagaggg agacagaagc
     6001 cgtatcaatt tagtcgtata ctcaacacag ggaaactgca tttactgatg gctgagcttg
     6061 tctgagacga tatcaggatt cccctgccaa tatcttcatg gacgtcactt gtcaccataa
     6121 ttggtgactt atagaagtta ttaatgtact agaaattata gtacagaaat cttattttag
     6181 gactatagta ccaatagcct ttttttgtgg tgctggggat agaacccagg gtctttcaca
     6241 tgtaagcatt cataccatca ctgagctaca atccctggtt atcagcttct cactttattt
     6301 accttcccct gactttgaca gccctgtcta gtttggaact tattatgtaa tccacgatgg
     6361 ccttgaattt acagccatcc tcagcctctc cagtgctagg attataaata tatctgacta
     6421 gcttattttt ttcattttgt tcaggttttt aatgagtgtc ttggtttcag atatgaaaaa
     6481 cagaatttgg aagaaagcca gttgggccag tctgtggtag agcatgcact caaagttgaa
     6541 gcaagatgtt aatgagttct aggctggctt aggcttcata gcaagatcct atctcataaa
     6601 acaaaaagtt aactggtgat tccctggagg tgagaggggt gaggagagag tgatagttaa
     6661 tgaatacaaa gttctttgag ggaaaatgag aatattctga aattggctat ggcgatactc
     6721 atacatttgt gaatgtgcaa ggaacacttc agatgaatga cttttgttgt atatggatta
     6781 ggttgcaata aaactggcat ttaaaatgtt atct
//
