LOCUS       NM_019777               3203 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus inhibitor of kappaB kinase epsilon (Ikbke), mRNA.
ACCESSION   NM_019777
VERSION     NM_019777.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3203)
  AUTHORS   Weiss,U., Mungo,E., Hass,M., Benning,D., Gurke,R., Hahnefeld,L.,
            Dorochow,E., Schlaudraff,J., Schmid,T., Kuntschar,S., Meyer,S.,
            Medert,R., Freichel,M., Geisslinger,G. and Niederberger,E.
  TITLE     Knock-Out of IKKepsilon Ameliorates Atherosclerosis and Fatty Liver
            Disease by Alterations of Lipid Metabolism in the PCSK9 Model in
            Mice
  JOURNAL   Int J Mol Sci 25 (19), 10721 (2024)
   PUBMED   39409049
  REMARK    GeneRIF: Knock-Out of IKKepsilon Ameliorates Atherosclerosis and
            Fatty Liver Disease by Alterations of Lipid Metabolism in the PCSK9
            Model in Mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3203)
  AUTHORS   Cho,H.H., Rhee,S., Cho,D.I., Jun,J.H., Heo,H., Cho,S.H., Kim,D.,
            Wang,M., Kang,B.G., Yoo,S.J., Cho,M., Lim,S.Y., Cho,J.Y.,
            Jeong,I.S., Kim,Y.S. and Ahn,Y.
  TITLE     IKKepsilon-deficient macrophages impede cardiac repair after
            myocardial infarction by enhancing the macrophage-myofibroblast
            transition
  JOURNAL   Exp Mol Med 56 (9), 2052-2064 (2024)
   PUBMED   39261656
  REMARK    GeneRIF: IKKepsilon-deficient macrophages impede cardiac repair
            after myocardial infarction by enhancing the
            macrophage-myofibroblast transition.
REFERENCE   3  (bases 1 to 3203)
  AUTHORS   Gao,B., Wu,X., Bu,L., Jiang,Q., Wang,L., Liu,H., Zhang,X., Wu,Y.,
            Li,X., Li,J., Liang,Y., Xu,L., Xie,W. and Guo,J.
  TITLE     Atypical inflammatory kinase IKBKE phosphorylates and inactivates
            FoxA1 to promote liver tumorigenesis
  JOURNAL   Sci Adv 10 (6), eadk2285 (2024)
   PUBMED   38324694
  REMARK    GeneRIF: Atypical inflammatory kinase IKBKE phosphorylates and
            inactivates FoxA1 to promote liver tumorigenesis.
REFERENCE   4  (bases 1 to 3203)
  AUTHORS   Eren,R.O., Kaya,G.G., Schwarzer,R. and Pasparakis,M.
  TITLE     IKKepsilon and TBK1 prevent RIPK1 dependent and independent
            inflammation
  JOURNAL   Nat Commun 15 (1), 130 (2024)
   PUBMED   38167258
  REMARK    GeneRIF: IKKepsilon and TBK1 prevent RIPK1 dependent and
            independent inflammation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3203)
  AUTHORS   Watanabe,S., Murata,Y., Oka,Y., Oiwa,K., Horiuchi,M., Iguchi,Y.,
            Komine,O., Sobue,A., Katsuno,M., Ogi,T. and Yamanaka,K.
  TITLE     Mitochondria-associated membrane collapse impairs TBK1-mediated
            proteostatic stress response in ALS
  JOURNAL   Proc Natl Acad Sci U S A 120 (47), e2315347120 (2023)
   PUBMED   37967220
REFERENCE   6  (bases 1 to 3203)
  AUTHORS   Ishii,K.J., Coban,C., Kato,H., Takahashi,K., Torii,Y.,
            Takeshita,F., Ludwig,H., Sutter,G., Suzuki,K., Hemmi,H., Sato,S.,
            Yamamoto,M., Uematsu,S., Kawai,T., Takeuchi,O. and Akira,S.
  TITLE     A Toll-like receptor-independent antiviral response induced by
            double-stranded B-form DNA
  JOURNAL   Nat Immunol 7 (1), 40-48 (2006)
   PUBMED   16286919
  REMARK    Erratum:[Nat Immunol. 2006 Apr;7(4):427]
REFERENCE   7  (bases 1 to 3203)
  AUTHORS   Sweeney,S.E., Hammaker,D., Boyle,D.L. and Firestein,G.S.
  TITLE     Regulation of c-Jun phosphorylation by the I kappa B kinase-epsilon
            complex in fibroblast-like synoviocytes
  JOURNAL   J Immunol 174 (10), 6424-6430 (2005)
   PUBMED   15879144
  REMARK    GeneRIF: In stimulated murine fibroblast-like synoviocyte cultures,
            induction of matrix metalloproteinases MMP3 and MMP13 is
            significantly greater in the IKK epsilon-positive cells compared
            with IKK epsilon-deficient cultures.
REFERENCE   8  (bases 1 to 3203)
  AUTHORS   Hemmi,H., Takeuchi,O., Sato,S., Yamamoto,M., Kaisho,T., Sanjo,H.,
            Kawai,T., Hoshino,K., Takeda,K. and Akira,S.
  TITLE     The roles of two IkappaB kinase-related kinases in
            lipopolysaccharide and double stranded RNA signaling and viral
            infection
  JOURNAL   J Exp Med 199 (12), 1641-1650 (2004)
   PUBMED   15210742
REFERENCE   9  (bases 1 to 3203)
  AUTHORS   Kravchenko,V.V., Mathison,J.C., Schwamborn,K., Mercurio,F. and
            Ulevitch,R.J.
  TITLE     IKKi/IKKepsilon plays a key role in integrating signals induced by
            pro-inflammatory stimuli
  JOURNAL   J Biol Chem 278 (29), 26612-26619 (2003)
   PUBMED   12736252
  REMARK    GeneRIF: IKKi/IKKepsilon plays a key role in integrating signals
            induced by pro-inflammatory stimuli.
REFERENCE   10 (bases 1 to 3203)
  AUTHORS   Shimada,T., Kawai,T., Takeda,K., Matsumoto,M., Inoue,J.,
            Tatsumi,Y., Kanamaru,A. and Akira,S.
  TITLE     IKK-i, a novel lipopolysaccharide-inducible kinase that is related
            to IkappaB kinases
  JOURNAL   Int Immunol 11 (8), 1357-1362 (1999)
   PUBMED   10421793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK088580.1.
            
            On Apr 6, 2007 this sequence version replaced NM_019777.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088580.1, AK153046.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3203              AK088580.1         3-3205
FEATURES             Location/Qualifiers
     source          1..3203
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="NOD"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 56.93 cM"
     gene            1..3203
                     /gene="Ikbke"
                     /gene_synonym="IKK-E; IKK-i; IKKepsilon; Ikki"
                     /note="inhibitor of kappaB kinase epsilon"
                     /db_xref="GeneID:56489"
                     /db_xref="MGI:MGI:1929612"
     exon            1..233
                     /gene="Ikbke"
                     /gene_synonym="IKK-E; IKK-i; IKKepsilon; Ikki"
                     /inference="alignment:Splign:2.1.0"
     exon            234..322
                     /gene="Ikbke"
                     /gene_synonym="IKK-E; IKK-i; IKKepsilon; Ikki"
                     /inference="alignment:Splign:2.1.0"
     exon            323..433
                     /gene="Ikbke"
                     /gene_synonym="IKK-E; IKK-i; IKKepsilon; Ikki"
                     /inference="alignment:Splign:2.1.0"
     CDS             347..2500
                     /gene="Ikbke"
                     /gene_synonym="IKK-E; IKK-i; IKKepsilon; Ikki"
                     /EC_number="2.7.11.10"
                     /note="inducible IKappaB kinase; IKK-epsilon; I-kappa-B
                     kinase epsilon; inducible I kappa-B kinase; inhibitor of
                     kappa light polypeptide gene enhancer in B-cells, kinase
                     epsilon"
                     /codon_start=1
                     /product="inhibitor of nuclear factor kappa-B kinase
                     subunit epsilon"
                     /protein_id="NP_062751.2"
                     /db_xref="CCDS:CCDS15269.1"
                     /db_xref="GeneID:56489"
                     /db_xref="MGI:MGI:1929612"
                     /translation="MQSTTNYLWHTDDLLGQGATASVYKARNKKSGEVVAVKVFNSAS
                     YRRPPEVQVREFEVLRRLNHQNIVKLFAVEETGGSRQKVLIMEYCSSGSLLSVLEDPE
                     NTFGLSEEEFLVVLRCVVAGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLSDFGA
                     ARKLDDDEKFVSVYGTEEYLHPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGS
                     LPFIPFGGPRRNKEIMYRITTEKPAGAISGTQKQENGPLEWSYSLPITCRLSMGLQNQ
                     LVPILANILEVEEDKCWGFDQFFAETSDILQRTVIHVFSLPQAVLHHVYIHAHNTIAI
                     FLEAVYEQTNVTPKHQEYLFEGHPCVLEPSLSAQHIAHTAASSPLTLFSMSSDTPKGL
                     AFRDPALDVPKFVPKVDLQADYSTAKGVLGAGYQALWLARVLLDGQALMLRGLHWVLE
                     VLQDTCQQTLEVTRTALLYLSSSLGTERFSSGAGMPDVQERKEATELRTRLQTLSEIL
                     SKCSHNVTETQRSLSCLGEELLKNRDQIHEDNKSIQKIQCCLDKMHFIYKQFKKSRMR
                     PGLSYNEEQIHKLDKVNFSHLAKRLLQVFQEECVQTYQVSLVTHGKRMRQVQRAQNHL
                     HLIGHSVATCNSEARGAQESLNKIFDQLLLDRASEQGAEVSPQPMAPHPGPDPKDLVF
                     HMQELCNDMKLLAFDLQDNNRLIERLHRVPSAPDV"
     exon            434..574
                     /gene="Ikbke"
                     /gene_synonym="IKK-E; IKK-i; IKKepsilon; Ikki"
                     /inference="alignment:Splign:2.1.0"
     exon            575..704
                     /gene="Ikbke"
                     /gene_synonym="IKK-E; IKK-i; IKKepsilon; Ikki"
                     /inference="alignment:Splign:2.1.0"
     exon            705..886
                     /gene="Ikbke"
                     /gene_synonym="IKK-E; IKK-i; IKKepsilon; Ikki"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1047
                     /gene="Ikbke"
                     /gene_synonym="IKK-E; IKK-i; IKKepsilon; Ikki"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1158
                     /gene="Ikbke"
                     /gene_synonym="IKK-E; IKK-i; IKKepsilon; Ikki"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1338
                     /gene="Ikbke"
                     /gene_synonym="IKK-E; IKK-i; IKKepsilon; Ikki"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1535
                     /gene="Ikbke"
                     /gene_synonym="IKK-E; IKK-i; IKKepsilon; Ikki"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1600
                     /gene="Ikbke"
                     /gene_synonym="IKK-E; IKK-i; IKKepsilon; Ikki"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1692
                     /gene="Ikbke"
                     /gene_synonym="IKK-E; IKK-i; IKKepsilon; Ikki"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1779
                     /gene="Ikbke"
                     /gene_synonym="IKK-E; IKK-i; IKKepsilon; Ikki"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1855
                     /gene="Ikbke"
                     /gene_synonym="IKK-E; IKK-i; IKKepsilon; Ikki"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..1971
                     /gene="Ikbke"
                     /gene_synonym="IKK-E; IKK-i; IKKepsilon; Ikki"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2048
                     /gene="Ikbke"
                     /gene_synonym="IKK-E; IKK-i; IKKepsilon; Ikki"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2088
                     /gene="Ikbke"
                     /gene_synonym="IKK-E; IKK-i; IKKepsilon; Ikki"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..2190
                     /gene="Ikbke"
                     /gene_synonym="IKK-E; IKK-i; IKKepsilon; Ikki"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2287
                     /gene="Ikbke"
                     /gene_synonym="IKK-E; IKK-i; IKKepsilon; Ikki"
                     /inference="alignment:Splign:2.1.0"
     exon            2288..2394
                     /gene="Ikbke"
                     /gene_synonym="IKK-E; IKK-i; IKKepsilon; Ikki"
                     /inference="alignment:Splign:2.1.0"
     exon            2395..2466
                     /gene="Ikbke"
                     /gene_synonym="IKK-E; IKK-i; IKKepsilon; Ikki"
                     /inference="alignment:Splign:2.1.0"
     exon            2467..3203
                     /gene="Ikbke"
                     /gene_synonym="IKK-E; IKK-i; IKKepsilon; Ikki"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3180..3185
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ikbke"
                     /gene_synonym="IKK-E; IKK-i; IKKepsilon; Ikki"
                     /note="hexamer: AATAAA"
     polyA_site      3203
                     /gene="Ikbke"
                     /gene_synonym="IKK-E; IKK-i; IKKepsilon; Ikki"
                     /note="major polyA site"
ORIGIN      
        1 aggaagtatg atagttaaga gcctgggact gggtacccca ctgctctcag agaggcagga
       61 aagagacctt caggctcaag accatcacct gctttgcctg tggatcctgg ggggccccat
      121 agctaccagg atcttctagg cactgcccag gattgacttc aaggcctgaa tccctggggg
      181 tgccacccag ttccacaagt ctgcattgcc ctgcaactga gataggagat gggctcagct
      241 cctggacttg ccccagacag aaagcaaaac acacacttgc cagggagagt ctttgcctga
      301 ttctgagcca cttggagtgc aggaagaaga tagccaagcc caggagatgc agagtaccac
      361 taactacctg tggcatactg atgacctgct agggcagggg gccactgcca gtgtgtacaa
      421 ggcccgaaac aagaaatccg gggaggtggt tgctgtaaag gtcttcaact cagccagcta
      481 tcggcgacct cctgaggttc aggtgaggga gtttgaggtc ctgcggaggc tgaatcacca
      541 gaacatcgtg aagctattcg cagtggagga aacgggaggc agccggcaga aggtgctaat
      601 catggagtac tgctccagtg ggagcctgct gagcgtgctg gaagaccctg agaacacgtt
      661 cgggctttct gaagaggagt tcctagtggt gctgcgctgt gtggtggctg gcatgaacca
      721 cctgcgggag aatggcattg tccatcggga catcaaacct gggaacatca tgcgcctggt
      781 gggcgaggag gggcagagca tctataagct gtctgacttc ggggctgccc gcaagctgga
      841 cgatgatgag aagtttgttt ctgtctatgg tacagaggaa tacctgcacc ctgacatgta
      901 tgagcgtgca gtgctgcgca aaccccagca aaaggcattt ggtgtgactg tggatctctg
      961 gagtattggg gtgaccctgt accacgcagc cacaggcagt ctgcccttca tccccttcgg
     1021 tgggccccgg cgcaacaaag agatcatgta cagaatcacc acagagaagc cagccggggc
     1081 catttcaggg actcagaagc aggaaaatgg tcccttggag tggagctaca gcctccccat
     1141 cacctgtaga ctgtccatgg gactgcagaa ccagctggtg cccatcctgg ccaacatcct
     1201 ggaggtggaa gaggataagt gctggggctt tgatcagttc ttcgcggaga ccagtgacat
     1261 tctgcagcga acggtcatcc acgtcttttc cctaccccag gccgttttgc atcatgtcta
     1321 catccacgcc cacaacacga ttgccatctt tttggaggct gtatatgagc agaccaacgt
     1381 gacccccaaa caccaggagt acctcttcga gggtcaccct tgtgtccttg agccaagcct
     1441 ctcagcccag cacatcgccc acacagctgc cagcagccct ctaactctgt tcagcatgtc
     1501 cagcgacaca cctaaggggc tggccttcag ggaccctgct ctggatgtcc caaagttcgt
     1561 ccctaaggtt gacctacagg ccgattacag cacagctaag ggggtgctgg gcgctggcta
     1621 ccaggccctg tggctggcgc gggtcctgct ggatggacag gcgttgatgc ttcgggggtt
     1681 acattgggtc ctggaggtgc ttcaggacac gtgccagcag acactggagg tcacacggac
     1741 agccctcctc tacctcagca gcagcctggg cactgaaagg ttcagcagtg gagcggggat
     1801 gcctgacgtc caggaacgaa aggaggccac agagctaaga accaggctgc agactctctc
     1861 agagatcctg tctaaatgtt cccacaatgt cacagaaacc caaaggagcc tgagctgtct
     1921 gggtgaagag cttttaaaga accgggacca gattcatgag gataacaaaa gtatccagaa
     1981 gattcagtgt tgtttggaca agatgcactt catctacaaa cagttcaaga aatccaggat
     2041 gaggccaggg ctcagctaca atgaggagca gatccacaag ctggataagg taaatttcag
     2101 tcatctagcc aagaggctgc tgcaggtgtt ccaggaggag tgtgtgcaga cgtatcaggt
     2161 gtcgctggtc acacacggca agcggatgag gcaggtgcag agggcccaga accacctgca
     2221 tctcattggc cactctgtgg ccacctgtaa ctcggaagcc cggggagccc aggagagtct
     2281 gaacaagatc tttgatcagc tccttctgga cagagcttcc gaacagggag ctgaggtgtc
     2341 accgcaacct atggctcctc atcccggccc tgatccgaag gacctggtct tccacatgca
     2401 ggagctttgt aatgatatga agctattggc ctttgatctc caggacaaca accgactcat
     2461 cgaacggtta catagagttc catcggcacc agatgtctga gctccctggg ggttcacaag
     2521 gcactcagaa gcaatagaaa cattcatatt gtacccctac actgtgagac caaattcagg
     2581 gcaagttctg gttccatctc actagcctac ctccctcttg gccattggcc attggccaac
     2641 aaactagcat tactttgact gtcctcttgg gaagcagcta ggacagggac tcctggccat
     2701 cccaggcagt atctacagaa gagaccatgc ggctaccaca gccttatcaa gacaccaaga
     2761 ctgttcttcc tcacccaggc tctggaggtc tggtcttgga aagaaaaggc tcagccctct
     2821 cacgctctgc acttcccagg accagcaggc gtctcctgtg gcttctcctg cctctccagg
     2881 gtgctggatc agaatgctta ttcttggttg tttcctgtgc tgcttcctga gtgtccccat
     2941 ccctggcctc aggcaaccca caaacggccc ctctgtgctt ggtctagatg cacctgcatt
     3001 tgagaaagtg ggtggttgag gctaactgct ggtgctttga ggattctcct tgaccttttc
     3061 tccgaggaac gcttggttct aagaaacagc tggtcagtat caaccacagc catgctaact
     3121 ggacagatgt tggaacccaa agtcctaagg agagagcagg cctgcacctt cagacatgga
     3181 ataaatacat cgccttttct gtt
//
