LOCUS       NM_001159774            3598 bp    mRNA    linear   ROD 27-SEP-2023
DEFINITION  Mus musculus inhibitor of kappaB kinase beta (Ikbkb), transcript
            variant 1, mRNA.
ACCESSION   NM_001159774
VERSION     NM_001159774.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3598)
  AUTHORS   Rao S, Liu M, Iosef C, Knutsen C and Alvira CM.
  TITLE     Endothelial-specific loss of IKKbeta disrupts pulmonary endothelial
            angiogenesis and impairs postnatal lung growth
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 325 (3), L299-L313 (2023)
   PUBMED   37310763
  REMARK    GeneRIF: Endothelial-specific loss of IKKbeta disrupts pulmonary
            endothelial angiogenesis and impairs postnatal lung growth.
REFERENCE   2  (bases 1 to 3598)
  AUTHORS   Rocha SM, Kirkley KS, Chatterjee D, Aboellail TA, Smeyne RJ and
            Tjalkens RB.
  TITLE     Microglia-specific knock-out of NF-kappaB/IKK2 increases the
            accumulation of misfolded alpha-synuclein through the inhibition of
            p62/sequestosome-1-dependent autophagy in the rotenone model of
            Parkinson's disease
  JOURNAL   Glia 71 (9), 2154-2179 (2023)
   PUBMED   37199240
REFERENCE   3  (bases 1 to 3598)
  AUTHORS   Paluschinski M, Kordes C, Vucur M, Buettner V, Roderburg C, Xu HC,
            Shinte PV, Lang PA, Luedde T and Castoldi M.
  TITLE     Differential Modulation of miR-122 Transcription by TGFbeta1/BMP6:
            Implications for Nonresolving Inflammation and Hepatocarcinogenesis
  JOURNAL   Cells 12 (15), 1955 (2023)
   PUBMED   37566034
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3598)
  AUTHORS   Vucur M, Ghallab A, Schneider AT, Adili A, Cheng M, Castoldi M,
            Singer MT, Buttner V, Keysberg LS, Kusgens L, Kohlhepp M, Gorg B,
            Gallage S, Barragan Avila JE, Unger K, Kordes C, Leblond AL,
            Albrecht W, Loosen SH, Lohr C, Jordens MS, Babler A, Hayat S,
            Schumacher D, Koenen MT, Govaere O, Boekschoten MV, Jors S,
            Villacorta-Martin C, Mazzaferro V, Llovet JM, Weiskirchen R, Kather
            JN, Starlinger P, Trauner M, Luedde M, Heij LR, Neumann UP, Keitel
            V, Bode JG, Schneider RK, Tacke F, Levkau B, Lammers T, Fluegen G,
            Alexandrov T, Collins AL, Nelson G, Oakley F, Mann DA, Roderburg C,
            Longerich T, Weber A, Villanueva A, Samson AL, Murphy JM, Kramann
            R, Geisler F, Costa IG, Hengstler JG, Heikenwalder M and Luedde T.
  TITLE     Sublethal necroptosis signaling promotes inflammation and liver
            cancer
  JOURNAL   Immunity 56 (7), 1578-1595 (2023)
   PUBMED   37329888
REFERENCE   5  (bases 1 to 3598)
  AUTHORS   Velasco WV, Khosravi N, Castro-Pando S, Torres-Garza N, Grimaldo
            MT, Krishna A, Clowers MJ, Umer M, Tariq Amir S, Del Bosque D,
            Daliri S, De La Garza MM, Ramos-Castaneda M, Evans SE and Moghaddam
            SJ.
  TITLE     Toll-like receptors 2, 4, and 9 modulate promoting effect of
            COPD-like airway inflammation on K-ras-driven lung cancer through
            activation of the MyD88/NF-kB pathway in the airway epithelium
  JOURNAL   Front Immunol 14, 1118721 (2023)
   PUBMED   37283745
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3598)
  AUTHORS   Nemoto S, DiDonato JA and Lin A.
  TITLE     Coordinate regulation of IkappaB kinases by mitogen-activated
            protein kinase kinase kinase 1 and NF-kappaB-inducing kinase
  JOURNAL   Mol Cell Biol 18 (12), 7336-7343 (1998)
   PUBMED   9819420
REFERENCE   7  (bases 1 to 3598)
  AUTHORS   Hu MC and Wang Y.
  TITLE     IkappaB kinase-alpha and -beta genes are coexpressed in adult and
            embryonic tissues but localized to different human chromosomes
  JOURNAL   Gene 222 (1), 31-40 (1998)
   PUBMED   9813230
REFERENCE   8  (bases 1 to 3598)
  AUTHORS   Nakano H, Shindo M, Sakon S, Nishinaka S, Mihara M, Yagita H and
            Okumura K.
  TITLE     Differential regulation of IkappaB kinase alpha and beta by two
            upstream kinases, NF-kappaB-inducing kinase and mitogen-activated
            protein kinase/ERK kinase kinase-1
  JOURNAL   Proc Natl Acad Sci U S A 95 (7), 3537-3542 (1998)
   PUBMED   9520401
REFERENCE   9  (bases 1 to 3598)
  AUTHORS   Ghosh S, May MJ and Kopp EB.
  TITLE     NF-kappa B and Rel proteins: evolutionarily conserved mediators of
            immune responses
  JOURNAL   Annu Rev Immunol 16, 225-260 (1998)
   PUBMED   9597130
  REMARK    Review article
REFERENCE   10 (bases 1 to 3598)
  AUTHORS   Verma IM, Stevenson JK, Schwarz EM, Van Antwerp D and Miyamoto S.
  TITLE     Rel/NF-kappa B/I kappa B family: intimate tales of association and
            dissociation
  JOURNAL   Genes Dev 9 (22), 2723-2735 (1995)
   PUBMED   7590248
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY015258.1, AK144603.1 and AA203913.1.
            
            [WARNING] On Oct 12, 2023 this sequence was replaced by
            NM_001159774.2.
            
            Transcript Variant: This variant (1) encodes the longer protein
            (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC037723.2, AK144603.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 BY015258.1         2-9
            9-3571              AK144603.1         2-3564
            3572-3598           AA203913.1         71-97
FEATURES             Location/Qualifiers
     source          1..3598
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 11.42 cM"
     gene            1..3598
                     /gene="Ikbkb"
                     /gene_synonym="IKK-2; IKK-B; IKK-beta; IKK2; IKKbeta;
                     IKK[b]; NFKBIKB"
                     /note="inhibitor of kappaB kinase beta"
                     /db_xref="GeneID:16150"
                     /db_xref="MGI:MGI:1338071"
     exon            1..114
                     /gene="Ikbkb"
                     /gene_synonym="IKK-2; IKK-B; IKK-beta; IKK2; IKKbeta;
                     IKK[b]; NFKBIKB"
                     /inference="alignment:Splign:2.1.0"
     exon            115..237
                     /gene="Ikbkb"
                     /gene_synonym="IKK-2; IKK-B; IKK-beta; IKK2; IKKbeta;
                     IKK[b]; NFKBIKB"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..2406
                     /gene="Ikbkb"
                     /gene_synonym="IKK-2; IKK-B; IKK-beta; IKK2; IKKbeta;
                     IKK[b]; NFKBIKB"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.11.10"
                     /note="isoform 1 is encoded by transcript variant 1;
                     inhibitor of nuclear factor kappa-B kinase subunit beta;
                     I-kappa-B kinase 2; I-kappa-B-kinase beta; nuclear factor
                     NF-kappa-B inhibitor kinase beta; inhibitor of kappa light
                     polypeptide gene enhancer in B-cells, kinase beta;
                     serine/threonine protein kinase IKBKB"
                     /codon_start=1
                     /product="inhibitor of nuclear factor kappa-B kinase
                     subunit beta isoform 1"
                     /protein_id="NP_001153246.1"
                     /db_xref="CCDS:CCDS52522.1"
                     /db_xref="GeneID:16150"
                     /db_xref="MGI:MGI:1338071"
                     /translation="MSWSPSLPTQTCGAWEMKERLGTGGFGNVIRWHNQATGEQIAIK
                     QCRQELSPKNRDRWCLEIQIMRRLNHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGG
                     DLRRYLNQFENCCGLREGAVLTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEKRL
                     IHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITG
                     FRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGAVKFSSSLPFPNNLNSVLAERLEKW
                     LQLMLMWHPRQRGTDPQYGPNGCFRALDDILNLKLVHVLNMVTGTVHTYPVTEDESLQ
                     SLKTRIQEDTGILETDQELLQEAGLVLLPDKPATQCISDSKTNEGLTLDMDLVFLFDN
                     SKINYETQITPRPQPESVSCILQEPKRNLSFFQLRKVWGQVWHSIQTLKEDCNRLQQG
                     QRAAMMSLLRNNSCLSKMKNAMASTAQQLKAKLDFFKTSIQIDLEKYKEQTEFGITSD
                     KLLLAWREMEQAVEQCGRENDVKHLVERMMALQTDIVDLQRSPMGRKQGGTLDDLEEQ
                     ARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQKALE
                     LLPKVEEVVSLMNEDERTVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNVSRLS
                     HPGQLMSQPSSACDSLPESDKKSEELVAEAHALCSRLESALQDTVKEQDRSFTTLDWS
                     WLQMEDEERCSLEQACD"
     exon            238..332
                     /gene="Ikbkb"
                     /gene_synonym="IKK-2; IKK-B; IKK-beta; IKK2; IKKbeta;
                     IKK[b]; NFKBIKB"
                     /inference="alignment:Splign:2.1.0"
     exon            333..450
                     /gene="Ikbkb"
                     /gene_synonym="IKK-2; IKK-B; IKK-beta; IKK2; IKKbeta;
                     IKK[b]; NFKBIKB"
                     /inference="alignment:Splign:2.1.0"
     exon            451..520
                     /gene="Ikbkb"
                     /gene_synonym="IKK-2; IKK-B; IKK-beta; IKK2; IKKbeta;
                     IKK[b]; NFKBIKB"
                     /inference="alignment:Splign:2.1.0"
     exon            521..609
                     /gene="Ikbkb"
                     /gene_synonym="IKK-2; IKK-B; IKK-beta; IKK2; IKKbeta;
                     IKK[b]; NFKBIKB"
                     /inference="alignment:Splign:2.1.0"
     exon            610..699
                     /gene="Ikbkb"
                     /gene_synonym="IKK-2; IKK-B; IKK-beta; IKK2; IKKbeta;
                     IKK[b]; NFKBIKB"
                     /inference="alignment:Splign:2.1.0"
     exon            700..824
                     /gene="Ikbkb"
                     /gene_synonym="IKK-2; IKK-B; IKK-beta; IKK2; IKKbeta;
                     IKK[b]; NFKBIKB"
                     /inference="alignment:Splign:2.1.0"
     exon            825..932
                     /gene="Ikbkb"
                     /gene_synonym="IKK-2; IKK-B; IKK-beta; IKK2; IKKbeta;
                     IKK[b]; NFKBIKB"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1062
                     /gene="Ikbkb"
                     /gene_synonym="IKK-2; IKK-B; IKK-beta; IKK2; IKKbeta;
                     IKK[b]; NFKBIKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1257
                     /gene="Ikbkb"
                     /gene_synonym="IKK-2; IKK-B; IKK-beta; IKK2; IKKbeta;
                     IKK[b]; NFKBIKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1372
                     /gene="Ikbkb"
                     /gene_synonym="IKK-2; IKK-B; IKK-beta; IKK2; IKKbeta;
                     IKK[b]; NFKBIKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1496
                     /gene="Ikbkb"
                     /gene_synonym="IKK-2; IKK-B; IKK-beta; IKK2; IKKbeta;
                     IKK[b]; NFKBIKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1648
                     /gene="Ikbkb"
                     /gene_synonym="IKK-2; IKK-B; IKK-beta; IKK2; IKKbeta;
                     IKK[b]; NFKBIKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1710
                     /gene="Ikbkb"
                     /gene_synonym="IKK-2; IKK-B; IKK-beta; IKK2; IKKbeta;
                     IKK[b]; NFKBIKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1820
                     /gene="Ikbkb"
                     /gene_synonym="IKK-2; IKK-B; IKK-beta; IKK2; IKKbeta;
                     IKK[b]; NFKBIKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..1870
                     /gene="Ikbkb"
                     /gene_synonym="IKK-2; IKK-B; IKK-beta; IKK2; IKKbeta;
                     IKK[b]; NFKBIKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..1970
                     /gene="Ikbkb"
                     /gene_synonym="IKK-2; IKK-B; IKK-beta; IKK2; IKKbeta;
                     IKK[b]; NFKBIKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2118
                     /gene="Ikbkb"
                     /gene_synonym="IKK-2; IKK-B; IKK-beta; IKK2; IKKbeta;
                     IKK[b]; NFKBIKB"
                     /inference="alignment:Splign:2.1.0"
     exon            2119..2246
                     /gene="Ikbkb"
                     /gene_synonym="IKK-2; IKK-B; IKK-beta; IKK2; IKKbeta;
                     IKK[b]; NFKBIKB"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2337
                     /gene="Ikbkb"
                     /gene_synonym="IKK-2; IKK-B; IKK-beta; IKK2; IKKbeta;
                     IKK[b]; NFKBIKB"
                     /inference="alignment:Splign:2.1.0"
     exon            2338..3592
                     /gene="Ikbkb"
                     /gene_synonym="IKK-2; IKK-B; IKK-beta; IKK2; IKKbeta;
                     IKK[b]; NFKBIKB"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgacgtcag ggcaggaagt gtttgaggaa gtggcgctgg gctggctgcg tggggacccc
       61 gagttttcat gtcctcagcg ggtgtcgctg gcggccccgc ggcccccggg gcagagttag
      121 cagggcatcg atatgagctg gtcaccgtcc ctcccaaccc agacatgtgg agcctgggaa
      181 atgaaagaac gcctggggac cgggggattt ggaaacgtca tccggtggca caatcaggcg
      241 acaggtgaac agatcgccat caagcaatgc cgacaggagc tcagcccaaa gaacagagac
      301 cgctggtgcc tcgaaatcca gatcatgaga aggctgaacc atcccaatgt ggtggctgcc
      361 cgggatgtcc cagaggggat gcagaacctg gcacccaatg atttgccact gctggccatg
      421 gagtactgcc aaggaggaga tctccgaaga tacttgaacc agttcgagaa ctgctgtggc
      481 ctgcgggaag gagctgtcct taccctgctg agtgacatcg catcggctct tagatacctt
      541 cacgaaaaca gaatcatcca tcgagacctg aagccagaaa acatcgttct gcagcaagga
      601 gagaaaagat taatacacaa aattattgat ctaggatatg ccaaggagct ggatcagggc
      661 agtctgtgca cgtcatttgt ggggactctg caatacctgg cgccagagct tctggagcag
      721 cagaagtaca ccgtgaccgt tgactactgg agcttcggca ccctggcctt cgagtgcatc
      781 actggcttcc ggcccttcct ccctaactgg cagcctgtgc agtggcactc caaagtccgg
      841 cagaagagcg aagtggacat cgttgttagt gaagacttga atggagcagt gaagttttca
      901 agttcgctac ccttccccaa taatcttaac agtgtcttgg ctgaacggct ggagaagtgg
      961 ctgcagctga tgcttatgtg gcaccctcgg caaaggggca cggatcccca gtatggcccc
     1021 aacggctgct tcagagccct ggatgacatc ttgaacttga agctggttca tgtcttgaac
     1081 atggtcacag gcaccgttca cacatacccc gtgacggagg atgagagtct gcagagctta
     1141 aaaaccagaa tccaggaaga cacggggatc ctggagacag accaggagct gctgcaagag
     1201 gcagggctgg tgctgctccc tgacaagcct gctactcagt gcatctcaga cagcaagaca
     1261 aacgagggcc tcacgttgga catggatctt gtttttctct ttgacaacag taaaatcaac
     1321 tatgagactc agatcacccc ccgaccccaa ccggaaagtg tcagctgtat ccttcaggag
     1381 cccaagcgga acctctcctt cttccagctg aggaaagtgt ggggccaagt ctggcacagc
     1441 atccagacgc tgaaggaaga ctgtaaccgg ctgcagcagg gacagcgagc agccatgatg
     1501 agtctcctcc ggaataacag ctgcctctct aagatgaaga acgccatggc ctccacggcc
     1561 cagcagctca aggccaagct ggacttcttc aaaaccagca tccagatcga cctggagaag
     1621 tataaagagc agaccgagtt tgggatcacc tcagataaat tgctgctggc ttggcgggag
     1681 atggagcagg ctgtggagca gtgtgggcgg gagaatgacg tgaagcatct agtagagcgg
     1741 atgatggcac tgcagactga cattgtggac ctgcagagga gcccgatggg tcggaagcag
     1801 gggggcaccc tggatgacct agaggaacaa gcgagggagc tctaccgaag actcagggag
     1861 aagccaagag accaaaggac agaaggtgac agccaggaga tggtacggct gctgcttcag
     1921 gcaatccaaa gctttgagaa gaaagttcgg gtgatttata cacagctcag taagaccgtg
     1981 gtttgtaagc agaaggcact ggagttgctg cccaaggtag aagaggtagt gagccttatg
     2041 aacgaggacg agaggaccgt ggtccggctt caggagaagc ggcagaagga actctggaac
     2101 ctcctgaaga tcgcctgtag caaagtccga ggtcccgtga gtggaagccc agacagcatg
     2161 aatgtgtctc gactcagtca ccctggtcag ctaatgtccc agccttccag tgcctgtgac
     2221 agcttacctg aatcagacaa gaaaagtgaa gaactggtgg ccgaagccca cgccctctgc
     2281 tcccggctag aaagtgcgct gcaggacact gtgaaggagc aagacagaag cttcacgact
     2341 ctagactgga gctggttaca gatggaggat gaagaaaggt gtagcctgga gcaggcctgt
     2401 gactgaggtg cccatgagct ggcccgtggc tctgcatgtg acgatgttct ggtatctcca
     2461 ggtggacatc tcactctgcc agcagctgtg atacttgccc gcagcagcct aggctggccc
     2521 tgtccacaca ctggattctc gcccacagaa gcacaacaat gcaggtacaa gcacttgcag
     2581 cagcgacgct tcatggctgc tgtacaaaga aagcgacaca gagaaatgac aagtgtctat
     2641 cttgagtgtt tccagacagc agacagcctg tctgctttgg actcctgggg gaggaagctc
     2701 tgccctgccc acccctcctc tccttacagc tggacgtcat ccggatccag ctctcttaga
     2761 cagttaatcc taagtttgac tatcctatat ctctcttcct cttcacttct cccctggtaa
     2821 atgtttcaac cttctgtgct ggtcgctgtg gcaaacgacc tttgactatg ctgtagtgat
     2881 ggcgatgcca aactccctgc tgtttctggt cctttaagcc acaaagtgac ttacaaagcc
     2941 aggcagaaca gaaatgcagc tacatatctt gagtcccaaa gattacctag aatcaattgt
     3001 cacagagaaa aaaggaagat gaaggtgtta tgccaactac taccctactg aacactgcga
     3061 ctcctgggtg cctgtcaggt gtgtgtggat attgctgcct cttaaattag ctagcaatat
     3121 tattaaattg gttcatttta taaatagttt ctattttttg taacattact cagatatgta
     3181 tcctgggctc aaaggtgtat ttccatagta taccatcact agtacttctg agctcaaaac
     3241 tcaacatcat gggaaagttt gtaaaattga atagtgtgtc tatgtctaga tcatgagcca
     3301 tttttaacat cacacaaaac ttgtgtgttt gtgtgcatgt gtgtgtgtaa aagcaaaaac
     3361 cggctcaggt tatcataggc aggtatattt aattagagaa tacgtaacgc tggagcagag
     3421 aaatgtcaga gtggccaccg cagaggcagt atgaagcatc gacggtcaaa tgagttcaga
     3481 ggtgctgcac gctttgattg ttcctgagag attgacactg tgcactggta aactgtctga
     3541 aagctctgac aataaagatg ctggcttaag ctcagtgtaa attcacccat gaaaaaaa
//
