LOCUS       NM_026166               3251 bp    mRNA    linear   ROD 03-FEB-2024
DEFINITION  Mus musculus IKBKB interacting protein (Ikbip), transcript variant
            1, mRNA.
ACCESSION   NM_026166 XM_985608
VERSION     NM_026166.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3251)
  AUTHORS   Wu,H., Liu,H., Zhao,X., Zheng,Y., Liu,B., Zhang,L. and Gao,C.
  TITLE     IKIP Negatively Regulates NF-kappaB Activation and Inflammation
            through Inhibition of IKKalpha/beta Phosphorylation
  JOURNAL   J Immunol 204 (2), 418-427 (2020)
   PUBMED   31826938
REFERENCE   2  (bases 1 to 3251)
  AUTHORS   Hofer-Warbinek,R., Schmid,J.A., Mayer,H., Winsauer,G., Orel,L.,
            Mueller,B., Wiesner,Ch., Binder,B.R. and de Martin,R.
  TITLE     A highly conserved proapoptotic gene, IKIP, located next to the
            APAF1 gene locus, is regulated by p53
  JOURNAL   Cell Death Differ 11 (12), 1317-1325 (2004)
   PUBMED   15389287
REFERENCE   3  (bases 1 to 3251)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY277133.1, CF171082.1 and AC140410.3.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_026166.3.
            
            On Jan 10, 2007 this sequence version replaced NM_026166.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004670.1, SRR1660817.177702.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-295               BY277133.1         33-327
            296-625             CF171082.1         278-607
            626-3251            AC140410.3         133462-136087
FEATURES             Location/Qualifiers
     source          1..3251
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 45.54 cM"
     gene            1..3251
                     /gene="Ikbip"
                     /gene_synonym="1200009F10Rik; 1700023M03Rik; Ikip"
                     /note="IKBKB interacting protein"
                     /db_xref="GeneID:67454"
                     /db_xref="MGI:MGI:1914704"
     exon            1..258
                     /gene="Ikbip"
                     /gene_synonym="1200009F10Rik; 1700023M03Rik; Ikip"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1210
                     /gene="Ikbip"
                     /gene_synonym="1200009F10Rik; 1700023M03Rik; Ikip"
                     /note="isoform 1 is encoded by transcript variant 1;
                     inhibitor of nuclear factor kappa-B kinase-interacting
                     protein; IKK-interacting protein; i kappa-B
                     kinase-interacting protein"
                     /codon_start=1
                     /product="inhibitor of nuclear factor kappa-B
                     kinase-interacting protein isoform 1"
                     /protein_id="NP_080442.2"
                     /db_xref="CCDS:CCDS36031.1"
                     /db_xref="GeneID:67454"
                     /db_xref="MGI:MGI:1914704"
                     /translation="MSEVKSRKKPGPKVAAPEPEKRSDGRKNPEARGDAGWADPRTGL
                     SLLSLAMTLGLAWLVFQQSEKFAKVEKQYRLLQTESSEFQGLQSKISLISSKLESTEN
                     TLQEATSSISLMTQFEQEVSGLQRSIRDIETSEEMLTQKMQNLNEKFQNITDFWKRTL
                     AEMIDDTAVFKSEVKDTHSEVTLKINSADQEIKSLTERLKDLEDSTLRNIRTVSRQEE
                     EDLLRVEAQLSSDTKAVKKLEEEQHTLLARDEDLTNKLSSYEPKVEECKAHLPTIENA
                     VHSVLRVSQDLIGTERKMEELTMQMFNMEDDMLRAVSEIMEMQKTLEGIQYDNSLLKM
                     QNELVVLKGKVHDFIAYSSAREKGTLGEYSLGNKGTDEY"
     exon            259..376
                     /gene="Ikbip"
                     /gene_synonym="1200009F10Rik; 1700023M03Rik; Ikip"
                     /inference="alignment:Splign:2.1.0"
     exon            377..3251
                     /gene="Ikbip"
                     /gene_synonym="1200009F10Rik; 1700023M03Rik; Ikip"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgtggcct tccgaagctg ctctgcagcc acgtcccacg gcccccctcc aaagccatcc
       61 tggcttcaag atcttcaggg atccagacat gtccgaagtg aagagccgaa agaagccggg
      121 gcccaaagtg gctgctcctg agcccgagaa gcggagtgat ggcaggaaaa accccgaggc
      181 gcggggggac gcgggctggg cggacccccg cactgggctc agcctgctgt ctctggcgat
      241 gaccctgggc ctggcctggc ttgtatttca acaatcagaa aagtttgcga aggtagaaaa
      301 acaataccgg ttactgcaaa cagagagcag cgagtttcag ggcctccaga gtaaaatcag
      361 tttaatttcc agcaagcttg agtctactga aaataccctg caggaagcta catcatccat
      421 atctttgatg acccaatttg aacaggaagt atctggcctc caaagatcca tacgtgatat
      481 tgagactagc gaagagatgc tcacacaaaa gatgcaaaac cttaatgaga aattccagaa
      541 cattacagac ttctggaaga gaacactggc agaaatgatc gatgacacag ccgtcttcaa
      601 atcagaagtg aaggatacac attctgaagt taccctgaag attaactccg cggatcaaga
      661 aataaaatcg ctcactgaac gtctaaaaga tttagaagac agcacactgc gaaacatcag
      721 aacagtgagc aggcaagaag aggaagatct tctacgagtc gaggcccagc ttagctctga
      781 taccaaagca gttaagaagc tagaagaaga acagcacacg ctcctagcca gagacgaaga
      841 tctgaccaac aaactctcca gctacgaacc caaagtagaa gagtgcaagg cacacttgcc
      901 aaccatagaa aatgctgtcc actcggttct cagagtctct caggatctga tagggacaga
      961 aaggaagatg gaggagctga cgatgcagat gttcaacatg gaggacgaca tgctgagggc
     1021 tgtgtctgag atcatggaga tgcagaaaac cctggagggg atccagtatg acaacagctt
     1081 actaaagatg cagaacgagc tggtcgttct aaaaggaaaa gttcatgact tcatagcata
     1141 ttcaagtgca cgggaaaagg ggactttggg agagtatagc ctaggaaata agggaactga
     1201 tgagtattaa atatactgca caccttctga tgggctgcac taccaagtgg gaatcattca
     1261 ctcctacatt ttttaggttt ttttttttga tctgcctcat gttactcgag aataagtgga
     1321 gtgtgcgcca tatggagtat gcatctaatc aaactttttt gtctttttaa tcttaaaact
     1381 tactttaact atgttcatag caattcttct aaaatatata ttgctccact tttttaggca
     1441 gtatatttaa tatttacatg tctttccaat gattaataga cattatgagt tgcattattc
     1501 tatctatcta tctatctatc tatctatcta tctatctatt ctggagatag acagacagat
     1561 aatctgtagc aaatattaaa acctcttacc atttcactgt gaccctcatt atctgttttc
     1621 taagctatgt ctgtttctca caacttttct gtctcctgct cttgcagcca gttggtaaca
     1681 taccttcctc tcccaggttt ttggggctct tttttttttt ttttttaaat tcagacaacc
     1741 aagttcattg gaagtgtatg taaaatagaa ggtaaccttc ctgcaggaga accaaggggc
     1801 tctcctgtga ggtagtgcca cgttatgaaa actatgaaaa ctgaaaagta tcctcccttt
     1861 tgcaaaggtt ctaagctgtg ttacagatac ttacaagagg tttaagatgt gagtgaacgt
     1921 gtccctattg tgttctcatt tatagccttt tctatgaact ggtgatgttt tgaagtatga
     1981 gtttatgaag tctctttgtg aacctggact tttatttcta aagtttgaac tgtgtgacac
     2041 tagagtttac tgaatacaat taatagatgc ttaaaataag aacatgttgg gcctgtgcct
     2101 attttaaaga taaaataaca tagcaataaa ttgtgataat gacatattta catcattatt
     2161 ttaaagattc tccaatgtat gaaactaaat ttgtttcaca tattaatttt ttaaaaagta
     2221 gggctggagc taagtacggt ggcgcacagc tttgatacca gcactccaga ggtaaaggca
     2281 gtcggctctc taagttcaag atcaccctgg tctacatagt aagactgtgt ctcaaaacaa
     2341 aacaaaagaa aaacaaaaat taggacaagg agatagttca ataaatgaga ggcttgctgt
     2401 gtaagcacaa ggaccaggat cagggtttaa tacccgacac tgacataaaa agctgtgtct
     2461 tgccgggcgt ggtggtgcac gcctttaatc ccagcacttg ggaggcagag gcaggcgtat
     2521 ttctgagttc ggggccagcc tggtctacaa agtgagttcc aggacagcca gggctacaca
     2581 gagaaaccct gtctcaaaaa ataaaaaata aaaaataata aaaaaaaaaa gctgggtcta
     2641 gcatcccctg cctataatac cagccctgga aaacagagac atgagaaaac tattgaacat
     2701 gtgtgtctgt gtattccttt gctaagaaat ttgatgtctc aggggttaag agcactggtt
     2761 gttcttgcag aggacttggg tttgattccc agtgcccacg tgatggctca caaccatctg
     2821 taactcagct cccaggagac ccagcacagc cttatgactc ctgcaagtac catgcatggc
     2881 gtgcacgcgg tgcacagaca catacaggca ggccactcat atgcataaaa taaatgtatt
     2941 ttaacttcct gtttaacaaa atcgtcattg tagattaacg tttaacgaat tttcctttgt
     3001 ttctttcttt ctttgtttcg aagggttttt ttgttttgtt ttgttttgat tttgagacag
     3061 aatctcaaga tgtagcccag gttagtctta agtcaccatc ttcctgctcc tgcgtttcaa
     3121 gtaacaggga ccataggtct aaatcatggc acaggacttc atattgttgt gctttatggc
     3181 aaattcccag tattataatc cacactttcg tatctctgta attgataata aattttatat
     3241 agcagttagc a
//
