LOCUS       NM_011879               1996 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus IK cytokine (Ik), mRNA.
ACCESSION   NM_011879
VERSION     NM_011879.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1996)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1996)
  AUTHORS   Park,H.L., Lee,S.M., Min,J.K., Moon,S.J., Kim,I., Kang,K.W.,
            Park,S., Choi,S., Jung,H.N., Lee,D.H. and Nam,J.H.
  TITLE     IK acts as an immunoregulator of inflammatory arthritis by
            suppressing TH17 cell differentiation and macrophage activation
  JOURNAL   Sci Rep 7, 40280 (2017)
   PUBMED   28071693
  REMARK    GeneRIF: Our observations suggest that tIK cytokine can
            counterbalance the induction of inflammatory cells related to
            rheumatoid arthritis(RA) and thus could be a new therapeutic agent
            for the treatment of RA.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1996)
  AUTHORS   Lee,S., Han,S., Jeong,A.L., Park,J.S. and Yang,Y.
  TITLE     Depletion of IK causes mitotic arrest through aberrant regulation
            of mitotic kinases and phosphatases
  JOURNAL   FEBS Lett 588 (17), 2844-2850 (2014)
   PUBMED   24996188
  REMARK    GeneRIF: IK is an essential protein for achieving correct mitotic
            progress through the regulation of mitotic kinases and phosphatases
REFERENCE   4  (bases 1 to 1996)
  AUTHORS   Park,H.L., Kim,Y.J., Na,H.N., Park,M.Y., Kim,J.Y., Yun,C.W. and
            Nam,J.H.
  TITLE     IK induced by coxsackievirus B3 infection transiently downregulates
            expression of MHC class II through increasing cAMP
  JOURNAL   Viral Immunol 26 (1), 13-24 (2013)
   PUBMED   23409929
  REMARK    GeneRIF: Taken together, these results imply that IK plays a role
            in downregulating MHC class II expression on B cells during
            coxsackievirus B3 infection through the induction of cAMP.
REFERENCE   5  (bases 1 to 1996)
  AUTHORS   Youngren,K.K., Coveney,D., Peng,X., Bhattacharya,C., Schmidt,L.S.,
            Nickerson,M.L., Lamb,B.T., Deng,J.M., Behringer,R.R., Capel,B.,
            Rubin,E.M., Nadeau,J.H. and Matin,A.
  TITLE     The Ter mutation in the dead end gene causes germ cell loss and
            testicular germ cell tumours
  JOURNAL   Nature 435 (7040), 360-364 (2005)
   PUBMED   15902260
REFERENCE   6  (bases 1 to 1996)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   7  (bases 1 to 1996)
  AUTHORS   Assier,E., Bouzinba-Segard,H., Stolzenberg,M.C., Stephens,R.,
            Bardos,J., Freemont,P., Charron,D., Trowsdale,J. and Rich,T.
  TITLE     Isolation, sequencing and expression of RED, a novel human gene
            encoding an acidic-basic dipeptide repeat
  JOURNAL   Gene 230 (2), 145-154 (1999)
   PUBMED   10216252
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG084120.2, BC029694.1 and BM211698.2.
            
            On Nov 20, 2007 this sequence version replaced NM_011879.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK087976.1, BC029671.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                BG084120.2         1-60
            61-1992             BC029694.1         1-1932
            1993-1996           BM211698.2         1-4                 c
FEATURES             Location/Qualifiers
     source          1..1996
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.46 cM"
     gene            1..1996
                     /gene="Ik"
                     /gene_synonym="MuRED"
                     /note="IK cytokine"
                     /db_xref="GeneID:24010"
                     /db_xref="MGI:MGI:1345142"
     exon            1..133
                     /gene="Ik"
                     /gene_synonym="MuRED"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..1791
                     /gene="Ik"
                     /gene_synonym="MuRED"
                     /note="arginine/glutamic acid/aspartic acid repeat
                     containing protein; IK factor; cytokine IK"
                     /codon_start=1
                     /product="protein Red"
                     /protein_id="NP_036009.1"
                     /db_xref="CCDS:CCDS57119.1"
                     /db_xref="GeneID:24010"
                     /db_xref="MGI:MGI:1345142"
                     /translation="MPERDSEPFSNPLAPDGHDVDDPHSFHQSKLTNEDFRKLLMTPR
                     AAPTSAPPSKSRHHEMPREYNEDEDPAARRRKKKSYYAKLRQQEIERERELAEKYRDR
                     AKERRDGVNKDYEETELISTTANYRAVGPTAEADKSAAEKRRQLIQESKFLGGDMEHT
                     HLVKGLDFALLQKVRAEIASKEKEEEELMEKPQKETKKDEDPENKIEFKTRLGRNVYR
                     MLFKSKSYERNELFLPGRMAYVVDLDDEYADTDIPTTLIRSKADCPTMEAQTTLTTND
                     IVISKLTQILSYLRQGTRNKKLKKKDKGKLEEKKPPEADMNIFEDIGDYVPSTTKTPR
                     DKERERYRERERDRERDRDRERDRERDRERERERDREREREEEKKRHSYFEKPKVDDE
                     PMDVDKGPGSAKELIKSINEKFAGSAGWEGTESLKKPEDKKQLGDFFGMSNSYAECYP
                     ATMDDMAVDSDEEVDYSKMDQGNKKGPLGRWDFDTQEEYSEYMNNKEALPKAAFQYGI
                     KMSEGRKTRRFKETNDKAELDRQWKKISAIIEKRKRMEADGVEVKRPKY"
     exon            134..200
                     /gene="Ik"
                     /gene_synonym="MuRED"
                     /inference="alignment:Splign:2.1.0"
     exon            201..293
                     /gene="Ik"
                     /gene_synonym="MuRED"
                     /inference="alignment:Splign:2.1.0"
     exon            294..353
                     /gene="Ik"
                     /gene_synonym="MuRED"
                     /inference="alignment:Splign:2.1.0"
     exon            354..521
                     /gene="Ik"
                     /gene_synonym="MuRED"
                     /inference="alignment:Splign:2.1.0"
     exon            522..636
                     /gene="Ik"
                     /gene_synonym="MuRED"
                     /inference="alignment:Splign:2.1.0"
     exon            637..707
                     /gene="Ik"
                     /gene_synonym="MuRED"
                     /inference="alignment:Splign:2.1.0"
     exon            708..754
                     /gene="Ik"
                     /gene_synonym="MuRED"
                     /inference="alignment:Splign:2.1.0"
     exon            755..918
                     /gene="Ik"
                     /gene_synonym="MuRED"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1027
                     /gene="Ik"
                     /gene_synonym="MuRED"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1067
                     /gene="Ik"
                     /gene_synonym="MuRED"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1293
                     /gene="Ik"
                     /gene_synonym="MuRED"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1312
                     /gene="Ik"
                     /gene_synonym="MuRED"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1391
                     /gene="Ik"
                     /gene_synonym="MuRED"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1472
                     /gene="Ik"
                     /gene_synonym="MuRED"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1530
                     /gene="Ik"
                     /gene_synonym="MuRED"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1619
                     /gene="Ik"
                     /gene_synonym="MuRED"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1728
                     /gene="Ik"
                     /gene_synonym="MuRED"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1763
                     /gene="Ik"
                     /gene_synonym="MuRED"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1996
                     /gene="Ik"
                     /gene_synonym="MuRED"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1972..1977
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ik"
                     /gene_synonym="MuRED"
                     /note="hexamer: ATTAAA"
     polyA_site      1992
                     /gene="Ik"
                     /gene_synonym="MuRED"
                     /note="major polyA site"
ORIGIN      
        1 cgtgtggtga cgcgaaggaa gacaggtttt cgtggtgcat tgtggataaa agtttgtcgc
       61 cgctgtcttg ttagggggac atttcgcgat tgcggacgtt gagaggccgc tgccaaaatg
      121 ccagaacgag atagtgagcc cttctctaac cctttggctc cagatggcca cgatgtggat
      181 gatcctcatt ccttccacca atcaaaactt accaatgaag acttcaggaa acttcttatg
      241 accccaagag ctgcacctac ttctgcgcca ccttctaagt cacgtcacca tgagatgcca
      301 agggagtaca atgaggatga agacccagct gcacgaagga ggaaaaagaa aagttattat
      361 gccaagcttc gccagcaaga aattgagaga gagagagaac tcgcagagaa ataccgggac
      421 cgtgccaagg aacggagaga tggtgtgaac aaagactatg aggaaactga gctgataagt
      481 accacagcca actacagggc tgtgggcccc actgctgagg cggacaaatc agcagcagag
      541 aagagaagac agttgattca ggagtccaaa ttcttgggtg gtgatatgga acacacccat
      601 ttggtgaaag gtttggattt tgcgttgctt caaaaggtgc gcgctgagat tgccagcaaa
      661 gagaaggagg aagaggaact catggaaaag ccccaaaagg aaaccaagaa agatgaggat
      721 cctgagaaca aaattgaatt taaaacacgc cttggccgga atgtgtatcg gatgcttttc
      781 aagagtaaat catatgagcg aaatgagctg ttcttaccag gacgtatggc ctatgtagta
      841 gacctggatg atgagtacgc agacacagat atccccacca ctctcatacg cagcaaagct
      901 gattgcccca ctatggaggc ccagactaca ctgactacaa atgacattgt tattagcaag
      961 ctcacccaga ttttgtcata cctgaggcag gggacccgaa acaagaagct caagaagaag
     1021 gataaaggaa aactggaaga gaagaaacct cctgaggctg acatgaacat ttttgaagac
     1081 attggggatt acgttccttc tacaaccaag acacctcggg acaaggaacg tgagagatac
     1141 cgggaacgtg aacgtgatcg ggaacgggac agagacaggg agcgagacag ggagcgagac
     1201 cgtgagaggg agagagagcg agaccgggaa cgggaacgag aggaggaaaa gaaaaggcac
     1261 agctactttg agaagccaaa agtggatgat gagcccatgg atgttgacaa aggacctgga
     1321 tctgcaaaag agttgatcaa gtccatcaat gaaaaattcg ctgggtctgc tggctgggaa
     1381 ggcactgaat cgttgaagaa gccagaagat aagaagcagc tgggcgattt ctttggcatg
     1441 tccaacagtt acgcagaatg ctatccagcc acgatggatg acatggctgt agatagtgat
     1501 gaagaggtag attatagcaa aatggaccag ggtaacaaga agggtccctt aggccgctgg
     1561 gacttcgata ctcaggagga atacagcgag tacatgaaca acaaggaggc tctgcccaag
     1621 gctgcattcc agtatggcat caagatgtct gaaggacgga aaaccagacg attcaaagaa
     1681 accaatgata aggcagagct tgatcgacag tggaagaaaa taagtgcaat cattgagaag
     1741 aggaagagga tggaagcaga tggggtcgaa gtgaaaagac caaagtacta atctctagtt
     1801 ccagctgtca ccacgtggct gttcttagtt gcttgcttct acaattcctc agacggttgc
     1861 aaactgttgt tgtttgtgaa agtttataaa tgtttattgt ataactcttt atagatctgt
     1921 gtcccacatg ctaagattaa tggcaatgca acaccatgtc cagcatgttc cattaaatgt
     1981 agttaaacct gctgtc
//
