LOCUS       NM_001033767            2648 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus interferon inducible GTPase 1C (Iigp1c), mRNA.
ACCESSION   NM_001033767 XM_140378 XM_894548 XM_915019 XM_923533
VERSION     NM_001033767.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2648)
  AUTHORS   Zhang Z, Xun Y, Rong S, Yan L, SoRelle JA, Li X, Tang M, Keller K,
            Ludwig S, Moresco EMY and Beutler B.
  TITLE     Loss of immunity-related GTPase GM4951 leads to nonalcoholic fatty
            liver disease without obesity
  JOURNAL   Nat Commun 13 (1), 4136 (2022)
   PUBMED   35842425
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2648)
  AUTHORS   Schwerbel K, Kamitz A, Krahmer N, Hallahan N, Jahnert M, Gottmann
            P, Lebek S, Schallschmidt T, Arends D, Schumacher F, Kleuser B,
            Haltenhof T, Heyd F, Gancheva S, Broman KW, Roden M, Joost HG,
            Chadt A, Al-Hasani H, Vogel H, Jonas W and Schurmann A.
  TITLE     Immunity-related GTPase induces lipophagy to prevent excess hepatic
            lipid accumulation
  JOURNAL   J Hepatol 73 (4), 771-782 (2020)
   PUBMED   32376415
REFERENCE   3  (bases 1 to 2648)
  AUTHORS   Burckstummer T, Baumann C, Bluml S, Dixit E, Durnberger G, Jahn H,
            Planyavsky M, Bilban M, Colinge J, Bennett KL and Superti-Furga G.
  TITLE     An orthogonal proteomic-genomic screen identifies AIM2 as a
            cytoplasmic DNA sensor for the inflammasome
  JOURNAL   Nat Immunol 10 (3), 266-272 (2009)
   PUBMED   19158679
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK149556.1 and AK149583.1.
            
            [WARNING] On Apr 9, 2024 this sequence was replaced by
            NM_001033767.4.
            
            On Oct 31, 2007 this sequence version replaced NM_001033767.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK149583.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AK149556.1         2-4
            4-1778              AK149583.1         2-1776
            1779-1836           AK149556.1         1671-1728
            1837-2648           AK149583.1         1835-2646
FEATURES             Location/Qualifiers
     source          1..2648
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 34.36 cM"
     gene            1..2648
                     /gene="Iigp1c"
                     /gene_synonym="EG240327; Gm4951; Ifgga2"
                     /note="interferon inducible GTPase 1C"
                     /db_xref="GeneID:240327"
                     /db_xref="MGI:MGI:3644953"
     exon            1..93
                     /gene="Iigp1c"
                     /gene_synonym="EG240327; Gm4951; Ifgga2"
                     /inference="alignment:Splign:2.1.0"
     exon            94..202
                     /gene="Iigp1c"
                     /gene_synonym="EG240327; Gm4951; Ifgga2"
                     /inference="alignment:Splign:2.1.0"
     exon            203..2648
                     /gene="Iigp1c"
                     /gene_synonym="EG240327; Gm4951; Ifgga2"
                     /inference="alignment:Splign:2.1.0"
     CDS             223..1443
                     /gene="Iigp1c"
                     /gene_synonym="EG240327; Gm4951; Ifgga2"
                     /note="interferon-gamma-inducible GTPase Ifgga2 protein"
                     /codon_start=1
                     /product="uncharacterized protein LOC240327"
                     /protein_id="NP_001028939.1"
                     /db_xref="CCDS:CCDS29268.1"
                     /db_xref="GeneID:240327"
                     /db_xref="MGI:MGI:3644953"
                     /translation="MGQLFSSRRSEDQDLSSSFIEYLKECEKGINIIPHEIITSIEIN
                     MKKGNIQEVNSTVRDMLREIDNTPLNVALTGETGSGKSSFINTLRGIGHEEGGAAHTG
                     VTDKTKERHPYEHPKMPNVVFWDLPGTGSEDFQPKTYLEKMKFYEYDFFIIISATRFK
                     KNDIDLAKAIGIMKKEFYFVRTQVDSDLRNEEDFKPQTFDREKVLQDIRLNCVNTFRE
                     NGIAEPPIFLISNKNVCHYDFPVLMDKLISDLPVFKRQNFMFSLPNITDSVIEKKRNF
                     LRWKTWLEGFADGLLSFFLESDLETLEKSMKFYRTVFGVDDASLQRLARAWEIDQVDQ
                     VRAMIKSPAVFTPTDEETIQERLSRYNQEFCLANGYLLPKNHCREILYLKLYFLDMVT
                     EDAKTLLKEICLRN"
     regulatory      1822..1827
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Iigp1c"
                     /gene_synonym="EG240327; Gm4951; Ifgga2"
                     /note="putative"
     polyA_site      1836
                     /gene="Iigp1c"
                     /gene_synonym="EG240327; Gm4951; Ifgga2"
                     /note="putative"
ORIGIN      
        1 gctgagaaac agaagtagac tcaagccaag agcacaccga gggctattct tctctggagc
       61 agtgagtgca tccactggac acaggatttt ctgtgcagca gatttactgt aaactccagt
      121 ggaagctaga ctggaggaaa agatgaccca ctgtttaaag tttctgctat aacctgctgc
      181 ggagcaattc taggatttgt tgtgccttta ttgcttgaag tgatgggtca actgttctct
      241 tcacgtagga gtgaggacca agatttgtcc tccagcttta ttgaatactt aaaggaatgt
      301 gagaaaggaa tcaatatcat tcctcatgag atcatcactt cgattgaaat aaacatgaaa
      361 aaagggaaca ttcaggaggt aaactctaca gtcagagaca tgttaagaga aattgataat
      421 accccgctca atgttgctct caccggggag actggatcag ggaagtccag cttcatcaac
      481 accctgagag gcattgggca tgaagaggga ggtgcagctc acactggggt gacggacaaa
      541 accaaggaga gacatccata cgaacacccc aaaatgccca atgtggtttt ttgggacctg
      601 cctgggactg gaagtgaaga tttccaacca aaaacttatc tcgagaaaat gaagttctat
      661 gagtatgact tcttcattat tatttcggcc acacgcttca agaaaaatga tatagacctc
      721 gcaaaagcaa tcggaataat gaaaaaggaa ttctacttcg tgagaacaca ggtggactct
      781 gacttaagaa atgaagagga tttcaaacct caaacctttg acagagaaaa agtcctgcag
      841 gacattcgtc ttaactgtgt gaacaccttt agggagaatg gcattgctga gccacctatc
      901 tttctgatct ctaacaaaaa tgtttgtcac tatgacttcc ccgtcctgat ggacaagctg
      961 ataagtgacc tccctgtctt caagagacaa aattttatgt tctccttacc caatattaca
     1021 gattcggtca ttgaaaagaa gcgaaatttt ctgaggtgga agacttggct ggaaggcttt
     1081 gcagatgggc tactgagctt cttcttagaa agtgatttgg agactctgga gaaaagcatg
     1141 aagttctacc gcactgtgtt tggagtggat gatgcatctt tgcagagatt ggctagggcc
     1201 tgggaaatag atcaggtaga tcaggtgagg gccatgataa aatctcctgc cgtgttcaca
     1261 cctacagatg aagaaacaat acaagaaagg ctttcaagat ataatcagga gttctgtctg
     1321 gctaatgggt acttacttcc taaaaatcat tgtagagaaa tactttacct gaagttgtat
     1381 ttccttgaca tggtgactga ggatgctaaa actcttctta aagagatatg tttaagaaac
     1441 tagttgctac cgggcactgg tggtacatgc ctttaatcct agcactgggg aggcagaggc
     1501 aggtggattt ctgagttcga ggccagcctg gtctacagag tgagttccag gacaaccagg
     1561 gcctacaatg agaaaccctg tctcgaaaaa ctccaaaaga aaaaaaagaa aaagaaagaa
     1621 agagagagag agagagagac tagttgcctt ctaattaggc tgaagtcctg tgactttcaa
     1681 aaaatcagaa tcaataaaca gaaaaacagg acactgatac tgtaaaacaa tatactgggt
     1741 ttatccaggt tattcgggct ttatccatat ttagtgatta tgtatccaca ttacctagat
     1801 aaaggggatc agatatgtat aaataaactg atagctaaaa actatcccct cactttgagt
     1861 aaactttcag atcaataatt ttacttacat ttaaatttgt ttaatataaa tcgacatcca
     1921 agttcagggt tagcattgaa gtgtttagta ttgtcaactg aacagactct agagtcacat
     1981 gaaagatgag tctgggggat tgcatttggg aaattatttt gcttatgtta attgaggtaa
     2041 gaaatccttt ccactgtggg tggcaccatt ccctagctgg caattgtcaa ctgtgtatat
     2101 ggagagaggt ggtaagtacc agcgtatttc cattctttca tagccctctg gtggtttttg
     2161 ttgttgtttg ttttttattg ttgattttta actatagatg gtatgacact agctgccaca
     2221 agatactgct ctgccttctt gaaaattacc tatataacct taaacttgat actgtagact
     2281 ttcttgatag agattttata agagaaacct taagtgggtt ggagagatgg ctcagtaaat
     2341 aaagtagacc ttgcaactat gaagacccga gttcagattc ccagaaccca cataaagcca
     2401 gctaagcatc tgtaatccat gcaattctat tgtgagatgg gaggcataac gagaaatatt
     2461 ttgggagatc atggggccag gtatcctgcc acatgcagca gtaaataaga ggccctgact
     2521 caagcaagtg gaaggtaaaa gccaacacga aagcttgtcc tctgatctct gcatacatgc
     2581 catgtcatgt tcatgcctga tatcacacat ggatatgcac acacaaaaaa gaaatttttt
     2641 ttcattcc
//
