LOCUS       NM_021792               3068 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus interferon inducible GTPase 1 (Iigp1), transcript
            variant 1, mRNA.
ACCESSION   NM_021792 XM_011246977
VERSION     NM_021792.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3068)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   2  (bases 1 to 3068)
  AUTHORS   Tian,B., Yuan,Y., Yang,Y., Luo,Z., Sui,B., Zhou,M., Fu,Z.F. and
            Zhao,L.
  TITLE     Interferon-Inducible GTPase 1 Impedes the Dimerization of Rabies
            Virus Phosphoprotein and Restricts Viral Replication
  JOURNAL   J Virol 94 (21), e01203-20 (2020)
   PUBMED   32796066
  REMARK    GeneRIF: Interferon-Inducible GTPase 1 Impedes the Dimerization of
            Rabies Virus Phosphoprotein and Restricts Viral Replication.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3068)
  AUTHORS   Schulte,K., Pawlowski,N., Faelber,K., Frohlich,C., Howard,J. and
            Daumke,O.
  TITLE     The immunity-related GTPase Irga6 dimerizes in a parallel
            head-to-head fashion
  JOURNAL   BMC Biol 14, 14 (2016)
   PUBMED   26934976
  REMARK    GeneRIF: The study determined the crystal structure of an
            oligomerization-impaired Irga6 mutant bound to a non-hydrolyzable
            GTP analog.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3068)
  AUTHORS   Hermanns,T., Muller,U.B., Konen-Waisman,S., Howard,J.C. and
            Steinfeldt,T.
  TITLE     The Toxoplasma gondii rhoptry protein ROP18 is an Irga6-specific
            kinase and regulated by the dense granule protein GRA7
  JOURNAL   Cell Microbiol 18 (2), 244-259 (2016)
   PUBMED   26247512
  REMARK    GeneRIF: These data identify Toxoplasma gondii GRA7 as a regulator
            for ROP18-specific inactivation of murine Irga6.
REFERENCE   5  (bases 1 to 3068)
  AUTHORS   Ferreira-da-Silva Mda,F., Springer-Frauenhoff,H.M., Bohne,W. and
            Howard,J.C.
  TITLE     Identification of the microsporidian Encephalitozoon cuniculi as a
            new target of the IFNgamma-inducible IRG resistance system
  JOURNAL   PLoS Pathog 10 (10), e1004449 (2014)
   PUBMED   25356593
  REMARK    Erratum:[PLoS Pathog. 2014 Dec;10(12):. da Fonseca
            Ferreira-da-Silva, Marialice [corrected to Ferreira-da-Silva,
            Marialice da Fonseca]]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3068)
  AUTHORS   Lemon,W.J., Bernert,H., Sun,H., Wang,Y. and You,M.
  TITLE     Identification of candidate lung cancer susceptibility genes in
            mouse using oligonucleotide arrays
  JOURNAL   J Med Genet 39 (9), 644-655 (2002)
   PUBMED   12205107
REFERENCE   7  (bases 1 to 3068)
  AUTHORS   Zerrahn,J., Schaible,U.E., Brinkmann,V., Guhlich,U. and
            Kaufmann,S.H.
  TITLE     The IFN-inducible Golgi- and endoplasmic reticulum- associated
            47-kDa GTPase IIGP is transiently expressed during listeriosis
  JOURNAL   J Immunol 168 (7), 3428-3436 (2002)
   PUBMED   11907101
REFERENCE   8  (bases 1 to 3068)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
REFERENCE   9  (bases 1 to 3068)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 3068)
  AUTHORS   Boehm,U., Guethlein,L., Klamp,T., Ozbek,K., Schaub,A., Futterer,A.,
            Pfeffer,K. and Howard,J.C.
  TITLE     Two families of GTPases dominate the complex cellular response to
            IFN-gamma
  JOURNAL   J Immunol 161 (12), 6715-6723 (1998)
   PUBMED   9862701
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151990.6, AK153060.1, AJ007971.1 and AF194871.1.
            
            On or before Oct 27, 2017 this sequence version replaced
            XM_011246977.2, NM_021792.4.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.122459.1, BI657333.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               AC151990.6         122481-122583
            104-120             AK153060.1         4-20
            121-2400            AJ007971.1         1-2280
            2401-2426           AF194871.1         2194-2219
            2427-3068           AF194871.1         2221-2862
FEATURES             Location/Qualifiers
     source          1..3068
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 34.36 cM"
     gene            1..3068
                     /gene="Iigp1"
                     /gene_synonym="2900074L10Rik; Ifgga1; Iigp; Irga6"
                     /note="interferon inducible GTPase 1"
                     /db_xref="GeneID:60440"
                     /db_xref="MGI:MGI:1926259"
     exon            1..103
                     /gene="Iigp1"
                     /gene_synonym="2900074L10Rik; Ifgga1; Iigp; Irga6"
                     /inference="alignment:Splign:2.1.0"
     exon            104..204
                     /gene="Iigp1"
                     /gene_synonym="2900074L10Rik; Ifgga1; Iigp; Irga6"
                     /inference="alignment:Splign:2.1.0"
     exon            205..3047
                     /gene="Iigp1"
                     /gene_synonym="2900074L10Rik; Ifgga1; Iigp; Irga6"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..1466
                     /gene="Iigp1"
                     /gene_synonym="2900074L10Rik; Ifgga1; Iigp; Irga6"
                     /note="interferon-gamma-inducible GTPase Ifgga1 protein"
                     /codon_start=1
                     /product="interferon-inducible GTPase 1"
                     /protein_id="NP_068564.4"
                     /db_xref="CCDS:CCDS29270.1"
                     /db_xref="GeneID:60440"
                     /db_xref="MGI:MGI:1926259"
                     /translation="MGQLFSSPKSDENNDLPSSFTGYFKKFNTGRKIISQEILNLIEL
                     RMRKGNIQLTNSAISDALKEIDSSVLNVAVTGETGSGKSSFINTLRGIGNEEEGAAKT
                     GVVEVTMERHPYKHPNIPNVVFWDLPGIGSTNFPPNTYLEKMKFYEYDFFIIISATRF
                     KKNDIDIAKAISMMKKEFYFVRTKVDSDITNEADGKPQTFDKEKVLQDIRLNCVNTFR
                     ENGIAEPPIFLLSNKNVCHYDFPVLMDKLISDLPIYKRHNFMVSLPNITDSVIEKKRQ
                     FLKQRIWLEGFAADLVNIIPSLTFLLDSDLETLKKSMKFYRTVFGVDETSLQRLARDW
                     EIEVDQVEAMIKSPAVFKPTDEETIQERLSRYIQEFCLANGYLLPKNSFLKEIFYLKY
                     YFLDMVTEDAKTLLKEICLRN"
     regulatory      3012..3017
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Iigp1"
                     /gene_synonym="2900074L10Rik; Ifgga1; Iigp; Irga6"
                     /note="hexamer: AATAAA"
     regulatory      3026..3031
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Iigp1"
                     /gene_synonym="2900074L10Rik; Ifgga1; Iigp; Irga6"
                     /note="hexamer: AATAAA"
     polyA_site      3039
                     /gene="Iigp1"
                     /gene_synonym="2900074L10Rik; Ifgga1; Iigp; Irga6"
     polyA_site      3047
                     /gene="Iigp1"
                     /gene_synonym="2900074L10Rik; Ifgga1; Iigp; Irga6"
                     /note="major polyA site"
ORIGIN      
        1 ggggcaggag tggatttcat tggaagagac tagagcacac acaggagggt gcttcctgca
       61 gtggaactac agtgtgtgaa tccactggac gcaggagttt ctgataaagc aggggtgggt
      121 ctcatgtgaa gagcctgtag cagtgaaggt tgcttcctga agctgaacta cagtaaacaa
      181 atccagtgga cacaggagtt tctgtgcctt tattgcttga agtcatgggt cagctgttct
      241 cttcacctaa gagtgatgag aataatgatt tgccctccag ctttactggt tattttaaga
      301 aatttaatac gggaagaaaa atcatttctc aagagatcct caatttgatt gaattaagga
      361 tgagaaaagg gaatattcag ttgacaaact ctgcaatcag tgatgcatta aaagaaatcg
      421 atagtagtgt gctcaatgtt gctgtcaccg gggagacggg atcagggaag tccagcttca
      481 tcaataccct gagaggcatt gggaatgaag aagaaggtgc agctaaaact ggggtggtgg
      541 aggtaaccat ggaaagacat ccatacaaac accccaatat acccaatgtg gttttttggg
      601 acctgcctgg gattggaagc acaaatttcc caccaaacac ttacctggag aaaatgaagt
      661 tctatgagta cgatttcttc attattattt cggccacacg cttcaagaaa aatgatatag
      721 acattgccaa agcaatcagc atgatgaaga aggaattcta cttcgtgaga accaaggtgg
      781 actctgacat aacaaatgaa gcagatggca aacctcaaac ctttgacaaa gaaaaggtcc
      841 tgcaggacat ccgccttaac tgtgtgaaca cctttaggga gaatggcatt gctgagccac
      901 caatcttcct gctctctaac aaaaatgttt gtcactatga cttccccgtc ctgatggaca
      961 agctgataag tgacctccct atctacaaga gacacaattt tatggtctcc ttacccaata
     1021 tcacagattc agtcattgaa aagaagcggc aatttctgaa gcagaggatt tggctggaag
     1081 gatttgctgc tgacctagtg aatatcatcc cttctctgac ctttctcttg gacagtgatt
     1141 tggagactct gaagaaaagc atgaaattct accgcactgt gtttggagtg gatgaaacat
     1201 ctttgcagag attagctagg gactgggaaa tagaggtgga tcaggtggag gccatgataa
     1261 aatctcctgc tgtgttcaaa cctacagatg aagaaacaat acaagaaagg ctttcaagat
     1321 atattcagga gttctgtttg gctaatgggt acttacttcc taaaaatagt tttcttaaag
     1381 aaatatttta cctgaaatat tatttccttg acatggtgac tgaggatgct aaaactcttc
     1441 ttaaagagat atgtttaaga aactagttgc cttctaatta agctgaagtc ctgtgactgt
     1501 caagaaaata gaatcaatta aagaaaaaca ggacactgat actgtaaaac aatatactgg
     1561 gtttatccag gttattcggg ctttatccac ctttactgat tatgtatcca cattaggtag
     1621 agcaagggga tcagatatgt ataaataaac tgatagctaa aaactatccc ctcactttga
     1681 gtaaactctt agatcaagta attttactta tatttacatt tgttcaatat aaatcaacat
     1741 ccgtgttcag ggttagcatt gaggtgttta gttttgtcaa cccaacagac tctagagact
     1801 catgaaagat gagtctgggg gattgcattt gggaaattat tttgcttatg ttaattgagg
     1861 taggaaaccc tttcctctgt gggtggcacc attccctagc tggcaatcgt caactgtgta
     1921 tttggagaga ggtgctaagt agcagcatat ttacattatt tcataactct ccactggttt
     1981 ttattgtagt tgtttttaaa ctgtagatgg aatgaaacta gctgcctcaa gattcttgat
     2041 aatgacctat ataaccttaa acttgatact gtagtctttc ttgaaagaga tattaaagag
     2101 aaaccataac tgggctagag agatggctca gtagataaag tagaacttgt aagtttgaag
     2161 acttaagttc agatacccag aacccacata aagccagcta atcatctgta atccatgcac
     2221 ttctatggtg agatgggagg tagaatgaga aaaattttgg aagattgtgg ggccagctat
     2281 cctgccacat gcagtagtaa ataagaggcc ctgactcaag caagtggaag gtaaaagata
     2341 acaagcaagc tcatcctttg atctctgcat acatgcatcg tcatgttcat gcctgatatc
     2401 acatatggaa atatacacac aaaaaagttt tttcattaaa aaaaaaaaag aagaagggag
     2461 gtttggggca atagctcatt ggtataatac ctgcctcacg ctcatgaggc ctcaagttca
     2521 tcccctagaa ctccagaaaa aggcaaaaag gggatgtctt cgaggttaaa agagttggcc
     2581 cagtggttaa gaatactggc tactcttgca aaggaccagg atttaactgc cagaacccac
     2641 agagtagctc acagttacct gcaaattctg tctcagggga tctgatctca tcctctcacc
     2701 tccacaggga ccaggaacat gtttatatgg tacatggaca tacatgtaag gcaaacattc
     2761 atacaataaa aataaattaa gaaacatttt aaatatgtaa ttaaattaaa aagggaaaga
     2821 taaatcacag tagcctcaat aaggactaag aattttacaa aaatcctatt tagtcagaat
     2881 ccttgagaaa atactaaaga aggtttctaa ttctatgcca gaactagggg acatgatgaa
     2941 atttctctgc tttataatga ttagtgtttt gaatgctatg acaataaagg gctgctctat
     3001 tccatatgaa taataaaagt catttaataa attctttctg aaaaaaaaaa aaaaaaaaaa
     3061 aaaaaaaa
//
