LOCUS       NM_001135198            3062 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus interactor of HORMAD1 1 (Iho1), transcript variant 2,
            mRNA.
ACCESSION   NM_001135198 XM_006511760 XM_486258 XM_910378
VERSION     NM_001135198.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3062)
  AUTHORS   Biot,M., Toth,A., Brun,C., Guichard,L., de Massy,B. and Grey,C.
  TITLE     Principles of chromosome organization for meiotic recombination
  JOURNAL   Mol Cell 84 (10), 1826-1841 (2024)
   PUBMED   38657614
REFERENCE   2  (bases 1 to 3062)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3062)
  AUTHORS   Laroussi,H., Juarez-Martinez,A.B., Le Roy,A., Boeri Erba,E.,
            Gabel,F., de Massy,B. and Kadlec,J.
  TITLE     Characterization of the REC114-MEI4-IHO1 complex regulating meiotic
            DNA double-strand break formation
  JOURNAL   EMBO J 42 (16), e113866 (2023)
   PUBMED   37431931
  REMARK    GeneRIF: Characterization of the REC114-MEI4-IHO1 complex
            regulating meiotic DNA double-strand break formation.
REFERENCE   4  (bases 1 to 3062)
  AUTHORS   Guan,Y., Lin,H., Leu,N.A., Ruthel,G., Fuchs,S.Y., Busino,L., Luo,M.
            and Wang,P.J.
  TITLE     SCF ubiquitin E3 ligase regulates DNA double-strand breaks in early
            meiotic recombination
  JOURNAL   Nucleic Acids Res 50 (9), 5129-5144 (2022)
   PUBMED   35489071
REFERENCE   5  (bases 1 to 3062)
  AUTHORS   Papanikos,F., Clement,J.A.J., Testa,E., Ravindranathan,R., Grey,C.,
            Dereli,I., Bondarieva,A., Valerio-Cabrera,S., Stanzione,M.,
            Schleiffer,A., Jansa,P., Lustyk,D., Fei,J.F., Adams,I.R.,
            Forejt,J., Barchi,M., de Massy,B. and Toth,A.
  TITLE     Mouse ANKRD31 Regulates Spatiotemporal Patterning of Meiotic
            Recombination Initiation and Ensures Recombination between X and Y
            Sex Chromosomes
  JOURNAL   Mol Cell 74 (5), 1069-1085 (2019)
   PUBMED   31000436
REFERENCE   6  (bases 1 to 3062)
  AUTHORS   Kumar,R., Oliver,C., Brun,C., Juarez-Martinez,A.B., Tarabay,Y.,
            Kadlec,J. and de Massy,B.
  TITLE     Mouse REC114 is essential for meiotic DNA double-strand break
            formation and forms a complex with MEI4
  JOURNAL   Life Sci Alliance 1 (6), e201800259 (2018)
   PUBMED   30569039
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3062)
  AUTHORS   Stanzione,M., Baumann,M., Papanikos,F., Dereli,I., Lange,J.,
            Ramlal,A., Trankner,D., Shibuya,H., de Massy,B., Watanabe,Y.,
            Jasin,M., Keeney,S. and Toth,A.
  TITLE     Meiotic DNA break formation requires the unsynapsed chromosome
            axis-binding protein IHO1 (CCDC36) in mice
  JOURNAL   Nat Cell Biol 18 (11), 1208-1220 (2016)
   PUBMED   27723721
REFERENCE   8  (bases 1 to 3062)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161260.2.
            
            On or before Apr 10, 2020 this sequence version replaced
            XM_006511760.2, NM_001135198.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2322865.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                AC161260.2         38191-38245
            56-122              AC161260.2         41535-41601
            123-294             AC161260.2         48456-48627
            295-458             AC161260.2         52532-52695
            459-507             AC161260.2         57006-57054
            508-595             AC161260.2         57437-57524
            596-699             AC161260.2         63303-63406
            700-3062            AC161260.2         64163-66525
FEATURES             Location/Qualifiers
     source          1..3062
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 59.32 cM"
     gene            1..3062
                     /gene="Iho1"
                     /gene_synonym="Ccdc36"
                     /note="interactor of HORMAD1 1"
                     /db_xref="GeneID:434438"
                     /db_xref="MGI:MGI:3612242"
     exon            1..55
                     /gene="Iho1"
                     /gene_synonym="Ccdc36"
                     /inference="alignment:Splign:2.1.0"
     exon            56..122
                     /gene="Iho1"
                     /gene_synonym="Ccdc36"
                     /inference="alignment:Splign:2.1.0"
     exon            123..294
                     /gene="Iho1"
                     /gene_synonym="Ccdc36"
                     /inference="alignment:Splign:2.1.0"
     exon            295..458
                     /gene="Iho1"
                     /gene_synonym="Ccdc36"
                     /inference="alignment:Splign:2.1.0"
     exon            459..507
                     /gene="Iho1"
                     /gene_synonym="Ccdc36"
                     /inference="alignment:Splign:2.1.0"
     exon            508..595
                     /gene="Iho1"
                     /gene_synonym="Ccdc36"
                     /inference="alignment:Splign:2.1.0"
     exon            596..699
                     /gene="Iho1"
                     /gene_synonym="Ccdc36"
                     /inference="alignment:Splign:2.1.0"
     exon            700..3062
                     /gene="Iho1"
                     /gene_synonym="Ccdc36"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3035..3040
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Iho1"
                     /gene_synonym="Ccdc36"
                     /note="hexamer: ATTAAA"
     regulatory      3042..3047
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Iho1"
                     /gene_synonym="Ccdc36"
                     /note="hexamer: ATTATA"
     polyA_site      3059
                     /gene="Iho1"
                     /gene_synonym="Ccdc36"
     polyA_site      3062
                     /gene="Iho1"
                     /gene_synonym="Ccdc36"
                     /note="major polyA site"
ORIGIN      
        1 cttcggcgcc caggaagccg caggaaggca ggcgtgtgct gtcgcgtgtg gcgagaagca
       61 caaaaaatga attttaatgt ctggaatgtt aaagagatgc tcagcatccc ctcaggctct
      121 gggatcacta aaccatctaa ctggaataat aatcagactg actgttctct cagtgattcc
      181 cagttcctct ttggatctca gttctgtcct gaaaattcag agactctgct accgtccttg
      241 gatgctggtg cttgcttaag acacccaaaa cagacacaac agaattctgt ggatagtgaa
      301 cctagtattt tcataaaata ccaggcaaag ccccagttgc ttggaggcga tacaaaagat
      361 gaaagcttat tttctcttcc tttgccagtt gggaaatcaa aaggactctc aaaacagttt
      421 gaggagaaaa aacgaagggc aacggaccaa tctgacagtg agaccctgca cagctttgtt
      481 tctcattttc cagaagtcat taacaagttg cagacatctg tggaaaagac tgaggaaaat
      541 ctcagctcta gaagccagtc tattttagat tctgtggaga ccatagccaa gacttttcaa
      601 gagactgcac gggtccagca cgacctgatg gttgagtcag tgagagacaa aggcagcatg
      661 gagcaggcca tccttgagat ccagcggaca tgtgcagcta gacaagcaga atttatggag
      721 atgaaatcca ccctgaagaa ccttgaagtt ttagttgtgg agcagactaa gaacttgcag
      781 cagttttgtg acaacctgag ccagctcatt gtgcctggta tcctagaaga gctgaaaaaa
      841 ttcacctctg tgcctcaggt ggctgggcat ctgaaagaca gcacctctca gacctcacca
      901 tctctgaccc agagcctcca ttttaccagg caggaaaagc atccctctga ggagccagct
      961 acttggcagg cccaggaggc tcctgcagga aatcccagta cgagttccca gaggcctggg
     1021 gagtgtggtg tctgggatga aggagcagag agtggtgttt ttcaaaaggc tgcattgcca
     1081 acagatgggc tccatagagg cgatgggcat gtaaagaaca agaccgtgcc gacttactgc
     1141 aagaactggg tcatgaccac cagaagcgtc agtaaccact tctctaacct cccaagccag
     1201 agggctggca atggccaagg tctgatggcc caaggagctt cacagcggga cgtaagtaag
     1261 tttgaagcca gagtgaagaa tgcctgcccc gaatatgggc cccaaagcat gtgttctttt
     1321 gactcacttg aacagtcagc aaccgaacag aaaggcaggc cctgcagaaa aaggaggaga
     1381 ggcaagaagc aacaacccca gagatcaaag agaggtgggc ttctagatag gaagcaagga
     1441 cagacctcaa aggcggcctg tgctttcata gctaggcatc actgccccca gtctccagtg
     1501 tgtgatccac aggggcccct catctgttgg ctgactccga gaagttccac aaagtcaacc
     1561 tgtcacattt tgggaggaac gggagagacc agtcagacag caagggcagc acaagggaac
     1621 ctcgtgcagc attcccagcg ctcttccaca gacagcagct cccagggaga ccagcagata
     1681 aattggttca gtgacctcag ccttgaaaac ctagagccgc cacagtgtaa gaagggaggg
     1741 acgaatttgc tctgtgaccc ggattttgat agcagcgatg ataatttcta acctgccagc
     1801 agtgacttta gctgatggtt tgttatctca gaacgacaaa ctgtaggaca ttggattgag
     1861 caacagcaca cagcatctga agctggctta tccagcctca gaatcagagg ccttgactga
     1921 ctgtggccag taggaggaag gggagaatcc agtactttca gtatcagttg ctgctcacag
     1981 cgggaagtta cggggaagaa atgtgtggag acagtgaaga gaactcaggg agtagcctgt
     2041 ggtgaggcat cagaaagtgg ctgtatgtcc ttggtgaaaa cattggcatt ggcttcctta
     2101 cgggatacaa tttagaagaa ctctcagaaa ctttgtgact gtgtgagtag ctctcaagac
     2161 gttccctgca cctgactggt accttcctga gcctcagctt tatctttacc tagtgctgtc
     2221 aaagagtttt gtcttttccc tgagaggtca tgttacaggg tacactatta gacagaggtt
     2281 tattatgcag ccttggctgg ctttgaattt ataattcttc tatctcagcc ttcagaatgt
     2341 tggtactata agcatgtctc gattctcaac tgtaaatgag actacttaag aacagagtgt
     2401 taatcctggt gctggtgatg cacaccttta atcccagcac tggggaggca gaggcaggca
     2461 gatctctgag tttgaggcca gcctggtcta cagagcgaat tccaggacag ccagagctac
     2521 acagagaaat cttgtcctga aaagccaaaa acaacaacaa taacaacaac aactcaaaac
     2581 aaacaaagaa cagagtatta aagctgctta tgaaagtggg gtgtggtgac tcacccctga
     2641 gattcagcag gaacgcttcc ttccagccct tccccagact acagggccat cagaaggaag
     2701 ctttgagacc aaaggacctt attcctgttg aacaattgta gtattggtta tattttattt
     2761 ttctctcttg ttgatgttta ttgttttact attttaattc aaagttgaaa tcctgtgaat
     2821 ttaaataaat tttcaggggg ttggggattt agctcagtgg taaagtgctt gcctagcaag
     2881 cccaaggccc tgggttcggt cctcagctcc ggaaaaaaga aaaaaaaaaa aaataaaaat
     2941 aaattttcag tatttgtgaa tgagcccttc tagaaccatc tgactgtaaa gtgccaaaga
     3001 tggccctgtg ttatcagttt ctgctgttga gataattaaa aattatacta tatctctgac
     3061 aa
//
