LOCUS       NP_001128670             574 aa            linear   ROD 12-FEB-2025
DEFINITION  interactor of HORMAD1 protein 1 isoform 1 [Mus musculus].
ACCESSION   NP_001128670 XP_006511823 XP_486258 XP_915471
VERSION     NP_001128670.1
DBSOURCE    REFSEQ: accession NM_001135198.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 574)
  AUTHORS   Biot,M., Toth,A., Brun,C., Guichard,L., de Massy,B. and Grey,C.
  TITLE     Principles of chromosome organization for meiotic recombination
  JOURNAL   Mol Cell 84 (10), 1826-1841 (2024)
   PUBMED   38657614
REFERENCE   2  (residues 1 to 574)
  AUTHORS   Dereli,I., Telychko,V., Papanikos,F., Raveendran,K., Xu,J.,
            Boekhout,M., Stanzione,M., Neuditschko,B., Imjeti,N.S.,
            Selezneva,E., Tuncay,H., Demir,S., Giannattasio,T., Gentzel,M.,
            Bondarieva,A., Stevense,M., Barchi,M., Schnittger,A., Weir,J.R.,
            Herzog,F., Keeney,S. and Toth,A.
  TITLE     Seeding the meiotic DNA break machinery and initiating
            recombination on chromosome axes
  JOURNAL   Nat Commun 15 (1), 2941 (2024)
   PUBMED   38580643
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 574)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 574)
  AUTHORS   Laroussi,H., Juarez-Martinez,A.B., Le Roy,A., Boeri Erba,E.,
            Gabel,F., de Massy,B. and Kadlec,J.
  TITLE     Characterization of the REC114-MEI4-IHO1 complex regulating meiotic
            DNA double-strand break formation
  JOURNAL   EMBO J 42 (16), e113866 (2023)
   PUBMED   37431931
  REMARK    GeneRIF: Characterization of the REC114-MEI4-IHO1 complex
            regulating meiotic DNA double-strand break formation.
REFERENCE   5  (residues 1 to 574)
  AUTHORS   Guan,Y., Lin,H., Leu,N.A., Ruthel,G., Fuchs,S.Y., Busino,L., Luo,M.
            and Wang,P.J.
  TITLE     SCF ubiquitin E3 ligase regulates DNA double-strand breaks in early
            meiotic recombination
  JOURNAL   Nucleic Acids Res 50 (9), 5129-5144 (2022)
   PUBMED   35489071
REFERENCE   6  (residues 1 to 574)
  AUTHORS   Papanikos,F., Clement,J.A.J., Testa,E., Ravindranathan,R., Grey,C.,
            Dereli,I., Bondarieva,A., Valerio-Cabrera,S., Stanzione,M.,
            Schleiffer,A., Jansa,P., Lustyk,D., Fei,J.F., Adams,I.R.,
            Forejt,J., Barchi,M., de Massy,B. and Toth,A.
  TITLE     Mouse ANKRD31 Regulates Spatiotemporal Patterning of Meiotic
            Recombination Initiation and Ensures Recombination between X and Y
            Sex Chromosomes
  JOURNAL   Mol Cell 74 (5), 1069-1085 (2019)
   PUBMED   31000436
REFERENCE   7  (residues 1 to 574)
  AUTHORS   Kumar,R., Oliver,C., Brun,C., Juarez-Martinez,A.B., Tarabay,Y.,
            Kadlec,J. and de Massy,B.
  TITLE     Mouse REC114 is essential for meiotic DNA double-strand break
            formation and forms a complex with MEI4
  JOURNAL   Life Sci Alliance 1 (6), e201800259 (2018)
   PUBMED   30569039
  REMARK    Publication Status: Online-Only
REFERENCE   8  (residues 1 to 574)
  AUTHORS   Stanzione,M., Baumann,M., Papanikos,F., Dereli,I., Lange,J.,
            Ramlal,A., Trankner,D., Shibuya,H., de Massy,B., Watanabe,Y.,
            Jasin,M., Keeney,S. and Toth,A.
  TITLE     Meiotic DNA break formation requires the unsynapsed chromosome
            axis-binding protein IHO1 (CCDC36) in mice
  JOURNAL   Nat Cell Biol 18 (11), 1208-1220 (2016)
   PUBMED   27723721
REFERENCE   9  (residues 1 to 574)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161260.2.
            
            On or before Apr 10, 2020 this sequence version replaced
            XP_006511823.1, XP_915471.3, XP_486258.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2322865.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..574
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 59.32 cM"
     Protein         1..574
                     /product="interactor of HORMAD1 protein 1 isoform 1"
                     /note="coiled-coil domain-containing protein 36;
                     interactor of HORMAD1 protein 1; coiled-coil domain
                     containing 36"
                     /calculated_mol_wt=63209
     Region          19..572
                     /region_name="IHO1"
                     /note="Interactor of HORMAD1 protein 1; pfam15771"
                     /db_xref="CDD:464859"
     Region          113..133
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6PDM4.3)"
     Region          267..324
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6PDM4.3)"
     Region          372..393
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6PDM4.3)"
     Region          426..457
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6PDM4.3)"
     Site            476
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q6PDM4.3)"
     Site            569
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q6PDM4.3)"
     Site            570
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q6PDM4.3)"
     CDS             1..574
                     /gene="Iho1"
                     /gene_synonym="Ccdc36"
                     /coded_by="NM_001135198.2:67..1791"
                     /note="isoform 1 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS57701.1"
                     /db_xref="GeneID:434438"
                     /db_xref="MGI:MGI:3612242"
ORIGIN      
        1 mnfnvwnvke mlsipsgsgi tkpsnwnnnq tdcslsdsqf lfgsqfcpen setllpslda
       61 gaclrhpkqt qqnsvdseps ifikyqakpq llggdtkdes lfslplpvgk skglskqfee
      121 kkrratdqsd setlhsfvsh fpevinklqt svekteenls srsqsildsv etiaktfqet
      181 arvqhdlmve svrdkgsmeq aileiqrtca arqaefmemk stlknlevlv veqtknlqqf
      241 cdnlsqlivp gileelkkft svpqvaghlk dstsqtspsl tqslhftrqe khpseepatw
      301 qaqeapagnp stssqrpgec gvwdegaesg vfqkaalptd glhrgdghvk nktvptyckn
      361 wvmttrsvsn hfsnlpsqra gngqglmaqg asqrdvskfe arvknacpey gpqsmcsfds
      421 leqsateqkg rpcrkrrrgk kqqpqrskrg glldrkqgqt skaacafiar hhcpqspvcd
      481 pqgplicwlt prsstkstch ilggtgetsq taraaqgnlv qhsqrsstds ssqgdqqinw
      541 fsdlslenle ppqckkggtn llcdpdfdss ddnf
//
