LOCUS       NM_001313683            1616 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus Indian hedgehog (Ihh), transcript variant 2, mRNA.
ACCESSION   NM_001313683
VERSION     NM_001313683.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1616)
  AUTHORS   Song,C., Sawall,J.K., Ji,X., Song,F., Liao,X., Peng,R., Ren,H.,
            Koyama,E., Pacifici,M. and Long,F.
  TITLE     Tgfbeta signaling stimulates glycolysis to promote the genesis of
            synovial joint interzone in developing mouse embryonic limbs
  JOURNAL   Sci Adv 11 (2), eadq4991 (2025)
   PUBMED   39772668
REFERENCE   2  (bases 1 to 1616)
  AUTHORS   Moldovan,G.E., Massri,N., Vegter,E.L., Pauneto-Delgado,I.N.,
            Burns,G.W., Joshi,N., Gu,B., Arora,R. and Fazleabas,A.T.
  TITLE     YAP1 and WWTR1 are required for murine pregnancy initiation
  JOURNAL   Reproduction 169 (1), e240355 (2025)
   PUBMED   39503541
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1616)
  AUTHORS   Hata,K., Wakamori,K., Hirakawa-Yamamura,A., Ichiyama-Kobayashi,S.,
            Yamaguchi,M., Okuzaki,D., Takahata,Y., Murakami,T., Uzawa,N.,
            Yamashiro,T. and Nishimura,R.
  TITLE     Serinc5 Regulates Sequential Chondrocyte Differentiation by
            Inhibiting Sox9 Function in Pre-Hypertrophic Chondrocytes
  JOURNAL   J Cell Physiol 240 (1), e31490 (2025)
   PUBMED   39568258
REFERENCE   4  (bases 1 to 1616)
  AUTHORS   Almubarak,A., Zhang,Q., Zhang,C.H., Abdelwahab,N., Kume,T.,
            Lassar,A.B. and Berry,F.B.
  TITLE     FOXC1 and FOXC2 regulate growth plate chondrocyte maturation
            towards hypertrophy in the embryonic mouse limb skeleton
  JOURNAL   Development 151 (16) (2024)
   PUBMED   39012257
REFERENCE   5  (bases 1 to 1616)
  AUTHORS   Yoshida,S., Kawamura,A., Aoki,K., Wiriyasermkul,P., Sugimoto,S.,
            Tomiyoshi,J., Tajima,A., Ishida,Y., Katoh,Y., Tsukada,T.,
            Tsuneoka,Y., Yamada,K., Nagamori,S., Nakayama,K. and Yoshida,K.
  TITLE     Positive regulation of Hedgehog signaling via phosphorylation of
            GLI2/GLI3 by DYRK2 kinase
  JOURNAL   Proc Natl Acad Sci U S A 121 (28), e2320070121 (2024)
   PUBMED   38968120
REFERENCE   6  (bases 1 to 1616)
  AUTHORS   Valentini,R.P., Brookhiser,W.T., Park,J., Yang,T., Briggs,J.,
            Dressler,G. and Holzman,L.B.
  TITLE     Post-translational processing and renal expression of mouse Indian
            hedgehog
  JOURNAL   J Biol Chem 272 (13), 8466-8473 (1997)
   PUBMED   9079674
REFERENCE   7  (bases 1 to 1616)
  AUTHORS   Bitgood,M.J. and McMahon,A.P.
  TITLE     Hedgehog and Bmp genes are coexpressed at many diverse sites of
            cell-cell interaction in the mouse embryo
  JOURNAL   Dev Biol 172 (1), 126-138 (1995)
   PUBMED   7589793
REFERENCE   8  (bases 1 to 1616)
  AUTHORS   Marigo,V., Roberts,D.J., Lee,S.M., Tsukurov,O., Levi,T.,
            Gastier,J.M., Epstein,D.J., Gilbert,D.J., Copeland,N.G.,
            Seidman,C.E. et al.
  TITLE     Cloning, expression, and chromosomal location of SHH and IHH: two
            human homologues of the Drosophila segment polarity gene hedgehog
  JOURNAL   Genomics 28 (1), 44-51 (1995)
   PUBMED   7590746
REFERENCE   9  (bases 1 to 1616)
  AUTHORS   Chang,D.T., Lopez,A., von Kessler,D.P., Chiang,C., Simandl,B.K.,
            Zhao,R., Seldin,M.F., Fallon,J.F. and Beachy,P.A.
  TITLE     Products, genetic linkage and limb patterning activity of a murine
            hedgehog gene
  JOURNAL   Development 120 (11), 3339-3353 (1994)
   PUBMED   7720571
REFERENCE   10 (bases 1 to 1616)
  AUTHORS   Echelard,Y., Epstein,D.J., St-Jacques,B., Shen,L., Mohler,J.,
            McMahon,J.A. and McMahon,A.P.
  TITLE     Sonic hedgehog, a member of a family of putative signaling
            molecules, is implicated in the regulation of CNS polarity
  JOURNAL   Cell 75 (7), 1417-1430 (1993)
   PUBMED   7916661
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139023.15, AK144322.1 and AK090147.1.
            
            Transcript Variant: This variant (2) differs in the 3' coding
            region and 3' UTR compared to variant 1. The encoded isoform (2)
            has a distinct, shorter C-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK090147.1, BY733449.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849389, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: experimental evidence
                                                (PMID:9079674)
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                AC139023.15        142890-142971       c
            83-1034             AK144322.1         85-1036
            1035-1255           AK090147.1         809-1029
            1256-1615           AK090147.1         1031-1390
            1616-1616           AC139023.15        139022-139022       c
FEATURES             Location/Qualifiers
     source          1..1616
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 38.55 cM"
     gene            1..1616
                     /gene="Ihh"
                     /gene_synonym="HHG-2"
                     /note="Indian hedgehog"
                     /db_xref="GeneID:16147"
                     /db_xref="MGI:MGI:96533"
     exon            1..773
                     /gene="Ihh"
                     /gene_synonym="HHG-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             459..1247
                     /gene="Ihh"
                     /gene_synonym="HHG-2"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; indian hedgehog protein"
                     /codon_start=1
                     /product="indian hedgehog protein isoform 2 precursor"
                     /protein_id="NP_001300612.1"
                     /db_xref="GeneID:16147"
                     /db_xref="MGI:MGI:96533"
                     /translation="MSPAWLRPRLRFCLFLLLLLLVPAARGCGPGRVVGSRRRPPRKL
                     VPLAYKQFSPNVPEKTLGASGRYEGKIARSSERFKELTPNYNPDIIFKDEENTGADRL
                     MTQRCKDRLNSLAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDR
                     NKYGLLARLAVEAGFDWVYYESKAHVHCSVKSGEPLLPGGWARGRGRREWAGSAKPAR
                     AKEKMASGGWRRGPEGRGFPRRRRRRRRQRSLQLLWTACSSHVR"
     exon            774..1616
                     /gene="Ihh"
                     /gene_synonym="HHG-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1595..1600
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ihh"
                     /gene_synonym="HHG-2"
                     /note="hexamer: AATAAA"
     polyA_site      1616
                     /gene="Ihh"
                     /gene_synonym="HHG-2"
                     /note="major polyA site"
ORIGIN      
        1 ctcactcgac cccgggctgc gccgcagacg gcagcagctc ccgctctgcc cgagccgcct
       61 gaccgccggg ccggggtgct aaccgcgggt cccttcagtc cgccggccgg gccagcccag
      121 cccagcccgc cggccctcag ccccgccgcc cgccgccccc cgccgtcgcc gcgttgccaa
      181 aacaaacggg ccggcctatt tattggcggc cggcgagccg ggcagctcag agtcgaggcg
      241 ccgaggggga cagcacgccg ccaccagcca gggccccggg cccccgcccc gcacctgagt
      301 cccgtcggcc ttgagccgcg tcgcgctgcc catggcgccc ccgcatggag tccccaagag
      361 ccacccagac gcctgagtcc ccgaagctgt cccagccacg cgcccaccta tcagcccacc
      421 aggcgccctc gcccgctgct ctcccgggct acccggccat gtctcccgcc tggctccggc
      481 cccgactgcg gttctgtctg ttcctgctgc tgctgcttct ggtgccggcg gcgcggggct
      541 gcgggccggg ccgggtggtg ggcagccgcc ggaggccgcc tcgcaagctc gtgcctcttg
      601 cctacaagca gttcagcccc aacgtgccgg agaagaccct gggcgccagc gggcgctacg
      661 aaggcaagat cgcgcgcagc tctgagcgct tcaaagagct cacccccaac tacaatcccg
      721 acatcatctt caaggacgag gagaacacgg gtgccgaccg cctcatgacc cagcgctgca
      781 aggaccgtct gaactcactg gccatctctg tcatgaacca gtggcctggt gtgaaactgc
      841 gggtgaccga aggctgggat gaagatggcc atcactcaga ggagtcttta cactatgagg
      901 gccgcgcggt ggatatcacc acctcagacc gtgaccgaaa taagtatgga ctgctggcgc
      961 gcttagcagt ggaggccggc ttcgactggg tgtattacga gtccaaggcc cacgtgcatt
     1021 gctctgtcaa gtctggtgag ccgctgctgc cggggggctg ggcccggggc cggggccgca
     1081 gggagtgggc aggcagcgca aagcccgcta gggccaagga gaagatggcc tccgggggat
     1141 ggaggcgggg acccgaggga agaggatttc cgaggcggcg gcggcggcgg cggcggcagc
     1201 gctccctgca gctgctttgg actgcttgct cctcccatgt ccggtagtgt cccggcagga
     1261 gcctagagag acagggccta tttcccgaac cactgagtgc tgacctggtg gtccacagcc
     1321 cagagactgc cacaggaagt gcaagacaga acaagttgaa gagatgaagg aagccaggtt
     1381 ggcaggcacc actgtccccg atccaggccc atgcagaaca aggcatgatg gggctagggg
     1441 ccagagtgtg tctagacatc agagtgcccg accagaagcc tagagtttca gaatctacca
     1501 cgcaaatgca ggtcaggcct cccagagggg cgcaggcgtc cccaatctcc tccccagagc
     1561 cccaaagctg gacattttgg aggtaaatgg actcaataaa gtggattttt cccaga
//
