LOCUS       NM_018738               2064 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus interferon gamma induced GTPase (Igtp), mRNA.
ACCESSION   NM_018738
VERSION     NM_018738.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2064)
  AUTHORS   Dockterman,J., Reitano,J.R., Everitt,J.I., Wallace,G.D.,
            Hendrix,M., Taylor,G.A. and Coers,J.
  TITLE     Irgm proteins attenuate inflammatory disease in mouse models of
            genital Chlamydia infection
  JOURNAL   mBio 15 (4), e0030324 (2024)
   PUBMED   38501887
REFERENCE   2  (bases 1 to 2064)
  AUTHORS   Chandrasekaran,S., Kochanowsky,J.A., Merritt,E.F., Lagas,J.S.,
            Swannigan,A. and Koshy,A.A.
  TITLE     IFN-gamma stimulated murine and human neurons mount anti-parasitic
            defenses against the intracellular parasite Toxoplasma gondii
  JOURNAL   Nat Commun 13 (1), 4605 (2022)
   PUBMED   35941154
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2064)
  AUTHORS   Christgen,S., Place,D.E., Zheng,M., Briard,B., Yamamoto,M. and
            Kanneganti,T.D.
  TITLE     The IFN-inducible GTPase IRGB10 regulates viral replication and
            inflammasome activation during influenza A virus infection in mice
  JOURNAL   Eur J Immunol 52 (2), 285-296 (2022)
   PUBMED   34694641
REFERENCE   4  (bases 1 to 2064)
  AUTHORS   Aditi, Downing,S.M., Schreiner,P.A., Kwak,Y.D., Li,Y., Shaw,T.I.,
            Russell,H.R. and McKinnon,P.J.
  TITLE     Genome instability independent of type I interferon signaling
            drives neuropathology caused by impaired ribonucleotide excision
            repair
  JOURNAL   Neuron 109 (24), 3962-3979 (2021)
   PUBMED   34655526
REFERENCE   5  (bases 1 to 2064)
  AUTHORS   Dockterman,J., Fee,B.E., Taylor,G.A. and Coers,J.
  TITLE     Murine Irgm Paralogs Regulate Nonredundant Functions To Execute
            Host Defense to Toxoplasma gondii
  JOURNAL   Infect Immun 89 (11), e0020221 (2021)
   PUBMED   34338548
REFERENCE   6  (bases 1 to 2064)
  AUTHORS   Collazo,C.M., Yap,G.S., Sempowski,G.D., Lusby,K.C., Tessarollo,L.,
            Vande Woude,G.F., Sher,A. and Taylor,G.A.
  TITLE     Inactivation of LRG-47 and IRG-47 reveals a family of interferon
            gamma-inducible genes with essential, pathogen-specific roles in
            resistance to infection
  JOURNAL   J Exp Med 194 (2), 181-188 (2001)
   PUBMED   11457893
REFERENCE   7  (bases 1 to 2064)
  AUTHORS   Taylor,G.A., Collazo,C.M., Yap,G.S., Nguyen,K., Gregorio,T.A.,
            Taylor,L.S., Eagleson,B., Secrest,L., Southon,E.A., Reid,S.W.,
            Tessarollo,L., Bray,M., McVicar,D.W., Komschlies,K.L., Young,H.A.,
            Biron,C.A., Sher,A. and Vande Woude,G.F.
  TITLE     Pathogen-specific loss of host resistance in mice lacking the
            IFN-gamma-inducible gene IGTP
  JOURNAL   Proc Natl Acad Sci U S A 97 (2), 751-755 (2000)
   PUBMED   10639151
REFERENCE   8  (bases 1 to 2064)
  AUTHORS   Yang,D., Yu,J., Luo,Z., Carthy,C.M., Wilson,J.E., Liu,Z. and
            McManus,B.M.
  TITLE     Viral myocarditis: identification of five differentially expressed
            genes in coxsackievirus B3-infected mouse heart
  JOURNAL   Circ Res 84 (6), 704-712 (1999)
   PUBMED   10189358
REFERENCE   9  (bases 1 to 2064)
  AUTHORS   Taylor,G.A., Stauber,R., Rulong,S., Hudson,E., Pei,V.,
            Pavlakis,G.N., Resau,J.H. and Vande Woude,G.F.
  TITLE     The inducibly expressed GTPase localizes to the endoplasmic
            reticulum, independently of GTP binding
  JOURNAL   J Biol Chem 272 (16), 10639-10645 (1997)
   PUBMED   9099712
REFERENCE   10 (bases 1 to 2064)
  AUTHORS   Taylor,G.A., Jeffers,M., Largaespada,D.A., Jenkins,N.A.,
            Copeland,N.G. and Vande Woude,G.F.
  TITLE     Identification of a novel GTPase, the inducibly expressed GTPase,
            that accumulates in response to interferon gamma
  JOURNAL   J Biol Chem 271 (34), 20399-20405 (1996)
   PUBMED   8702776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928857.15, AK002843.1 and AA275064.1.
            
            On Sep 20, 2008 this sequence version replaced NM_018738.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088315.1, AK169307.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                AL928857.15        31465-31527
            64-2022             AK002843.1         2-1960
            2023-2064           AA275064.1         182-223
FEATURES             Location/Qualifiers
     source          1..2064
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 36.01 cM"
     gene            1..2064
                     /gene="Igtp"
                     /gene_synonym="Irgm3"
                     /note="interferon gamma induced GTPase"
                     /db_xref="GeneID:16145"
                     /db_xref="MGI:MGI:107729"
     exon            1..224
                     /gene="Igtp"
                     /gene_synonym="Irgm3"
                     /inference="alignment:Splign:2.1.0"
     exon            225..474
                     /gene="Igtp"
                     /gene_synonym="Irgm3"
                     /inference="alignment:Splign:2.1.0"
     CDS             436..1707
                     /gene="Igtp"
                     /gene_synonym="Irgm3"
                     /codon_start=1
                     /product="immunity-related GTPase family M protein 3"
                     /protein_id="NP_061208.3"
                     /db_xref="CCDS:CCDS24725.1"
                     /db_xref="GeneID:16145"
                     /db_xref="MGI:MGI:107729"
                     /translation="MDLVTKLPQNIWKTFTLFINMANYLKRLISPWSKSMTAGESLYS
                     SQNSSSPEVIEDIGKAVTEGNLQKVIGIVKDEIQSKSRYRVKIAVTGDSGNGMSSFIN
                     ALRFIGHEEEDSAPTGVVRTTKKPACYSSDSHFPYVELWDLPGLGATAQSVESYLEEM
                     QISTFDLIIIVASEQFSSNHVKLAITMQRMRKRFYVVWTKLDRDLSTSTFPEPQLLQS
                     IQRNIRENLQQAQVRDPPLFLISCFSPSFHDFPELRNTLQKDIFSIRYRDPLEIISQV
                     CDKCISNKAFSLKEDQMLMKDLEAAVSSEDDTANLERGLQTYQKLFGVDDGSLQQVAR
                     STGRLEMGSRALQFQDLIKMDRRLELMMCFAVNKFLRLLESSWWYGLWNVVTRYFRHQ
                     RHKLVIEIVAENTKTSLRKALKDSVLPPEIH"
     exon            475..2023
                     /gene="Igtp"
                     /gene_synonym="Irgm3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1977..1982
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Igtp"
                     /gene_synonym="Irgm3"
                     /note="hexamer: AATAAA"
     polyA_site      2002
                     /gene="Igtp"
                     /gene_synonym="Irgm3"
                     /note="major polyA site"
ORIGIN      
        1 ccttggggag gaggcaggca gggctcacgc ctagaagttg gggacttaca tctgggccaa
       61 catagataga gcagggtctg agaggaaacc taggagctca ggctgccctt cagctgctcc
      121 tgcctcttct aatcgctctt ccccacagga ccctgcccca ccacacttct ctctctcctg
      181 accgtcctga gcctggattg cagctttgta aggcttctga gcaggttctg aaggagagta
      241 aagagtgcaa ggcctagagc agacccacag agttcaggcc cacagacata gaccttcata
      301 ctccataaag ttgaagagag aagaaagaag ccgaggacca ccggcccagc cattttagct
      361 gagactccag agcgttcact cagacagcgg agagctgtgg agagagagag agagagagca
      421 gggcacacac gtcccatgga tttagtcaca aagttgccac aaaatatctg gaagactttt
      481 acacttttca taaacatggc aaattatctc aagcgcctca tcagcccgtg gtctaaatct
      541 atgactgctg gtgagtcact ttattccagc cagaactcat cctctccaga agtcattgaa
      601 gatattggta aggcggtgac agagggaaat ttacagaaag tgataggtat agtcaaagat
      661 gaaattcaga gtaagtcaag atacagagta aagattgctg tgactgggga ctctggcaat
      721 ggcatgtcat ctttcatcaa tgcccttagg ttcattggac atgaggagga ggattcagct
      781 cccactgggg tggtgaggac cactaagaaa ccagcctgct actcctctga ctcccacttt
      841 ccctatgtgg agctgtggga cctgcctggc ttaggggcca cagcccagag tgtggagagc
      901 tacctggagg agatgcagat cagcacattt gaccttatca tcatcgtagc ttctgagcag
      961 ttcagctcaa atcatgtgaa gctggccata accatgcaga ggatgagaaa gaggttctat
     1021 gtcgtctgga ccaagctgga cagggacctc agcacaagta ccttccctga accccagcta
     1081 ctgcagagta tccaaaggaa tatccgggag aatctccagc aggctcaggt gagggacccc
     1141 cccctattcc tgatatcctg ttttagcccg tcttttcacg acttcccaga gcttagaaac
     1201 acactgcaaa aagacatctt cagcatcagg tacagagatc ccttagagat catttctcaa
     1261 gtctgcgaca agtgcatcag caataaggcg ttctctctga aggaagatca gatgctcatg
     1321 aaagacctgg aggcagctgt cagctccgag gatgacactg ccaacctgga gaggggtctc
     1381 cagacctacc agaagctctt tggtgtggat gatgggtcac ttcagcaggt agctcggagt
     1441 acagggagac tggagatggg ctccagggct ctgcagttcc aggacttgat caagatggac
     1501 aggagactgg agctgatgat gtgttttgcc gtgaacaagt tcctcaggct tctcgaaagc
     1561 tcatggtggt atggcttgtg gaacgtcgtc acccgctact tcagacacca gaggcacaag
     1621 ctcgtcattg aaatagtggc tgagaacacc aagacctccc tgaggaaagc tctaaaggac
     1681 tctgtcctcc ctcccgaaat tcactgagaa gagtctggct caccctcagg tggaattcag
     1741 gctgcctcag ggtctttttg cttagagccc tagctagtca ctagaaagga acaacagctg
     1801 aggcaacagc ttgtaatgat gcttaataat tttagaggaa atggcccatc ttcctatatt
     1861 caactgtaat agcccgttcc ttcaaagtgc aagtatttgc caggataatc agccaaggtt
     1921 tcctagttca gtacctagat tgttaggctt ttagtcttca ttgtgatgca tgtttaaata
     1981 aaactctttt ccctcctaaa aacattaaag ttgccttcat cgaaaaaaaa aaaaaaaaaa
     2041 aaaaaaaaaa aaaaaaaaaa aaaa
//
