LOCUS       NP_061208                423 aa            linear   ROD 11-FEB-2025
DEFINITION  immunity-related GTPase family M protein 3 [Mus musculus].
ACCESSION   NP_061208
VERSION     NP_061208.3
DBSOURCE    REFSEQ: accession NM_018738.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 423)
  AUTHORS   Dockterman,J., Reitano,J.R., Everitt,J.I., Wallace,G.D.,
            Hendrix,M., Taylor,G.A. and Coers,J.
  TITLE     Irgm proteins attenuate inflammatory disease in mouse models of
            genital Chlamydia infection
  JOURNAL   mBio 15 (4), e0030324 (2024)
   PUBMED   38501887
REFERENCE   2  (residues 1 to 423)
  AUTHORS   Chandrasekaran,S., Kochanowsky,J.A., Merritt,E.F., Lagas,J.S.,
            Swannigan,A. and Koshy,A.A.
  TITLE     IFN-gamma stimulated murine and human neurons mount anti-parasitic
            defenses against the intracellular parasite Toxoplasma gondii
  JOURNAL   Nat Commun 13 (1), 4605 (2022)
   PUBMED   35941154
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 423)
  AUTHORS   Christgen,S., Place,D.E., Zheng,M., Briard,B., Yamamoto,M. and
            Kanneganti,T.D.
  TITLE     The IFN-inducible GTPase IRGB10 regulates viral replication and
            inflammasome activation during influenza A virus infection in mice
  JOURNAL   Eur J Immunol 52 (2), 285-296 (2022)
   PUBMED   34694641
REFERENCE   4  (residues 1 to 423)
  AUTHORS   Aditi, Downing,S.M., Schreiner,P.A., Kwak,Y.D., Li,Y., Shaw,T.I.,
            Russell,H.R. and McKinnon,P.J.
  TITLE     Genome instability independent of type I interferon signaling
            drives neuropathology caused by impaired ribonucleotide excision
            repair
  JOURNAL   Neuron 109 (24), 3962-3979 (2021)
   PUBMED   34655526
REFERENCE   5  (residues 1 to 423)
  AUTHORS   Dockterman,J., Fee,B.E., Taylor,G.A. and Coers,J.
  TITLE     Murine Irgm Paralogs Regulate Nonredundant Functions To Execute
            Host Defense to Toxoplasma gondii
  JOURNAL   Infect Immun 89 (11), e0020221 (2021)
   PUBMED   34338548
REFERENCE   6  (residues 1 to 423)
  AUTHORS   Collazo,C.M., Yap,G.S., Sempowski,G.D., Lusby,K.C., Tessarollo,L.,
            Vande Woude,G.F., Sher,A. and Taylor,G.A.
  TITLE     Inactivation of LRG-47 and IRG-47 reveals a family of interferon
            gamma-inducible genes with essential, pathogen-specific roles in
            resistance to infection
  JOURNAL   J Exp Med 194 (2), 181-188 (2001)
   PUBMED   11457893
REFERENCE   7  (residues 1 to 423)
  AUTHORS   Taylor,G.A., Collazo,C.M., Yap,G.S., Nguyen,K., Gregorio,T.A.,
            Taylor,L.S., Eagleson,B., Secrest,L., Southon,E.A., Reid,S.W.,
            Tessarollo,L., Bray,M., McVicar,D.W., Komschlies,K.L., Young,H.A.,
            Biron,C.A., Sher,A. and Vande Woude,G.F.
  TITLE     Pathogen-specific loss of host resistance in mice lacking the
            IFN-gamma-inducible gene IGTP
  JOURNAL   Proc Natl Acad Sci U S A 97 (2), 751-755 (2000)
   PUBMED   10639151
REFERENCE   8  (residues 1 to 423)
  AUTHORS   Yang,D., Yu,J., Luo,Z., Carthy,C.M., Wilson,J.E., Liu,Z. and
            McManus,B.M.
  TITLE     Viral myocarditis: identification of five differentially expressed
            genes in coxsackievirus B3-infected mouse heart
  JOURNAL   Circ Res 84 (6), 704-712 (1999)
   PUBMED   10189358
REFERENCE   9  (residues 1 to 423)
  AUTHORS   Taylor,G.A., Stauber,R., Rulong,S., Hudson,E., Pei,V.,
            Pavlakis,G.N., Resau,J.H. and Vande Woude,G.F.
  TITLE     The inducibly expressed GTPase localizes to the endoplasmic
            reticulum, independently of GTP binding
  JOURNAL   J Biol Chem 272 (16), 10639-10645 (1997)
   PUBMED   9099712
REFERENCE   10 (residues 1 to 423)
  AUTHORS   Taylor,G.A., Jeffers,M., Largaespada,D.A., Jenkins,N.A.,
            Copeland,N.G. and Vande Woude,G.F.
  TITLE     Identification of a novel GTPase, the inducibly expressed GTPase,
            that accumulates in response to interferon gamma
  JOURNAL   J Biol Chem 271 (34), 20399-20405 (1996)
   PUBMED   8702776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928857.15, AK002843.1 and AA275064.1.
            
            On Sep 20, 2008 this sequence version replaced NP_061208.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088315.1, AK169307.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..423
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 36.01 cM"
     Protein         1..423
                     /product="immunity-related GTPase family M protein 3"
                     /calculated_mol_wt=48363
     Region          51..412
                     /region_name="IIGP"
                     /note="Interferon-inducible GTPase (IIGP); pfam05049"
                     /db_xref="CDD:461536"
     CDS             1..423
                     /gene="Igtp"
                     /gene_synonym="Irgm3"
                     /coded_by="NM_018738.4:436..1707"
                     /db_xref="CCDS:CCDS24725.1"
                     /db_xref="GeneID:16145"
                     /db_xref="MGI:MGI:107729"
ORIGIN      
        1 mdlvtklpqn iwktftlfin manylkrlis pwsksmtage slyssqnsss peviedigka
       61 vtegnlqkvi givkdeiqsk sryrvkiavt gdsgngmssf inalrfighe eedsaptgvv
      121 rttkkpacys sdshfpyvel wdlpglgata qsvesyleem qistfdliii vaseqfssnh
      181 vklaitmqrm rkrfyvvwtk ldrdlststf pepqllqsiq rnirenlqqa qvrdpplfli
      241 scfspsfhdf pelrntlqkd ifsiryrdpl eiisqvcdkc isnkafslke dqmlmkdlea
      301 avsseddtan lerglqtyqk lfgvddgslq qvarstgrle mgsralqfqd likmdrrlel
      361 mmcfavnkfl rllesswwyg lwnvvtryfr hqrhklviei vaentktslr kalkdsvlpp
      421 eih
//
