LOCUS       NM_001326702           16247 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus immunoglobulin superfamily, member 9B (Igsf9b),
            transcript variant 2, mRNA.
ACCESSION   NM_001326702 XM_006510194
VERSION     NM_001326702.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 16247)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 16247)
  AUTHORS   Cheng,S., Butrus,S., Tan,L., Xu,R., Sagireddy,S.,
            Trachtenberg,J.T., Shekhar,K. and Zipursky,S.L.
  TITLE     Vision-dependent specification of cell types and function in the
            developing cortex
  JOURNAL   Cell 185 (2), 311-327 (2022)
   PUBMED   35063073
REFERENCE   3  (bases 1 to 16247)
  AUTHORS   Chowdhury,M.I.H., Nishioka,T., Mishima,N., Ohtsuka,T., Kaibuchi,K.
            and Tsuboi,D.
  TITLE     Prickle2 and Igsf9b Coordinately Regulate the Cytoarchitecture of
            the Axon Initial Segment
  JOURNAL   Cell Struct Funct 45 (2), 143-154 (2020)
   PUBMED   32641624
  REMARK    GeneRIF: Prickle2 and Igsf9b Coordinately Regulate the
            Cytoarchitecture of the Axon Initial Segment.
REFERENCE   4  (bases 1 to 16247)
  AUTHORS   Babaev,O., Cruces-Solis,H., Piletti Chatain,C., Hammer,M.,
            Wenger,S., Ali,H., Karalis,N., de Hoz,L., Schluter,O.M.,
            Yanagawa,Y., Ehrenreich,H., Taschenberger,H., Brose,N. and
            Krueger-Burg,D.
  TITLE     IgSF9b regulates anxiety behaviors through effects on centromedial
            amygdala inhibitory synapses
  JOURNAL   Nat Commun 9 (1), 5400 (2018)
   PUBMED   30573727
  REMARK    GeneRIF: IgSF9b is a key regulator of inhibition in the amygdala
            and IgSF9b-expressing synapses in the CeM may represent a target
            for anxiolytic therapies.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 16247)
  AUTHORS   Bibollet-Bahena,O., Okafuji,T., Hokamp,K., Tear,G. and
            Mitchell,K.J.
  TITLE     A dual-strategy expression screen for candidate connectivity labels
            in the developing thalamus
  JOURNAL   PLoS One 12 (5), e0177977 (2017)
   PUBMED   28558017
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 16247)
  AUTHORS   Woo,J., Kwon,S.K., Nam,J., Choi,S., Takahashi,H., Krueger,D.,
            Park,J., Lee,Y., Bae,J.Y., Lee,D., Ko,J., Kim,H., Kim,M.H.,
            Bae,Y.C., Chang,S., Craig,A.M. and Kim,E.
  TITLE     The adhesion protein IgSF9b is coupled to neuroligin 2 via S-SCAM
            to promote inhibitory synapse development
  JOURNAL   J Cell Biol 201 (6), 929-944 (2013)
   PUBMED   23751499
  REMARK    GeneRIF: Here we report that IgSF9b is a novel, brain-specific,
            homophilic adhesion molecule that is strongly expressed in
            GABAergic interneurons.
REFERENCE   7  (bases 1 to 16247)
  AUTHORS   Mishra,A., Knerr,B., Paixao,S., Kramer,E.R. and Klein,R.
  TITLE     The protein dendrite arborization and synapse maturation 1 (Dasm-1)
            is dispensable for dendrite arborization
  JOURNAL   Mol Cell Biol 28 (8), 2782-2791 (2008)
   PUBMED   18268009
REFERENCE   8  (bases 1 to 16247)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117198.3 and AC154374.1.
            
            On May 24, 2016 this sequence version replaced XM_006510194.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849376 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-414               AC117198.3         17205-17618         c
            415-612             AC117198.3         7121-7318           c
            613-759             AC117198.3         5009-5155           c
            760-911             AC154374.1         27803-27954
            912-1029            AC154374.1         28257-28374
            1030-1171           AC154374.1         29654-29795
            1172-1317           AC154374.1         29972-30117
            1318-1460           AC154374.1         32621-32763
            1461-1601           AC154374.1         33065-33205
            1602-1718           AC154374.1         33292-33408
            1719-1869           AC154374.1         33657-33807
            1870-1993           AC154374.1         34625-34748
            1994-2169           AC154374.1         37294-37469
            2170-2396           AC154374.1         38928-39154
            2397-2481           AC154374.1         39987-40071
            2482-2643           AC154374.1         42099-42260
            2644-2689           AC154374.1         42950-42995
            2690-4345           AC154374.1         43526-45181
            4346-4467           AC154374.1         52959-53080
            4468-16247          AC154374.1         56218-67997
FEATURES             Location/Qualifiers
     source          1..16247
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 12.69 cM"
     gene            1..16247
                     /gene="Igsf9b"
                     /gene_synonym="AI854107; Gm508; mKIAA1030"
                     /note="immunoglobulin superfamily, member 9B"
                     /db_xref="GeneID:235086"
                     /db_xref="MGI:MGI:2685354"
     exon            1..414
                     /gene="Igsf9b"
                     /gene_synonym="AI854107; Gm508; mKIAA1030"
                     /inference="alignment:Splign:2.1.0"
     CDS             351..4676
                     /gene="Igsf9b"
                     /gene_synonym="AI854107; Gm508; mKIAA1030"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; protein turtle homolog B"
                     /codon_start=1
                     /product="protein turtle homolog B isoform 2 precursor"
                     /protein_id="NP_001313631.1"
                     /db_xref="CCDS:CCDS52746.2"
                     /db_xref="GeneID:235086"
                     /db_xref="MGI:MGI:2685354"
                     /translation="MIWYVATLIASVISTRGLVAQGAHGLREEPEFVTARAGEGVVLR
                     CDVIHPVTGQPPPYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGRASLHDKASLRLEQ
                     VRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPPTFTETPPQYIEAKEGGSITMT
                     CTAFGNPKPIVTWLKEGTLLGASAKYQVSDGSLTVTSVSREDRGAYTCRAYSIQGEAV
                     HTTHLLVQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYWQDENVYFQNDL
                     KLRVRILIDGTLIIFRVKPEDAGKYTCVPSNSLGRSPSASAYLTVQYPARVLNMPPVI
                     YVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGSIRIEEATEEAL
                     GTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRELLIPCAAAGDPFP
                     VITWRKVGKPSRSKHNALPSGSLQFRALSKEDHGEWECVATNVVTSITASTHLTVIGT
                     SPHAPGSVRVHVSMTTANVSWEPGYDGGYEQTFSVWYGPLMKRAQFGPHDWLSLSVPP
                     GPSWLLVDSLEPETAYQFSVLAQNRLGTSAFSEVVTVNTLAFPVTTPEPLVLVTPPRC
                     LTANRTQQGVLLSWLPPANHSFPIDRYIMEFRVGERWEMLDDAIPGTDGDFFAKDLSQ
                     DTWYEFRVLAVMQDLISEPSNIAGVSSTDIFPQPDLTDDGLARPVLAGIVATICFLAA
                     AILFSTLAACFVNKQRKRKLKRKKDPPLSITHCRKSLESPLSSGKVSPESIRTLRAPS
                     ESSDDQGQPAAKRMLSPTREKELSLYKKTKRAISSRKYSVAKAEAEAEATTPIELISR
                     GPDGRFVMGPSEMEPSVKGRRIEGFPFAEETDMYPEFRQSDEENEDPLVPTSVAALKP
                     QLTPMSSSQDSYLPPPAYSPRFQPRGLEGPSGLGGRLQATGQARPPAPRPFQHGQYYG
                     YLSSSSPGEVEPPPFYMPEVGSPLSSVMSSPPLHTEGPFGHPTIPEENGENASNSTLP
                     LTQTPTGGRSPEPWGRPEFPFGGLETPAMMFPHQLHPCDVAESLQPKACLPRGLPPAP
                     LQVPAAYPGMLSLEAPKGWVGKSPGRGPIPAPPATKWQERPMQPLVSQGQLRHTSQGM
                     GIPVLPYPEPAEPGGHGGPSTFGLDTRWYEPQPRPRPSPRQARRAEPSLHQVVLQPSR
                     LSPLTQSPLSSRTGSPELAARARPRPGLLQQAEMSEITLQPPAAVSFSRKSTPSSTGS
                     PSQSSRSGSPSYRPTMGFTTLATGYPSPPPGPAPPAPGDTLDVFGQTPSPRRMGEEPL
                     RPEPPTTLPTSGILPPAPGNAAVPERLEALRYQRIKKPKKSSKGSSKSKKRSDGSASQ
                     AQQLPSSQVLWPDEAVCLRKKKRHSRPDPFARLSDLCHRQLPEDQTAILNSVDHDDPG
                     HATLL"
     exon            415..612
                     /gene="Igsf9b"
                     /gene_synonym="AI854107; Gm508; mKIAA1030"
                     /inference="alignment:Splign:2.1.0"
     exon            613..759
                     /gene="Igsf9b"
                     /gene_synonym="AI854107; Gm508; mKIAA1030"
                     /inference="alignment:Splign:2.1.0"
     exon            760..911
                     /gene="Igsf9b"
                     /gene_synonym="AI854107; Gm508; mKIAA1030"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1029
                     /gene="Igsf9b"
                     /gene_synonym="AI854107; Gm508; mKIAA1030"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1171
                     /gene="Igsf9b"
                     /gene_synonym="AI854107; Gm508; mKIAA1030"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1317
                     /gene="Igsf9b"
                     /gene_synonym="AI854107; Gm508; mKIAA1030"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1460
                     /gene="Igsf9b"
                     /gene_synonym="AI854107; Gm508; mKIAA1030"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1601
                     /gene="Igsf9b"
                     /gene_synonym="AI854107; Gm508; mKIAA1030"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1718
                     /gene="Igsf9b"
                     /gene_synonym="AI854107; Gm508; mKIAA1030"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1869
                     /gene="Igsf9b"
                     /gene_synonym="AI854107; Gm508; mKIAA1030"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..1993
                     /gene="Igsf9b"
                     /gene_synonym="AI854107; Gm508; mKIAA1030"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2169
                     /gene="Igsf9b"
                     /gene_synonym="AI854107; Gm508; mKIAA1030"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2396
                     /gene="Igsf9b"
                     /gene_synonym="AI854107; Gm508; mKIAA1030"
                     /inference="alignment:Splign:2.1.0"
     exon            2397..2481
                     /gene="Igsf9b"
                     /gene_synonym="AI854107; Gm508; mKIAA1030"
                     /inference="alignment:Splign:2.1.0"
     exon            2482..2643
                     /gene="Igsf9b"
                     /gene_synonym="AI854107; Gm508; mKIAA1030"
                     /inference="alignment:Splign:2.1.0"
     exon            2644..2689
                     /gene="Igsf9b"
                     /gene_synonym="AI854107; Gm508; mKIAA1030"
                     /inference="alignment:Splign:2.1.0"
     exon            2690..4345
                     /gene="Igsf9b"
                     /gene_synonym="AI854107; Gm508; mKIAA1030"
                     /inference="alignment:Splign:2.1.0"
     exon            4346..4467
                     /gene="Igsf9b"
                     /gene_synonym="AI854107; Gm508; mKIAA1030"
                     /inference="alignment:Splign:2.1.0"
     exon            4468..16247
                     /gene="Igsf9b"
                     /gene_synonym="AI854107; Gm508; mKIAA1030"
                     /inference="alignment:Splign:2.1.0"
     regulatory      15008..15013
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Igsf9b"
                     /gene_synonym="AI854107; Gm508; mKIAA1030"
                     /note="hexamer: AATAAA"
     polyA_site      15032
                     /gene="Igsf9b"
                     /gene_synonym="AI854107; Gm508; mKIAA1030"
     regulatory      16225..16230
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Igsf9b"
                     /gene_synonym="AI854107; Gm508; mKIAA1030"
                     /note="hexamer: AATAAA"
     polyA_site      16244
                     /gene="Igsf9b"
                     /gene_synonym="AI854107; Gm508; mKIAA1030"
                     /note="major polyA site"
ORIGIN      
        1 gcgcagcgac ggactaagag tttagccaat cagtgcctag actcgtgagc actgtccaat
       61 aaacagccgc caggggcgga ccaccaggac aggcccggct aggcttcacc gtggacctgg
      121 ctgcgctctg cctcggttgg cagtgcaggt gccgctgcgc cggggcccgg gaggctgcgc
      181 gcgccgagac gagcggagcc aggaagggat ggagagcggg ccgcccgggc tacaggagca
      241 ccggcaaggg gcgtaggcgg gcgagaagcg ggcactgagg cacgagaagt gtgcagacgc
      301 aggagcactt tgcgatagga tgaggctctt ggctggcgcg cggtagtact atgatttggt
      361 atgtggccac tttgatagca agtgtgatca gcacccgagg tcttgtggct caaggtgccc
      421 acggcctgcg agaggaaccc gagtttgtga ctgctcgagc cggcgaaggt gtggttctgc
      481 gatgcgacgt aatccaccca gtgacaggac agcccccacc ctatgttgta gagtggttca
      541 agtttggggt ccccatccct atcttcatca agtttggcta ctatccccca catgtggacc
      601 ctgagtatgc aggccgggcc agtcttcatg ataaagcatc tctgcggctg gagcaggtgc
      661 gctctgagga ccagggttgg tacgagtgca aggtactcat gctggaccag cagtatgaca
      721 cattccacaa cggcagctgg gtccatctca ccattaacgc ccctcccacc tttacagaaa
      781 caccccccca gtacatcgag gccaaggaag gtggaagtat taccatgacg tgtactgctt
      841 tcgggaaccc taagcccatc gtcacctggc tcaaggaagg gaccctcctc ggtgctagtg
      901 caaagtatca ggtgagtgac ggtagcctaa cggtgacgtc agtcagtcgg gaggacagag
      961 gcgcctatac gtgtcgagca tatagcatcc agggtgaggc tgtgcacaca acccatctgc
     1021 ttgttcaagg gcctcccttc attgtttccc ctcctgagaa catcaccgtc aacatctccc
     1081 aggatgctct gcttacctgc agggcagagg cgtatcccgg caacctcacc tacacctggt
     1141 actggcagga tgagaacgtc tacttccaga atgacctgaa gctaagggtg cggatcctga
     1201 ttgatgggac actgatcatc ttccgagtga agccagagga tgctgggaag tatacctgtg
     1261 tccctagcaa cagcctgggg cgctccccct ctgcctcagc atacctgact gtgcagtacc
     1321 cagcccgtgt cctcaacatg ccccctgtaa tttatgtgcc cgtgggaatc catggctata
     1381 tccgctgtcc tgtggatgca gagccacctg ctactgtggt gaagtggaat aaggatggcc
     1441 ggcccctgca ggtagagaag aacttgggtt ggaccttgat ggaggatggc tctattcgca
     1501 ttgaggaggc cacagaggag gctcttggca cttacacctg tgtgccttac aacaccttgg
     1561 ggactatggg ccagtctgcc cctgcacggc ttgtcctgaa ggaccccccg tacttcacgg
     1621 tgctaccagg ctgggaatac aggcaggagg ctggccggga gctgctcatt ccctgtgcag
     1681 ctgcagggga ccccttccct gtcatcacct ggaggaaggt agggaagccc agcagaagca
     1741 agcacaacgc actgcccagc gggagtctcc agtttcgtgc cctgagtaag gaggaccacg
     1801 gggagtggga atgtgttgcc accaatgtgg tcacaagcat cactgccagc acccacctca
     1861 ctgtcatcgg caccagtccc catgccccag gcagtgtccg ggtccatgtc tccatgacaa
     1921 ctgccaacgt gtcctgggag ccgggctatg atggaggcta cgagcagaca ttctcagttt
     1981 ggtacggacc tctgatgaag cgggctcagt ttgggcccca cgactggctg tccttgtcag
     2041 tgccaccggg ccccagctgg ttgctggtag acagcctgga gcctgagacc gcataccagt
     2101 tcagtgtcct ggcccagaac aggctgggaa ccagcgcctt cagtgaggtg gtcactgtga
     2161 acactttagc attccctgtt acaactccag aacccctggt gctggtgacc ccaccaaggt
     2221 gcctcacagc caaccggacc cagcagggtg tgctcctgtc ctggctccca cctgccaacc
     2281 acagcttccc catcgaccgc tatatcatgg agttccgagt tggggagcgc tgggagatgc
     2341 tggatgacgc cattccaggc actgacggag atttttttgc caaggatctg tcacaggata
     2401 cctggtatga attccgggtt ttggctgtca tgcaggatct gatcagcgag cccagcaaca
     2461 tcgccggtgt ctccagcaca gacatcttcc cgcagccaga cctgaccgat gatgggctgg
     2521 cccggccagt gttggctggg atagtggcca ccatctgctt cctggcagct gccatcctct
     2581 tcagcactct ggctgcctgc tttgtcaaca agcagcgcaa gcgcaaactc aagcggaaga
     2641 aagatcctcc gctctccatc actcactgta ggaagagtct tgagtctccc ttgtcctctg
     2701 gcaaggtgag tcccgagagc atccgcacac tccgagcccc gtctgaatcc tctgacgacc
     2761 agggccagcc tgcggccaag aggatgctga gccctacaag ggaaaaagag ctgtccctat
     2821 acaaaaaaac caagagggct atcagcagca ggaagtatag tgtggccaag gctgaggccg
     2881 aagctgaggc taccacaccc attgaactga tcagtagagg cccggatggc cgctttgtca
     2941 tgggcccatc ggagatggag ccctctgtga agggtcggcg aatcgagggc ttccccttcg
     3001 ctgaggagac ggacatgtac cctgagttcc ggcagtcaga tgaggagaat gaagacccac
     3061 tggtgcccac gtctgtggct gctctgaagc ctcagctgac cccaatgtct tccagccagg
     3121 actcttacct gccaccacca gcatacagtc ctcggttcca gcctcgtggg ctcgagggcc
     3181 cgagcggact gggaggacga ctccaggcta ctggccaagc gaggcctcct gcccctcggc
     3241 ccttccagca cggccagtat tatgggtacc tcagcagcag cagccctggg gaagtggagc
     3301 ctccaccctt ctatatgcca gaagtgggca gccccttgag ctctgtcatg tcgtccccac
     3361 ccctgcacac cgaggggcct tttggccacc ccaccatccc tgaggaaaac ggagagaatg
     3421 cttctaacag cactttaccc ttgactcaga cacctacagg agggcgctcc cctgagccct
     3481 ggggccggcc agaatttccc tttgggggac tggagacccc agctatgatg ttcccccacc
     3541 agctgcaccc ctgtgatgtg gccgagagtt tgcagcccaa ggcctgcctg ccccgaggac
     3601 tgcccccagc ccctctccag gtgcctgctg cctatccggg catgctatct ctggaggcac
     3661 caaagggctg ggtaggcaag tcacctggca ggggtcccat cccggcgccc cctgccacca
     3721 agtggcagga aagacctatg caacctctgg tcagccaagg gcagctaaga cataccagcc
     3781 aaggtatggg gataccggtg ttgccttacc cggagccagc cgagcccggg gggcatggtg
     3841 gccccagcac atttggcctg gatacccggt ggtatgagcc ccagcctcgg ccccggccca
     3901 gcccccggca ggcccggcgt gccgagccca gtttacatca agtggtgcta cagccctctc
     3961 ggctctcacc tctgacccaa agccccctta gttcccgcac tggctcccct gagctcgctg
     4021 ctcgtgcccg acctcgacca ggcctcctgc agcaggcaga gatgtcagag atcaccctgc
     4081 agccgccagc tgcggtcagc ttctctcgaa agtcaacacc atcatccacg ggatctcctt
     4141 cgcagagcag ccgcagtggg agccccagct acaggcccac aatgggcttc actactctgg
     4201 ccacgggcta cccttctcct ccacctggcc ctgcccctcc ggcaccaggg gacaccttgg
     4261 atgtgtttgg acagacgcct tcccctcgga ggatggggga ggagccactc cggccagagc
     4321 ccccaacaac cttacctact tcaggaatac ttccacctgc acccgggaac gctgctgtgc
     4381 ctgagaggct ggaggctctg agataccaac ggataaagaa gcccaaaaag tcatccaagg
     4441 gctcttcgaa gtcaaagaaa cgatccgacg gttctgcctc ccaggctcag cagcttccca
     4501 gctctcaggt tctgtggccc gacgaagctg tctgcctccg caagaagaag agacactctc
     4561 gtcctgatcc ctttgcccgg ctctcagact tgtgccaccg tcagcttccg gaagaccaga
     4621 cagcaatcct caacagcgtg gatcatgatg acccaggcca cgctactctg ctatgacgtg
     4681 acatcactct aaatgtcccc agggtggggt gctaggctaa aggggtggag agggaccatt
     4741 gtacagggcc ctgtcctcct ctgcctatca tgggatggct caggcccttg tcctgtgtgt
     4801 gtcattgtcc ctcgtgccag tggggacctc tgccccacta tctagccagc tagctttgct
     4861 catgggacag aggactgggg gaagagctta taactgtggg tcagagttgg gaatatatgg
     4921 gaatggaaaa catctctctc tatgccacct ctctctccca cttggctaga ttgattcttc
     4981 tcacctcttt aaatgtctta tgaagtgagg aagtggaaag caatggcttt tagttctctg
     5041 catttgtttc agttttccaa gtcctgggag ggggttagag ttatatcctg ccctcctaac
     5101 tccacatata tatagatata gatacaaatg cacttgtgtg tagttggtgg gtttctctat
     5161 gtgtatatat atgtacattg aagctaagtg cttttctccc tgtggtcagt gagggactga
     5221 ggaagatact caacagcggg catggtgagt agggcctgct acgaactggg ggttgtcttc
     5281 atgtctgtct tgggagatca ctccggctaa aacaggattc atgcttccca gctgagttct
     5341 ccattgttct atctatcctc tcccatctgg agcagaaatg gggtcccacc atgattctta
     5401 gctccctgct tgatgggcta gcaacaagtt aacatctgaa ctaaacagag ccttttgttg
     5461 cctggttgct aggtgaagaa agcatggcca ggcttaaggc ccgactgaca tctttctttc
     5521 ttctgcagtt cagctcttcc cacagatgta gtgcttgttt agcggcgggg ctgaccggca
     5581 ggcctcgtgt acaaccccct gctcatgtgg tcatgcctca gtgtcttctg gtgcagccag
     5641 ggctatcagc cctgcaacca aaggccctcc tgttctgtag ccacctgtgc tgagcactag
     5701 gctgccgcaa gctctgttta tacccatctc tgctcggcag tctgctcccc cgctgccgat
     5761 tggttcctcc ttttcttttg tgtctgctaa ttccccagat tgattaattg ccatttgtgg
     5821 gagctgcctg tggctccttg gcatactctc tatgtgctgc ctgccaactc tgctctgccc
     5881 tgggggtcct tctccacccc ctggacccaa tctctagtgc atgagatgaa gaaatggggg
     5941 tgcctcatat tgttgagttc tggggtgctc cttcctcatt gctcctatgt gaaactgcct
     6001 gagtgaggca cagggatgaa ggtggaaggg gtggtgggca ggcaccaggg tcctaatcct
     6061 ttctctgtcc aaatattgtt ctggttcaaa ctgttagcac tcaaaagttt tcctaatgcc
     6121 acttataaat tcagatgctt gtctggcttc ttaaaaggtt atggtgttac tcagtagtag
     6181 aaaagaggga gagtaggccc accttctcct tccctctggc ttagcctaaa gtagtgggaa
     6241 ctgccagctt cctggaagta tctcttcttg gtgctgctgt atccatctct ctccagtgac
     6301 tgccttggac agtagccatg cctactggaa ggtttctgct ggtcccacag aaactgccgg
     6361 tcctttgacc tagtgacttt gttgatgtcc caggggctgg gaaactgttc cttttcagag
     6421 cttccatctc gggggattga ctgcatacgc agccaggcct tggtgctccc ttctctctcc
     6481 ttgagagctg gggatggact ccacacttga ggcttcacct tgcaagtcct atcaccacag
     6541 ctttcttctg gacatggcaa aaagaggtgc tgagggcaga gcttcttttg ctctgagatt
     6601 agggccacat accttagacc ctccaactga tgtgattttc agagatgttg gagaccactg
     6661 gcccctagac ctcaactctg acgaagcaga agggttgagt tggaagactc acgttctttc
     6721 tcaaaagcgg cacactgctt cttccactgt gacaccatgg gctgctaact cagtgtctct
     6781 gggtctgctg ggaacaaggc tacctgaaat actggggcag tatttggaga ttagtactgg
     6841 cctagcctat agtgtttgct tgctgtctca catcacgtga ctcctgaacc atggagtgta
     6901 aaggcaggat gtcagggccc ctagattttg tattgaactt ggacaactat tctgaggacc
     6961 ctcctgggaa ttttggccac tgtctgggct ttgaagttac aactgagaag aggttgctgt
     7021 caaagactgc ttctttggga tgttgtaggg ccaagagcct cagtccatgg ctaggcttgc
     7081 aggctgggct tgcaggctgt gctaacaaag gtgctgactc cttttttctc ttcttgcctc
     7141 tggcagggct ccttacctct gccttgctga ccaaatcgtg taaactgctt ttgactggcc
     7201 actgggtgac agctgtgctc ttgtgtcccc tgggctcaga aggggcacaa ggtctaccca
     7261 ttccgaagtg gcctctcata cagtcttctc ctaagaggtc ttccttcttg tgactttcct
     7321 tagaggccag cagcattcct gaaattcagg aaactgtttc agcccttcct ttgatgactg
     7381 catagcaaac tggcagatac agtccccatg gtcagtggct gaccagggtg tcataggcgc
     7441 gatctcaatt gctagatgtg agcacacgct tgacagtctg tttagaaatg tgtgatgttg
     7501 gggtgtattc acttctaggg accaattacc tttacactct tcctctgaac ttagcagtga
     7561 caactattaa gcttcctagg gctttcacct ttcttgctgt gggggaatca tgtcttccaa
     7621 attctcccct ttgggtctgg tagccttgca gaagtatctc agttcaaaac ctattcctgt
     7681 cctcagtttt ttgttttttt tttttttttt tttttttttt tttggtgtgt gtgtgtgtgt
     7741 gtatgccttt ccttctgcac tgtacctgga gatgctatcc cagtgtttaa gccaccagtc
     7801 aggaagagca taaactggct ctctaagggc ccagaaagat tgcaattatt tgacaggaag
     7861 aggatgaaac ataagaagtg aatcttgttt cttgaattga tggctgacca cacagatcta
     7921 gctttcagag agttctatgt gctcatggtt atgggtggct attgatccaa tgtctagtgc
     7981 tggccctgtc taatgaccag cccatctcct tcccagtttt cttttcttct ctctttttaa
     8041 acattggata ttttctttat ttacctttta aatgttgtcc cctttcccat taccccctac
     8101 ccagaacccc cctatcccat ccctctttcc cctgcttcta tgagaatatt cccctatccc
     8161 ccactcctgc ctccctgccc ttgaacttcc ctacactgga atatcgagcc ttcacaggac
     8221 caagggcctc tccttccatt gatgaactcc ttggttggtg gtttagtccc tgggagctct
     8281 gggggatctg gttggttgat attgttcttt ctttggggtt gcaaacccct tcgactcctt
     8341 ctgtcctttt tctaactcct ccattgggga ccccattggg gaccctgtgc ccagtcttct
     8401 tagaggaact agggcaggaa agaaggcttc tgagattctt tctcggcagg gaaaggtgcc
     8461 tcacactcaa cgcacagtgt gagcaagatc tatgcgctgt ctccaggggc ctgggttatg
     8521 tatttagggg agatttcagc agggtaggtt ggaacagtta cttattggca tttctttcag
     8581 tgtgttctct ctttattttt ttcacagtga tctaacctag ttgagcttga ccggatttta
     8641 tttgctcatt cttctgcccc ttttatgcag aggaacctgg gtgaggttgg gatgagggac
     8701 tcttttgctt cctcctcctg gtgatgttgg tacccattgg cttcagggga ggcatcccag
     8761 aacattaggg catcatagct gcttcttagg atctaagtct gatactgagg ccatttcttc
     8821 tgactttgtt ggaaaaaccc ttttaagaag gcttggggtg gactgggaaa agtatagata
     8881 agtacatttt gttagtatat agagaactct aggaagtgaa cagctaatgg tttggatttg
     8941 ctttgtttgc atgtaagaag tgctttgggg aactctgcag ggacttaggg gtggggggat
     9001 agagtcaaga gcagagatgt ggggcatggg aggtgctgct gctcctgttt ttctctcgga
     9061 tcccgagcgt tctcactcgt gctccttggc tgggcccttc cctttgtgca agctccaggc
     9121 cgtgctgatt atctccgtct ctttgggagc aggctcagga tgtggcttag cagtcatcct
     9181 acactgaata tagtagttga tagggcaggt gggattgagg aagaggagtt agactcaagg
     9241 agtgtgagac ttagaaggat gggagactgg tcttcaaatg cccatggtag ctccttgtcg
     9301 gtggaaaggg aagggttgtt ctcgggagct tggtccttat tcttatggct gctgtagcag
     9361 gctgtgtctg aaagtgccta gtggacactg gtgctgatgg tggagaggag ttgtgcctcc
     9421 agtcttgtca gttttcttct tgagctatcg agaatgcctt catcctgcag gctaacagtg
     9481 gccttgtgac tagaggcttt gctttcaatt tctcttcctt tgataggtta aagataccac
     9541 actgtagcta tgacagttaa ctaatttcat ctgaaaccag acaccatcta ttgtgtcctt
     9601 actctgtaga acttcctctt ggatcaagag gaaaaactga agatctcttt aagagaagtc
     9661 aataaactga gaatcaaagc ctggttggac tctaagaact cttcccacgt cctgcaactt
     9721 ggtgttttcg tggctggctt ataacccctt cacttttaat gctgaatcag catgggtcca
     9781 gagccttgtg ttagggcccc tgtctctgct tccaaataag ctttcagaaa aaatacactg
     9841 tctgcaccag atgtttggtg tcatggattg ccaagaggat tgaagttgtt tcatgacccc
     9901 atttaaaaaa aaaaaaaaac aaaaccaacc ctaatcaatt gagtctggtc taaagacact
     9961 cctagatcat tgggaattct ttgtagattt aaaaaaaaaa tgcatcaatg caaatctttt
    10021 tcatgactgg tcatgtctta ggagggggaa gagttgggat atcctaactg caaaatagtt
    10081 gggtacatca gcagcgggcc attgaacctc ttagaggttc tcctctgcag tgggtcaact
    10141 gaagcagtta gagattctta ggcatgctgg tgaagagtgg tcagctttgc accactggct
    10201 aaggaattca accaaagcag cacaagcgac tcagcttgaa gccagggcct ccaccatcta
    10261 cctttcccat ccaacttaac tccatggcaa catgaatgag taggcttgct gttcttttgg
    10321 gtcttaaaga aatttgcccc accaatccca tctcccacca acattgactt cctggatctg
    10381 ttttaaggaa atgcagagca aactctccct tcacccacat tcagaccatc caggctctct
    10441 ttccttcttg ccccgacttg tgtgtggctc caggacccct agcttgtgca tggtttccgc
    10501 tagggaggtg gttgggttag ggggagaatt ggggagggga gggattggac tggggaaggg
    10561 gatttgcatt ttcaacctta aactactgaa agcatgcttt ggggtgacct ctgggatttt
    10621 cacataaact atggttaggg aaaaatgcct gttgctcctt atatgggagg tagggacttg
    10681 ggggactttt gccttccttt tggcttagga atctattcta tttgaggaga ataagcctca
    10741 tagttacctt gcaaaccctg gaagggaaac ttatttattc tatcaccaag tatttatatt
    10801 gcctactgag gacaactgag cagtctgtcg ggggctgaca ttgccctgtg tcagagaaat
    10861 ggaataatct cacctgtttc tctgcaggtg tcaggttatc tgcctggtca tgaaccccca
    10921 agccaactga ttattccagt gttcagaatt aagtgtatta gatgggtgtg agtatctgtg
    10981 atgggtgtga tgtatgcatg tgtgtgctgt gtgtgcagtg tgtatgtatt gtatgggtat
    11041 gctttgtatg tgtgtttgat gcgagtgtgg gtgtgaggga attgtagaga caccactttg
    11101 cctgggtagc atcaggccta gttatggctg actctttctt tgctagacaa acttctgctt
    11161 tggcaggagg ctcatactca taatatacca ccttgagtgt atttttatgg agattgtata
    11221 taaaattata taaatatata taacttgttc tattttaagg caaaaggaga cttactgggg
    11281 agggggcaag actcagatgc aatagtgctg gctaaccgtg ggagcttcag gtaagttgtc
    11341 cacatgggga gtgggggggg ggtgatgtaa gcagggagtg gggctcgtgc ccgctgcaca
    11401 tatatataaa tataaagaaa acttatatag agctatctat ctagcatatc tatatatcta
    11461 tatatctata tgatgtcata gtttgcttta tttttgtacc tgtgcttaga gacactttga
    11521 gcagtatcgc ctcccccagg tggtccgggg tgctagctca tgccttgatc ccactgatat
    11581 ttctccatcc tcctcaagac agactgtgtt ggaagctgct tgagtctttc tggtagatat
    11641 gtgtatatat gaacaaaaac aaaaacaaaa aaaccacaaa aaaacaacaa aaaacaaaaa
    11701 aacaaaacta aagtcattta tagaaaggac aggcaagccg aaggcgccaa gctgctggat
    11761 ctgcatgtct cctgtcaggg gggttcccta actcctgctg tctggtagat gtgctcagtg
    11821 tagaaaggac gatggagagc ttagcatgaa tccatacccc tctggctaag ggttggtact
    11881 cagttctttg gaaacgattt agctcggcat cttggacaga gggagctcag attctctagg
    11941 tcgtctggta acacctgtcc tgctttgtag cacctgggct caagcagccc ccgtgtgagg
    12001 tggtaggaag gtttttgaag ctgactgcgt gggttcagtc ttggagaaga tacaccctgg
    12061 taattactgc tgcagagtct tggaaccagc atgaatgtga tatctagtat aaatatagca
    12121 tctgtgcttt ttcatttatt tttaattgga aaataaactg ttgtcggaaa tggggcagtc
    12181 tagtcccaga acactgagcg gaagatcagg aaaggggcac tgacaccggt taggatgtga
    12241 gggataggtc ctactgctgg ctgcttggcc cgggactctg aagttaacaa atgtattgga
    12301 agaaggtggt ttggatggag attccgggag ttcacttgcg tttgggaagg aaactgtgtg
    12361 ctctgaagaa tacctcttta agaattcaag acctcacata tgctgcgagg gccccatgcc
    12421 ctgcagcctt agctggcgtc tcctggtgct agctctttct tctcatgtgc caagtgatca
    12481 gagtggtgtc cttgaagctg atgcaaagcc aggggagact caaggctgaa gtctctccag
    12541 tcttcctgct tctcacttaa gaaaaggcaa aagtgccccc ccccacacca atctgtccaa
    12601 acaaaacatg atgctagcca agagctctta tttcagatgc ctcaactgtg ggaagggctt
    12661 ttatgttttt gtttttgttt ttgttttttt ctggtggggg aggggagtga aaggcagagt
    12721 aggctggaga ggagcttgag tctaactcct gacccttaag gagaccttat gattcctttg
    12781 atgatctttt caaaatatta aaaaaatgtc caagggtatt gtgagaaaat gggttctcct
    12841 gtggtccatg tcggactgga tgggctccag cacctgctct aacttaggag gccgagggag
    12901 gatagcaggt gtttcttgta gatttcctga gagattgggc aagaggaaga acagcaaatt
    12961 ctttgtccct ttctagcttg agtcccctcc tcacttacca aagaggggat tgggattcca
    13021 ttgtttgttt tttgttgttg ttgtttttgt tttttgcctc acttttggtc ataagctatc
    13081 agcagagcag atcatgttag catctcaggg ctcatagctc atactccatg aagcccaggt
    13141 ttgctctgac tctactcttt ccccgttgag ctaaaggctt ggtccttaga aacctcagca
    13201 gcatcaagga acatgagatt gccctcctat ttcatgatgt ccaattggat tcctctctgg
    13261 aaacgggaag atggacatgt ccttcacctt gaagttttag ggcttgagga atgtgccact
    13321 attactctgt ctatgacctc agtcagacgg tgcaaagtgt gcactggagg agaagggagt
    13381 cggggctcag tatccatcac ctagtctata gaagagccag ctttccatga tggaacgcag
    13441 agctaaggag gccaggatct gactatgtat ggaaagagca agctagctga acgttgagtc
    13501 tcttagttaa tgggactggt gttaatggga aggctgctct gagaaagcta ctgccaggat
    13561 cctgaactgt ttccaatact tgtgattcac cttggtccct aggtcatggg agatttgttg
    13621 acttgtgatg ctctttcttc ttggtaggag ataggggaaa tctaaggaga cttagtttgg
    13681 ctacctctgt ctgttatatg gaatgaacgt ggaaacagat gtggaaattg ttctcctaag
    13741 ggttgatgca gctctgtcct ttccccattg tccttaacca ggagacttgg ggaaagggac
    13801 acctctacca ctcatcagtt gcttgggcct caccttatgc tgtaggtact aactatgtgg
    13861 agccatttgg acaatacaaa agcatggggg gaggggcagg acacagctgt ggatcatgat
    13921 gttagagtag gggggtttgt tctgtagtca agaaagtgac tgaaaggagt tgctgtatgg
    13981 aatgaccttg atgccagaac tcaagactga gctctcacaa aaggagcagc tgaccattga
    14041 gcgctgtatg cactgtcaga cagtcttaca gctccattca gatttaattt tctaactgcc
    14101 atttgtgggg tcggagactg agggcaggaa tgggacatgc tttcccaagt tacctgtcct
    14161 tatacaatcc ttgactgagc agagggtgcc ctgctttggt cagcaactct ggggccccct
    14221 tcatcgccgc ctcttctctc tttcatgagg aggaactgta tcatcttgga cacagttctt
    14281 ccctcgtgca gttaaaggca gtttttgttg tatgaattct ttccctcctg tgtcccatta
    14341 gtgtgtagac acacggcagt ggggaggtga aggatcctgg tgctccctgt caggctccct
    14401 cacagactgc acacctcttg cccctgacag cctcctggct gttagtctta acatatctgg
    14461 acgtgactat caatatcgtc atgagatttc ttgctctcat ttcagacctt tattcttcct
    14521 ttggctttcg ttgggggctc ttcctccccc atgcctagtc ttctcatgaa gatggttcaa
    14581 acctcatttc tatttcttga atgttgagta ttacatcaca gcgctagggt gcttcatggt
    14641 gctgctcctg aagaggccag ctggacggga tcagtccgct tcgtcccact ggttccttag
    14701 agcttgctgt atcttgtccc tattagatgt ttttccttgt gggttggggt gggagagtta
    14761 ggggtagttt ttgtgttctc tctctctctc tctctctctc tctccccttt ctctctccct
    14821 tcctctttct ctctatatgt atgtatgtat ggattggtta aagtcagtta tcatgggcag
    14881 ctgactttga ctccaaatta aagttaaact acacattgta cagctgcaca cagaacacct
    14941 ttgagtgtga atttggatgg caactagagg catacttttt gaacttcagg tatgtaactg
    15001 aaaagtaaat aaaaacacta ttttttcagt aacctttttt tttccttcta aaagataact
    15061 taaaaatcaa actatacgaa cattaaattg gtgctgtacc aaagccttat gacatattcc
    15121 acactccgta tatcctgtct cccgggagct ctctgcttat tactcttttc aaaagcctgg
    15181 gaatgccagt gagcgtcaag cctgggtctg ggtgctgggg acccgtgggc caaggggact
    15241 cgtgggagca gaagatgatg gtggaggtgg gggtacccat cttctgcctg agcagatact
    15301 gaagggaaag caggtgttgg tgtgtgtggc atgcatgtgt gtgtgcgcgc gcgcatgcgt
    15361 gcgcacgtgt gcatgagctc acctgtgcat agtgccgagg agcatgctat gctacctggg
    15421 cactgaaagg gagacccagg ttggcctggg tgtgggttgg ctgtgggagt gaggggcacg
    15481 ccccttccct tttccatttc ccctttcttg taggttagta atggaggtgt atcagaaaca
    15541 gctacactct caaacaggtg cttttccccc ttcagaaatc tccaaactaa gtatctctct
    15601 gtgaagggcc tgtccatggg gcaggcacct cagctaccaa atcctaaccg cctacggctg
    15661 agaggaaccc ttttcctctc tagcccttgc ctagtttttt ggggacaaag gttcctccag
    15721 ggatctctgc gtcccctgtt ccttggcctg ggtgggcttc ttagcccatt gagaaggcct
    15781 cactgtggct gacccatagc tgtacctgct ccgtggtcct aatcaataat gcctgccctg
    15841 gcggctgagg accatgattc ctttggcctc agacttgtca gtgtgaagtt gagcaccagc
    15901 ccagatttat tcgggaggaa atctacagtc ggcctccacc tagactgtga ctctaggctc
    15961 cacctgctgg tgctcttggg cttgctgaaa ctaaccaact catccccagt aacactgcat
    16021 gtccatatcc gcaaacaaca acaacagtac ataagcaagc gcagggaaag agagagaaag
    16081 aagacacatc caacatctag atgtgtagtc agtgagggaa cccctgggaa cattgcaagc
    16141 taagctgatt tcaaaacgtt tagtatttaa attacttctc atgtaacatt actctgcttc
    16201 agaaatgttt tgtattttga tataaataaa aatttgctta aaaagtt
//
