LOCUS       NP_001139272            1179 aa            linear   ROD 26-JUN-2024
DEFINITION  protein turtle homolog A precursor [Mus musculus].
ACCESSION   NP_001139272
VERSION     NP_001139272.1
DBSOURCE    REFSEQ: accession NM_001145800.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1179)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 1179)
  AUTHORS   Wang,X.X., Zhang,S., Dong,P.P., Li,Y.H., Zhang,L., Shi,S.H.,
            Yu,Z.Q. and Chen,S.
  TITLE     MRCKbeta links Dasm1 to actin rearrangements to promote dendrite
            development
  JOURNAL   J Biol Chem 296, 100730 (2021)
   PUBMED   33933448
  REMARK    GeneRIF: MRCKbeta links Dasm1 to actin rearrangements to promote
            dendrite development.
REFERENCE   3  (residues 1 to 1179)
  AUTHORS   Bibollet-Bahena,O., Okafuji,T., Hokamp,K., Tear,G. and
            Mitchell,K.J.
  TITLE     A dual-strategy expression screen for candidate connectivity labels
            in the developing thalamus
  JOURNAL   PLoS One 12 (5), e0177977 (2017)
   PUBMED   28558017
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1179)
  AUTHORS   Gu,Z., Imai,F., Kim,I.J., Fujita,H., Katayama,Ki., Mori,K.,
            Yoshihara,Y. and Yoshida,Y.
  TITLE     Expression of the immunoglobulin superfamily cell adhesion
            molecules in the developing spinal cord and dorsal root ganglion
  JOURNAL   PLoS One 10 (3), e0121550 (2015)
   PUBMED   25826454
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1179)
  AUTHORS   Mishra,A., Traut,M.H., Becker,L., Klopstock,T., Stein,V. and
            Klein,R.
  TITLE     Genetic evidence for the adhesion protein IgSF9/Dasm1 to regulate
            inhibitory synapse development independent of its intracellular
            domain
  JOURNAL   J Neurosci 34 (12), 4187-4199 (2014)
   PUBMED   24647940
  REMARK    GeneRIF: These results provide genetic evidence for a specific role
            of IgSF9 in inhibitory synapse development/maintenance, presumably
            by its cell adhesion molecule-like activity.
REFERENCE   6  (residues 1 to 1179)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   7  (residues 1 to 1179)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   8  (residues 1 to 1179)
  AUTHORS   Doudney,K., Murdoch,J.N., Braybrook,C., Paternotte,C., Bentley,L.,
            Copp,A.J. and Stanier,P.
  TITLE     Cloning and characterization of Igsf9 in mouse and human: a new
            member of the immunoglobulin superfamily expressed in the
            developing nervous system
  JOURNAL   Genomics 79 (5), 663-670 (2002)
   PUBMED   11991715
REFERENCE   9  (residues 1 to 1179)
  AUTHORS   Kibar,Z., Vogan,K.J., Groulx,N., Justice,M.J., Underhill,D.A. and
            Gros,P.
  TITLE     Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is
            altered in the mouse neural tube mutant Loop-tail
  JOURNAL   Nat Genet 28 (3), 251-255 (2001)
   PUBMED   11431695
REFERENCE   10 (residues 1 to 1179)
  AUTHORS   Doudney,K., Murdoch,J.N., Paternotte,C., Bentley,L., Gregory,S.,
            Copp,A.J. and Stanier,P.
  TITLE     Comparative physical and transcript maps of approximately 1 Mb
            around loop-tail, a gene for severe neural tube defects on distal
            mouse chromosome 1 and human chromosome 1q22-q23
  JOURNAL   Genomics 72 (2), 180-192 (2001)
   PUBMED   11401431
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121551.11 and BC040281.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145121.1, SRR9219380.1826.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1179
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 79.86 cM"
     Protein         1..1179
                     /product="protein turtle homolog A precursor"
                     /note="protein turtle homolog A; igSF9A; immunoglobulin
                     superfamily member 9A; dendrite arborization and synapse
                     maturation protein 1; NCAM-like protein NRT1"
                     /calculated_mol_wt=125159
     sig_peptide     1..20
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2190
     mat_peptide     21..1179
                     /product="Protein turtle homolog A. /id=PRO_0000306108"
                     /note="propagated from UniProtKB/Swiss-Prot (Q05BQ1.2)"
                     /calculated_mol_wt=125159
     Region          28..110
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          37..41
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          54..58
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          91..95
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          136..223
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          154..158
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          167..171
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Site            188
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q05BQ1.2)"
     Region          189..193
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          203..208
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          226..305
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Site            239
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q05BQ1.2)"
     Site            256
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q05BQ1.2)"
     Region          322..404
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          333..344
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          353..358
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          378..382
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          392..397
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          418..503
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          436..440
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          449..453
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          469..473
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          483..488
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          496..499
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          508..599
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(508,576,591)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Site            513
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q05BQ1.2)"
     Site            524
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q05BQ1.2)"
     Site            order(592..593,595..596)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          625..715
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(704..705,707..708)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Site            735..755
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q05BQ1.2)"
     Region          767..807
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q05BQ1.2)"
     Site            809
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P0C5H6; propagated from
                     UniProtKB/Swiss-Prot (Q05BQ1.2)"
     Region          819..842
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q05BQ1.2)"
     Region          942..974
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q05BQ1.2)"
     Region          1016..1079
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q05BQ1.2)"
     Region          1177..1179
                     /region_name="PDZ-binding"
                     /note="propagated from UniProtKB/Swiss-Prot (Q05BQ1.2)"
     CDS             1..1179
                     /gene="Igsf9"
                     /gene_synonym="644ETD8; Dasm1; Kiaa1355-hp; mKIAA1355;
                     Ncaml; NRT1"
                     /coded_by="NM_001145800.1:257..3796"
                     /db_xref="CCDS:CCDS15515.1"
                     /db_xref="GeneID:93842"
                     /db_xref="MGI:MGI:2135283"
ORIGIN      
        1 miwclrltvl sliisqgadg rrkpevvsvv gragesavlg cdllppaghp plhviewlrf
       61 gfllpifiqf glyspridpd yvgrvrlqtg aslqieglrv edqgwyecrv lfldqhspeq
      121 dfangswvhl tvnsppqfqe tpplvlevke leavtlrcva rgspqpyvtw kfrgqdlgkg
      181 qgqvqvqngt lwirrvergs agdytcqass segsithatq llvlgppviv vppsnstvns
      241 sqdvslacra eaypanltys wfqdgvnvfh isrlqsrvri lvdgslwlqa tqpddaghyt
      301 cvpsngflhp psasayltvl ypaqvtvmpp etplptgmrg vircpvranp pllfvtwtkd
      361 gqalqldkfp gwslgpegsl iialgnenal geysctpyns lgtagpspvt qvllkappaf
      421 idqpkeeyfq evgrellipc sargdpppiv swakvgrglq gqaqvdsnns lvlrpltkea
      481 qgrwecsasn avarvttstn vyvlgtsphv vtnvsvvplp kganvswepg fdggylqrfs
      541 vwytplakrp drahhdwvsl avpigathll vpglqahaqy qfsvlaqnkl gsgpfseivl
      601 sipeglpttp aapglpptei ppplspprgl vavrtprgvl lhwdppelip grldgyileg
      661 rqgsqgweil dqgvagteiq llvpglikdv lyefrlvafa dsyvsdpsnv anistsglev
      721 ypsrtqlpgl lpqpvlagvv ggvcflgvav lvsilaaclm nrrraarrhr krlrqdppli
      781 fsprgksgsh sapgsgspds vtkfklqgsp vpslrqsllw geparppsph pdsplgrgpl
      841 plepicrgpd grfvmgptva psqeklcler seprtsakrl aqsfdcssss psgvpqplci
      901 tdispvgqpl aavpsplpgp gpllqylslp ffremnvdgd wppleeptpa pppdfmdsqp
      961 cptssflppp dsppanlrav lpgtlmgvgv sseppytala dwtlrervlp gllsaaprgs
     1021 ltsqssgrgs asflrppsta psaggsylsp apgdtsswas gperwprreh vvtvskrrnt
     1081 svdenyewds efpgdmelle twhpglassr thpelepelg vktpeescll npthaagpea
     1141 rcaalreefl afrrrrdatr arlpayqqsi sypeqatll
//
