LOCUS       NM_080419               2280 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus immunoglobulin superfamily, member 8 (Igsf8), mRNA.
ACCESSION   NM_080419
VERSION     NM_080419.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2280)
  AUTHORS   Li,Y., Wu,X., Sheng,C., Liu,H., Liu,H., Tang,Y., Liu,C., Ding,Q.,
            Xie,B., Xiao,X., Zheng,R., Yu,Q., Guo,Z., Ma,J., Wang,J., Gao,J.,
            Tian,M., Wang,W., Zhou,J., Jiang,L., Gu,M., Shi,S., Paull,M.,
            Yang,G., Yang,W., Landau,S., Bao,X., Hu,X., Liu,X.S. and Xiao,T.
  TITLE     IGSF8 is an innate immune checkpoint and cancer immunotherapy
            target
  JOURNAL   Cell 187 (11), 2703-2716 (2024)
   PUBMED   38657602
  REMARK    GeneRIF: IGSF8 is an innate immune checkpoint and cancer
            immunotherapy target.
REFERENCE   2  (bases 1 to 2280)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2280)
  AUTHORS   Jimbo,K., Nakajima-Takagi,Y., Ito,T., Koide,S., Nannya,Y.,
            Iwama,A., Tojo,A. and Konuma,T.
  TITLE     Immunoglobulin superfamily member 8 maintains myeloid leukemia stem
            cells through inhibition of beta-catenin degradation
  JOURNAL   Leukemia 36 (6), 1550-1562 (2022)
   PUBMED   35418614
  REMARK    GeneRIF: Immunoglobulin superfamily member 8 maintains myeloid
            leukemia stem cells through inhibition of beta-catenin degradation.
REFERENCE   4  (bases 1 to 2280)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2280)
  AUTHORS   Apostolo,N., Smukowski,S.N., Vanderlinden,J., Condomitti,G.,
            Rybakin,V., Ten Bos,J., Trobiani,L., Portegies,S., Vennekens,K.M.,
            Gounko,N.V., Comoletti,D., Wierda,K.D., Savas,J.N. and de Wit,J.
  TITLE     Synapse type-specific proteomic dissection identifies IgSF8 as a
            hippocampal CA3 microcircuit organizer
  JOURNAL   Nat Commun 11 (1), 5171 (2020)
   PUBMED   33057002
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2280)
  AUTHORS   Stipp,C.S., Kolesnikova,T.V. and Hemler,M.E.
  TITLE     EWI-2 is a major CD9 and CD81 partner and member of a novel Ig
            protein subfamily
  JOURNAL   J Biol Chem 276 (44), 40545-40554 (2001)
   PUBMED   11504738
REFERENCE   7  (bases 1 to 2280)
  AUTHORS   Kibar,Z., Vogan,K.J., Groulx,N., Justice,M.J., Underhill,D.A. and
            Gros,P.
  TITLE     Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is
            altered in the mouse neural tube mutant Loop-tail
  JOURNAL   Nat Genet 28 (3), 251-255 (2001)
   PUBMED   11431695
REFERENCE   8  (bases 1 to 2280)
  AUTHORS   Doudney,K., Murdoch,J.N., Paternotte,C., Bentley,L., Gregory,S.,
            Copp,A.J. and Stanier,P.
  TITLE     Comparative physical and transcript maps of approximately 1 Mb
            around loop-tail, a gene for severe neural tube defects on distal
            mouse chromosome 1 and human chromosome 1q22-q23
  JOURNAL   Genomics 72 (2), 180-192 (2001)
   PUBMED   11401431
REFERENCE   9  (bases 1 to 2280)
  AUTHORS   Underhill,D.A., Vogan,K.J., Kibar,Z., Morrison,J., Rommens,J. and
            Gros,P.
  TITLE     Transcription mapping and expression analysis of candidate genes in
            the vicinity of the mouse Loop-tail mutation
  JOURNAL   Mamm Genome 11 (8), 633-638 (2000)
   PUBMED   10920231
REFERENCE   10 (bases 1 to 2280)
  AUTHORS   Eddleston,J., Murdoch,J.N., Copp,A.J. and Stanier,P.
  TITLE     Physical and transcriptional map of a 3-Mb region of mouse
            chromosome 1 containing the gene for the neural tube defect mutant
            loop-tail (Lp)
  JOURNAL   Genomics 56 (2), 149-159 (1999)
   PUBMED   10051400
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU059206.1, BC048387.1 and AC074311.28.
            
            On Sep 1, 2015 this sequence version replaced NM_080419.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048387.1, AK158522.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                BU059206.1         1-40
            41-2274             BC048387.1         1-2234
            2275-2280           AC074311.28        83235-83240
FEATURES             Location/Qualifiers
     source          1..2280
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 79.59 cM"
     gene            1..2280
                     /gene="Igsf8"
                     /gene_synonym="ESTM34; EWI-2; KCT-4; PGRL"
                     /note="immunoglobulin superfamily, member 8"
                     /db_xref="GeneID:140559"
                     /db_xref="MGI:MGI:2154090"
     exon            1..227
                     /gene="Igsf8"
                     /gene_synonym="ESTM34; EWI-2; KCT-4; PGRL"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..2005
                     /gene="Igsf8"
                     /gene_synonym="ESTM34; EWI-2; KCT-4; PGRL"
                     /note="CD81 partner 3; prostaglandin regulatory-like
                     protein; glu-Trp-Ile EWI motif-containing protein 2;
                     keratinocyte-associated transmembrane protein 4; PG
                     regulatory-like protein"
                     /codon_start=1
                     /product="immunoglobulin superfamily member 8 precursor"
                     /protein_id="NP_536344.1"
                     /db_xref="CCDS:CCDS15511.1"
                     /db_xref="GeneID:140559"
                     /db_xref="MGI:MGI:2154090"
                     /translation="MGVPSPTPLSSLLLLLLILGTRCYARQVHVPRGPLYRVAGTAVS
                     ISCNVSDYEGPAQQDFEWFMYRPEAPATSLGIVSTKDSQFSYAVFGPRVASGDLQVQR
                     LKGDSVVLKIARLQAQDSGFYECYTPSTDTQYLGNYSAKVELRVLPDELQVSAAPPGP
                     RGRQAATSPSRLTVHEGQELALGCLAQTKTKKHTHLSVSFGRAIPEAPVGRATLQEVV
                     GLHSDMAVEAGAPYAERLASGELRLSKEGTDRYRMVVGGAQAGDSGTYHCTAAEWIQD
                     PDGSWVQVAEKRAVLAHVDVQTLSSQLAVTVGPGERRIGPGEPLELLCNVSGALPPPG
                     RHAAYSVGWEMAPAGAPGPGRLVAQLDTEGIGSLGPGYEDRHIAMEKVASRTYRLRLE
                     AARPADAGTYRCLAKAYVRGSGTRLREAASARSRPLPVHVREEGVVLEAVAWLAGGTV
                     YRGETASLLCNISVRGGPPGLRLAASWWVERPEEGELSTGPAQLVGGVGQDGVAELGV
                     RPGGGPVSVELVGPRSHRLRLHGLGPEDEGIYHCAPSAWVQHADYSWYQAGSARSGPV
                     TVYPYTHAVDTLFVPLLVGTGVALVTGASVLATITCCFMKRMRKR"
     exon            228..605
                     /gene="Igsf8"
                     /gene_synonym="ESTM34; EWI-2; KCT-4; PGRL"
                     /inference="alignment:Splign:2.1.0"
     exon            606..1067
                     /gene="Igsf8"
                     /gene_synonym="ESTM34; EWI-2; KCT-4; PGRL"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1475
                     /gene="Igsf8"
                     /gene_synonym="ESTM34; EWI-2; KCT-4; PGRL"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1889
                     /gene="Igsf8"
                     /gene_synonym="ESTM34; EWI-2; KCT-4; PGRL"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..2020
                     /gene="Igsf8"
                     /gene_synonym="ESTM34; EWI-2; KCT-4; PGRL"
                     /inference="alignment:Splign:2.1.0"
     exon            2021..2280
                     /gene="Igsf8"
                     /gene_synonym="ESTM34; EWI-2; KCT-4; PGRL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2255..2260
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Igsf8"
                     /gene_synonym="ESTM34; EWI-2; KCT-4; PGRL"
                     /note="hexamer: AATAAA"
     polyA_site      2274
                     /gene="Igsf8"
                     /gene_synonym="ESTM34; EWI-2; KCT-4; PGRL"
                     /note="major polyA site"
ORIGIN      
        1 gaagaagggt ggagggcggg gagttggcgg ctcccgctcg gctgggctct gcgcacccac
       61 gcttcactgc tccgctttct gccccccacc tgggcatgcg ccccccgcgg ccctggcccc
      121 ccagagccca cgccgccccc aggagtctcc tcagagccgc ctacgcagaa tgggcgtccc
      181 tagccccacg ccgctgagtt cgctcctgct gctgctgcta atacttggaa ccaggtgcta
      241 cgcccggcag gtgcatgtcc ccaggggacc tctttaccgg gtggctggca ccgctgtctc
      301 tatctcctgc aacgtgagtg actatgaggg ccctgcccag caagacttcg agtggttcat
      361 gtacagacca gaggccccag ctacgtccct gggcattgtc agcaccaagg atagccagtt
      421 ctcctatgct gtctttgggc ctcgtgtggc atctggtgac ctgcaggtgc agcgcctgaa
      481 gggagattcg gtggtgctca agattgctcg cctgcaggcc caggactctg gcttttatga
      541 gtgctacacc ccctccacag atacgcagta cctgggcaac tacagtgcca aggtggagct
      601 gagagttctt ccagatgagc tgcaggtatc tgctgcccct ccagggcccc gagggcgcca
      661 ggctgccacc tccccctcac gcctcacagt gcacgagggg caggagcttg cgctgggctg
      721 cctggctcag accaaaacaa agaaacacac acacctgtcg gtgtcctttg ggagagccat
      781 tccggaggcg ccagtggggc gagccactct acaggaagta gtgggactgc actccgacat
      841 ggcggtggag gctggagcgc cctacgctga gaggctagct tctggggagc ttcggctgag
      901 caaggaaggg actgatcggt accgaatggt ggttgggggt gcccaggctg gagactcggg
      961 cacctaccac tgtacggccg ctgagtggat tcaggatcct gacggctcct gggtccaggt
     1021 cgcagagaag agggcagtcc tggctcatgt tgatgtgcag actctgtcca gccagctggc
     1081 ggtgaccgtg ggacctggtg aacgtcggat tggcccaggc gaacccttag aactgctgtg
     1141 caatgtgtcc ggtgcactgc ccccaccagg ccgtcatgct gcgtactctg tgggctggga
     1201 gatggcccct gcaggggctc ctggacccgg ccgcctggtg gcccagctgg acacggaagg
     1261 tataggcagc ctgggccctg gctatgagga ccggcacatt gccatggaga aagtagcatc
     1321 cagaacctac cgactgcggc tggaggctgc caggcccgct gatgcaggca cctaccgctg
     1381 cctcgccaaa gcctatgttc gagggtctgg gacccggctt cgtgaagcgg ccagtgctcg
     1441 ttcccggcct ctccctgtgc atgtgagaga agaaggcgtg gtgctagagg ctgtggcgtg
     1501 gctagcaggg ggcactgtgt accggggaga aacggcctcc ctgctatgca acatatctgt
     1561 gcggggcggc cccccagggc tgcgactagc agccagctgg tgggtggaga ggccagagga
     1621 gggcgagctg agcactggcc ctgctcagct tgtgggtgga gtgggtcagg acggtgtggc
     1681 agagctggga gtccggcctg gagggggtcc tgtcagtgtg gagctggtgg gacccagaag
     1741 tcatcggcta agactgcacg gcttggggcc tgaggatgaa ggcatatacc actgtgcccc
     1801 aagtgcctgg gtgcagcatg cggactacag ctggtaccag gcaggcagtg cgcgctccgg
     1861 gcctgtcaca gtctacccct acacgcatgc tgtggatacc ctatttgtgc ccctgttggt
     1921 gggtacagga gtcgccctag ttaccggcgc cagcgtcctg gctaccatca cctgctgctt
     1981 tatgaagagg atgcggaagc ggtgatctgt agcaccccag ttcttgcagg tgttgactgt
     2041 cttccagcca gtgccacccc tcctctggtt gcctggatac cctctccctc tgtccagccc
     2101 acctttaatt tatttgacca gccatcacct agagtgggag acatggctcc cctgttccct
     2161 ccttccctca agtttcctgg ctgccgttct tagtcccaca ctcatgttgt aggaagtcca
     2221 gttcctgtcc tcaaactagt ttttctaaaa tgtgaataaa ctggttttgt aaaatcgagg
//
