LOCUS       NM_170599               3430 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus immunoglobulin superfamily, member 11 (Igsf11), mRNA.
ACCESSION   NM_170599 XM_358850
VERSION     NM_170599.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3430)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3430)
  AUTHORS   Pelz,L., Dossou,L., Kompier,N., Juttner,R., Siemonsmeier,G.,
            Meyer,N., Lowenstein,E.D., Lahmann,I., Kettenmann,H., Birchmeier,C.
            and Rathjen,F.G.
  TITLE     The IgCAM BT-IgSF (IgSF11) is essential for connexin43-mediated
            astrocyte-astrocyte coupling in mice
  JOURNAL   eNeuro 11 (3) (2024) In press
   PUBMED   38388443
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (bases 1 to 3430)
  AUTHORS   Kim,G.M., Kim,J., Lee,J.Y., Park,M.C. and Lee,S.Y.
  TITLE     IgSF11 deficiency alleviates osteoarthritis in mice by suppressing
            early subchondral bone changes
  JOURNAL   Exp Mol Med 55 (12), 2576-2585 (2023)
   PUBMED   38036734
  REMARK    GeneRIF: IgSF11 deficiency alleviates osteoarthritis in mice by
            suppressing early subchondral bone changes.
REFERENCE   4  (bases 1 to 3430)
  AUTHORS   Montag,D., Pelz,L. and Rathjen,F.G.
  TITLE     Lack of the Ig cell adhesion molecule BT-IgSF (IgSF11) induced
            behavioral changes in the open maze, water maze and resident
            intruder test
  JOURNAL   PLoS One 18 (1), e0280133 (2023)
   PUBMED   36607983
  REMARK    GeneRIF: Lack of the Ig cell adhesion molecule BT-IgSF (IgSF11)
            induced behavioral changes in the open maze, water maze and
            resident intruder test.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3430)
  AUTHORS   Manuel,M., Tan,K.B., Kozic,Z., Molinek,M., Marcos,T.S.,
            Razak,M.F.A., Dobolyi,D., Dobie,R., Henderson,B.E.P.,
            Henderson,N.C., Chan,W.K., Daw,M.I., Mason,J.O. and Price,D.J.
  TITLE     Pax6 limits the competence of developing cerebral cortical cells to
            respond to inductive intercellular signals
  JOURNAL   PLoS Biol 20 (9), e3001563 (2022)
   PUBMED   36067211
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3430)
  AUTHORS   Jang,S., Oh,D., Lee,Y., Hosy,E., Shin,H., van Riesen,C.,
            Whitcomb,D., Warburton,J.M., Jo,J., Kim,D., Kim,S.G., Um,S.M.,
            Kwon,S.K., Kim,M.H., Roh,J.D., Woo,J., Jun,H., Lee,D., Mah,W.,
            Kim,H., Kaang,B.K., Cho,K., Rhee,J.S., Choquet,D. and Kim,E.
  TITLE     Synaptic adhesion molecule IgSF11 regulates synaptic transmission
            and plasticity
  JOURNAL   Nat Neurosci 19 (1), 84-93 (2016)
   PUBMED   26595655
REFERENCE   7  (bases 1 to 3430)
  AUTHORS   Gu,Z., Imai,F., Kim,I.J., Fujita,H., Katayama,Ki., Mori,K.,
            Yoshihara,Y. and Yoshida,Y.
  TITLE     Expression of the immunoglobulin superfamily cell adhesion
            molecules in the developing spinal cord and dorsal root ganglion
  JOURNAL   PLoS One 10 (3), e0121550 (2015)
   PUBMED   25826454
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3430)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   9  (bases 1 to 3430)
  AUTHORS   Sansom,S.N., Griffiths,D.S., Faedo,A., Kleinjan,D.J., Ruan,Y.,
            Smith,J., van Heyningen,V., Rubenstein,J.L. and Livesey,F.J.
  TITLE     The level of the transcription factor Pax6 is essential for
            controlling the balance between neural stem cell self-renewal and
            neurogenesis
  JOURNAL   PLoS Genet 5 (6), e1000511 (2009)
   PUBMED   19521500
REFERENCE   10 (bases 1 to 3430)
  AUTHORS   Suzu,S., Hayashi,Y., Harumi,T., Nomaguchi,K., Yamada,M.,
            Hayasawa,H. and Motoyoshi,K.
  TITLE     Molecular cloning of a novel immunoglobulin superfamily gene
            preferentially expressed by brain and testis
  JOURNAL   Biochem Biophys Res Commun 296 (5), 1215-1221 (2002)
   PUBMED   12207903
  REMARK    GeneRIF: Molecular cloning of BT-IgSF which is preferentially
            expressed by brain and testis
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC057555.1.
            
            On or before Sep 3, 2004 this sequence version replaced
            XM_358850.2, NM_170599.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057555.1, AB079880.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3430
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 26.87 cM"
     gene            1..3430
                     /gene="Igsf11"
                     /gene_synonym="1700025L02Rik; BT-IgSF; Igsf13"
                     /note="immunoglobulin superfamily, member 11"
                     /db_xref="GeneID:207683"
                     /db_xref="MGI:MGI:2388477"
     exon            1..215
                     /gene="Igsf11"
                     /gene_synonym="1700025L02Rik; BT-IgSF; Igsf13"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..1450
                     /gene="Igsf11"
                     /gene_synonym="1700025L02Rik; BT-IgSF; Igsf13"
                     /note="brain and testis-specific immunoglobulin
                     superfamily protein; immunoglobulin superfamily, member
                     13"
                     /codon_start=1
                     /product="immunoglobulin superfamily member 11 precursor"
                     /protein_id="NP_733548.2"
                     /db_xref="CCDS:CCDS28175.1"
                     /db_xref="GeneID:207683"
                     /db_xref="MGI:MGI:2388477"
                     /translation="MTRRRSAPASWLLVSLLGVATSLEVSESPGSVQVARGQTAVLPC
                     AFSTSAALLNLNVIWMVIPLSNANQPEQVILYQGGQMFDGALRFHGRVGFTGTMPATN
                     VSIFINNTQLSDTGTYQCLVNNLPDRGGRNIGVTGLTVLVPPSAPQCQIQGSQDLGSD
                     VILLCSSEEGIPRPTYLWEKLDNTLKLPPTATQDQVQGTVTIRNISALSSGLYQCVAS
                     NAIGTSTCLLDLQVISPQPRSVGVIAGAVGTGAVLIVICLALISGAFFYWRSKNKEEE
                     EEEIPNEIREDDLPPKCSSAKAFHTEISSSENNTLTSSNTYNSRYWNNNPKPHRNTES
                     FNHFSDLRQSFSGNAVIPSIYANGNHLVLGPHKTLVVTANRGSSPQVLPRNNGSVSRK
                     PWPQHTHSYTVSQMTLERIGAVPVMVPAQSRAGSLV"
     exon            216..379
                     /gene="Igsf11"
                     /gene_synonym="1700025L02Rik; BT-IgSF; Igsf13"
                     /inference="alignment:Splign:2.1.0"
     exon            380..587
                     /gene="Igsf11"
                     /gene_synonym="1700025L02Rik; BT-IgSF; Igsf13"
                     /inference="alignment:Splign:2.1.0"
     exon            588..743
                     /gene="Igsf11"
                     /gene_synonym="1700025L02Rik; BT-IgSF; Igsf13"
                     /inference="alignment:Splign:2.1.0"
     exon            744..866
                     /gene="Igsf11"
                     /gene_synonym="1700025L02Rik; BT-IgSF; Igsf13"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1017
                     /gene="Igsf11"
                     /gene_synonym="1700025L02Rik; BT-IgSF; Igsf13"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..3414
                     /gene="Igsf11"
                     /gene_synonym="1700025L02Rik; BT-IgSF; Igsf13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1582..1587
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Igsf11"
                     /gene_synonym="1700025L02Rik; BT-IgSF; Igsf13"
                     /note="hexamer: AATAAA"
     polyA_site      1617
                     /gene="Igsf11"
                     /gene_synonym="1700025L02Rik; BT-IgSF; Igsf13"
                     /note="major polyA site"
     regulatory      3392..3397
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Igsf11"
                     /gene_synonym="1700025L02Rik; BT-IgSF; Igsf13"
                     /note="hexamer: AATAAA"
     polyA_site      3414
                     /gene="Igsf11"
                     /gene_synonym="1700025L02Rik; BT-IgSF; Igsf13"
                     /note="major polyA site"
ORIGIN      
        1 cggctggtgg tggccgcggc ggccggcgag cccgggacgc ccgagcctgc cccgagcctc
       61 ggcggagcgg agtggcctcg gcgctcccgt gtcccgcttg gtcccacgct gcaccccgcc
      121 gcccaggagc ccggcggacg gcggctcccc cggcggctcc ggcatgactc ggcggcgctc
      181 cgctccggcg tcctggctgc tcgtgtcgct gctcggtgtc gcaacatccc tggaagtgtc
      241 cgagagccca ggcagtgtcc aggtggcccg gggccagaca gcagtcctgc cctgcgcctt
      301 ctccaccagt gctgccctcc tgaacctcaa tgtcatttgg atggtcattc ccctctccaa
      361 tgcaaaccag cccgaacagg tcattcttta tcagggtgga caaatgtttg acggcgccct
      421 ccggttccac gggagggtag gatttaccgg caccatgcct gctaccaatg tctcgatctt
      481 catcaataac acacagctgt cagatacggg cacgtaccag tgcttggtga ataaccttcc
      541 agacagaggg ggcagaaaca tcggggtcac tggcctcaca gtgttagtcc ccccttctgc
      601 tccacaatgc caaatccaag gatcccagga cctcggcagt gacgtcatcc ttctgtgtag
      661 ttcagaggaa ggcatccctc ggcccacgta cctttgggag aagttagata atacgctcaa
      721 gctacctcca acagccactc aggaccaggt ccagggaaca gtcaccatcc ggaatatcag
      781 tgccctctct tccggtctgt accagtgtgt ggcttctaat gccatcggga ccagcacctg
      841 tctgctggac ctccaggtta tctcacccca gccccggagc gttggagtaa tagccggagc
      901 ggttggcacc ggtgctgttc ttatcgtcat ctgccttgca ctaatttcag gggcgttctt
      961 ttactggaga agcaaaaaca aagaggagga ggaggaagaa attcctaatg aaatcagaga
     1021 ggatgatctt ccccctaaat gctcttctgc caaagccttc cacacggaga tatcctcctc
     1081 agaaaataac acgctgacct cttccaatac ctacaacagt cgatactgga acaacaatcc
     1141 aaaaccccat agaaacacag agtctttcaa ccacttcagt gacttacgcc agtctttctc
     1201 tggcaatgca gttatcccat caatctatgc aaatgggaac catctggttt tgggtccaca
     1261 taagactctg gtagttacag ccaacagagg gtcatcacct caggtcttgc ccaggaacaa
     1321 tggttcagtc agcaggaagc cttggcctca acacactcat tcctacacag taagccaaat
     1381 gaccctggag cgcatcggtg cagtgcctgt catggtgcct gcccagagtc gagcagggtc
     1441 cctggtatag gatgactgag gaaaccatgt tcagaagaga ataaatggac cgccttcagg
     1501 caagggggga gcactgcctt caggcaaggg gggagcactg ccttcaggca agagggagag
     1561 tgggatgggt gagtgctgaa aaataaactt ttgttacgat tccattagca aaaagcacaa
     1621 agaggaggcg tgtgtgaagt ggcctggggt tgttccataa tgaagactca agaagactgt
     1681 ttccccacca cagatgtcct gagattcagt taaaacgaaa catgctgcat ctccagagat
     1741 gtgccaagcc aaggagaatg ctagaagcag agtaaagctt accccccaaa ctgtggtcca
     1801 gctggacccc ttctttaatt cttgcctaac ttaattattt tcaggaccct tcaagtgcca
     1861 ggtggaattt acataatgaa attatttttt aaaaataggt gtccttaggg agagaaaaca
     1921 ggagcaagct catggtctgg cctagtctcc ctctcccact ccttctgatg acactagcaa
     1981 tgcattccat ctgacctgac tttatcatag aggcaaaatt gttcagaaca ctggctggag
     2041 atggggagaa ataaggaaac ttcttgtgaa caccctacac acacacacac acacacacac
     2101 acacacacac acacacacac acacacacac acacacacat ttatttacct cctcctgaac
     2161 catgaatcgt attggtgatt ttgctatatt gacagattct catctgttac actctaggat
     2221 ctctcacagg tctgtggcaa ttactgttca tgatttcctg aaaaaatatt tttttaaaag
     2281 aaaactattt tttttaaata ctagagagac agtggactag gaaagcgaga acttgccgcc
     2341 ttgtctagtg actgtattca atgactgaac agaggccccc cccaccatac aagagtttta
     2401 ggtgattgag tgggtggaac cagctggagc caggtgggag gggcctttac attgccagca
     2461 gggccccaaa gaattgagat tgtgtatggc aaccgttaat gaggacagcg cctgatgcct
     2521 tttgtaccga ggaagataat tgcctcttgt ttgacaagta gagtttagta ggttattaca
     2581 aaaagggcaa gagttgtttt ggttttgttt ctttcaaaat aatttttttt caaaagaata
     2641 acaagggtta ggcaaatggg ggaccttcct gtgtgctctt gggggtctgc tcagcatctg
     2701 gaaatttggg tgtgcgattt tccctgaaca cattgcatac cagtgtaaaa agactctgcc
     2761 tccccccttt ttggcttttt tactgggctt ggctggcctt gcagtttacc agattcattt
     2821 acagactctc tgctctgtat ggcgccgcct gccatgtctg tcttggtgac tatcctgcct
     2881 taatcacttt gctttagggc aactcatggt gatctcttcc aagatctgtt tttaaattgt
     2941 ttggactact tgagccacaa ctctcagagg acattccttt tttttttttt ttttttttct
     3001 cctttcttcc attgctttgt ccctcttccc ctgtgcttcc tgccttcttt ccctgtccca
     3061 tgggcacagt cctcacaggg agtggcctcc tctctccagt gatgtaagtg aatggaagcc
     3121 atcactggct gcacatacct ttttcaaaag ggacactcgg gaagtcactg ctgtgaccgt
     3181 ttcgatgttg ataagaaggt gaatttactg tagtgttacc accttctccc cacttgatgg
     3241 ttcttgactt tgtaaaaatt taaataaatg aatgtctata ctttttaagg aaaagagaaa
     3301 ataccatgtc acagaaaagg tgaaactatt agatgctgtt tagaaagcat ttatcttgca
     3361 tttctttatt ctttctaatt acctaaaatt caataaaagt ttattcatat aaaaaaaaaa
     3421 aaaaaaaaaa
//
