LOCUS       NP_733548                428 aa            linear   ROD 30-APR-2024
DEFINITION  immunoglobulin superfamily member 11 precursor [Mus musculus].
ACCESSION   NP_733548 XP_358850
VERSION     NP_733548.2
DBSOURCE    REFSEQ: accession NM_170599.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 428)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 428)
  AUTHORS   Pelz,L., Dossou,L., Kompier,N., Juttner,R., Siemonsmeier,G.,
            Meyer,N., Lowenstein,E.D., Lahmann,I., Kettenmann,H., Birchmeier,C.
            and Rathjen,F.G.
  TITLE     The IgCAM BT-IgSF (IgSF11) is essential for connexin43-mediated
            astrocyte-astrocyte coupling in mice
  JOURNAL   eNeuro 11 (3) (2024) In press
   PUBMED   38388443
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (residues 1 to 428)
  AUTHORS   Kim,G.M., Kim,J., Lee,J.Y., Park,M.C. and Lee,S.Y.
  TITLE     IgSF11 deficiency alleviates osteoarthritis in mice by suppressing
            early subchondral bone changes
  JOURNAL   Exp Mol Med 55 (12), 2576-2585 (2023)
   PUBMED   38036734
  REMARK    GeneRIF: IgSF11 deficiency alleviates osteoarthritis in mice by
            suppressing early subchondral bone changes.
REFERENCE   4  (residues 1 to 428)
  AUTHORS   Montag,D., Pelz,L. and Rathjen,F.G.
  TITLE     Lack of the Ig cell adhesion molecule BT-IgSF (IgSF11) induced
            behavioral changes in the open maze, water maze and resident
            intruder test
  JOURNAL   PLoS One 18 (1), e0280133 (2023)
   PUBMED   36607983
  REMARK    GeneRIF: Lack of the Ig cell adhesion molecule BT-IgSF (IgSF11)
            induced behavioral changes in the open maze, water maze and
            resident intruder test.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 428)
  AUTHORS   Manuel,M., Tan,K.B., Kozic,Z., Molinek,M., Marcos,T.S.,
            Razak,M.F.A., Dobolyi,D., Dobie,R., Henderson,B.E.P.,
            Henderson,N.C., Chan,W.K., Daw,M.I., Mason,J.O. and Price,D.J.
  TITLE     Pax6 limits the competence of developing cerebral cortical cells to
            respond to inductive intercellular signals
  JOURNAL   PLoS Biol 20 (9), e3001563 (2022)
   PUBMED   36067211
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 428)
  AUTHORS   Jang,S., Oh,D., Lee,Y., Hosy,E., Shin,H., van Riesen,C.,
            Whitcomb,D., Warburton,J.M., Jo,J., Kim,D., Kim,S.G., Um,S.M.,
            Kwon,S.K., Kim,M.H., Roh,J.D., Woo,J., Jun,H., Lee,D., Mah,W.,
            Kim,H., Kaang,B.K., Cho,K., Rhee,J.S., Choquet,D. and Kim,E.
  TITLE     Synaptic adhesion molecule IgSF11 regulates synaptic transmission
            and plasticity
  JOURNAL   Nat Neurosci 19 (1), 84-93 (2016)
   PUBMED   26595655
REFERENCE   7  (residues 1 to 428)
  AUTHORS   Gu,Z., Imai,F., Kim,I.J., Fujita,H., Katayama,Ki., Mori,K.,
            Yoshihara,Y. and Yoshida,Y.
  TITLE     Expression of the immunoglobulin superfamily cell adhesion
            molecules in the developing spinal cord and dorsal root ganglion
  JOURNAL   PLoS One 10 (3), e0121550 (2015)
   PUBMED   25826454
  REMARK    Publication Status: Online-Only
REFERENCE   8  (residues 1 to 428)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   9  (residues 1 to 428)
  AUTHORS   Sansom,S.N., Griffiths,D.S., Faedo,A., Kleinjan,D.J., Ruan,Y.,
            Smith,J., van Heyningen,V., Rubenstein,J.L. and Livesey,F.J.
  TITLE     The level of the transcription factor Pax6 is essential for
            controlling the balance between neural stem cell self-renewal and
            neurogenesis
  JOURNAL   PLoS Genet 5 (6), e1000511 (2009)
   PUBMED   19521500
REFERENCE   10 (residues 1 to 428)
  AUTHORS   Suzu,S., Hayashi,Y., Harumi,T., Nomaguchi,K., Yamada,M.,
            Hayasawa,H. and Motoyoshi,K.
  TITLE     Molecular cloning of a novel immunoglobulin superfamily gene
            preferentially expressed by brain and testis
  JOURNAL   Biochem Biophys Res Commun 296 (5), 1215-1221 (2002)
   PUBMED   12207903
  REMARK    GeneRIF: Molecular cloning of BT-IgSF which is preferentially
            expressed by brain and testis
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC057555.1.
            
            On or before Sep 3, 2004 this sequence version replaced
            XP_358850.2, NP_733548.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057555.1, AB079880.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..428
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 26.87 cM"
     Protein         1..428
                     /product="immunoglobulin superfamily member 11 precursor"
                     /note="brain and testis-specific immunoglobulin
                     superfamily protein; immunoglobulin superfamily, member
                     13"
                     /calculated_mol_wt=43713
     sig_peptide     1..22
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2373
     mat_peptide     23..428
                     /product="Immunoglobulin superfamily member 11.
                     /id=PRO_0000317371"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C673.1)"
                     /calculated_mol_wt=43713
     Region          27..141
                     /region_name="V-set"
                     /note="Immunoglobulin V-set domain; pfam07686"
                     /db_xref="CDD:462230"
     Site            102
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P0C673.1)"
     Region          147..219
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Site            241..261
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C673.1)"
     Site            375
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (P0C673.1)"
     Region          376..396
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C673.1)"
     CDS             1..428
                     /gene="Igsf11"
                     /gene_synonym="1700025L02Rik; BT-IgSF; Igsf13"
                     /coded_by="NM_170599.2:164..1450"
                     /db_xref="CCDS:CCDS28175.1"
                     /db_xref="GeneID:207683"
                     /db_xref="MGI:MGI:2388477"
ORIGIN      
        1 mtrrrsapas wllvsllgva tslevsespg svqvargqta vlpcafstsa allnlnviwm
       61 viplsnanqp eqvilyqggq mfdgalrfhg rvgftgtmpa tnvsifinnt qlsdtgtyqc
      121 lvnnlpdrgg rnigvtgltv lvppsapqcq iqgsqdlgsd villcsseeg iprptylwek
      181 ldntlklppt atqdqvqgtv tirnisalss glyqcvasna igtstclldl qvispqprsv
      241 gviagavgtg avliviclal isgaffywrs knkeeeeeei pneireddlp pkcssakafh
      301 teisssennt ltssntynsr ywnnnpkphr ntesfnhfsd lrqsfsgnav ipsiyangnh
      361 lvlgphktlv vtanrgsspq vlprnngsvs rkpwpqhths ytvsqmtler igavpvmvpa
      421 qsragslv
//
