LOCUS       NM_183335               2513 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Mus musculus immunoglobulin superfamily, member 1 (Igsf1),
            transcript variant 3, mRNA.
ACCESSION   NM_183335
VERSION     NM_183335.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2513)
  AUTHORS   Brule,E., Silander,T.L., Wang,Y., Zhou,X., Bak,B., Groeneweg,S. and
            Bernard,D.J.
  TITLE     IGSF1 Deficiency Leads to Reduced TSH Production Independent of
            Alterations in Thyroid Hormone Action in Male Mice
  JOURNAL   Endocrinology 163 (8) (2022)
   PUBMED   35708735
  REMARK    GeneRIF: IGSF1 Deficiency Leads to Reduced TSH Production
            Independent of Alterations in Thyroid Hormone Action in Male Mice.
REFERENCE   2  (bases 1 to 2513)
  AUTHORS   Joustra,S.D., Roelfsema,F., van Trotsenburg,A.S.P., Schneider,H.J.,
            Kosilek,R.P., Kroon,H.M., Logan,J.G., Butterfield,N.C., Zhou,X.,
            Toufaily,C., Bak,B., Turgeon,M.O., Brule,E., Steyn,F.J.,
            Gurnell,M., Koulouri,O., Le Tissier,P., Fontanaud,P., Duncan
            Bassett,J.H., Williams,G.R., Oostdijk,W., Wit,J.M., Pereira,A.M.,
            Biermasz,N.R., Bernard,D.J. and Schoenmakers,N.
  TITLE     IGSF1 Deficiency Results in Human and Murine Somatotrope
            Neurosecretory Hyperfunction
  JOURNAL   J Clin Endocrinol Metab 105 (3), e70-e84 (2020)
   PUBMED   31650157
REFERENCE   3  (bases 1 to 2513)
  AUTHORS   Wang,Y., Brule,E., Silander,T., Bak,B., Joustra,S.D. and
            Bernard,D.J.
  TITLE     The short mRNA isoform of the immunoglobulin superfamily, member 1
            gene encodes an intracellular glycoprotein
  JOURNAL   PLoS One 12 (7), e0180731 (2017)
   PUBMED   28686733
  REMARK    GeneRIF: Contrary to earlier predictions, neither the murine nor
            rat IGSF1-2 is secreted from heterologous or homologous cells. In
            addition, neither protein associates with the plasma membrane.
            Rather, IGSF1-2 appears to be retained in the endoplasmic
            reticulum.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2513)
  AUTHORS   Turgeon,M.O., Silander,T.L., Doycheva,D., Liao,X.H., Rigden,M.,
            Ongaro,L., Zhou,X., Joustra,S.D., Wit,J.M., Wade,M.G., Heuer,H.,
            Refetoff,S. and Bernard,D.J.
  TITLE     TRH Action Is Impaired in Pituitaries of Male IGSF1-Deficient Mice
  JOURNAL   Endocrinology 158 (4), 815-830 (2017)
   PUBMED   28324000
  REMARK    GeneRIF: Igsf1-deficient males exhibit normal serum TSH levels as
            well as normal numbers of TSH-expressing thyrotropes. However,
            pituitary expression of the TSH subunit genes and TSH protein
            content are reduced, as is expression of the receptor for
            thyrotropin-releasing hormone (TRH
REFERENCE   5  (bases 1 to 2513)
  AUTHORS   Gu,Z., Imai,F., Kim,I.J., Fujita,H., Katayama,Ki., Mori,K.,
            Yoshihara,Y. and Yoshida,Y.
  TITLE     Expression of the immunoglobulin superfamily cell adhesion
            molecules in the developing spinal cord and dorsal root ganglion
  JOURNAL   PLoS One 10 (3), e0121550 (2015)
   PUBMED   25826454
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2513)
  AUTHORS   Shimogori,T., Lee,D.A., Miranda-Angulo,A., Yang,Y., Wang,H.,
            Jiang,L., Yoshida,A.C., Kataoka,A., Mashiko,H., Avetisyan,M.,
            Qi,L., Qian,J. and Blackshaw,S.
  TITLE     A genomic atlas of mouse hypothalamic development
  JOURNAL   Nat Neurosci 13 (6), 767-775 (2010)
   PUBMED   20436479
REFERENCE   7  (bases 1 to 2513)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   8  (bases 1 to 2513)
  AUTHORS   Bischof,J.M. and Wevrick,R.
  TITLE     Genome-wide analysis of gene transcription in the hypothalamus
  JOURNAL   Physiol Genomics 22 (2), 191-196 (2005)
   PUBMED   15870395
REFERENCE   9  (bases 1 to 2513)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (bases 1 to 2513)
  AUTHORS   Bernard,D.J., Burns,K.H., Haupt,B., Matzuk,M.M. and Woodruff,T.K.
  TITLE     Normal reproductive function in InhBP/p120-deficient mice
  JOURNAL   Mol Cell Biol 23 (14), 4882-4891 (2003)
   PUBMED   12832474
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY227773.1 and AY227771.1.
            
            On Oct 24, 2009 this sequence version replaced NM_183335.1.
            
            Transcript Variant: This variant (3) lacks most of the 5' UTR and
            uses a different segment for its 3' coding region and 3' UTR,
            compared to variant 1. The resulting protein (isoform 3) has a
            shorter and distinct C-terminus when it is compared to isoform
            long.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY227773.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-683               AY227773.1         1-683
            684-2309            AY227771.1         814-2439
            2310-2513           AY227773.1         2310-2513
FEATURES             Location/Qualifiers
     source          1..2513
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 26.06 cM"
     gene            1..2513
                     /gene="Igsf1"
                     /gene_synonym="5330413N23; 5530402E03; InhBP/p120;
                     mKIAA0364"
                     /note="immunoglobulin superfamily, member 1"
                     /db_xref="GeneID:209268"
                     /db_xref="MGI:MGI:2147913"
     exon            1..86
                     /gene="Igsf1"
                     /gene_synonym="5330413N23; 5530402E03; InhBP/p120;
                     mKIAA0364"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..2335
                     /gene="Igsf1"
                     /gene_synonym="5330413N23; 5530402E03; InhBP/p120;
                     mKIAA0364"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; betaglycan and inhibin binding protein; inhBP;
                     inhibin-binding protein"
                     /codon_start=1
                     /product="immunoglobulin superfamily member 1 isoform 3
                     precursor"
                     /protein_id="NP_899178.2"
                     /db_xref="CCDS:CCDS40966.1"
                     /db_xref="GeneID:209268"
                     /db_xref="MGI:MGI:2147913"
                     /translation="MMLRTFTLLLLCIWLNPGMTSLAVESQPELWIESNYPQAPWENI
                     TLWCKSPSRVSSKFLLLKDNSQMTWIRPPYKTFQVSFFIGALTESNTGLYRCCYWKEK
                     GWSKPSKILELEAPGQLPKPIFWIQAETPPLPGCNVNIFCHGWLQDLVFMLFKEGYTE
                     PVDYQVPTGTMAIFSIDNLAPENEGVYICRTHIQMLPTLWSEPSNPLKLVVAGLYPKP
                     TLTAHPGPILAPGESLSLRCQGPIYGMTFALMRLEDLKKSFYHKKPIKNEAYFYFQDL
                     KIQDTGHYLCFYYDGSYRGSLLSDILKIWVTDTFPKTWLLVQPSPVIQMGQNVSLRCG
                     GLMDGVGLALYKKGEEKPLQFLDASSNTGNNSFFLKNVTYRDAGIYSCHYYLTWKTSI
                     KMATYNTVELMVVAWPSSVFKVGKTITLQCRVSHPVLEFSLEWEERTTFQKFSVDGDF
                     LITDIEGQGTGTYSCSYRIEAHPNTWSHRSKPLKLVGPAGFLTWNSILNEAVRVSLTM
                     QLASLLLLVVWIRWKCRRLRLREAWLLGTAQGVAMLFILMALLCCGLCNGALTEEIEI
                     VMPTPKPELWAETNFPLAPWKNLTLWCRSPSGSTKEFVLLKDGTGWIATRPASEQVRA
                     AFPLGALTHSHTGSYHCHSWEEMAVSEPSEALELVGTDILPKPVISASLPIRGQELQI
                     RCKGWLEGLGFALYKKGEQEPVQQLGAVGREAFFTIQRMEDKDEGNYSCRTHTEMQPF
                     KWSEPSEPLELVIKDGRTKAQN"
     exon            87..113
                     /gene="Igsf1"
                     /gene_synonym="5330413N23; 5530402E03; InhBP/p120;
                     mKIAA0364"
                     /inference="alignment:Splign:2.1.0"
     exon            114..395
                     /gene="Igsf1"
                     /gene_synonym="5330413N23; 5530402E03; InhBP/p120;
                     mKIAA0364"
                     /inference="alignment:Splign:2.1.0"
     exon            396..683
                     /gene="Igsf1"
                     /gene_synonym="5330413N23; 5530402E03; InhBP/p120;
                     mKIAA0364"
                     /inference="alignment:Splign:2.1.0"
     exon            684..968
                     /gene="Igsf1"
                     /gene_synonym="5330413N23; 5530402E03; InhBP/p120;
                     mKIAA0364"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1262
                     /gene="Igsf1"
                     /gene_synonym="5330413N23; 5530402E03; InhBP/p120;
                     mKIAA0364"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1514
                     /gene="Igsf1"
                     /gene_synonym="5330413N23; 5530402E03; InhBP/p120;
                     mKIAA0364"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1635
                     /gene="Igsf1"
                     /gene_synonym="5330413N23; 5530402E03; InhBP/p120;
                     mKIAA0364"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1706
                     /gene="Igsf1"
                     /gene_synonym="5330413N23; 5530402E03; InhBP/p120;
                     mKIAA0364"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1739
                     /gene="Igsf1"
                     /gene_synonym="5330413N23; 5530402E03; InhBP/p120;
                     mKIAA0364"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..2030
                     /gene="Igsf1"
                     /gene_synonym="5330413N23; 5530402E03; InhBP/p120;
                     mKIAA0364"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2309
                     /gene="Igsf1"
                     /gene_synonym="5330413N23; 5530402E03; InhBP/p120;
                     mKIAA0364"
                     /inference="alignment:Splign:2.1.0"
     exon            2310..2513
                     /gene="Igsf1"
                     /gene_synonym="5330413N23; 5530402E03; InhBP/p120;
                     mKIAA0364"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actacaccag agggcctcca ggcctggaca ggccacagcc taagccatga tgcttcggac
       61 cttcactctt ttgctccttt gcatttggct caatccgggt atgacttcac tggcagtgga
      121 gtctcaacca gagctatgga tagagtccaa ctacccccag gccccttggg agaacatcac
      181 actctggtgc aaaagcccct ctcgggtatc cagcaagttc ctgcttctga aggataactc
      241 acagatgacc tggattcgtc ctccttacaa gacattccaa gtttcattct tcataggtgc
      301 ccttactgag tccaatacag gtctttatcg atgctgctac tggaaggaga aaggctggtc
      361 aaaacccagt aaaattctag agctagaagc accaggccaa ctccctaaac ccatcttctg
      421 gatccaggca gagacccccc ctcttcctgg atgcaatgtt aacatcttct gccatggatg
      481 gctccaggat ttggtattta tgctgtttaa agagggatac acagagcccg tagattacca
      541 agtcccaact gggacaatgg ccatcttctc cattgataac ttggcacccg agaatgaagg
      601 ggtttacatc tgccgcactc atatccagat gctccccact ctgtggtcag agcccagcaa
      661 tcccctgaag ttggtggtag caggtctcta ccccaaacca actctgacag cccatcctgg
      721 gcccatcctg gcacccggag aaagcctgag tctcaggtgt caagggccaa tatatggaat
      781 gacgtttgct ttaatgaggt tggaagactt gaagaaatca ttttaccaca agaagccaat
      841 aaaaaatgag gcatatttct acttccagga tctgaagata caggatacag ggcactacct
      901 ctgtttttac tatgatgggt catacagggg ctctctgctt agtgatatcc tgaaaatctg
      961 ggtgactgac actttcccta agacctggct acttgttcag cccagtcctg tgattcaaat
     1021 gggtcagaac gtgagcctga ggtgtggagg actgatggat ggagtgggtc ttgcactcta
     1081 caagaaggga gaagaaaagc cccttcagtt tctggatgcc tccagcaaca ctggcaacaa
     1141 ttcattcttc ctaaagaatg tgacctacag ggatgctggc atctatagct gtcactatta
     1201 tcttacttgg aagacatcca ttaagatggc aacatacaac actgtggagc tgatggttgt
     1261 agcttggccc agttccgtgt tcaaagtagg aaagaccatc acccttcagt gccgagtgtc
     1321 tcatccagtg cttgaatttt ctttggaatg ggaagaaaga acaacattcc aaaaattctc
     1381 agtagatgga gacttcctca tcactgacat tgaagggcaa ggcacaggaa cctacagttg
     1441 cagctatcgt attgaggcac accctaacac ctggtcacat cgcagtaagc ctctgaagtt
     1501 ggtgggacca gcaggcttcc tcacctggaa ttccattctg aatgaagctg tcagggtgtc
     1561 cttaaccatg cagcttgctt ccttgctctt gctagtggta tggatccggt ggaagtgtcg
     1621 gagactgagg ctcagagaag cctggttgtt gggaacagct caaggggtcg ccatgctctt
     1681 catactcatg gcccttcttt gctgtggact gtgcaatggg gcattgacag aggagattga
     1741 aatagtcatg ccaaccccta agcctgaact gtgggcagag acgaacttcc ctctggcccc
     1801 gtggaagaac ttaaccctct ggtgcagaag cccatctggc tcaactaagg agtttgtgtt
     1861 actgaaggac gggaccgggt ggattgcaac ccgcccggcc tcagagcagg tccgggctgc
     1921 cttccctctt ggcgccctga cccacagcca caccgggagt taccattgcc attcatggga
     1981 ggagatggct gtgtcggagc ctagtgaagc gcttgaacta gtggggacag acatccttcc
     2041 caaacctgtc atttcggctt cccttccaat ccggggccag gaactgcaga tccgctgtaa
     2101 aggatggctg gaaggtttgg ggtttgctct gtataagaag ggagagcagg aacctgtcca
     2161 gcaacttggt gctgttggga gagaagcctt ctttacaatt caaagaatgg aggataaaga
     2221 tgagggcaat tacagctgcc gcacacacac tgaaatgcag cccttcaagt ggtctgagcc
     2281 cagtgagccc ctggagcttg tcataaaaga tgggcgaacc aaggctcaga actaatagcg
     2341 tcccgaagaa agatgactct ttcagtatac tcctttgcct gttccagtaa cagtgaagat
     2401 ttctctggag acaatgaggg acagggatga gggatcccta taaaaacaaa caaataaaca
     2461 aaaccatcaa tgcatatatg tctgaataaa atgcatatag cggacttctt cct
//
