LOCUS       NM_177591               4432 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus immunoglobulin superfamily, member 1 (Igsf1),
            transcript variant 1, mRNA.
ACCESSION   NM_177591
VERSION     NM_177591.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4432)
  AUTHORS   Brule,E., Silander,T.L., Wang,Y., Zhou,X., Bak,B., Groeneweg,S. and
            Bernard,D.J.
  TITLE     IGSF1 Deficiency Leads to Reduced TSH Production Independent of
            Alterations in Thyroid Hormone Action in Male Mice
  JOURNAL   Endocrinology 163 (8) (2022)
   PUBMED   35708735
  REMARK    GeneRIF: IGSF1 Deficiency Leads to Reduced TSH Production
            Independent of Alterations in Thyroid Hormone Action in Male Mice.
REFERENCE   2  (bases 1 to 4432)
  AUTHORS   Joustra,S.D., Roelfsema,F., van Trotsenburg,A.S.P., Schneider,H.J.,
            Kosilek,R.P., Kroon,H.M., Logan,J.G., Butterfield,N.C., Zhou,X.,
            Toufaily,C., Bak,B., Turgeon,M.O., Brule,E., Steyn,F.J.,
            Gurnell,M., Koulouri,O., Le Tissier,P., Fontanaud,P., Duncan
            Bassett,J.H., Williams,G.R., Oostdijk,W., Wit,J.M., Pereira,A.M.,
            Biermasz,N.R., Bernard,D.J. and Schoenmakers,N.
  TITLE     IGSF1 Deficiency Results in Human and Murine Somatotrope
            Neurosecretory Hyperfunction
  JOURNAL   J Clin Endocrinol Metab 105 (3), e70-e84 (2020)
   PUBMED   31650157
REFERENCE   3  (bases 1 to 4432)
  AUTHORS   Wang,Y., Brule,E., Silander,T., Bak,B., Joustra,S.D. and
            Bernard,D.J.
  TITLE     The short mRNA isoform of the immunoglobulin superfamily, member 1
            gene encodes an intracellular glycoprotein
  JOURNAL   PLoS One 12 (7), e0180731 (2017)
   PUBMED   28686733
  REMARK    GeneRIF: Contrary to earlier predictions, neither the murine nor
            rat IGSF1-2 is secreted from heterologous or homologous cells. In
            addition, neither protein associates with the plasma membrane.
            Rather, IGSF1-2 appears to be retained in the endoplasmic
            reticulum.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4432)
  AUTHORS   Turgeon,M.O., Silander,T.L., Doycheva,D., Liao,X.H., Rigden,M.,
            Ongaro,L., Zhou,X., Joustra,S.D., Wit,J.M., Wade,M.G., Heuer,H.,
            Refetoff,S. and Bernard,D.J.
  TITLE     TRH Action Is Impaired in Pituitaries of Male IGSF1-Deficient Mice
  JOURNAL   Endocrinology 158 (4), 815-830 (2017)
   PUBMED   28324000
  REMARK    GeneRIF: Igsf1-deficient males exhibit normal serum TSH levels as
            well as normal numbers of TSH-expressing thyrotropes. However,
            pituitary expression of the TSH subunit genes and TSH protein
            content are reduced, as is expression of the receptor for
            thyrotropin-releasing hormone (TRH
REFERENCE   5  (bases 1 to 4432)
  AUTHORS   Gu,Z., Imai,F., Kim,I.J., Fujita,H., Katayama,Ki., Mori,K.,
            Yoshihara,Y. and Yoshida,Y.
  TITLE     Expression of the immunoglobulin superfamily cell adhesion
            molecules in the developing spinal cord and dorsal root ganglion
  JOURNAL   PLoS One 10 (3), e0121550 (2015)
   PUBMED   25826454
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4432)
  AUTHORS   Shimogori,T., Lee,D.A., Miranda-Angulo,A., Yang,Y., Wang,H.,
            Jiang,L., Yoshida,A.C., Kataoka,A., Mashiko,H., Avetisyan,M.,
            Qi,L., Qian,J. and Blackshaw,S.
  TITLE     A genomic atlas of mouse hypothalamic development
  JOURNAL   Nat Neurosci 13 (6), 767-775 (2010)
   PUBMED   20436479
REFERENCE   7  (bases 1 to 4432)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   8  (bases 1 to 4432)
  AUTHORS   Bischof,J.M. and Wevrick,R.
  TITLE     Genome-wide analysis of gene transcription in the hypothalamus
  JOURNAL   Physiol Genomics 22 (2), 191-196 (2005)
   PUBMED   15870395
REFERENCE   9  (bases 1 to 4432)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (bases 1 to 4432)
  AUTHORS   Bernard,D.J., Burns,K.H., Haupt,B., Matzuk,M.M. and Woodruff,T.K.
  TITLE     Normal reproductive function in InhBP/p120-deficient mice
  JOURNAL   Mol Cell Biol 23 (14), 4882-4891 (2003)
   PUBMED   12832474
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC100420.1, AY227771.1 and BQ032431.1.
            
            On Oct 24, 2009 this sequence version replaced NM_177591.3.
            
            Transcript Variant: This variant (1) encodes the longest protein
            (isoform long).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY227771.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                BC100420.1         1-93
            94-4409             AY227771.1         88-4403
            4410-4432           BQ032431.1         1-23                c
FEATURES             Location/Qualifiers
     source          1..4432
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 26.06 cM"
     gene            1..4432
                     /gene="Igsf1"
                     /gene_synonym="5330413N23; 5530402E03; InhBP/p120;
                     mKIAA0364"
                     /note="immunoglobulin superfamily, member 1"
                     /db_xref="GeneID:209268"
                     /db_xref="MGI:MGI:2147913"
     exon            1..93
                     /gene="Igsf1"
                     /gene_synonym="5330413N23; 5530402E03; InhBP/p120;
                     mKIAA0364"
                     /inference="alignment:Splign:2.1.0"
     exon            94..222
                     /gene="Igsf1"
                     /gene_synonym="5330413N23; 5530402E03; InhBP/p120;
                     mKIAA0364"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..4136
                     /gene="Igsf1"
                     /gene_synonym="5330413N23; 5530402E03; InhBP/p120;
                     mKIAA0364"
                     /note="isoform long precursor is encoded by transcript
                     variant 1; betaglycan and inhibin binding protein; inhBP;
                     inhibin-binding protein"
                     /codon_start=1
                     /product="immunoglobulin superfamily member 1 isoform long
                     precursor"
                     /protein_id="NP_808259.2"
                     /db_xref="CCDS:CCDS40964.1"
                     /db_xref="GeneID:209268"
                     /db_xref="MGI:MGI:2147913"
                     /translation="MMLRTFTLLLLCIWLNPGMTSLAVESQPELWIESNYPQAPWENI
                     TLWCKSPSRVSSKFLLLKDNSQMTWIRPPYKTFQVSFFIGALTESNTGLYRCCYWKEK
                     GWSKPSKILELEAPGQLPKPIFWIQAETPPLPGCNVNIFCHGWLQDLVFMLFKEGYTE
                     PVDYQVPTGTMAIFSIDNLAPENEGVYICRTHIQMLPTLWSEPSNPLKLVVAGLYPKP
                     TLTAHPGPILAPGESLSLRCQGPIYGMTFALMRLEDLKKSFYHKKPIKNEAYFYFQDL
                     KIQDTGHYLCFYYDGSYRGSLLSDILKIWVTDTFPKTWLLVQPSPVIQMGQNVSLRCG
                     GLMDGVGLALYKKGEEKPLQFLDASSNTGNNSFFLKNVTYRDAGIYSCHYYLTWKTSI
                     KMATYNTVELMVVAWPSSVFKVGKTITLQCRVSHPVLEFSLEWEERTTFQKFSVDGDF
                     LITDIEGQGTGTYSCSYRIEAHPNTWSHRSKPLKLVGPAGFLTWNSILNEAVRVSLTM
                     QLASLLLLVVWIRWKCRRLRLREAWLLGTAQGVAMLFILMALLCCGLCNGALTEEIEI
                     VMPTPKPELWAETNFPLAPWKNLTLWCRSPSGSTKEFVLLKDGTGWIATRPASEQVRA
                     AFPLGALTHSHTGSYHCHSWEEMAVSEPSEALELVGTDILPKPVISASLPIRGQELQI
                     RCKGWLEGLGFALYKKGEQEPVQQLGAVGREAFFTIQRMEDKDEGNYSCRTHTEMQPF
                     KWSEPSEPLELVIKEMYPKPFFKTWASPVVTPGSRVTFNCSTSHEHMSFILYKDGNEI
                     ASSDLAWGNPGGSTAHFLIISVGIGDGGNYSCRYYDFSIWSEPSNPVELVVTEFYPKP
                     TLLAQPGPVVLPGKNVTLRCQGIFQGMRFALLQEGTHTPLQFQSTSGTSADFLLHTVG
                     AQDFGNYSCVYYETTMSNRGSSLSTPLMIWVTDTFPRPWLSAEPSSVVTMGQNVTLWC
                     QGPVRGVGYILHKEGEATSMQLWGSTSNEGAFPIINISGASIGRYSCCYHPDWMSPIK
                     IQPSNTLELIVTGLLPKPSLLVQPGPMVAPGENVTLQCQGELPDSTFVLLKEGTRQPL
                     EQQRPSGYRADFWMPVVRDQDSGVYSCVYYLDSAPLVASNHSNSLEIWVTDKPPKPSL
                     SAWPSTIFKLGKDITLQCRGPLPGVEFVLEHDGEEAPQQFSEDGDFVIDNLEGKGIGN
                     YSCSYRLQAYPDIWSEPSDTLELVGAAGPVAQECTVGNIVRSTLIVVVVVALGIVLAV
                     EWKKWPRLRTRGSETDGRDQTVVLEECNQEGEPGTTTNSPSSASQEVSVELTVPI"
     exon            223..249
                     /gene="Igsf1"
                     /gene_synonym="5330413N23; 5530402E03; InhBP/p120;
                     mKIAA0364"
                     /inference="alignment:Splign:2.1.0"
     exon            250..531
                     /gene="Igsf1"
                     /gene_synonym="5330413N23; 5530402E03; InhBP/p120;
                     mKIAA0364"
                     /inference="alignment:Splign:2.1.0"
     exon            532..819
                     /gene="Igsf1"
                     /gene_synonym="5330413N23; 5530402E03; InhBP/p120;
                     mKIAA0364"
                     /inference="alignment:Splign:2.1.0"
     exon            820..1104
                     /gene="Igsf1"
                     /gene_synonym="5330413N23; 5530402E03; InhBP/p120;
                     mKIAA0364"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1398
                     /gene="Igsf1"
                     /gene_synonym="5330413N23; 5530402E03; InhBP/p120;
                     mKIAA0364"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1650
                     /gene="Igsf1"
                     /gene_synonym="5330413N23; 5530402E03; InhBP/p120;
                     mKIAA0364"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1771
                     /gene="Igsf1"
                     /gene_synonym="5330413N23; 5530402E03; InhBP/p120;
                     mKIAA0364"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..1842
                     /gene="Igsf1"
                     /gene_synonym="5330413N23; 5530402E03; InhBP/p120;
                     mKIAA0364"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..1875
                     /gene="Igsf1"
                     /gene_synonym="5330413N23; 5530402E03; InhBP/p120;
                     mKIAA0364"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..2166
                     /gene="Igsf1"
                     /gene_synonym="5330413N23; 5530402E03; InhBP/p120;
                     mKIAA0364"
                     /inference="alignment:Splign:2.1.0"
     exon            2167..2445
                     /gene="Igsf1"
                     /gene_synonym="5330413N23; 5530402E03; InhBP/p120;
                     mKIAA0364"
                     /inference="alignment:Splign:2.1.0"
     exon            2446..2733
                     /gene="Igsf1"
                     /gene_synonym="5330413N23; 5530402E03; InhBP/p120;
                     mKIAA0364"
                     /inference="alignment:Splign:2.1.0"
     exon            2734..3021
                     /gene="Igsf1"
                     /gene_synonym="5330413N23; 5530402E03; InhBP/p120;
                     mKIAA0364"
                     /inference="alignment:Splign:2.1.0"
     exon            3022..3309
                     /gene="Igsf1"
                     /gene_synonym="5330413N23; 5530402E03; InhBP/p120;
                     mKIAA0364"
                     /inference="alignment:Splign:2.1.0"
     exon            3310..3597
                     /gene="Igsf1"
                     /gene_synonym="5330413N23; 5530402E03; InhBP/p120;
                     mKIAA0364"
                     /inference="alignment:Splign:2.1.0"
     exon            3598..3876
                     /gene="Igsf1"
                     /gene_synonym="5330413N23; 5530402E03; InhBP/p120;
                     mKIAA0364"
                     /inference="alignment:Splign:2.1.0"
     exon            3877..4000
                     /gene="Igsf1"
                     /gene_synonym="5330413N23; 5530402E03; InhBP/p120;
                     mKIAA0364"
                     /inference="alignment:Splign:2.1.0"
     exon            4001..4417
                     /gene="Igsf1"
                     /gene_synonym="5330413N23; 5530402E03; InhBP/p120;
                     mKIAA0364"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4381..4386
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Igsf1"
                     /gene_synonym="5330413N23; 5530402E03; InhBP/p120;
                     mKIAA0364"
                     /note="hexamer: AATAAA"
     polyA_site      4412
                     /gene="Igsf1"
                     /gene_synonym="5330413N23; 5530402E03; InhBP/p120;
                     mKIAA0364"
                     /note="major polyA site"
ORIGIN      
        1 gtccttagac agctcttccc atgcccggca gtttgcggca tctggaggag ctctctggag
       61 aatctccaac ctcagagcga gccttctact accattctac tacgttttaa gaagcaaagc
      121 cttcaagact tggaatacta caccagaggg cctccaggcc tggacaggcc acagcctaag
      181 ccatgatgct tcggaccttc actcttttgc tcctttgcat ttggctcaat ccgggtatga
      241 cttcactggc agtggagtct caaccagagc tatggataga gtccaactac ccccaggccc
      301 cttgggagaa catcacactc tggtgcaaaa gcccctctcg ggtatccagc aagttcctgc
      361 ttctgaagga taactcacag atgacctgga ttcgtcctcc ttacaagaca ttccaagttt
      421 cattcttcat aggtgccctt actgagtcca atacaggtct ttatcgatgc tgctactgga
      481 aggagaaagg ctggtcaaaa cccagtaaaa ttctagagct agaagcacca ggccaactcc
      541 ctaaacccat cttctggatc caggcagaga ccccccctct tcctggatgc aatgttaaca
      601 tcttctgcca tggatggctc caggatttgg tatttatgct gtttaaagag ggatacacag
      661 agcccgtaga ttaccaagtc ccaactggga caatggccat cttctccatt gataacttgg
      721 cacccgagaa tgaaggggtt tacatctgcc gcactcatat ccagatgctc cccactctgt
      781 ggtcagagcc cagcaatccc ctgaagttgg tggtagcagg tctctacccc aaaccaactc
      841 tgacagccca tcctgggccc atcctggcac ccggagaaag cctgagtctc aggtgtcaag
      901 ggccaatata tggaatgacg tttgctttaa tgaggttgga agacttgaag aaatcatttt
      961 accacaagaa gccaataaaa aatgaggcat atttctactt ccaggatctg aagatacagg
     1021 atacagggca ctacctctgt ttttactatg atgggtcata caggggctct ctgcttagtg
     1081 atatcctgaa aatctgggtg actgacactt tccctaagac ctggctactt gttcagccca
     1141 gtcctgtgat tcaaatgggt cagaacgtga gcctgaggtg tggaggactg atggatggag
     1201 tgggtcttgc actctacaag aagggagaag aaaagcccct tcagtttctg gatgcctcca
     1261 gcaacactgg caacaattca ttcttcctaa agaatgtgac ctacagggat gctggcatct
     1321 atagctgtca ctattatctt acttggaaga catccattaa gatggcaaca tacaacactg
     1381 tggagctgat ggttgtagct tggcccagtt ccgtgttcaa agtaggaaag accatcaccc
     1441 ttcagtgccg agtgtctcat ccagtgcttg aattttcttt ggaatgggaa gaaagaacaa
     1501 cattccaaaa attctcagta gatggagact tcctcatcac tgacattgaa gggcaaggca
     1561 caggaaccta cagttgcagc tatcgtattg aggcacaccc taacacctgg tcacatcgca
     1621 gtaagcctct gaagttggtg ggaccagcag gcttcctcac ctggaattcc attctgaatg
     1681 aagctgtcag ggtgtcctta accatgcagc ttgcttcctt gctcttgcta gtggtatgga
     1741 tccggtggaa gtgtcggaga ctgaggctca gagaagcctg gttgttggga acagctcaag
     1801 gggtcgccat gctcttcata ctcatggccc ttctttgctg tggactgtgc aatggggcat
     1861 tgacagagga gattgaaata gtcatgccaa cccctaagcc tgaactgtgg gcagagacga
     1921 acttccctct ggccccgtgg aagaacttaa ccctctggtg cagaagccca tctggctcaa
     1981 ctaaggagtt tgtgttactg aaggacggga ccgggtggat tgcaacccgc ccggcctcag
     2041 agcaggtccg ggctgccttc cctcttggcg ccctgaccca cagccacacc gggagttacc
     2101 attgccattc atgggaggag atggctgtgt cggagcctag tgaagcgctt gaactagtgg
     2161 ggacagacat ccttcccaaa cctgtcattt cggcttccct tccaatccgg ggccaggaac
     2221 tgcagatccg ctgtaaagga tggctggaag gtttggggtt tgctctgtat aagaagggag
     2281 agcaggaacc tgtccagcaa cttggtgctg ttgggagaga agccttcttt acaattcaaa
     2341 gaatggagga taaagatgag ggcaattaca gctgccgcac acacactgaa atgcagccct
     2401 tcaagtggtc tgagcccagt gagcccctgg agcttgtcat aaaagaaatg taccccaagc
     2461 ctttcttcaa gacctgggct agccctgtgg tcactcctgg ttcccgagtg actttcaatt
     2521 gttccacctc ccatgaacac atgagcttta ttctttataa ggatggcaat gaaattgcat
     2581 ccagtgacct agcctgggga aacccaggag gcagtacagc ccactttctg atcatttcag
     2641 tgggcattgg tgatggagga aactatagct gtcgttatta tgacttttcc atctggtctg
     2701 agcccagcaa ccctgtggag ctcgttgtga cagaattcta ccctaaaccc acactcctgg
     2761 cacagccagg ccctgtggtg cttcctggga agaatgtgac cctgcgctgc caaggaattt
     2821 tccagggcat gaggtttgcc ctcttgcagg agggtactca taccccttta cagttccaaa
     2881 gtacctcggg gacctcagct gacttcctcc tccacactgt tggagcacag gactttggga
     2941 actacagctg tgtctactat gagacaacca tgtcgaacag gggctcatcc cttagcaccc
     3001 ctcttatgat ctgggtgact gatacattcc ccagaccatg gttgtctgct gagcctagtt
     3061 ctgtggtcac catggggcag aatgttactc tatggtgtca aggaccagtc cgtggagttg
     3121 ggtacattct gcacaaagaa ggagaagcca cttcgatgca gctttggggg tccactagca
     3181 atgaaggagc attccctatc atcaatatat ctggtgctag cataggacgt tatagctgct
     3241 gttaccaccc tgactggatg agccctatca agatacagcc tagcaacact ctggaactca
     3301 tagtcactgg tttactccct aagcccagcc tgttagtcca gcctggtccc atggtagccc
     3361 ctggagaaaa cgtgactctt caatgtcaag gagaactgcc agattcaaca tttgtcctgt
     3421 tgaaggaggg gacgcgacag cccttagaac aacagaggcc aagtgggtac agagctgact
     3481 tctggatgcc agtggtgagg gatcaagatt ctggtgttta cagctgtgtt tattatctgg
     3541 attctgctcc ccttgtggct tcgaatcaca gcaactctct agagatctgg gtgactgata
     3601 agccccctaa accctctctg tcagcctggc ccagcaccat cttcaaacta ggcaaggaca
     3661 tcacccttca gtgccgagga cccctgccag gagttgaatt tgtgctagag catgatggag
     3721 aagaggctcc acaacagttt tccgaggatg gagattttgt catcgacaac ttggaaggga
     3781 aaggcattgg aaactacagt tgcagctacc ggctgcaggc ctaccctgat atctggtcag
     3841 agcccagcga taccctggag ctggttggag ctgcagggcc tgttgctcaa gagtgcactg
     3901 tgggtaacat tgtccgaagt accctgattg tggtggttgt ggtagccttg gggatagtgc
     3961 tagccgtaga gtggaagaag tggcctcgac ttcggactag gggctctgag acagatggaa
     4021 gagatcagac cgtagtcctt gaagagtgta accaagaagg agaaccaggc actaccacca
     4081 attctccttc atctgcctcg caagaagtct cagtggaact gacagttcca atataattac
     4141 cctctccttt ataagagctt tcctctttta tcttttacct gtagagacct gaaaatccca
     4201 cttgtttacc ctagaattca gtggcattta ctgcttcttg atctctaacc acttgagttg
     4261 ggtcaagagg attctgggcg tggcaagctc tacaggtcaa gctgtttcct ctatcctggt
     4321 aactcctcac tgtactgatt tactggtgca tgcaattctg ttaaaaaatg tattcttctg
     4381 aataaagaga atattcacta tttaactgca aaccaaaaaa aaaaaaaaaa aa
//
