LOCUS       NM_001190325             870 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus immunoglobulin lambda-like polypeptide 1 (Igll1),
            mRNA.
ACCESSION   NM_001190325
VERSION     NM_001190325.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 870)
  AUTHORS   Aranburu,A., Engstrom,E., Gerasimcik,N., Alsen,S., Camponeschi,A.,
            Yrlid,U., Grimsholm,O. and Martensson,I.L.
  TITLE     Clonal relationships of memory B cell subsets in autoimmune mice
  JOURNAL   Front Immunol 14, 1129234 (2023)
   PUBMED   36936947
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 870)
  AUTHORS   Khass,M., Rashid,H., Burrows,P.D., Javed,A. and Schroeder,H.W.
  TITLE     Loss of early B cell protein lambda5 decreases bone mass and
            accelerates skeletal aging
  JOURNAL   Front Immunol 13, 906649 (2022)
   PUBMED   36189270
  REMARK    Erratum:[Front Immunol. 2023 Feb 13;13:1114732. doi:
            10.3389/fimmu.2022.1114732.. PMID: 36861066]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 870)
  AUTHORS   Wong,J.B., Hewitt,S.L., Heltemes-Harris,L.M., Mandal,M.,
            Johnson,K., Rajewsky,K., Koralov,S.B., Clark,M.R., Farrar,M.A. and
            Skok,J.A.
  TITLE     B-1a cells acquire their unique characteristics by bypassing the
            pre-BCR selection stage
  JOURNAL   Nat Commun 10 (1), 4768 (2019)
   PUBMED   31628339
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 870)
  AUTHORS   Khass,M., Rashid,H., Burrows,P.D., Bridges,S.L. Jr., Javed,A. and
            Schroeder,H.W. Jr.
  TITLE     Disruption of the preB Cell Receptor Complex Leads to Decreased
            Bone Mass
  JOURNAL   Front Immunol 10, 2063 (2019)
   PUBMED   31552025
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 870)
  AUTHORS   Yang,Y., Kong,S., Zhang,Y., Melo-Cardenas,J., Gao,B., Zhang,Y.,
            Zhang,D.D., Zhang,B., Song,J., Thorp,E., Zhang,K., Zhang,J. and
            Fang,D.
  TITLE     The endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1
            controls a critical checkpoint in B cell development in mice
  JOURNAL   J Biol Chem 293 (33), 12934-12944 (2018)
   PUBMED   29907570
REFERENCE   6  (bases 1 to 870)
  AUTHORS   Kitamura,D., Kudo,A., Schaal,S., Muller,W., Melchers,F. and
            Rajewsky,K.
  TITLE     A critical role of lambda 5 protein in B cell development
  JOURNAL   Cell 69 (5), 823-831 (1992)
   PUBMED   1591779
REFERENCE   7  (bases 1 to 870)
  AUTHORS   Okabe,T., Watanabe,T. and Kudo,A.
  TITLE     A pre-B- and B cell-specific DNA-binding protein, EBB-1, which
            binds to the promoter of the VpreB1 gene
  JOURNAL   Eur J Immunol 22 (1), 37-43 (1992)
   PUBMED   1730258
REFERENCE   8  (bases 1 to 870)
  AUTHORS   Kudo,A., Sakaguchi,N. and Melchers,F.
  TITLE     Organization of the murine Ig-related lambda 5 gene transcribed
            selectively in pre-B lymphocytes
  JOURNAL   EMBO J 6 (1), 103-107 (1987)
   PUBMED   3107979
  REMARK    Erratum:[EMBO J 1987 Dec 20;6(13):4242]
REFERENCE   9  (bases 1 to 870)
  AUTHORS   Sakaguchi,N. and Melchers,F.
  TITLE     Lambda 5, a new light-chain-related locus selectively expressed in
            pre-B lymphocytes
  JOURNAL   Nature 324 (6097), 579-582 (1986)
   PUBMED   3024017
REFERENCE   10 (bases 1 to 870)
  AUTHORS   Sakaguchi,N., Berger,C.N. and Melchers,F.
  TITLE     Isolation of a cDNA copy of an RNA species expressed in murine
            pre-B cells
  JOURNAL   EMBO J 5 (9), 2139-2147 (1986)
   PUBMED   2430794
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166832.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849375,
                              SAMN00849383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-290               AC166832.2         31053-31342         c
            291-406             AC166832.2         29786-29901         c
            407-870             AC166832.2         28028-28491         c
FEATURES             Location/Qualifiers
     source          1..870
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 10.45 cM"
     gene            1..870
                     /gene="Igll1"
                     /gene_synonym="Igl-5; Igll; Lambda5"
                     /note="immunoglobulin lambda-like polypeptide 1"
                     /db_xref="GeneID:16136"
                     /db_xref="MGI:MGI:96529"
     exon            1..290
                     /gene="Igll1"
                     /gene_synonym="Igl-5; Igll; Lambda5"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..726
                     /gene="Igll1"
                     /gene_synonym="Igl-5; Igll; Lambda5"
                     /note="immunoglobulin lambda chain 5; lambda 5; ig
                     lambda-5; CD179 antigen-like family member B"
                     /codon_start=1
                     /product="immunoglobulin lambda-like polypeptide 1
                     precursor"
                     /protein_id="NP_001177254.1"
                     /db_xref="CCDS:CCDS49775.1"
                     /db_xref="GeneID:16136"
                     /db_xref="MGI:MGI:96529"
                     /translation="MKLRVGQTLGTIPRQCEVLLLLLLLGLVDGVHHILSPSSAERSR
                     AVGPGASVGSNRPSLWALPGRLLFQIIPRGAGPRCSPHRLPSKPQFWYVFGGGTQLTI
                     LGQPKSDPLVTLFLPSLKNLQANKATLVCLVSEFYPGTLVVDWKVDGVPVTQGVETTQ
                     PSKQTNNKYMVSSYLTLISDQWMPHSRYSCRVTHEGNTVEKSVSPAECS"
     exon            291..406
                     /gene="Igll1"
                     /gene_synonym="Igl-5; Igll; Lambda5"
                     /inference="alignment:Splign:2.1.0"
     exon            407..870
                     /gene="Igll1"
                     /gene_synonym="Igl-5; Igll; Lambda5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      850..855
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Igll1"
                     /gene_synonym="Igl-5; Igll; Lambda5"
                     /note="hexamer: AATAAA"
     polyA_site      869
                     /gene="Igll1"
                     /gene_synonym="Igl-5; Igll; Lambda5"
                     /note="major polyA site"
ORIGIN      
        1 ctggaatagc ttttggccac cagaggagga acaatccttt tgccgggaga tctacactgc
       61 aagtgaggct agagttgact ttggacttga gggtcaatga agctcagagt aggacagact
      121 ctgggcacta tccccaggca gtgtgaagtt ctcctcctgc tgctgctgtt gggtctagtg
      181 gatggtgtcc accacatact ttccccaagc tcagcagaaa ggagcagagc tgtgggccct
      241 ggagcttcag tgggaagcaa caggcctagc ctatgggccc ttcccggcag gctcctgttc
      301 cagatcatcc cacggggagc aggtcccagg tgctcgcccc ataggcttcc atctaagccc
      361 cagttttggt atgtctttgg tggtgggacc cagctcacaa tcctaggtca gcccaagtct
      421 gaccccttgg tcactctgtt cctgccttcc ttaaagaatc ttcaggccaa caaggccaca
      481 ctagtgtgtt tggtgagcga attctaccca ggtactttgg tggtggactg gaaggtagat
      541 ggggtccctg tcactcaggg tgtagagaca acccaaccct ccaaacagac caacaacaaa
      601 tacatggtca gcagctacct gacactgata tctgaccagt ggatgcctca cagtagatac
      661 agctgccggg tcactcatga aggaaacact gtggagaaga gtgtgtcacc tgctgagtgt
      721 tcttagacca caatcctccc tgaagcctca ggggcctgga tctgaagtgc cagaaaaagt
      781 tgttttttgt tttgtttttt gttttttttc ccattaacca tctcactgtc tttcctgtgc
      841 ctaatactca ataaatatct taccaccaac
//
