LOCUS       NM_009212               5562 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus immunoglobulin mu DNA binding protein 2 (Ighmbp2),
            mRNA.
ACCESSION   NM_009212
VERSION     NM_009212.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5562)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5562)
  AUTHORS   Martin,P.B., Holbrook,S.E., Hicks,A.N., Hines,T.J., Bogdanik,L.P.,
            Burgess,R.W. and Cox,G.A.
  TITLE     Clinically relevant mouse models of Charcot-Marie-Tooth type 2S
  JOURNAL   Hum Mol Genet 32 (8), 1276-1288 (2023)
   PUBMED   36413117
REFERENCE   3  (bases 1 to 5562)
  AUTHORS   Vadla,G.P., Ricardez Hernandez,S.M., Mao,J., Garro-Kacher,M.O.,
            Lorson,Z.C., Rice,R.P., Hansen,S.A., Lorson,C.L., Singh,K. and
            Lorson,M.A.
  TITLE     ABT1 modifies SMARD1 pathology via interactions with IGHMBP2 and
            stimulation of ATPase and helicase activity
  JOURNAL   JCI Insight 8 (2), e164608 (2023)
   PUBMED   36480289
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5562)
  AUTHORS   Smith,C.E., Lorson,M.A., Ricardez Hernandez,S.M., Al Rawi,Z.,
            Mao,J., Marquez,J., Villalon,E., Keilholz,A.N., Smith,C.L.,
            Garro-Kacher,M.O., Morcos,T., Davis,D.J., Bryda,E.C., Nichols,N.L.
            and Lorson,C.L.
  TITLE     The Ighmbp2D564N mouse model is the first SMARD1 model to
            demonstrate respiratory defects
  JOURNAL   Hum Mol Genet 31 (8), 1293-1307 (2022)
   PUBMED   34726235
REFERENCE   5  (bases 1 to 5562)
  AUTHORS   Villalon,E., Lee,N.N., Marquez,J. and Lorson,C.L.
  TITLE     Muscle fiber-type selective propensity to pathology in the nmd
            mouse model of SMARD1
  JOURNAL   Biochem Biophys Res Commun 516 (1), 313-319 (2019)
   PUBMED   31256932
REFERENCE   6  (bases 1 to 5562)
  AUTHORS   Shieh,S.Y., Stellrecht,C.M. and Tsai,M.J.
  TITLE     Molecular characterization of the rat insulin enhancer-binding
            complex 3b2. Cloning of a binding factor with putative helicase
            motifs
  JOURNAL   J Biol Chem 270 (37), 21503-21508 (1995)
   PUBMED   7665561
REFERENCE   7  (bases 1 to 5562)
  AUTHORS   Cook,S.A., Johnson,K.R., Bronson,R.T. and Davisson,M.T.
  TITLE     Neuromuscular degeneration (nmd): a mutation on mouse chromosome 19
            that causes motor neuron degeneration
  JOURNAL   Mamm Genome 6 (3), 187-191 (1995)
   PUBMED   7749225
REFERENCE   8  (bases 1 to 5562)
  AUTHORS   Sebastiani,G., Durocher,D., Gros,P., Nemer,M. and Malo,D.
  TITLE     Localization of the Catf1 transcription factor gene to mouse
            chromosome 19
  JOURNAL   Mamm Genome 6 (2), 147-148 (1995)
   PUBMED   7767002
REFERENCE   9  (bases 1 to 5562)
  AUTHORS   Tanner,A. and Dice,J.F.
  TITLE     Batten disease fibroblasts in culture accumulate mitochondrial ATP
            synthase subunit 9
  JOURNAL   Cell Biol Int 19 (1), 71-75 (1995)
   PUBMED   7613514
REFERENCE   10 (bases 1 to 5562)
  AUTHORS   Mizuta,T.R., Fukita,Y., Miyoshi,T., Shimizu,A. and Honjo,T.
  TITLE     Isolation of cDNA encoding a binding protein specific to
            5'-phosphorylated single-stranded DNA with G-rich sequences
  JOURNAL   Nucleic Acids Res 21 (8), 1761-1766 (1993)
   PUBMED   8493094
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL626765.22 and AC148174.7.
            
            On Jul 26, 2007 this sequence version replaced NM_009212.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK153763.1, AK155899.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-310               AL626765.22        65494-65803         c
            311-480             AL626765.22        64212-64381         c
            481-670             AL626765.22        62600-62789         c
            671-768             AL626765.22        62326-62423         c
            769-932             AL626765.22        59549-59712         c
            933-1133            AL626765.22        57149-57349         c
            1134-1281           AL626765.22        55681-55828         c
            1282-1456           AC148174.7         396-570
            1457-1639           AC148174.7         3254-3436
            1640-1758           AC148174.7         3680-3798
            1759-1853           AC148174.7         4760-4854
            1854-1977           AC148174.7         5637-5760
            1978-2832           AC148174.7         6431-7285
            2833-3002           AC148174.7         9952-10121
            3003-5562           AC148174.7         10461-13020
FEATURES             Location/Qualifiers
     source          1..5562
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 3.03 cM"
     gene            1..5562
                     /gene="Ighmbp2"
                     /gene_synonym="AEP; Catf1; nmd; RIPE3b1; sma; Smbp-2;
                     Smbp2; Smubp2"
                     /note="immunoglobulin mu DNA binding protein 2"
                     /db_xref="GeneID:20589"
                     /db_xref="MGI:MGI:99954"
     exon            1..310
                     /gene="Ighmbp2"
                     /gene_synonym="AEP; Catf1; nmd; RIPE3b1; sma; Smbp-2;
                     Smbp2; Smubp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..3206
                     /gene="Ighmbp2"
                     /gene_synonym="AEP; Catf1; nmd; RIPE3b1; sma; Smbp-2;
                     Smbp2; Smubp2"
                     /EC_number="3.6.4.13"
                     /EC_number="3.6.4.12"
                     /note="ATP-dependent helicase IGHMBP2; cardiac
                     transcription factor 1; neuromuscular degeneration;
                     immunoglobulin mu binding protein 2; antifreeze
                     enhancer-binding protein; immunoglobulin S mu binding
                     protein 2; p110 subunit"
                     /codon_start=1
                     /product="DNA-binding protein SMUBP-2"
                     /protein_id="NP_033238.2"
                     /db_xref="CCDS:CCDS29393.1"
                     /db_xref="GeneID:20589"
                     /db_xref="MGI:MGI:99954"
                     /translation="MASSTVESFVAQQLQLLELERDAEVEERRSWQEHSSLRELQSRG
                     VCLLKLQVSSQRTGLYGQRLVTFEPRKFGPAVVLPSNSFTSGDIVGLYDTNENSQLAT
                     GVLTRITQKSVTVAFDESHDLQLNLDRENTYRLLKLANDVTYKRLKKALMTLKKYHSG
                     PASSLIDILLGSSTPSPAMEIPPLSFYNTTLDLSQKEAVSFALAQKELAIIHGPPGTG
                     KTTTVVEIILQAVKQGLKVLCCAPSNIAVDNLVERLALCKKRILRLGHPARLLESVQH
                     HSLDAVLARSDNAQIVADIRRDIDQVFGKNKKTQDKREKGNFRSEIKLLRKELKEREE
                     AAIVQSLTAADVVLATNTGASSDGPLKLLPEDYFDVVVVDECAQALEASCWIPLLKAP
                     KCILAGDHRQLPPTTVSHRAALAGLSRSLMERLAEKHGAGVVRMLTVQYRMHQAIMCW
                     ASEAMYHGQLTSHPSVAGHLLKDLPGVTDTEETRVPLLLIDTAGCGLLELEEEDSQSK
                     GNPGEVRLVTLHIQALVDAGVQAGDIAVIAPYNLQVDLLRQSLSNKHPELEIKSVDGF
                     QGREKEAVLLTFVRSNRKGEVGFLAEDRRINVAVTRARRHVAVICDSHTVNNHAFLKT
                     LVDYFTEHGEVRTAFEYLDDIVPENYTHEGSQGHSRVPKPKCPSTSIRKPASDQESGQ
                     ETRAAPRHGRRKPSEKPPGSHVQSQHSSSANGSDRTGGPDRTEHFRATIEEFVASKES
                     QLEFPTSLSSHDRLRVHQLAEEFGLRHDSTGEGKARHITVSRRSPASSGSVAPQPSSP
                     PSPAQAEPEPRAEEPVTVVQAHCPVQLDLKALHLERLQRQQSSQAQTAKGQPGGDSRP
                     QKASQKKKKKEPKGPVMALPCEEDFDALVSAVVKADNTCSFSKCSASTTTLGQFCMHC
                     SHRYCLSHHLPEIHGCGEKARAHARQRISREGVLYAGSGTKDRALDPAKRAQLQRRLD
                     KKLGELSSQRTSRKKEKERGT"
     exon            311..480
                     /gene="Ighmbp2"
                     /gene_synonym="AEP; Catf1; nmd; RIPE3b1; sma; Smbp-2;
                     Smbp2; Smubp2"
                     /inference="alignment:Splign:2.1.0"
     exon            481..670
                     /gene="Ighmbp2"
                     /gene_synonym="AEP; Catf1; nmd; RIPE3b1; sma; Smbp-2;
                     Smbp2; Smubp2"
                     /inference="alignment:Splign:2.1.0"
     exon            671..768
                     /gene="Ighmbp2"
                     /gene_synonym="AEP; Catf1; nmd; RIPE3b1; sma; Smbp-2;
                     Smbp2; Smubp2"
                     /inference="alignment:Splign:2.1.0"
     exon            769..932
                     /gene="Ighmbp2"
                     /gene_synonym="AEP; Catf1; nmd; RIPE3b1; sma; Smbp-2;
                     Smbp2; Smubp2"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1133
                     /gene="Ighmbp2"
                     /gene_synonym="AEP; Catf1; nmd; RIPE3b1; sma; Smbp-2;
                     Smbp2; Smubp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1281
                     /gene="Ighmbp2"
                     /gene_synonym="AEP; Catf1; nmd; RIPE3b1; sma; Smbp-2;
                     Smbp2; Smubp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1456
                     /gene="Ighmbp2"
                     /gene_synonym="AEP; Catf1; nmd; RIPE3b1; sma; Smbp-2;
                     Smbp2; Smubp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1639
                     /gene="Ighmbp2"
                     /gene_synonym="AEP; Catf1; nmd; RIPE3b1; sma; Smbp-2;
                     Smbp2; Smubp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1758
                     /gene="Ighmbp2"
                     /gene_synonym="AEP; Catf1; nmd; RIPE3b1; sma; Smbp-2;
                     Smbp2; Smubp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1853
                     /gene="Ighmbp2"
                     /gene_synonym="AEP; Catf1; nmd; RIPE3b1; sma; Smbp-2;
                     Smbp2; Smubp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..1977
                     /gene="Ighmbp2"
                     /gene_synonym="AEP; Catf1; nmd; RIPE3b1; sma; Smbp-2;
                     Smbp2; Smubp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1978..2832
                     /gene="Ighmbp2"
                     /gene_synonym="AEP; Catf1; nmd; RIPE3b1; sma; Smbp-2;
                     Smbp2; Smubp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2833..3002
                     /gene="Ighmbp2"
                     /gene_synonym="AEP; Catf1; nmd; RIPE3b1; sma; Smbp-2;
                     Smbp2; Smubp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3003..5562
                     /gene="Ighmbp2"
                     /gene_synonym="AEP; Catf1; nmd; RIPE3b1; sma; Smbp-2;
                     Smbp2; Smubp2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3693..3698
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ighmbp2"
                     /gene_synonym="AEP; Catf1; nmd; RIPE3b1; sma; Smbp-2;
                     Smbp2; Smubp2"
                     /note="hexamer: ATTAAA"
     polyA_site      3714
                     /gene="Ighmbp2"
                     /gene_synonym="AEP; Catf1; nmd; RIPE3b1; sma; Smbp-2;
                     Smbp2; Smubp2"
                     /note="major polyA site"
     regulatory      4164..4169
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ighmbp2"
                     /gene_synonym="AEP; Catf1; nmd; RIPE3b1; sma; Smbp-2;
                     Smbp2; Smubp2"
                     /note="hexamer: ATTAAA"
     polyA_site      4185
                     /gene="Ighmbp2"
                     /gene_synonym="AEP; Catf1; nmd; RIPE3b1; sma; Smbp-2;
                     Smbp2; Smubp2"
ORIGIN      
        1 cagtagggaa cacctggagc agggaaacag ggatcctact gcaatcactg gcttggcggg
       61 gaacgcagga aacggaccgg ccgggaatcc gcgccctggc tgggagcgca gggccttttg
      121 cggattctgg tccagtgggg aacacggtcc gactggaact cgggtcccac aggactaaac
      181 tggccgagca ggaagcatca gtcaggggct gcatcgcgga gcagatggcc tcgtccaccg
      241 tggagagttt cgtggcccag cagctacagc tgctggagct ggagcgggac gccgaggtgg
      301 aggagcgcag gtcctggcag gaacacagtt ctctgagaga gcttcagagc cgaggggtgt
      361 gcttgctgaa gcttcaggta tccagccagc gcacagggct gtatgggcag cggctggtca
      421 cctttgagcc caggaagttt ggacctgcag tggtgcttcc tagcaacagc ttcacctctg
      481 gtgatattgt gggtctgtat gatactaatg aaaacagtca actggccact ggggtcctga
      541 cccgaatcac ccaaaaatca gtcacagtgg cttttgatga gtcccatgat ctccagctga
      601 acctggacag agagaatacc tacagactgc tgaagcttgc caacgatgtc acctacaaac
      661 gcctgaaaaa agcactgatg acactgaaga agtaccactc tgggccagca tcctccctca
      721 tagacatcct gttgggcagc tccaccccaa gtcctgccat ggaaataccc ccactctctt
      781 tctacaacac aactctggac ctttcccaga aagaagctgt gtcctttgca ctggcccaga
      841 aagaacttgc catcatccat gggcctcctg gcactgggaa aaccacaact gtggtggaaa
      901 taatccttca agctgtgaag caaggcttaa aggtcctgtg ctgtgctccc tccaacatcg
      961 ctgtggacaa cctggtggag cgtctggctc tgtgcaagaa gcggattctg cgcctgggtc
     1021 accccgcccg cctcctggag tccgttcagc accactcact ggatgcagtg ctagcacgca
     1081 gtgacaacgc ccagattgtt gctgacatca gaagggacat agaccaggtc tttggcaaga
     1141 acaaaaagac gcaggataag agagagaaag gtaattttcg aagtgaaatt aagctgctaa
     1201 ggaaggaact gaaggagagg gaagaagcag ccatagttca gagcctcact gcggcagatg
     1261 tggttctagc caccaacaca ggtgcatcgt ctgatggccc tctgaagctg ctgcctgagg
     1321 actactttga tgtggtggtg gtggacgaat gtgcccaggc cctagaagcc agctgctgga
     1381 tccccctgct gaaggcccca aagtgcatcc tagctgggga ccacagacag ctgccaccca
     1441 ccaccgtctc tcacagggcg gcactggctg ggctgtcccg cagcctgatg gagcgtctgg
     1501 cagagaagca tggtgctggt gtggtgagga tgctgacggt acagtaccga atgcaccagg
     1561 ccatcatgtg ctgggcctcg gaggccatgt accacgggca gcttacttcc catccctctg
     1621 tggcaggaca cctcctgaag gacctcccag gcgtgactga cacagaggag acacgtgtcc
     1681 cgctgctgct catagacacc gctggctgtg ggcttctgga gctggaggag gaggacagcc
     1741 agtccaaggg aaatccgggc gaagttcgcc tcgtcacttt gcacatccag gctctggtgg
     1801 atgctggggt ccaggcaggt gacattgccg tcatcgcacc ctacaacctt caggtggatc
     1861 tgctcagaca gagcctctcc aacaagcacc ctgagctgga gattaagtct gttgatggct
     1921 ttcaaggccg agagaaagag gctgtgctcc tgacctttgt caggtccaat aggaaaggtg
     1981 aagttggttt tctggctgag gacaggcgga ttaatgttgc tgttacccgt gctcggcggc
     2041 acgtggcagt catctgtgat tcccacactg tcaacaacca tgcttttttg aagaccttgg
     2101 tggattattt cacagagcat ggggaggtac gcacagcctt tgaatacctg gatgacatcg
     2161 tccctgagaa ctacacccat gagggttccc agggccacag ccgtgtcccc aaacccaagt
     2221 gccccagcac ctccatcagg aagcctgcca gtgatcagga gagtggccag gagaccagag
     2281 cagcccctag acatggccgc aggaagccaa gcgagaagcc cccgggctct cacgtccagt
     2341 cccagcacag ctccagtgca aatggctctg acagaactgg aggcccagac cggacagagc
     2401 actttagggc tacgattgag gagtttgtgg ctagcaagga gtcccagttg gagtttccca
     2461 catccctgag ttcccatgac aggctgcgag tccaccagtt agctgaggag ttcgggctga
     2521 ggcacgacag caccggggag gggaaggctc ggcacatcac agtgagcagg aggagccctg
     2581 ccagctctgg cagtgtagcc ccacagcctt cctcaccgcc cagccctgca caggctgagc
     2641 ctgagcctcg ggcagaggag cccgtcaccg tcgtgcaggc acattgccct gtacagctgg
     2701 atctgaaggc actgcatctg gagaggctgc agcggcagca aagctcccag gctcagacag
     2761 ccaagggtca gccaggtggg gactcgaggc cacagaaggc ttcacagaag aaaaagaaaa
     2821 aagaaccaaa aggtccagtt atggctctgc cctgtgagga ggacttcgac gccctggtgt
     2881 ctgctgtggt gaaggctgac aacacctgta gcttctccaa gtgctcggcc agcaccacca
     2941 ctctgggcca gttctgcatg cactgtagcc accgctactg cctcagccac catctgcctg
     3001 aaatccacgg ctgtggagaa aaggctcgtg cccatgcccg ccagaggatt agccgggaag
     3061 gagtgctgta tgcaggcagt gggaccaagg acagggccct ggacccggcc aagagggccc
     3121 agctgcagag gaggctggac aagaagctgg gcgagctcag cagccagagg acaagcagga
     3181 agaaggagaa ggagaggggg acatgaagcc acaccctcag ggagggctgt gtgggacaga
     3241 ggcagcaggt ggggacacgg tcctacactg gccatttctc tgcttgagct agtgtgcccc
     3301 tagtcctccc atggcaaggg tgctgtttgt gaggagatgc gcctagttac catcagagta
     3361 actgccttgc ctggccaggc cccattgatg ctttgagtgc cttgcatggc cagctagcca
     3421 tggccaccgt catcctgtct tctgcagtga cacagtgggc atggattgtg tggtctaggg
     3481 atgcgggaat ggctgtacgg gctcctagtc tgtaatggcc tggcctctgc tgcttggtga
     3541 ctggtgggaa gtagtccttc cagggcccca tacactgctc accctcagag actgcaccct
     3601 cgccagcact ctgtacctgt tgctcatggg aactttgaca gatgcaattt agcctcaggc
     3661 tcttgttcca aaataatata aattatttgc aaattaaagt gtacacacag tggatatttg
     3721 cttgtgttgg aggtgagcat tctttccttc tggcccagat gtcaccctgt acatgctgtg
     3781 actgggtagt ggtagcacct ccccagggca tccaatcgtg atgacagcct ggcatcatgg
     3841 acaggcatgg gagcagatgt gggcacttga ggaaagacac tggctcttgt tgcactggag
     3901 gctagtgacc actctgcccg ccttctagaa acccctctgt agaagaaaag gaagccaaag
     3961 agaaacaaat aaggctgcag gttgacctgg tgatattatc ctggagtctc tggatccagc
     4021 cacgcttcat ctccaactca tcctttccag cattctttag aattaagtcc ttttttttgg
     4081 ctgaacaaag tccacgttgg gtttctgtca cttgctgcca aagattcttt gctgatccag
     4141 ttgtgcctgc agctgtatat cttattaaag catgtttttg tttgaggggg gaggtgtgca
     4201 tacttggaga ggtcagcatg tgtgtgggag tcaagccgcc agcagccatc aggcctctcc
     4261 ttccatggtg tggtcccagg aatcactcgg gtcttcaggc tcggtggcag tacctgctac
     4321 atctggcttt tctacgtggg tgctggggat ctgaactcgg gttctcctgt ttgaatggca
     4381 agtggtttgc ctactcagct gtttccccag cccagcacat ctgctcttgc acagggtctg
     4441 cactgccctt acacagggtc tgcgtcctgg catggagatt gtgctgaacc agagtccctg
     4501 gccactgggg agagacgagg tctcggattg ccactgggag cagctcccat gtgtggtcca
     4561 aagcacagtg gaagattgac cttgccattc ctggaagtga gcatgtgtgg tttgggcccc
     4621 tgcacacggg tcttcacgcc tgtagtgtgc ctttgggtcc cacaagccct gtcctggatg
     4681 ttccccaccc tgactgttgc ttcgttaaaa tgctggattc caagtttgtg tttcccatcc
     4741 cagagaactc tcattaggaa aatgtgtctg attgcttgaa aaatgtctta tggcctccct
     4801 cagacagcat gctctacagt gtgcctccct cagataccat gctctacagt gtgcctccct
     4861 cagacaccat gctctatagt gtgccttcct cagataccat gctcaagcct tcacaggacc
     4921 aagggcctct cctcccattg atgtccaaca aggtcatcct ctacttcatg tgtggctgga
     4981 gtgtttgttc cctccaagtg tactctttgg ttcatggttt agttcctggg aaatctgggg
     5041 gtagtgttca tactgttgtt cctcctatag ggttgcaaac cacttcagct tctttggtcc
     5101 cctctcaaac tcctccattg gggactttgt gctcagtcta atggttgggg gcaagcatct
     5161 acctctgtat ttgtcaggca ccgatagaac ctttcaggag actgttatat cagactccca
     5221 tcatcaagta cttgttggca tccacaatag tgtctgggtt tggtaactat atgagatgga
     5281 tgcccaggtc tctggatggc ctttccttca gtctctactc cacattttgt ctctgtgtct
     5341 cctccaatgg gtttgtgttc ccccttctaa gaaggactga agtatccaca ctttggtctt
     5401 ccttcttctt aagcttcatg ggtgtgtggt gtgacttcag ggccaatatc tactgatcag
     5461 agagcgcata cggtgtgtgt tctttgtgat tgggttacct cactcagcat gatattttct
     5521 agttccatct gtttgcctaa gaatttaata aattcattga tt
//
